Aliases for IRF1 Gene
Aliases for IRF1 Gene
- Interferon Regulatory Factor 1 2 3 3 5
- IRF-1 3 4
- Interferon Regulatory Factor 1 Isoform D9,10+ 3
- Interferon Regulatory Factor 1 Isoform Delta4 3
- Interferon Regulatory Factor 1 Isoform Delta7 3
- Interferon Regulatory Factor 1 Isoform +I9 3
- Interferon Regulatory Factor 1 Isoform D78 3
- Interferon Regulatory Factor-1 2
- MAR 3
External Ids for IRF1 Gene
- HGNC: 6116
- Entrez Gene: 3659
- Ensembl: ENSG00000125347
- OMIM: 147575
- UniProtKB: P10914
Previous GeneCards Identifiers for IRF1 Gene
- GC05M131340
- GC05M132265
- GC05M131849
- GC05M131894
- GC05M131846
- GC05M127009
- GC05M131817
Summaries for IRF1 Gene
-
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
GeneCards Summary for IRF1 Gene
IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Gastric Cancer and Lung Cancer. Among its related pathways are Bacterial infections in CF airways and IL-1 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is IRF2.
UniProtKB/Swiss-Prot for IRF1 Gene
-
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
Additional gene information for IRF1 Gene
- Monarch Initiative
- Search for IRF1 at DataMed
- Search for IRF1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF1 Gene
Genomics for IRF1 Gene
GeneHancer (GH) Regulatory Elements for IRF1 Gene
Promoters and enhancers for IRF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IRF1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IRF1 gene promoter:
-
- STAT1
- GATA-1
- STAT1alpha
- STAT1beta
- C/EBPalpha
- IRF-7A
Regulatory Element Products
Genomic Locations for IRF1 Gene
Genomic Locations for IRF1 Gene
- chr5:132,481,609-132,490,798
- (GRCh38/hg38)
- Size:
- 9,190 bases
- Orientation:
- Minus strand
- chr5:131,817,301-131,826,490
- (GRCh37/hg19)
- Size:
- 9,190 bases
- Orientation:
- Minus strand
Genomic View for IRF1 Gene
Genes around IRF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by Entrez Gene
- 5q31.1 by HGNC
- 5q31.1 by Ensembl
IRF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IRF1 Gene
Proteins for IRF1 Gene
-
Protein details for IRF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10914-IRF1_HUMAN
- Recommended name:
- Interferon regulatory factor 1
- Protein Accession:
- P10914
- Q96GG7
Protein attributes for IRF1 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 36502 Da
- Quaternary structure:
-
- Monomer. Homodimer. Interacts with MYD88 and PIAS3 (By similarity). Interacts with EP300.
- Miscellaneous:
-
- Deletion or rearrangement of IRF1 are found in preleukemic myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML).
Protein Expression for IRF1 Gene
Post-translational modifications for IRF1 Gene
- Phosphorylated by CK2 and this positively regulates its activity.
- Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.
- Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.
- Ubiquitination at isoforms=299 and isoforms=50
- Modification sites at PhosphoSitePlus
Other Protein References for IRF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IRF1 (IRF1)
-
Custom Antibody ServicesOriGene Antibodies for IRF1
- Novus Biologicals Antibodies for IRF1
-
Abcam antibodies for IRF1
- Invitrogen Antibodies for IRF1 (AFLGC-IRF1)
- GeneTex IRF1 Antibody for IRF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IRF1
Protein Products
-
OriGene Purified Proteins for IRF1
- Search Origene for MassSpec and Protein Over-expression Lysates for IRF1
- Origene Custom Protein Services for IRF1
- ProSpec Recombinant Proteins for IRF1
- Search GeneTex for Proteins for IRF1
-
Abcam proteins for IRF1
Assay Products
No data available for DME Specific Peptides for IRF1 Gene
Domains & Families for IRF1 Gene
Gene Families for IRF1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for IRF1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IRF1 Gene
Graphical View of Domain Structure for InterPro Entry
P10914- Family:
-
- Belongs to the IRF family.
Function for IRF1 Gene
Molecular function for IRF1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by MYD88.
- UniProtKB/Swiss-Prot Induction:
- By viruses and interferon (IFN).
