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Aliases for IRAK2 Gene

Aliases for IRAK2 Gene

  • Interleukin 1 Receptor Associated Kinase 2 2 3 5
  • IRAK-2 3 4
  • Interleukin-1 Receptor-Associated Kinase-Like 2 3

External Ids for IRAK2 Gene

Previous GeneCards Identifiers for IRAK2 Gene

  • GC03P010135
  • GC03P010198
  • GC03P010181
  • GC03P010206
  • GC03P010142

Summaries for IRAK2 Gene

Entrez Gene Summary for IRAK2 Gene

  • IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRAK2 Gene

IRAK2 (Interleukin 1 Receptor Associated Kinase 2) is a Protein Coding gene. Diseases associated with IRAK2 include Lymphocytic Colitis. Among its related pathways are Activated TLR4 signalling and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK1.

UniProtKB/Swiss-Prot for IRAK2 Gene

  • Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Tocris Summary for IRAK2 Gene

  • The IRAKs (Interleukin-1 receptor-associated kinases) are serine-threonine kinases, EC, that are essential regulators of IL-1R and TLR-mediated signaling. Four IRAK isoforms have been identified to date, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.

Gene Wiki entry for IRAK2 Gene

Additional gene information for IRAK2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK2 Gene

Genomics for IRAK2 Gene

GeneHancer (GH) Regulatory Elements for IRAK2 Gene

Promoters and enhancers for IRAK2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J010164 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.6 586 2.4 HDGF ATF1 MLX ARID4B SIN3A ZNF2 ZNF48 YY1 SLC30A9 ZNF121 IRAK2 VHL GC03M010202
GH03J010185 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 34.3 +22.1 22089 2.5 SMARCE1 HDAC1 RFX1 SOX6 GABPA ZNF766 POLR2A HDAC2 MYNN ZNF239 IRAK2 GHRLOS TATDN2 GHRL FANCD2OS LINC00852 VHL GC03M010202
GH03J010247 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +84.4 84361 3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 TATDN2 ENSG00000272410 PIR57492 PIR49172 PIR36484 PIR45247 PIR32642 SETD5 BRPF1 EMC3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRAK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRAK2 gene promoter:
  • ATF-2
  • C/EBPalpha
  • Hlf
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • AP-1
  • ATF

Genomic Locations for IRAK2 Gene

Genomic Locations for IRAK2 Gene
78,881 bases
Plus strand
78,879 bases
Plus strand

Genomic View for IRAK2 Gene

Genes around IRAK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRAK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK2 Gene

Proteins for IRAK2 Gene

  • Protein details for IRAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor-associated kinase-like 2
    Protein Accession:
    Secondary Accessions:
    • B4DQZ6
    • Q08AG6
    • Q5K546

    Protein attributes for IRAK2 Gene

    625 amino acids
    Molecular mass:
    69433 Da
    Quaternary structure:
    • Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

    Three dimensional structures from OCA and Proteopedia for IRAK2 Gene

neXtProt entry for IRAK2 Gene

Post-translational modifications for IRAK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRAK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRAK2 Gene

Domains & Families for IRAK2 Gene

Gene Families for IRAK2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IRAK2 Gene

Suggested Antigen Peptide Sequences for IRAK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK2: view

Function for IRAK2 Gene

Molecular function for IRAK2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Phenotypes From GWAS Catalog for IRAK2 Gene

Gene Ontology (GO) - Molecular Function for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 10383454
GO:0005524 ATP binding IEA --
GO:0042803 protein homodimerization activity IPI 10383454
genes like me logo Genes that share ontologies with IRAK2: view
genes like me logo Genes that share phenotypes with IRAK2: view

Animal Models for IRAK2 Gene

MGI Knock Outs for IRAK2:

Animal Model Products

Clone Products

  • Addgene plasmids for IRAK2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRAK2 Gene

Localization for IRAK2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRAK2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
endosome 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with IRAK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRAK2 Gene

Pathways & Interactions for IRAK2 Gene

SuperPathways for IRAK2 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Toll Comparative Pathway
3 Bacterial infections in CF airways
4 TRAF Pathway
5 IL-1 signaling pathway
genes like me logo Genes that share pathways with IRAK2: view

Gene Ontology (GO) - Biological Process for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0001959 regulation of cytokine-mediated signaling pathway IMP 10383454
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0006468 protein phosphorylation TAS 9374458
genes like me logo Genes that share ontologies with IRAK2: view

No data available for SIGNOR curated interactions for IRAK2 Gene

Drugs & Compounds for IRAK2 Gene

(4) Drugs for IRAK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
IRAK inhibitor 2 Pharma 0
IRAK inhibitor 3 Pharma 0
IRAK inhibitor 4 Pharma IRAK inhibitor 0

