This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The prote... See more...

Aliases for IRF3 Gene

Aliases for IRF3 Gene

  • Interferon Regulatory Factor 3 2 3 4 5
  • IIAE7 3
  • IRF-3 4
  • IRF3 5

External Ids for IRF3 Gene

Previous GeneCards Identifiers for IRF3 Gene

  • GC19M050821
  • GC19M050530
  • GC19M054838
  • GC19M054854
  • GC19M050162
  • GC19M046539

Summaries for IRF3 Gene

Entrez Gene Summary for IRF3 Gene

  • This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]

GeneCards Summary for IRF3 Gene

IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and Herpes Simplex Encephalitis. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding. An important paralog of this gene is IRF5.

UniProtKB/Swiss-Prot Summary for IRF3 Gene

  • Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812).

Gene Wiki entry for IRF3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRF3 Gene

Genomics for IRF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IRF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRF3

Top Transcription factor binding sites by QIAGEN in the IRF3 gene promoter:
  • AP-1
  • ATF-2
  • NF-kappaB
  • NF-kappaB1
  • p300
  • p53
  • STAT1

Genomic Locations for IRF3 Gene

Latest Assembly
chr19:49,659,569-49,665,875
(GRCh38/hg38)
Size:
6,307 bases
Orientation:
Minus strand

Previous Assembly
chr19:50,162,829-50,169,114
(GRCh37/hg19 by Entrez Gene)
Size:
6,286 bases
Orientation:
Minus strand

chr19:50,162,826-50,169,132
(GRCh37/hg19 by Ensembl)
Size:
6,307 bases
Orientation:
Minus strand

Genomic View for IRF3 Gene

Genes around IRF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF3 Gene

Proteins for IRF3 Gene

  • Protein details for IRF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14653-IRF3_HUMAN
    Recommended name:
    Interferon regulatory factor 3
    Protein Accession:
    Q14653
    Secondary Accessions:
    • A8K7L2
    • B2RAZ3
    • Q5FBY1
    • Q5FBY2
    • Q5FBY4
    • Q7Z5G6

    Protein attributes for IRF3 Gene

    Size:
    427 amino acids
    Molecular mass:
    47219 Da
    Quaternary structure:
    • Monomer (PubMed:16846591, PubMed:16979567, PubMed:20049431). Homodimer; phosphorylation-induced (PubMed:22394562, PubMed:25636800, PubMed:26347139). Interacts (when phosphorylated) with CREBBP (PubMed:16154084, PubMed:27302953). Interacts with MAVS (via phosphorylated pLxIS motif) (PubMed:16153868, PubMed:25636800, PubMed:27302953). Interacts with TICAM1 (via phosphorylated pLxIS motif) (PubMed:12471095, PubMed:14739303, PubMed:25636800, PubMed:27302953). Interacts with STING1 (via phosphorylated pLxIS motif) (PubMed:22394562, PubMed:28331227, PubMed:25636800, PubMed:27302953). Interacts with IKBKE and TBK1 (PubMed:16281057, PubMed:23478265, PubMed:25636800). Interacts with TICAM2 (PubMed:14517278). Interacts with RBCK1 (PubMed:18711448). Interacts with HERC5 (PubMed:20308324). Interacts with DDX3X (phosphorylated at 'Ser-102'); the interaction allows the phosphorylation and activation of IRF3 by IKBKE (PubMed:23478265, PubMed:27980081). Interacts with TRIM21 and ULK1, in the presence of TRIM21; this interaction leads to IRF3 degradation by autophagy (PubMed:18641315, PubMed:26347139). Interacts with RIOK3; RIOK3 probably mediates the interaction of TBK1 with IRF3 (PubMed:19557502). Interacts with ILRUN; the interaction inhibits IRF3 binding to its DNA consensus sequence (PubMed:29802199). Interacts with LYAR; this interaction impairs IRF3 DNA-binding activity (PubMed:31413131). Interacts with TRAF3 (PubMed:27980081). Interacts with ZDHHC11; ZDHHC11 recruits IRF3 to STING1 upon DNA virus infection and thereby promotes IRF3 activation (PubMed:28331227). Interacts with HSP90AA1; the interaction mediates IRF3 association with TOMM70 (PubMed:20628368, PubMed:25609812). Interacts with BCL2; the interaction decreases upon Sendai virus infection (PubMed:25609812). Interacts with BAX; the interaction is direct, increases upon Sendai virus infection and mediates the formation of the apoptosis complex TOMM70:HSP90AA1:IRF3:BAX (PubMed:25609812).
    • (Microbial infection) Interacts with rotavirus A NSP1 (via pLxIS motif); this interaction leads to the proteasome-dependent degradation of IRF3.
    • (Microbial infection) Interacts with herpes virus 8/HHV-8 protein VIRF1 (PubMed:11314014).
    • (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction is involved in the suppression of IRF3 expression and phosphorylation by the virus.
    • (Microbial infection) Interacts with herpes virus 2/HHV-2 protein ICP27; this interaction inhibits IRF3 phosphorylation and nuclear translocation.