- GENATLAS Biochemistry:
- interferon regulatory factor 1,transcriptional activator for IFNA,IFNB and IFN-stimulated genes,a modulator of virus-induced signaling,antioncogene deleted in MDS,AML,differentiated gastric adenocarcinomas (see TSG5D),tumor suppressor transcription factor inducing apoptosis of tumorigenic cell lines
Phenotypes From GWAS Catalog for IRF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IMP,IDA | 15509808 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IMP | 15509808 |
| GO:0003677 | DNA binding | IEA,TAS | 11846971 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
Phenotypes for IRF1 Gene
- MGI mutant phenotypes for IRF1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for IRF1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IRF1
-
CRISPR Products
-
OriGene CRISPR knockouts for IRF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRF1
- genomics-online: gRNA clones - Search results for 119 available IRF1 gene related products
- Overview of 119 available IRF1 gene related products
- Applied Biological Materials CRISPR for IRF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRF1
- GenScript: Design CRISPR guide RNA sequences for IRF1
miRNA for IRF1 Gene
- miRTarBase miRNAs that target IRF1
-
- hsa-mir-383-5p (MIRT006535)
- hsa-mir-93-5p (MIRT027994)
- hsa-mir-296-3p (MIRT038441)
- hsa-mir-23a-3p (MIRT053354)
- hsa-mir-640 (MIRT637968)
- hsa-mir-378a-5p (MIRT637969)
- hsa-mir-6821-3p (MIRT637970)
- hsa-mir-6790-3p (MIRT637971)
- hsa-mir-4638-5p (MIRT637972)
- hsa-mir-1307-3p (MIRT637973)
- hsa-mir-3653-5p (MIRT637974)
- hsa-mir-3934-5p (MIRT637975)
- hsa-mir-764 (MIRT637976)
- hsa-mir-125a-3p (MIRT637977)
- hsa-mir-4671-3p (MIRT672602)
- hsa-mir-143-5p (MIRT672603)
- hsa-mir-142-3p (MIRT672604)
- hsa-mir-6073 (MIRT672605)
- hsa-mir-6499-3p (MIRT672606)
- hsa-mir-20b-3p (MIRT672607)
- hsa-mir-454-3p (MIRT672608)
- hsa-mir-3666 (MIRT672609)
- hsa-mir-4295 (MIRT672610)
- hsa-mir-301b-3p (MIRT672611)
- hsa-mir-301a-3p (MIRT672612)
- hsa-mir-130b-3p (MIRT672613)
- hsa-mir-130a-3p (MIRT672615)
- hsa-mir-7107-5p (MIRT677718)
- hsa-mir-1234-3p (MIRT677719)
- hsa-mir-193a-3p (MIRT727421)
- hsa-mir-193b-3p (MIRT727422)
- hsa-mir-502-5p (MIRT733577)
- gga-mir-23b-5p (MIRT734434)
Transcription Factor Targets for IRF1 Gene
Targeted motifs for IRF1 Gene
HOMER Transcription Factor Regulatory Elements motif IRF1
- Consensus sequence: GAAAGTGAAAGT Submotif: canonical Cell Type: PBMC GEO ID: GSE43036
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRF1
- Browse OriGene Inhibitory RNA Products For IRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF1
- genomics-online: shRNA clones - Search results for 119 available IRF1 gene related products
- Overview of 119 available IRF1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IRF1
- Addgene plasmids for IRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRF1
- Applied Biological Materials Clones for IRF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IRF1
No data available for Enzyme Numbers (IUBMB) for IRF1 Gene
Localization for IRF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IRF1 Gene
- Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 18035482 |
| GO:0005634 | nucleus | IEA,TAS | 11846971 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for IRF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Prolactin Signaling Pathway | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Immune response IFN alpha/beta signaling pathway | ||
| 4 | Interferon gamma signaling | ||
| 5 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
Pathways by source for IRF1 Gene
10 BioSystems pathways for IRF1 Gene
10 Reactome pathways for IRF1 Gene
5 KEGG pathways for IRF1 Gene
7 GeneGo (Thomson Reuters) pathways for IRF1 Gene
1 Qiagen pathway for IRF1 Gene
1 Cell Signaling Technology pathway for IRF1 Gene
Interacting Proteins for IRF1 Gene
Selected Interacting proteins:
P10914-IRF1_HUMAN
ENSP00000245414
for IRF1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IRF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002819 | regulation of adaptive immune response | TAS | 11846971 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 2475256 |
No data available for SIGNOR curated interactions for IRF1 Gene
Transcripts for IRF1 Gene
mRNA/cDNA for IRF1 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (351) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000245414 3579 bps (uc003kxa.3)
- ENST00000472045 5153 bps (uc063gux.1)
- ENST00000405885 2061 bps (uc063guy.1)
- ENST00000437654 832 bps (uc063gva.1)
- ENST00000459982 1231 bps (uc063gvb.1)
Unigene Clusters for IRF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IRF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRF1
- genomics-online: gRNA clones - Search results for 119 available IRF1 gene related products
- Overview of 119 available IRF1 gene related products
- Applied Biological Materials CRISPR for IRF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRF1
- GenScript: Design CRISPR guide RNA sequences for IRF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRF1
- Browse OriGene Inhibitory RNA Products For IRF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRF1
- genomics-online: shRNA clones - Search results for 119 available IRF1 gene related products
- Overview of 119 available IRF1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IRF1
- Addgene plasmids for IRF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRF1
- Applied Biological Materials Clones for IRF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for IRF1 Gene
mRNA differential expression in normal tissues according to GTEx for IRF1 Gene
This gene is overexpressed in Whole Blood (x14.2).
