IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided... See more...

Aliases for IRF2 Gene

Aliases for IRF2 Gene

  • Interferon Regulatory Factor 2 2 3 4 5
  • IRF-2 3 4

External Ids for IRF2 Gene

Previous GeneCards Identifiers for IRF2 Gene

  • GC04M186336
  • GC04M185988
  • GC04M186004
  • GC04M185684
  • GC04M185545
  • GC04M185308
  • GC04M181063

Summaries for IRF2 Gene

Entrez Gene Summary for IRF2 Gene

  • IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF2 Gene

IRF2 (Interferon Regulatory Factor 2) is a Protein Coding gene. Diseases associated with IRF2 include Eczema Herpeticum and Viral Infectious Disease. Among its related pathways are Dendritic Cells Developmental Lineage Pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is IRF1.

UniProtKB/Swiss-Prot Summary for IRF2 Gene

  • Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Gene Wiki entry for IRF2 Gene

Additional gene information for IRF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRF2 Gene

Genomics for IRF2 Gene

GeneHancer (GH) Regulatory Elements for IRF2 Gene

Promoters and enhancers for IRF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J184470 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 504.6 +0.6 599 6.7 FOXK2 ZBTB40 SIN3A NRF1 POLR2G NCOR1 PHF8 ZFX ZIC2 POLR2A IRF2 ENSG00000270426 ENSG00000271646 LINC02427-001 lnc-CASP3-7 CASP3 PRIMPOL ACSL1 LINC02427
GH04J185201 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500 -728.9 -728886 4.3 FOXK2 SIN3A POLR2G NCOR1 GTF2E2 PHF8 ZFX POLR2A ZBTB11 TCF7 CFAP97 RF00017-4477 SNX25 IRF2 PRIMPOL
GH04J184342 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.3 +128.1 128050 8.9 FOXK2 ZBTB40 ZNF217 EP300 POLR2G USF1 SP1 NCOR1 SIX5 KDM6A LINC02363 IRF2 ENSG00000251878 CASP3 PRIMPOL CFAP97 ACSL1 RF00017-4473
GH04J184381 Promoter/Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.7 +89.6 89552 7.3 EP300 SIN3A TCF12 POLR2G USF1 NCOR1 JUND FOS ZNF10 KDM6A IRF2 ENSG00000251878 LINC02362 RWDD4 ACSL1 RF00017-4474
GH04J184416 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +56.8 56813 3.2 SP1 JUND FOS EP300 RELA JUN BCL11A CTCF CBFB FOSL1 IRF2 CASP3 PRIMPOL ACSL1 RF00017-4474 LINC02362
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRF2

Top Transcription factor binding sites by QIAGEN in the IRF2 gene promoter:
  • ARP-1
  • CREB
  • deltaCREB
  • IRF-7A
  • STAT1
  • STAT3
  • STAT5A

Genomic Locations for IRF2 Gene

Genomic Locations for IRF2 Gene
chr4:184,387,713-184,474,580
(GRCh38/hg38)
Size:
86,868 bases
Orientation:
Minus strand
chr4:185,308,867-185,395,734
(GRCh37/hg19)
Size:
86,868 bases
Orientation:
Minus strand

Genomic View for IRF2 Gene

Genes around IRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2 Gene

Proteins for IRF2 Gene

  • Protein details for IRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14316-IRF2_HUMAN
    Recommended name:
    Interferon regulatory factor 2
    Protein Accession:
    P14316
    Secondary Accessions:
    • D6RCK5
    • H0Y8S3
    • Q6IAS7
    • Q96B99

    Protein attributes for IRF2 Gene

    Size:
    349 amino acids
    Molecular mass:
    39354 Da
    Quaternary structure:
    • Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity.
    Miscellaneous:
    • [Isoform 2]: Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression.

    Alternative splice isoforms for IRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF2 Gene

Post-translational modifications for IRF2 Gene

  • Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
  • The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IRF2 Gene

Domains & Families for IRF2 Gene

Gene Families for IRF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for IRF2 Gene

Suggested Antigen Peptide Sequences for IRF2 Gene

GenScript: Design optimal peptide antigens:
  • Interferon regulatory factor 2 (IRF2_HUMAN)
  • cDNA, FLJ93409, highly similar to Homo sapiens interferon regulatory factor 2 (IRF2), mRNA (Q6IAS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14316

UniProtKB/Swiss-Prot:

IRF2_HUMAN :
  • Belongs to the IRF family.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF2: view

Function for IRF2 Gene

Molecular function for IRF2 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
UniProtKB/Swiss-Prot Induction:
By viruses and IFN.
GENATLAS Biochemistry:
interferon regulatory factor 2,induced in IFN-stimulated cells,protooncogene,repressor of IRF1

Phenotypes From GWAS Catalog for IRF2 Gene

Gene Ontology (GO) - Molecular Function for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 9540062
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IMP 9540062
GO:0003677 DNA binding IEA,IDA 9540062
GO:0003700 DNA-binding transcription factor activity IMP,IEA 9540062
genes like me logo Genes that share ontologies with IRF2: view
genes like me logo Genes that share phenotypes with IRF2: view

