External Ids for IRF2 Gene
Previous GeneCards Identifiers for IRF2 Gene
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRF2 Gene
IRF2 (Interferon Regulatory Factor 2) is a Protein Coding gene. Diseases associated with IRF2 include Eczema Herpeticum and Mumps. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Type II interferon signaling (IFNG). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is IRF1.
UniProtKB/Swiss-Prot for IRF2 Gene
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.