    Three dimensional structures from OCA and Proteopedia for IRF3 Gene

    Alternative splice isoforms for IRF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF3 Gene

Post-translational modifications for IRF3 Gene

  • Constitutively phosphorylated on many Ser/Thr residues (PubMed:22394562, PubMed:23478265, PubMed:23746807). Activated following phosphorylation by TBK1 and IKBKE (PubMed:23478265, PubMed:23746807, PubMed:25636800). Innate adapter protein MAVS, STING1 or TICAM1 are first activated by viral RNA, cytosolic DNA, and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE (PubMed:25636800). These kinases then phosphorylate the adapter proteins on the pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25636800).
  • (Microbial infection) Phosphorylation and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
  • Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.
  • ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.
  • (Microbial infection) ISGylated. ISGylation is cleaved and removed by SARS-COV-2 nsp3 which attenuates type I interferon responses.
  • Ubiquitination at Lys70
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for IRF3

No data available for DME Specific Peptides for IRF3 Gene

Domains & Families for IRF3 Gene

Gene Families for IRF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for IRF3 Gene

GenScript: Design optimal peptide antigens:
  • Interferon regulatory factor 3a (E2GIM5_HUMAN)
  • Interferon regulatory factor 3b (E2GIM6_HUMAN)
  • Interferon regulatory factor 3f (E2GIM7_HUMAN)
  • Interferon regulatory factor 3d (E2GIM8_HUMAN)
  • Interferon regulatory factor 3e (E2GIM9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14653

UniProtKB/Swiss-Prot:

IRF3_HUMAN :
  • Belongs to the IRF family.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF3: view

Function for IRF3 Gene

Molecular function for IRF3 Gene

UniProtKB/Swiss-Prot Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812).
UniProtKB/Swiss-Prot EnzymeRegulation:
In the absence of viral infection, maintained as a monomer in an autoinhibited state (PubMed:16846591, PubMed:16979567, PubMed:20049431). Phosphorylation by TBK1 and IKBKE disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes (PubMed:25636800). Phosphorylation and activation follow the following steps: innate adapter protein MAVS, STING1 or TICAM1 are first activated by viral RNA, cytosolic DNA and bacterial lipopolysaccharide (LPS), respectively, leading to activation of the kinases TBK1 and IKBKE (PubMed:25636800). These kinases then phosphorylate the adapter proteins on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25636800, PubMed:27302953).
GENATLAS Biochemistry:
interferon regulatory factor 3

Phenotypes From GWAS Catalog for IRF3 Gene

Gene Ontology (GO) - Molecular Function for IRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA,IMP 17560375
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IMP 17560375
genes like me logo Genes that share ontologies with IRF3: view
genes like me logo Genes that share phenotypes with IRF3: view

Human Phenotype Ontology for IRF3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRF3 Gene

MGI Knock Outs for IRF3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF3

Clone products for research

  • Addgene plasmids for IRF3

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IRF3 Gene

Localization for IRF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF3 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). {ECO:0000269 PubMed:10805757, ECO:0000269 PubMed:25609812}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
mitochondrion 3
endoplasmic reticulum 3
endosome 3
cytoskeleton 2
peroxisome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA,IDA 17079289
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IGI 23729669
GO:0005739 mitochondrion IDA 25609812
genes like me logo Genes that share ontologies with IRF3: view

Pathways & Interactions for IRF3 Gene

genes like me logo Genes that share pathways with IRF3: view

Pathways by source for IRF3 Gene

2 Qiagen pathways for IRF3 Gene
  • TLR-TRIF Pathway
  • Toll-Like Receptors Pathway
1 Cell Signaling Technology pathway for IRF3 Gene
2 GeneTex pathways for IRF3 Gene

SIGNOR curated interactions for IRF3 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0002376 immune system process IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006915 apoptotic process TAS 20049431
genes like me logo Genes that share ontologies with IRF3: view

