This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (... See more...

Aliases for IRF5 Gene

Aliases for IRF5 Gene

  • Interferon Regulatory Factor 5 2 3 4 5
  • SLEB10 3
  • IRF-5 4
  • IRF5 5

External Ids for IRF5 Gene

Previous GeneCards Identifiers for IRF5 Gene

  • GC07P127056
  • GC07P128118
  • GC07P128131
  • GC07P128171
  • GC07P128365
  • GC07P128577
  • GC07P122939

Summaries for IRF5 Gene

Entrez Gene Summary for IRF5 Gene

  • This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

GeneCards Summary for IRF5 Gene

IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel Disease 14. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is IRF6.

UniProtKB/Swiss-Prot Summary for IRF5 Gene

  • Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity).

Gene Wiki entry for IRF5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRF5 Gene

Genomics for IRF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IRF5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRF5

Top Transcription factor binding sites by QIAGEN in the IRF5 gene promoter:
  • AP-1
  • p53

Genomic Locations for IRF5 Gene

Latest Assembly
chr7:128,937,032-128,950,038
(GRCh38/hg38)
Size:
13,007 bases
Orientation:
Plus strand

Previous Assembly
chr7:128,577,086-128,590,092
(GRCh37/hg19 by Entrez Gene)
Size:
13,007 bases
Orientation:
Plus strand

chr7:128,577,666-128,590,089
(GRCh37/hg19 by Ensembl)
Size:
12,424 bases
Orientation:
Plus strand

Genomic View for IRF5 Gene

Genes around IRF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF5 Gene

Proteins for IRF5 Gene

  • Protein details for IRF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13568-IRF5_HUMAN
    Recommended name:
    Interferon regulatory factor 5
    Protein Accession:
    Q13568
    Secondary Accessions:
    • A4D1J8
    • A8DUA8
    • A8DUA9
    • E7EQ16
    • E7EW54
    • Q1A7B4
    • Q64GA9
    • Q64GB1
    • Q64GB2
    • Q6RCM8
    • Q9BQF0

    Protein attributes for IRF5 Gene

    Size:
    498 amino acids
    Molecular mass:
    56044 Da
    Quaternary structure:
    • Homodimer, when phosphorylated (PubMed:25326418, PubMed:18836453). Interacts with TASL (via pLxIS motif); interaction takes place downstream of TLR7, TLR8 or TLR9, leading to its activation (PubMed:32433612). Interacts with MYD88 and TRAF6 (By similarity).

    Three dimensional structures from OCA and Proteopedia for IRF5 Gene

    Alternative splice isoforms for IRF5 Gene

neXtProt entry for IRF5 Gene

Post-translational modifications for IRF5 Gene

  • Phosphorylation of serine and threonine residues by IKBKB in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/EP300 and initiation of transcription.
  • 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.
  • Ubiquitination at Lys411 and Lys412
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for IRF5

No data available for DME Specific Peptides for IRF5 Gene

Domains & Families for IRF5 Gene

Gene Families for IRF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for IRF5 Gene

GenScript: Design optimal peptide antigens:
  • Interferon regulatory factor 5 (A4D1J8_HUMAN)
  • Interferon regulatory factor 5 (IRF5_HUMAN)
  • Interferon regulatory factor 5 variant 9 (Q64GA8_HUMAN)
  • Interferon regulatory factor 5 variant 8 (Q64GA9_HUMAN)
  • Interferon regulatory factor 5 variant 7 (Q64GB0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13568

UniProtKB/Swiss-Prot:

IRF5_HUMAN :
  • Belongs to the IRF family.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF5: view

Function for IRF5 Gene

Molecular function for IRF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
Maintained as a monomer in an autoinhibited state (PubMed:25326418, PubMed:18836453, PubMed:22412986). Phosphorylation and activation follow the following steps: innate adapter protein TASL recruits IRF5, thereby licensing IRF5 for phosphorylation by IKBKB (PubMed:32433612). Phosphorylated IRF5 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25326418, PubMed:32433612).
GENATLAS Biochemistry:
interferon regulatory factor 5,56kDa

Phenotypes From GWAS Catalog for IRF5 Gene

Gene Ontology (GO) - Molecular Function for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 12600985
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with IRF5: view
genes like me logo Genes that share phenotypes with IRF5: view

Human Phenotype Ontology for IRF5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRF5 Gene

MGI Knock Outs for IRF5:
  • Irf5 Irf5<tm1Ttg>
  • Irf5 Irf5<tm1e(EUCOMM)Wtsi>

miRNA for IRF5 Gene

miRTarBase miRNAs that target IRF5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF5

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IRF5 Gene

Localization for IRF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF5 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269 PubMed:12138184, ECO:0000269 PubMed:15556946, ECO:0000269 PubMed:15695821, ECO:0000269 PubMed:22412986, ECO:0000269 PubMed:25326418}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF5 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
mitochondrion 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA,IDA 22412986
GO:0005737 cytoplasm IEA,IDA 22412986
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IRF5 Gene

Pathways & Interactions for IRF5 Gene

genes like me logo Genes that share pathways with IRF5: view

Pathways by source for IRF5 Gene

SIGNOR curated interactions for IRF5 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006954 inflammatory response IEA --
GO:0019221 cytokine-mediated signaling pathway IDA 25326418
genes like me logo Genes that share ontologies with IRF5: view

