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This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternati... See more...
Aliases for IRF3 Gene
External Ids for IRF3 Gene
- HGNC: 6118
- Entrez Gene: 3661
- Ensembl: ENSG00000126456
- OMIM: 603734
- UniProtKB: Q14653
Previous GeneCards Identifiers for IRF3 Gene
- GC19M050821
- GC19M050530
- GC19M054838
- GC19M054854
- GC19M050162
- GC19M046539
Summaries for IRF3 Gene
-
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for IRF3 Gene
IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Viral Infectious Disease. Among its related pathways are Apoptosis Modulation and Signaling and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is IRF6.
UniProtKB/Swiss-Prot Summary for IRF3 Gene
-
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591).
Additional gene information for IRF3 Gene
- HGNC(6118)
- Entrez Gene(3661)
- Ensembl(ENSG00000126456)
- OMIM(603734)
- UniProtKB(Q14653)
- Open Targets Platform(ENSG00000126456)
- Monarch Initiative
- Search for IRF3 at DataMed
- Search for IRF3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRF3 Gene
Genomics for IRF3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IRF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IRF3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRF3
- Top Transcription factor binding sites by QIAGEN in the IRF3 gene promoter:
-
- AP-1
- ATF-2
- NF-kappaB
- NF-kappaB1
- p300
- p53
- STAT1
Genomic Locations for IRF3 Gene
Genomic Locations for IRF3 Gene
- chr19:49,659,569-49,665,875
- (GRCh38/hg38)
- Size:
- 6,307 bases
- Orientation:
- Minus strand
- chr19:50,162,826-50,169,132
- (GRCh37/hg19)
- Size:
- 6,307 bases
- Orientation:
- Minus strand
Genomic View for IRF3 Gene
Genes around IRF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
IRF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IRF3 Gene
Proteins for IRF3 Gene
-
Protein details for IRF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14653-IRF3_HUMAN
- Recommended name:
- Interferon regulatory factor 3
- Protein Accession:
- Q14653
- A8K7L2
- B2RAZ3
- Q5FBY1
- Q5FBY2
- Q5FBY4
- Q7Z5G6
Protein attributes for IRF3 Gene
- Size:
- 427 amino acids
- Molecular mass:
- 47219 Da
- Quaternary structure:
-
- Monomer (PubMed:16846591, PubMed:16979567, PubMed:20049431). Homodimer; phosphorylation-induced (PubMed:22394562, PubMed:25636800, PubMed:26347139). Interacts (when phosphorylated) with CREBBP (PubMed:16154084, PubMed:27302953). Interacts with MAVS (via phosphorylated pLxIS motif) (PubMed:16153868, PubMed:25636800, PubMed:27302953). Interacts with TICAM1 (via phosphorylated pLxIS motif) (PubMed:12471095, PubMed:14739303, PubMed:25636800, PubMed:27302953). Interacts with STING1 (via phosphorylated pLxIS motif) (PubMed:22394562, PubMed:25636800, PubMed:27302953). Interacts with IKBKE and TBK1 (PubMed:16281057, PubMed:23478265, PubMed:25636800). Interacts with TICAM2 (PubMed:14517278). Interacts with RBCK1 (PubMed:18711448). Interacts with HERC5 (PubMed:20308324). Interacts with DDX3X (phosphorylated at 'Ser-102'); the interaction allows the phosphorylation and activation of IRF3 by IKBKE (PubMed:23478265, PubMed:27980081). Interacts with TRIM21 and ULK1, in the presence of TRIM21; this interaction leads to IRF3 degradation by autophagy (PubMed:18641315, PubMed:26347139). Interacts with RIOK3; RIOK3 probably mediates the interaction of TBK1 with IRF3 (PubMed:19557502). Interacts with ILRUN; the interaction inhibits IRF3 binding to its DNA consensus sequence (PubMed:29802199). Interacts with LYAR; this interaction impairs IRF3 DNA-binding activity (PubMed:31413131). Interacts with TRAF3 (PubMed:27980081).
- (Microbial infection) Interacts with rotavirus A NSP1 (via pLxIS motif); this interaction leads to the proteasome-dependent degradation of IRF3.
- (Microbial infection) Interacts with herpes virus 8/HHV-8 protein VIRF1 (PubMed:11314014).
- (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction is involved in the suppression of IRF3 expression and phosphorylation by the virus.