Drugs & Compounds for IRF3 Gene

(6) Drugs for IRF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for IRF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF3: view

Transcripts for IRF3 Gene

mRNA/cDNA for IRF3 Gene

8 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF3

Clone products for research

  • Addgene plasmids for IRF3

Alternative Splicing Database (ASD) splice patterns (SP) for IRF3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for IRF3 Gene

GeneLoc Exon Structure for
IRF3

Expression for IRF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IRF3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4) and Blymphocyte (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRF3 Gene



Protein tissue co-expression partners for IRF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRF3

SOURCE GeneReport for Unigene cluster for IRF3 Gene:

Hs.75254

mRNA Expression by UniProt/SwissProt for IRF3 Gene:

Q14653-IRF3_HUMAN
Tissue specificity: Expressed constitutively in a variety of tissues.

Evidence on tissue expression from TISSUES for IRF3 Gene

  • Spleen(4.7)
  • Kidney(4.6)
  • Liver(4.6)
  • Eye(4.4)
  • Nervous system(4.1)
  • Lymph node(3.5)
  • Lung(3.3)
  • Blood(3.2)
  • Skin(3.1)
  • Intestine(3)
  • Bone marrow(2.9)
  • Heart(2.9)
  • Muscle(2.8)
  • Stomach(2.5)
  • Pancreas(2.4)
  • Thyroid gland(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with IRF3: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF3 Gene

Orthologs for IRF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia IRF3 29 30
  • 82.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Irf3 29
  • 77.46 (n)
Mouse
(Mus musculus)
Mammalia Irf3 29 16 30
  • 76.98 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia IRF3 30
  • 62 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia IRF3 30
  • 58 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7306 30
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493780 29
  • 48.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii irf3 29 30
  • 44.89 (n)
OneToOne
Species where no ortholog for IRF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IRF3 Gene

ENSEMBL:
Gene Tree for IRF3 (if available)
TreeFam:
Gene Tree for IRF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IRF3: view image
Alliance of Genome Resources:
Additional Orthologs for IRF3

Paralogs for IRF3 Gene

Paralogs for IRF3 Gene

(7) SIMAP similar genes for IRF3 Gene using alignment to 21 proteins:

  • IRF3_HUMAN
  • E2GIM5_HUMAN
  • E2GIM6_HUMAN
  • E2GIM7_HUMAN
  • E2GIM8_HUMAN
  • E2GIM9_HUMAN
  • M0QX56_HUMAN
  • M0QXC8_HUMAN
  • M0QYT9_HUMAN
  • M0QYX3_HUMAN
  • M0QZB7_HUMAN
  • M0QZB8_HUMAN
  • M0R007_HUMAN
  • M0R0R8_HUMAN
  • M0R0X9_HUMAN
  • M0R205_HUMAN
  • M0R3C2_HUMAN
  • M0R3E9_HUMAN
  • M0R3H7_HUMAN
  • Q71U93_HUMAN
  • Q96GL3_HUMAN
genes like me logo Genes that share paralogs with IRF3: view

Variants for IRF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRF3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs143769046 Likely Benign: Herpes simplex encephalitis, susceptibility to, 7; not provided 49,662,101(-) C/T
NM_001571.6(IRF3):c.829G>A (p.Ala277Thr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs74980832 Benign: not provided 49,662,594(-) C/G
NM_001571.6(IRF3):c.432G>C (p.Leu144=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs750526659 Risk Factor: Herpes simplex encephalitis, susceptibility to, 7. Encephalopathy, acute, infection-induced, Herpes-specific, 7 (IIAE7) [MIM:616532] 49,662,076(-) C/Tp.Arg285Gln
NM_001571.6(IRF3):c.854G>A (p.Arg285Gln)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs968457 Benign: not provided 49,663,393(-) C/Tp.Arg96Gln
NM_001571.6(IRF3):c.287G>A (p.Arg96Gln)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
rs1049486 -- p.Glu377Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IRF3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IRF3 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv475216 CNV novel sequence insertion 20440878
nsv579908 CNV loss 21841781
nsv579909 CNV loss 21841781
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for IRF3 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRF3 Gene

Human Gene Mutation Database (HGMD)
IRF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF3
Leiden Open Variation Database (LOVD)
IRF3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF3 Gene

Disorders for IRF3 Gene

MalaCards: The human disease database

(48) MalaCards diseases for IRF3 Gene - From: OMI, CVR, GTR, SWI, COP, and GCD