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Aliases for IRF5 Gene

Aliases for IRF5 Gene

  • Interferon Regulatory Factor 5 2 3 3 5
  • SLEB10 3
  • IRF-5 4

External Ids for IRF5 Gene

Previous GeneCards Identifiers for IRF5 Gene

  • GC07P127056
  • GC07P128118
  • GC07P128131
  • GC07P128171
  • GC07P128365
  • GC07P128577
  • GC07P122939

Summaries for IRF5 Gene

Entrez Gene Summary for IRF5 Gene

  • This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

GeneCards Summary for IRF5 Gene

IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel Disease 14. Among its related pathways are Toll-like Receptor Signaling Pathway and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is IRF6.

UniProtKB/Swiss-Prot for IRF5 Gene

  • Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.

Gene Wiki entry for IRF5 Gene

Additional gene information for IRF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF5 Gene

Genomics for IRF5 Gene

GeneHancer (GH) Regulatory Elements for IRF5 Gene

Promoters and enhancers for IRF5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J128936 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 684.9 +2.0 1974 5.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A IRF4 GLIS2 ZNF207 ZNF143 ATF7 IRF5 GC07P128994 GC07P128987 GC07P128989 GC07P128999 KCP ENSG00000242162 FLNC FLNC-AS1 ATP6V1F
GH07J128937 Enhancer 1 ENCODE dbSUPER 650.7 -1.2 -1210 0.2 ELF3 FOXA2 ARID4B ZBTB40 THRB ZSCAN9 RARA YY1 CREM THAP11 GC07P128994 GC07P128999 GC07P128987 IRF5 KCP ENSG00000242162 FLNC ATP6V1F FLNC-AS1 TSPAN33
GH07J128932 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 51.1 -3.2 -3172 3.3 HDGF PKNOX1 STAT5A BATF KLF5 IRF4 ZNF335 ZNF143 ATF7 ETV6 IRF5 ATP6V1F KCP ENSG00000242162 FLNC FLNC-AS1 TSPAN33 TPI1P2 TNPO3 LOC392787
GH07J128960 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 39.5 +25.0 24950 3.3 PKNOX1 RB1 EBF1 BATF RELA CTBP1 NFATC1 FOS IKZF2 RUNX3 IRF5 TNPO3 TPI1P2 ENSG00000242162 ATP6V1F TSPAN33 ENSG00000275106 RN7SL306P
GH07J129053 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +117.2 117193 2.9 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TNPO3 TPI1P2 GC07P129056 ENSG00000243679 ENSG00000242588 ENSG00000243302 ENSG00000230715 NRF1 RPS10P15 ENSG00000229413
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRF5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRF5 gene promoter:
  • AP-1
  • p53

Genomic Locations for IRF5 Gene

Genomic Locations for IRF5 Gene
12,431 bases
Plus strand
12,424 bases
Plus strand

Genomic View for IRF5 Gene

Genes around IRF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF5 Gene

Proteins for IRF5 Gene

  • Protein details for IRF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon regulatory factor 5
    Protein Accession:
    Secondary Accessions:
    • A4D1J8
    • A8DUA8
    • A8DUA9
    • E7EQ16
    • E7EW54
    • Q1A7B4
    • Q64GA9
    • Q64GB1
    • Q64GB2
    • Q6RCM8
    • Q9BQF0

    Protein attributes for IRF5 Gene

    498 amino acids
    Molecular mass:
    56044 Da
    Quaternary structure:
    • Homodimer, when phosphorylated.

    Three dimensional structures from OCA and Proteopedia for IRF5 Gene

    Alternative splice isoforms for IRF5 Gene

neXtProt entry for IRF5 Gene

Post-translational modifications for IRF5 Gene

  • Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.
  • Lys-63-linked polyubiquitination by TRAF6 is required for activation.
  • Ubiquitination at Lys412 and Lys411
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IRF5 Gene

Domains & Families for IRF5 Gene

Gene Families for IRF5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IRF family.
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF5: view

Function for IRF5 Gene

Molecular function for IRF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.
GENATLAS Biochemistry:
interferon regulatory factor 5,56kDa

Phenotypes From GWAS Catalog for IRF5 Gene

Gene Ontology (GO) - Molecular Function for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18836453
genes like me logo Genes that share ontologies with IRF5: view
genes like me logo Genes that share phenotypes with IRF5: view

Human Phenotype Ontology for IRF5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRF5 Gene

MGI Knock Outs for IRF5:
  • Irf5 Irf5<tm1Ttg>
  • Irf5 Irf5<tm1e(EUCOMM)Wtsi>

Animal Model Products

miRNA for IRF5 Gene

miRTarBase miRNAs that target IRF5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IRF5 Gene

Localization for IRF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF5 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF5 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
extracellular 2
peroxisome 2
endosome 1

Gene Ontology (GO) - Cellular Components for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22412986
GO:0005737 cytoplasm IDA 22412986
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IRF5 Gene