Three dimensional structures from OCA and Proteopedia for IRF3 Gene
Protein Expression for IRF3 Gene
Post-translational modifications for IRF3 Gene
- Constitutively phosphorylated on many Ser/Thr residues (PubMed:22394562, PubMed:23478265, PubMed:23746807). Activated following phosphorylation by TBK1 and IKBKE (PubMed:23478265, PubMed:23746807, PubMed:25636800). Innate adapter protein MAVS, STING1 or TICAM1 are first activated by viral RNA, cytosolic DNA, and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE (PubMed:25636800). These kinases then phosphorylate the adapter proteins on the pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25636800).
- (Microbial infection) Phosphorylation and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
- Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.
- ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.
-
Ubiquitination at Lys70
- NX_Q14653 (NX_Q14653-1)
- Modification sites at PhosphoSitePlus
Other Protein References for IRF3 Gene
- ENSEMBL proteins:
-
- ENSP00000310127
- ENSP00000470431
- ENSP00000468911
- ENSP00000471896
- ENSP00000366344
- ENSP00000469113
- ENSP00000470436
- ENSP00000471358
- ENSP00000472601
- ENSP00000472700
- ENSP00000470512
- ENSP00000470069
- ENSP00000472582
- ENSP00000473128
- ENSP00000472223
- ENSP00000469067
- ENSP00000471517
- ENSP00000471402
- ENSP00000473176
- ENSP00000470140
- ENSP00000473232
- ENSP00000470905
- ENSP00000366339
- ENSP00000400378
- REFSEQ proteins:
-
- XP_006723260.1
- XP_006723261.1
- XP_006723263.1
- XP_006723264.1
- XP_016882255.1
- XP_016882256.1
- XP_024307260.1
- XP_024307261.1
- XP_024307262.1
- XP_024307263.1
- XP_024307264.1
- XP_024307265.1
- XP_024307266.1
- NP_001184051.1
- NP_001184052.1
- NP_001184053.1
- NP_001184054.1
- NP_001184055.1
- NP_001184056.1
- NP_001184057.1
- NP_001562.1
Antibody Products
- LifeSpan BioSciences IRF3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for IRF3
- AM05643PU-N
- AM05643PU-S
- AP01444PU-N
- AP06528PU-N
- AP07295PU-N
- AP07507PU-N
- AP08862PU-N
- AP55779PU-N
- AP55779PU-S
- CF500465
- CF500476
- CF500520
- CF809316
- CF809334
- CF809425
- TA306189
- TA306190
- TA306191
- TA311893
- TA311896
- TA311897
- TA325570
- TA325571
- TA327312
- TA349361
- TA500465
- TA500465S
- TA500476
- TA500476S
- TA500520
- TA500520S
- TA809316
- TA809316S
- TA809334
- TA809334S
- TA809425
- TA809425S
- Novus Biologicals Antibodies for IRF3
-
Abcam antibodies for IRF3
- Invitrogen Antibodies for IRF3 (AFLGC-IRF3)
- antibodies-online: Show 83 available IRF3 Antibodies ranked by validation data
- Compare Top IRF3 Antibodies
-
Recommended
- 244 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 4 BCA Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 93 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 BCA Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for IRF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for IRF3
- Sino Biological Antibodies for IRF3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for IRF3
- Origene Custom Protein Services for IRF3
- ProSpec Recombinant Proteins for IRF3
-
Abcam proteins for IRF3
Assay Products
-
Signalway ELISA kits for IRF3
-
Abcam assays for IRF3
No data available for DME Specific Peptides for IRF3 Gene
Domains & Families for IRF3 Gene
Gene Families for IRF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for IRF3 Gene
- InterPro:
- Blocks:
-
- Interferon regulatory factor
- ProtoNet:
Suggested Antigen Peptide Sequences for IRF3 Gene
- GenScript: Design optimal peptide antigens:
-
- Interferon regulatory factor 3a (E2GIM5_HUMAN)
- Interferon regulatory factor 3b (E2GIM6_HUMAN)
- Interferon regulatory factor 3f (E2GIM7_HUMAN)
- Interferon regulatory factor 3d (E2GIM8_HUMAN)
- Interferon regulatory factor 3e (E2GIM9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14653- Family:
-
- Belongs to the IRF family.
Function for IRF3 Gene
Molecular function for IRF3 Gene
- UniProtKB/Swiss-Prot Function:
- Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- In the absence of viral infection, maintained as a monomer in an autoinhibited state (PubMed:16846591, PubMed:16979567, PubMed:20049431). Phosphorylation by TBK1 and IKBKE disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes (PubMed:25636800). Phosphorylation and activation follow the following steps: innate adapter protein MAVS, STING1 or TICAM1 are first activated by viral RNA, cytosolic DNA and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE (PubMed:25636800). These kinases then phosphorylate the adapter proteins on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25636800, PubMed:27302953).