(1) Additional Compounds for IRAK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with IRAK2: view

Transcripts for IRAK2 Gene

mRNA/cDNA for IRAK2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRAK2 Gene

Interleukin-1 receptor-associated kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for IRAK2

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK2 Gene

No ASD Table

Relevant External Links for IRAK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRAK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRAK2 Gene

mRNA differential expression in normal tissues according to GTEx for IRAK2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for IRAK2 Gene

This gene is overexpressed in Serum (25.7), Breast (21.6), and Bone marrow mesenchymal stem cell (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRAK2 Gene

Protein tissue co-expression partners for IRAK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRAK2 Gene:


SOURCE GeneReport for Unigene cluster for IRAK2 Gene:


mRNA Expression by UniProt/SwissProt for IRAK2 Gene:

Tissue specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for IRAK2 Gene

  • Heart(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with IRAK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRAK2 Gene

Orthologs for IRAK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRAK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRAK2 34 33
  • 97.96 (n)
(Canis familiaris)
Mammalia IRAK2 33
  • 85.39 (n)
VHL 34
  • 81 (a)
(Bos Taurus)
Mammalia IRAK2 34 33
  • 84.81 (n)
(Rattus norvegicus)
Mammalia Irak2 33
  • 77.05 (n)
(Mus musculus)
Mammalia Irak2 16 34 33
  • 76.34 (n)
(Monodelphis domestica)
Mammalia IRAK2 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia IRAK2 34
  • 50 (a)
(Gallus gallus)
Aves IRAK2 34 33
  • 58.08 (n)
(Anolis carolinensis)
Reptilia IRAK2 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia irak2 33
  • 47.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta pll 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea pik-1 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for IRAK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IRAK2 Gene

Gene Tree for IRAK2 (if available)
Gene Tree for IRAK2 (if available)
Evolutionary constrained regions (ECRs) for IRAK2: view image

Paralogs for IRAK2 Gene

Paralogs for IRAK2 Gene

genes like me logo Genes that share paralogs with IRAK2: view

Variants for IRAK2 Gene

Sequence variations from dbSNP and Humsavar for IRAK2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_041346 A lung adenocarcinoma sample p.Ser249Leu
VAR_041347 A lung adenocarcinoma sample p.Pro421Thr
rs1000048316 -- 10,188,951(+) G/C intron_variant
rs1000050180 -- 10,227,448(+) AAAAAA/AAAAA intron_variant
rs1000055181 -- 10,216,563(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IRAK2 Gene

Variant ID Type Subtype PubMed ID
dgv762e201 CNV deletion 23290073
dgv848e199 CNV deletion 23128226
esv1307821 CNV insertion 17803354
esv23190 CNV loss 19812545
esv2662021 CNV deletion 23128226
esv2664847 CNV deletion 23128226
esv2674709 CNV deletion 23128226
esv2724896 CNV deletion 23290073
esv3561455 CNV deletion 23714750
esv3568610 CNV loss 25503493
esv3595262 CNV gain 21293372
esv3595263 CNV loss 21293372
esv3595264 CNV loss 21293372
esv3595265 CNV loss 21293372
esv3595266 CNV loss 21293372
esv3595267 CNV loss 21293372
esv3595268 CNV loss 21293372
esv3595269 CNV loss 21293372
esv3595270 CNV loss 21293372
esv3595271 CNV loss 21293372
esv3595272 CNV loss 21293372
esv4117 OTHER complex 18987735
esv6737 CNV loss 19470904
nsv1073204 CNV deletion 25765185
nsv1109492 CNV deletion 24896259
nsv1121603 CNV deletion 24896259
nsv1123623 CNV deletion 24896259
nsv436362 CNV deletion 17901297
nsv436398 CNV deletion 17901297
nsv436869 CNV insertion 17901297
nsv437322 CNV loss 16327808
nsv522516 CNV gain 19592680
nsv523288 CNV loss 19592680
nsv524674 CNV loss 19592680
nsv589649 CNV loss 21841781
nsv821984 CNV loss 20364138
nsv821985 CNV loss 20364138

Variation tolerance for IRAK2 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.55; 93.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRAK2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK2 Gene

Disorders for IRAK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IRAK2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lymphocytic colitis
  • colitis, lymphocytic
- elite association - COSMIC cancer census association via MalaCards
Search IRAK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IRAK2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IRAK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRAK2 Gene

Publications for IRAK2 Gene

  1. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (PMID: 9374458) Muzio M … Dixit VM (Science (New York, N.Y.) 1997) 2 3 4 22 58
  2. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. (PMID: 10383454) Wesche H … Cao Z (The Journal of biological chemistry 1999) 3 4 22 58
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for IRAK2 Gene

Sources for IRAK2 Gene

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