Drugs & Compounds for IRF5 Gene

(1) Drugs for IRF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IRF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF5: view

Transcripts for IRF5 Gene

mRNA/cDNA for IRF5 Gene

7 REFSEQ mRNAs :
52 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF5

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for IRF5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - -

Relevant External Links for IRF5 Gene

GeneLoc Exon Structure for
IRF5

Expression for IRF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRF5 Gene

mRNA differential expression in normal tissues according to GTEx for IRF5 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for IRF5 Gene

This gene is overexpressed in Monocytes (25.1), Blymphocyte (18.8), and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRF5 Gene



Protein tissue co-expression partners for IRF5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRF5

SOURCE GeneReport for Unigene cluster for IRF5 Gene:

Hs.521181

Evidence on tissue expression from TISSUES for IRF5 Gene

  • Kidney(4.5)
  • Spleen(3)
  • Lymph node(2.9)
  • Blood(2.8)
  • Bone marrow(2.7)
  • Nervous system(2.6)
  • Skin(2.4)
  • Intestine(2.4)
  • Lung(2.2)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF5 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • salivary gland
  • skull
  • tongue
  • tooth
Thorax:
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • biliary tract
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with IRF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRF5 Gene

Orthologs for IRF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IRF5 29 30
  • 99.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IRF5 29 30
  • 90.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IRF5 29 30
  • 86.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Irf5 29
  • 86.02 (n)
Mouse
(Mus musculus)
Mammalia Irf5 29 16 30
  • 85.22 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IRF5 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IRF5 30
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IRF5 29 30
  • 65.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 24 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii irf5 30
  • 52 (a)
OneToOne
Species where no ortholog for IRF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IRF5 Gene

ENSEMBL:
Gene Tree for IRF5 (if available)
TreeFam:
Gene Tree for IRF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IRF5: view image
Alliance of Genome Resources:
Additional Orthologs for IRF5

Paralogs for IRF5 Gene

Paralogs for IRF5 Gene

(17) SIMAP similar genes for IRF5 Gene using alignment to 13 proteins:

  • IRF5_HUMAN
  • C9J7M2_HUMAN
  • C9JAU6_HUMAN
  • C9JB67_HUMAN
  • C9JYP7_HUMAN
  • F8WDH6_HUMAN
  • I6YQ35_HUMAN
  • I6Z0J2_HUMAN
  • I6ZKX6_HUMAN
  • I6ZU14_HUMAN
  • I6ZY36_HUMAN
  • Q64GA8_HUMAN
  • Q64GB0_HUMAN

Pseudogenes.org Pseudogenes for IRF5 Gene

genes like me logo Genes that share paralogs with IRF5: view

Variants for IRF5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRF5 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs10954213 Risk Factor: Systemic lupus erythematosus 10 128,949,373(+) G/A
NM_001098629.3(IRF5):c.*555G>A
THREE_PRIME_UTR
rs138098174 Likely Benign: not provided 128,945,952(+) C/T
NM_001098629.3(IRF5):c.303C>T (p.Arg101=)
SYNONYMOUS
rs139688977 Likely Benign: not provided 128,946,003(+) C/T
NM_001098629.3(IRF5):c.354C>T (p.Tyr118=)
SYNONYMOUS
rs145965576 Likely Benign: not provided 128,948,777(+) G/A
NM_001098629.3(IRF5):c.1504G>A (p.Gly502Ser)
MISSENSE
rs146462268 Benign: not provided 128,945,898(+) G/A
NM_001098629.3(IRF5):c.249G>A (p.Pro83=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IRF5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IRF5 Gene

Variant ID Type Subtype PubMed ID
esv22837 CNV gain 19812545
esv2670312 CNV deletion 23128226
esv2735137 CNV deletion 23290073
nsv608415 CNV loss 21841781
nsv831125 CNV loss 17160897

Variation tolerance for IRF5 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.63; 96.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRF5 Gene

Human Gene Mutation Database (HGMD)
IRF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF5
Leiden Open Variation Database (LOVD)
IRF5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF5 Gene

Disorders for IRF5 Gene

MalaCards: The human disease database

(25) MalaCards diseases for IRF5 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
systemic lupus erythematosus 10
  • systemic lupus erythematosus, susceptibility to, 10
inflammatory bowel disease 14
  • ibd14
rheumatoid arthritis
  • ra
diffuse cutaneous systemic sclerosis
  • dcssc
limited scleroderma
  • limited cutaneous systemic sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search IRF5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IRF5_HUMAN
  • Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17881657}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
  • Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:15657875}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17599733}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for IRF5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IRF5: view

No data available for Genatlas for IRF5 Gene

Publications for IRF5 Gene

  1. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. (PMID: 17599733) Sigurdsson S … Rönnblom L (Arthritis and rheumatism 2007) 3 4 22 40 72
  2. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. (PMID: 17881657) Dideberg V … Syvänen AC (Human molecular genetics 2007) 3 4 22 40 72
  3. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. (PMID: 16642019) Graham RR … Alarcón-Riquelme ME (Nature genetics 2006) 3 4 22 40 72
  4. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PMID: 15657875) Sigurdsson S … Syvänen AC (American journal of human genetics 2005) 3 4 22 40 72
  5. Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. (PMID: 18063667) Sigurdsson S … Syvänen AC (Human molecular genetics 2008) 3 22 40 72

Products for IRF5 Gene

Sources for IRF5 Gene