- GENATLAS Biochemistry:
- interferon regulatory factor 3
Phenotypes From GWAS Catalog for IRF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 17560375 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 17560375 |
| GO:0003677 | DNA binding | NAS | 12062447 |
Phenotypes for IRF3 Gene
- MGI mutant phenotypes for IRF3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IRF3:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased G1 DNA content
- Increased shRNA abundance
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased interferon-beta reporter expression
- Downregulation of RLR pathway after Sendai virus (SeV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Big cells
- Increased Dengue infection
- Increased infection with West Nile virus (WNV)
- Increased West Nile virus (WNV) infection
Animal Models for IRF3 Gene
- MGI Knock Outs for IRF3:
-
- Irf3 Irf3<tm1Ttg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IRF3 - Select products 50% OFF >
- * IRF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IRF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRF3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRF3
- Browse OriGene Inhibitory RNA Products For IRF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF3
Clone Products
- Applied Biological Materials (abm): Clones for IRF3 - Select products 50% OFF >
- * IRF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206641
- MR206641
- MR206641L3
- MR206641L4
- RC209951
- RC209951L1
- RC209951L2
- RC209951L3
- RC209951L4
- RC230792
- RC230792L3
- RC230792L4
- RC230836
- RC230836L3
- RC230836L4
- RC230998
- RC230998L3
- RC230998L4
- RC231144
- RC231144L3
- RC231144L4
- RC231203
- RC231203L3
- RC231203L4
- RC233320
- RC233629
- RG209951
- RG230792
- RG230836
- RG230998
- RG231144
- RG231203
- RG233320
- RG233629
- RR214920
- RR214920L3
- RR214920L4
- MR206641L3V
- MR206641L4V
- RC209951L1V
- RC209951L2V
- RC209951L3V
- RC209951L4V
- RC230792L3V
- RC230792L4V
- RC230836L3V
- RC230836L4V
- RC230998L3V
- RC230998L4V
- RC231144L3V
- RC231144L4V
- RC231203L3V
- RC231203L4V
- RR214920L3V
- RR214920L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IRF3
- Addgene plasmids for IRF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRF3
Cell Line Products
-
Horizon Cell Lines for IRF3
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IRF3 Gene
Localization for IRF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IRF3 Gene
- Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). {ECO:0000269 PubMed:10805757}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| mitochondrion | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 17079289 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IGI | 23729669 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for IRF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytosolic sensors of pathogen-associated DNA | ||
| 2 | Activated TLR4 signalling | ||
| 3 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 4 | Toll-like Receptor Signaling Pathway |
.37
.34
|
|
| 5 | Measles |
.35
|
.33
|
Pathways by source for IRF3 Gene
6 BioSystems pathways for IRF3 Gene
28 Reactome pathways for IRF3 Gene
1 PharmGKB pathway for IRF3 Gene
18 KEGG pathways for IRF3 Gene
1 GeneGo (Thomson Reuters) pathway for IRF3 Gene
- Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
2 R&D Systems pathways for IRF3 Gene
2 Qiagen pathways for IRF3 Gene
- TLR-TRIF Pathway
- Toll-Like Receptors Pathway
1 Cell Signaling Technology pathway for IRF3 Gene
2 GeneTex pathways for IRF3 Gene
Interacting Proteins for IRF3 Gene
Selected Interacting proteins:
Q14653-IRF3_HUMAN
ENSP00000471896
for IRF3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IRF3
SIGNOR curated interactions for IRF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0002376 | immune system process | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 8524823 |
| GO:0006915 | apoptotic process | TAS | 20049431 |
Transcripts for IRF3 Gene
mRNA/cDNA for IRF3 Gene
- 8 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309877 1691 nts (view in UCSC)
- ENST00000377135 1442 nts (view in UCSC)
- ENST00000377139 1595 nts (view in UCSC)
- ENST00000442265 315 nts (view in UCSC)
- ENST00000593337 633 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IRF3 - Select products 50% OFF >
- * IRF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IRF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRF3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRF3
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF3
Clone Products
- Applied Biological Materials (abm): Clones for IRF3 - Select products 50% OFF >
- * IRF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206641
- MR206641
- MR206641L3
- MR206641L4
- RC209951
- RC209951L1
- RC209951L2
- RC209951L3
- RC209951L4
- RC230792
- RC230792L3
- RC230792L4
- RC230836
- RC230836L3
- RC230836L4
- RC230998
- RC230998L3
- RC230998L4
- RC231144
- RC231144L3
- RC231144L4
- RC231203
- RC231203L3
- RC231203L4
- RC233320
- RC233629
- RG209951
- RG230792
- RG230836
- RG230998
- RG231144
- RG231203
- RG233320
- RG233629
- RR214920
- RR214920L3
- RR214920L4
- MR206641L3V
- MR206641L4V
- RC209951L1V
- RC209951L2V
- RC209951L3V
- RC209951L4V
- RC230792L3V
- RC230792L4V
- RC230836L3V
- RC230836L4V
- RC230998L3V
- RC230998L4V
- RC231144L3V
- RC231144L4V
- RC231203L3V
- RC231203L4V
- RR214920L3V
- RR214920L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IRF3
- Addgene plasmids for IRF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRF3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for IRF3 Gene
- GeneLoc Exon Structure for
- IRF3
Expression for IRF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (12.4) and Blymphocyte (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRF3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRF3
SOURCE GeneReport for Unigene cluster for IRF3 Gene:
Hs.75254mRNA Expression by UniProt/SwissProt for IRF3 Gene:
Q14653-IRF3_HUMAN
Tissue specificity:
Expressed constitutively in a variety of tissues.
