Aliases for IRF2BP1 Gene

Aliases for IRF2BP1 Gene

  • Interferon Regulatory Factor 2 Binding Protein 1 2 3 5
  • Probable RING-Type E3 Ubiquitin Transferase IRF2BP1 3 4
  • Interferon Regulatory Factor 2-Binding Protein 1 3 4
  • Probable E3 Ubiquitin-Protein Ligase IRF2BP1 3 4
  • IRF-2-Binding Protein 1 3 4
  • EC 2.3.2.27 4
  • IRF-2BP1 4

External Ids for IRF2BP1 Gene

Previous GeneCards Identifiers for IRF2BP1 Gene

  • GC19M051062
  • GC19M051078
  • GC19M046386
  • GC19M042820

Summaries for IRF2BP1 Gene

GeneCards Summary for IRF2BP1 Gene

IRF2BP1 (Interferon Regulatory Factor 2 Binding Protein 1) is a Protein Coding gene. Diseases associated with IRF2BP1 include Cecal Disease. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is IRF2BPL.

UniProtKB/Swiss-Prot Summary for IRF2BP1 Gene

  • Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

Additional gene information for IRF2BP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRF2BP1 Gene

Genomics for IRF2BP1 Gene

GeneHancer (GH) Regulatory Elements for IRF2BP1 Gene

Promoters and enhancers for IRF2BP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRF2BP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRF2BP1 gene promoter:
  • AP-2gamma
  • AREB6
  • Bach1
  • c-Ets-1
  • GATA-3
  • HEN1
  • Ik-2
  • Pax-6
  • SRF
  • SRF (504 AA)

Genomic Locations for IRF2BP1 Gene

Genomic Locations for IRF2BP1 Gene
chr19:45,883,607-45,886,170
(GRCh38/hg38)
Size:
2,564 bases
Orientation:
Minus strand
chr19:46,386,866-46,389,376
(GRCh37/hg19)
Size:
2,511 bases
Orientation:
Minus strand

Genomic View for IRF2BP1 Gene

Genes around IRF2BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF2BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF2BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2BP1 Gene

Proteins for IRF2BP1 Gene

  • Protein details for IRF2BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU81-I2BP1_HUMAN
    Recommended name:
    Interferon regulatory factor 2-binding protein 1
    Protein Accession:
    Q8IU81
    Secondary Accessions:
    • Q53EL7
    • Q6DC95
    • Q9BRZ9
    • Q9Y4P4

    Protein attributes for IRF2BP1 Gene

    Size:
    584 amino acids
    Molecular mass:
    61688 Da
    Quaternary structure:
    • Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2.

neXtProt entry for IRF2BP1 Gene

Post-translational modifications for IRF2BP1 Gene

  • Ubiquitination at Lys314 and Lys438
  • Modification sites at PhosphoSitePlus

Other Protein References for IRF2BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRF2BP1 Gene

Domains & Families for IRF2BP1 Gene

Gene Families for IRF2BP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IRF2BP1 Gene

Suggested Antigen Peptide Sequences for IRF2BP1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon regulatory factor 2-binding protein 1 (I2BP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IU81

UniProtKB/Swiss-Prot:

I2BP1_HUMAN :
  • Belongs to the IRF2BP family.
Family:
  • Belongs to the IRF2BP family.
genes like me logo Genes that share domains with IRF2BP1: view

Function for IRF2BP1 Gene

Molecular function for IRF2BP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for IRF2BP1 Gene

Phenotypes From GWAS Catalog for IRF2BP1 Gene

Gene Ontology (GO) - Molecular Function for IRF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003714 transcription corepressor activity IDA 18671972
GO:0005515 protein binding IPI 18671972
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with IRF2BP1: view
genes like me logo Genes that share phenotypes with IRF2BP1: view

Animal Model Products

CRISPR Products

miRNA for IRF2BP1 Gene

miRTarBase miRNAs that target IRF2BP1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRF2BP1 Gene

Localization for IRF2BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2BP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF2BP1 gene
Compartment Confidence
nucleus 5
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IRF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with IRF2BP1: view