Pathways & Interactions for IRF5 Gene

genes like me logo Genes that share pathways with IRF5: view

Pathways by source for IRF5 Gene

SIGNOR curated interactions for IRF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with IRF5: view

Drugs & Compounds for IRF5 Gene

(1) Drugs for IRF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IRF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF5: view

Transcripts for IRF5 Gene

Unigene Clusters for IRF5 Gene

Interferon regulatory factor 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - -

Relevant External Links for IRF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRF5 Gene

mRNA differential expression in normal tissues according to GTEx for IRF5 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for IRF5 Gene

This gene is overexpressed in Monocytes (25.1), Blymphocyte (18.8), and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRF5 Gene

Protein tissue co-expression partners for IRF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRF5 Gene:


SOURCE GeneReport for Unigene cluster for IRF5 Gene:


Evidence on tissue expression from TISSUES for IRF5 Gene

  • Kidney(4.3)
  • Spleen(2.6)
  • Blood(2.5)
  • Lymph node(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF5 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • salivary gland
  • skull
  • tongue
  • tooth
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • biliary tract
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with IRF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRF5 Gene

Orthologs for IRF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRF5 34 33
  • 99.74 (n)
(Canis familiaris)
Mammalia IRF5 34 33
  • 90.71 (n)
(Bos Taurus)
Mammalia IRF5 34 33
  • 86.91 (n)
(Rattus norvegicus)
Mammalia Irf5 33
  • 86.02 (n)
(Mus musculus)
Mammalia Irf5 16 34 33
  • 85.22 (n)
(Ornithorhynchus anatinus)
Mammalia IRF5 34
  • 79 (a)
(Monodelphis domestica)
Mammalia IRF5 34
  • 55 (a)
(Gallus gallus)
Aves IRF5 34 33
  • 65.05 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
(Danio rerio)
Actinopterygii irf5 34
  • 52 (a)
Species where no ortholog for IRF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF5 Gene

Gene Tree for IRF5 (if available)
Gene Tree for IRF5 (if available)
Evolutionary constrained regions (ECRs) for IRF5: view image

Paralogs for IRF5 Gene

Paralogs for IRF5 Gene

(17) SIMAP similar genes for IRF5 Gene using alignment to 13 proteins:

  • C9J7M2_HUMAN
  • C9JB67_HUMAN
  • I6YQ35_HUMAN
  • I6Z0J2_HUMAN
  • I6ZU14_HUMAN
  • I6ZY36_HUMAN
  • Q64GA8_HUMAN
  • Q64GB0_HUMAN Pseudogenes for IRF5 Gene

genes like me logo Genes that share paralogs with IRF5: view

Variants for IRF5 Gene

Sequence variations from dbSNP and Humsavar for IRF5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs10954213 risk-factor, Systemic lupus erythematosus 10 128,949,373(+) G/A 3_prime_UTR_variant
rs2004640 association, Systemic lupus erythematosus 10, Rheumatoid arthritis 128,938,247(+) T/G genic_upstream_transcript_variant, intron_variant, splice_donor_variant
rs2070197 risk-factor, Systemic lupus erythematosus, association wit 10 128,948,946(+) T/C 3_prime_UTR_variant
rs973851559 association, Systemic lupus erythematosus 10, Rheumatoid arthritis 128,938,247(+) T/GG genic_upstream_transcript_variant, intron_variant, splice_donor_variant
rs1000047647 -- 128,937,927(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IRF5 Gene

Variant ID Type Subtype PubMed ID
esv22837 CNV gain 19812545
esv2670312 CNV deletion 23128226
esv2735137 CNV deletion 23290073
nsv608415 CNV loss 21841781
nsv831125 CNV loss 17160897

Variation tolerance for IRF5 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.63; 96.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRF5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF5 Gene

Disorders for IRF5 Gene

MalaCards: The human disease database

(15) MalaCards diseases for IRF5 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus 10
  • systemic lupus erythematosus, susceptibility to, 10
inflammatory bowel disease 14
  • ibd14
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
limited scleroderma
  • crest syndrome
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards
Search IRF5 in MalaCards View complete list of genes associated with diseases


  • Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17881657}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:15657875}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17599733}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for IRF5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IRF5: view

No data available for Genatlas for IRF5 Gene

Publications for IRF5 Gene

  1. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. (PMID: 17599733) Sigurdsson S … Rönnblom L (Arthritis and rheumatism 2007) 3 4 22 44 58
  2. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. (PMID: 17881657) Dideberg V … Syvänen AC (Human molecular genetics 2007) 3 4 22 44 58
  3. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. (PMID: 16642019) Graham RR … Alarcón-Riquelme ME (Nature genetics 2006) 3 4 22 44 58
  4. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PMID: 15657875) Sigurdsson S … Syvänen AC (American journal of human genetics 2005) 3 4 22 44 58
  5. Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus. (PMID: 20112383) Feng D … Barnes BJ (Arthritis and rheumatism 2010) 3 22 44 58

Products for IRF5 Gene

Sources for IRF5 Gene

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