Animal Models for IRF2 Gene

MGI Knock Outs for IRF2:

Animal Model Products

CRISPR Products

Transcription Factor Targets for IRF2 Gene

Selected GeneGlobe predicted Target genes for IRF2
Targeted motifs for IRF2 Gene
HOMER Transcription Factor Regulatory Elements motif IRF2
  • Consensus sequence: GAAASYGAAASY Submotif: canonical Cell Type: Erythroblas GEO ID: GSE36985

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF2

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for IRF2 Gene

Localization for IRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with IRF2: view

Pathways & Interactions for IRF2 Gene

genes like me logo Genes that share pathways with IRF2: view

Pathways by source for IRF2 Gene

2 BioSystems pathways for IRF2 Gene
1 GeneGo (Thomson Reuters) pathway for IRF2 Gene
  • Immune response IFN alpha/beta signaling pathway
1 R&D Systems pathway for IRF2 Gene
1 Cell Signaling Technology pathway for IRF2 Gene

SIGNOR curated interactions for IRF2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 7507207
GO:0002376 immune system process IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 9540062
GO:0007596 blood coagulation TAS --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with IRF2: view

Drugs & Compounds for IRF2 Gene

(4) Drugs for IRF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for IRF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF2: view

Transcripts for IRF2 Gene

mRNA/cDNA for IRF2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF2

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - -
SP11: - - -

Relevant External Links for IRF2 Gene

GeneLoc Exon Structure for
IRF2

Expression for IRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRF2 Gene

mRNA differential expression in normal tissues according to GTEx for IRF2 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for IRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Blymphocyte (23.5), and CD8 Tcells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRF2 Gene



Protein tissue co-expression partners for IRF2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRF2

SOURCE GeneReport for Unigene cluster for IRF2 Gene:

Hs.654566

mRNA Expression by UniProt/SwissProt for IRF2 Gene:

P14316-IRF2_HUMAN
Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria.

Evidence on tissue expression from TISSUES for IRF2 Gene

  • Blood(4.5)
  • Liver(4.4)
  • Skin(4.3)
  • Intestine(3.4)
  • Nervous system(2.6)
  • Spleen(2.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with IRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF2 Gene

Orthologs for IRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF2 31 30
  • 99.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IRF2 31 30
  • 92.26 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF2 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF2 31 30
  • 89.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Irf2 17 31 30
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Irf2 30
  • 88.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IRF2 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRF2 31 30
  • 79.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF2 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irf2 30
  • 65.79 (n)
Str.2206 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.32603 30
zebrafish
(Danio rerio)
Actinopterygii irf2 30
  • 76.4 (n)
IRF2 (2 of 2) 31
  • 56 (a)
OneToMany
irf2a 31
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.42 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
OneToMany
Species where no ortholog for IRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF2 Gene

ENSEMBL:
Gene Tree for IRF2 (if available)
TreeFam:
Gene Tree for IRF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IRF2: view image

Paralogs for IRF2 Gene

Paralogs for IRF2 Gene

genes like me logo Genes that share paralogs with IRF2: view

Variants for IRF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRF2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
708814 Benign: not provided 184,388,899(-) G/A SYNONYMOUS_VARIANT
785109 Benign: not provided 184,390,739(-) C/T SYNONYMOUS_VARIANT
rs1554014177 Uncertain Significance: not provided 184,419,566(-) TTC/T FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for IRF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IRF2 Gene

Variant ID Type Subtype PubMed ID
esv29408 CNV loss 19812545
nsv1026074 CNV gain 25217958
nsv1074249 CNV deletion 25765185
nsv515626 CNV loss 19592680
nsv528892 CNV loss 19592680
nsv830167 CNV gain 17160897

Variation tolerance for IRF2 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRF2 Gene

Human Gene Mutation Database (HGMD)
IRF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF2 Gene

Disorders for IRF2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IRF2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IRF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IRF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IRF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRF2 Gene

Publications for IRF2 Gene

  1. Regulation of IRF2 transcriptional activity by its sumoylation. (PMID: 18514056) Han KJ … Shu HB (Biochemical and biophysical research communications 2008) 3 4 23 54
  2. Evaluation of the IRF-2 gene as a candidate for PSORS3. (PMID: 14962090) Foerster J … te Meerman G (The Journal of investigative dermatology 2004) 3 23 41 54
  3. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. (PMID: 15226432) Oshima S … Watanabe M (Molecular and cellular biology 2004) 3 4 23 54
  4. Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. (PMID: 12799427) Childs KS … Goodbourn S (Nucleic acids research 2003) 3 4 23 54
  5. Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. (PMID: 11721886) Nishio Y … Arinami T (Journal of human genetics 2001) 3 23 41 54

Products for IRF2 Gene

Sources for IRF2 Gene