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRF1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IRF1 Gene:
IRF1SOURCE GeneReport for Unigene cluster for IRF1 Gene:
Hs.436061Evidence on tissue expression from TISSUES for IRF1 Gene
- Pancreas(4.5)
- Blood(3.4)
- Lung(3.3)
- Spleen(3.1)
- Bone marrow(2.8)
- Lymph node(2.8)
- Liver(2.7)
- Intestine(2.6)
- Nervous system(2.4)
- Kidney(2.2)
- Skin(2.2)
- Heart(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF1 Gene
Germ Layers:
- endoderm
Systems:
- digestive
- respiratory
Regions:
Thorax:
- lung
Abdomen:
- stomach
Primer Products
-
OriGene qPCR primer pairs for IRF1
-
OriGene qPCR primer pairs and template standards for IRF1
- genomics-online: primer clones - Search results for 119 available IRF1 gene related products
- Overview of 119 available IRF1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRF1 Gene
Orthologs for IRF1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IRF1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IRF1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IRF1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Irf1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Irf1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IRF1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IRF1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IRF1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | IRF1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | irf1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68691 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | irf1b 34 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IRF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IRF1 Gene
- ENSEMBL:
- Gene Tree for IRF1 (if available)
- TreeFam:
- Gene Tree for IRF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IRF1: view image
Paralogs for IRF1 Gene
(6) SIMAP similar genes for IRF1 Gene using alignment to 9 proteins:
- IRF1_HUMAN
- C9J9C5_HUMAN
- C9JD95_HUMAN
- F8WCM1_HUMAN
- Q5FBX3_HUMAN
- Q6FHN8_HUMAN
- R4GNI0_HUMAN
- V9P8K4_HUMAN
- V9P921_HUMAN
Variants for IRF1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121912469 | pathogenic, Neoplasm of stomach, Gastric cancer (GASC) [MIM:613659] | 132,489,457(-) | T/A | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs121912470 | pathogenic, Non-small cell lung cancer, Gastric cancer (GASC) [MIM:613659] | 132,489,448(-) | A/G | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs1000551311 | -- | 132,492,305(-) | A/C | upstream_transcript_variant | |
| rs1000601295 | -- | 132,491,419(-) | A/G | upstream_transcript_variant | |
| rs1001813535 | -- | 132,488,401(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3416328 | CNV | duplication | 20981092 |
| nsv1161299 | CNV | deletion | 26073780 |
Residual Variation Intolerance Score:
19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.16;
3.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IRF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF1 Gene
Disorders for IRF1 Gene
(12) MalaCards diseases for IRF1 Gene - From: HGMD, LncRNADisease, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric cancer |
|
|
| lung cancer |
|
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| fanconi anemia, complementation group c |
|
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| panencephalitis, subacute sclerosing |
|
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| venezuelan equine encephalitis |
|
|
Search IRF1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IRF1_HUMAN- Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:10395927, ECO:0000269 PubMed:9679752}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for IRF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for IRF1 Gene
Publications for IRF1 Gene
- IRF-1 gene variations influence IgE regulation and atopy. (PMID: 18079498) Schedel M … Kabesch M (American journal of respiratory and critical care medicine 2008) 3 22 44 58
- Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression. (PMID: 17516545) Su ZZ … Fisher PB (Journal of cellular physiology 2007) 3 4 22 58
- No evidence for genetic association of interferon regulatory factor 1 in juvenile idiopathic arthritis. (PMID: 17328074) Fife MS … Woo P (Arthritis and rheumatism 2007) 3 22 44 58
- Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. (PMID: 16961714) Wang TN … Ko YC (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006) 3 22 44 58
- Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. (PMID: 15509808) Dornan D … Ball KL (Molecular and cellular biology 2004) 3 4 22 58
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Sources for IRF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44)