Pathways & Interactions for IRF2BP1 Gene

PathCards logo

SuperPathways for IRF2BP1 Gene

No Data Available

SIGNOR curated interactions for IRF2BP1 Gene

Activates:

Gene Ontology (GO) - Biological Process for IRF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 18671972
GO:0000209 protein polyubiquitination IDA 18671972
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with IRF2BP1: view

No data available for Pathways by source for IRF2BP1 Gene

Drugs & Compounds for IRF2BP1 Gene

No Compound Related Data Available

Transcripts for IRF2BP1 Gene

mRNA/cDNA for IRF2BP1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2BP1 Gene

No ASD Table

Relevant External Links for IRF2BP1 Gene

GeneLoc Exon Structure for
IRF2BP1
ECgene alternative splicing isoforms for
IRF2BP1

Expression for IRF2BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRF2BP1 Gene

Protein differential expression in normal tissues from HIPED for IRF2BP1 Gene

This gene is overexpressed in Fetal testis (7.9), Peripheral blood mononuclear cells (7.4), Liver, secretome (7.0), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRF2BP1 Gene



Protein tissue co-expression partners for IRF2BP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRF2BP1 Gene:

IRF2BP1

SOURCE GeneReport for Unigene cluster for IRF2BP1 Gene:

Hs.515477

Evidence on tissue expression from TISSUES for IRF2BP1 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Liver(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with IRF2BP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF2BP1 Gene

Orthologs for IRF2BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRF2BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF2BP1 33 32
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IRF2BP1 33
  • 96 (a)
OneToOne
LOC523963 32
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia IRF2BP1 33 32
  • 91.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf2bp1 32
  • 87.79 (n)
mouse
(Mus musculus)
Mammalia Irf2bp1 17 33 32
  • 87.44 (n)
oppossum
(Monodelphis domestica)
Mammalia IRF2BP1 33
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF2BP1 33
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii irf2bp1 33 32
  • 63.02 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11138 33
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-260 33
  • 26 (a)
OneToMany
Species where no ortholog for IRF2BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IRF2BP1 Gene

ENSEMBL:
Gene Tree for IRF2BP1 (if available)
TreeFam:
Gene Tree for IRF2BP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IRF2BP1: view image

Paralogs for IRF2BP1 Gene

Paralogs for IRF2BP1 Gene

(1) SIMAP similar genes for IRF2BP1 Gene using alignment to 1 proteins:

  • I2BP1_HUMAN
genes like me logo Genes that share paralogs with IRF2BP1: view

Variants for IRF2BP1 Gene

Sequence variations from dbSNP and Humsavar for IRF2BP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000950546 -- 45,885,757(-) C/A coding_sequence_variant, synonymous_variant
rs1001068744 -- 45,883,719(-) T/C 3_prime_UTR_variant
rs1001378441 -- 45,887,519(-) A/G upstream_transcript_variant
rs1001849374 -- 45,887,827(-) C/T upstream_transcript_variant
rs1001952552 -- 45,883,310(-) C/A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IRF2BP1 Gene

Variant ID Type Subtype PubMed ID
nsv510770 CNV deletion 20534489

Variation tolerance for IRF2BP1 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRF2BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF2BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF2BP1 Gene

Disorders for IRF2BP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IRF2BP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cecal disease
  • disorder of cecum
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IRF2BP1

genes like me logo Genes that share disorders with IRF2BP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRF2BP1 Gene

Publications for IRF2BP1 Gene

  1. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PMID: 18671972) Kimura M (FEBS letters 2008) 3 4 23 56
  2. Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. (PMID: 12799427) Childs KS … Goodbourn S (Nucleic acids research 2003) 2 3 4 56
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  4. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. (PMID: 29540532) Zuzow N … Bennett EJ (Molecular biology of the cell 2018) 3 56
  5. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. (PMID: 29643511) Pao KC … Virdee S (Nature 2018) 3 56

Products for IRF2BP1 Gene

Sources for IRF2BP1 Gene