Aliases for IREB2 Gene
External Ids for IREB2 Gene
Previous GeneCards Identifiers for IREB2 Gene
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
GeneCards Summary for IREB2 Gene
IREB2 (Iron Responsive Element Binding Protein 2) is a Protein Coding gene. Diseases associated with IREB2 include Neurodegeneration, Early-Onset, With Choreoathetoid Movements And Microcytic Anemia and Microcytic Anemia. Among its related pathways are Validated targets of C-MYC transcriptional activation and Iron metabolism in placenta. Gene Ontology (GO) annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is ACO1.
UniProtKB/Swiss-Prot Summary for IREB2 Gene
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.