Evidence on tissue expression from TISSUES for IRF3 Gene
- Spleen(4.7)
- Kidney(4.7)
- Liver(4.6)
- Eye(4.4)
- Nervous system(4.2)
- Lymph node(3.7)
- Lung(3.5)
- Blood(3.5)
- Skin(3.2)
- Intestine(3.2)
- Bone marrow(3.1)
- Heart(3.1)
- Muscle(3)
- Stomach(2.6)
- Pancreas(2.5)
- Thyroid gland(2.3)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for IRF3
-
OriGene qPCR primer pairs and template standards for IRF3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF3 Gene
Orthologs for IRF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | IRF3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Irf3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Irf3 30 17 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | IRF3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IRF3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-7306 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100493780 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | irf3 30 31 |
|
OneToOne |
- Species where no ortholog for IRF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IRF3 Gene
- ENSEMBL:
- Gene Tree for IRF3 (if available)
- TreeFam:
- Gene Tree for IRF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IRF3: view image
Paralogs for IRF3 Gene
(7) SIMAP similar genes for IRF3 Gene using alignment to 21 proteins:
- IRF3_HUMAN
- E2GIM5_HUMAN
- E2GIM6_HUMAN
- E2GIM7_HUMAN
- E2GIM8_HUMAN
- E2GIM9_HUMAN
- M0QX56_HUMAN
- M0QXC8_HUMAN
- M0QYT9_HUMAN
- M0QYX3_HUMAN
- M0QZB7_HUMAN
- M0QZB8_HUMAN
- M0R007_HUMAN
- M0R0R8_HUMAN
- M0R0X9_HUMAN
- M0R205_HUMAN
- M0R3C2_HUMAN
- M0R3E9_HUMAN
- M0R3H7_HUMAN
- Q71U93_HUMAN
- Q96GL3_HUMAN
Variants for IRF3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRF3 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 778853 | Benign: not provided | 49,663,393(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 781472 | Benign: not provided | 49,662,594(-) | C/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| rs1057519880 | Likely Pathogenic: Squamous cell carcinoma of the skin; Malignant melanoma of skin | 49,665,875(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| rs143769046 | Likely Benign: Herpes simplex encephalitis, susceptibility to, 7; not provided | 49,662,101(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
| rs750526659 | Risk Factor: Herpes simplex encephalitis, susceptibility to, 7. Encephalopathy, acute, infection-induced, Herpes-specific, 7 (IIAE7) [MIM:616532] | 49,662,076(-) | C/Tp.Arg285Gln | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1160655 | CNV | deletion | 26073780 |
| nsv469715 | CNV | gain+loss | 16826518 |
| nsv470150 | CNV | gain | 18288195 |
| nsv475216 | CNV | novel sequence insertion | 20440878 |
| nsv579908 | CNV | loss | 21841781 |
| nsv579909 | CNV | loss | 21841781 |
| nsv817854 | CNV | gain | 17921354 |
| nsv828578 | CNV | loss | 20364138 |
| nsv833864 | CNV | gain | 17160897 |
| nsv833865 | CNV | gain+loss | 17160897 |
| nsv953600 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.42;
81.88% of all genes are more intolerant (likely to be disease-causing)