Aliases for IRAK1 Gene
Aliases for IRAK1 Gene
External Ids for IRAK1 Gene
- HGNC: 6112
- Entrez Gene: 3654
- Ensembl: ENSG00000184216
- OMIM: 300283
- UniProtKB: P51617
Previous GeneCards Identifiers for IRAK1 Gene
- GC0XM147413
- GC0XM149730
- GC0XM150861
- GC0XM151743
- GC0XM152796
- GC0XM152929
- GC0XM153277
- GC0XM141927
Summaries for IRAK1 Gene
-
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRAK1 Gene
IRAK1 (Interleukin 1 Receptor Associated Kinase 1) is a Protein Coding gene. Diseases associated with IRAK1 include Pediatric Systemic Lupus Erythematosus and Lubs X-Linked Mental Retardation Syndrome. Among its related pathways are Activated TLR4 signalling and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK2.
UniProtKB/Swiss-Prot for IRAK1 Gene
-
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
-
The IRAKs (Interleukin-1 receptor-associated kinases) are serine-threonine kinases, EC 2.7.11.1, that are essential regulators of IL-1R and TLR-mediated signaling. Four IRAK isoforms have been identified to date, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.
Additional gene information for IRAK1 Gene
- Monarch Initiative
- Search for IRAK1 at DataMed
- Search for IRAK1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK1 Gene
Genomics for IRAK1 Gene
GeneHancer (GH) Regulatory Elements for IRAK1 Gene
Promoters and enhancers for IRAK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IRAK1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IRAK1 gene promoter:
-
- STAT3
- ATF-2
- c-Rel
- Elk-1
Regulatory Element Products
Genomic Locations for IRAK1 Gene
Genomic Locations for IRAK1 Gene
- chrX:154,010,500-154,024,584
- (GRCh38/hg38)
- Size:
- 14,085 bases
- Orientation:
- Minus strand
- chrX:153,275,951-153,285,431
- (GRCh37/hg19)
- Size:
- 9,481 bases
- Orientation:
- Minus strand
Genomic View for IRAK1 Gene
Genes around IRAK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq28 by Entrez Gene
- Xq28 by HGNC
- Xq28 by Ensembl
IRAK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IRAK1 Gene
Proteins for IRAK1 Gene
-
Protein details for IRAK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51617-IRAK1_HUMAN
- Recommended name:
- Interleukin-1 receptor-associated kinase 1
- Protein Accession:
- P51617
- D3DWW3
- D3DWW4
- Q7Z5V4
- Q96C06
- Q96RL2
Protein attributes for IRAK1 Gene
- Size:
- 712 amino acids
- Molecular mass:
- 76537 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer (By similarity). Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (PubMed:16951688). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (PubMed:9430229). Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (PubMed:10854325). Interacts with IL1RL1 (PubMed:16286016). Interacts with PELI1 and TRAF6 (PubMed:12496252). Interacts (when polyubiquitinated) with IKBKG/NEMO (PubMed:18347055). Interacts with RSAD2/viperin (By similarity). Interacts with IRAK1BP1 (By similarity). Interacts with PELI2 (By similarity). Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity). Interacts with IRAK4 (PubMed:11960013). Interacts with PELI3 (PubMed:12874243). Interacts with INAVA; the interaction takes place upon PRR stimulation (PubMed:28436939).
- (Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation.
Protein Expression for IRAK1 Gene
Post-translational modifications for IRAK1 Gene
- Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity.
- Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through Lys-63. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation.
- Ubiquitination at isoforms=2, 3, 4397, isoforms=2, 3, 4355, Lys342, Lys180, and isoforms=2, 3, 4134
- Modification sites at PhosphoSitePlus
Other Protein References for IRAK1 Gene
Antibody Products
- R&D Systems Antibodies for IRAK1 (IRAK1)
- Novus Biologicals Antibodies for IRAK1
-
Abcam antibodies for IRAK1
- Invitrogen Antibodies for IRAK1
- antibodies-online: Search results for 286 available IRAK1 Antibodies ranked by validation data
- Compare Top IRAK1 Antibodies
-
Recommended
- 180 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 74 WB Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 48 IF (p) Antibodies (anti-rat)
- 43 WB Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex IRAK1 Antibody for IRAK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IRAK1
Protein Products
-
OriGene Purified Proteins for IRAK1
- Search Origene for MassSpec and Protein Over-expression Lysates for IRAK1
- Origene Custom Protein Services for IRAK1
- GeneTex Proteins for IRAK1
-
ProSci Proteins for IRAK1
-
Abcam proteins for IRAK1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for IRAK1 (IRAK1)
-
Abcam assays for IRAK1
No data available for DME Specific Peptides for IRAK1 Gene
Domains & Families for IRAK1 Gene
Gene Families for IRAK1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for IRAK1 Gene
Suggested Antigen Peptide Sequences for IRAK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51617UniProtKB/Swiss-Prot:
IRAK1_HUMAN :- The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
- Domain:
-
- The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.
- Family:
-
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Function for IRAK1 Gene
Molecular function for IRAK1 Gene
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- GENATLAS Biochemistry:
- interleukin-1 receptor-associated kinase,100kDa,Drosophila Pelle homolog,forming a complex with IL1R1 after induction by IL1 through its association with IL1RAP and subsequently interacting with TRAF6 required for IL-1 mediated NFKB activation,see symbols
Enzyme Numbers (IUBMB) for IRAK1 Gene
Phenotypes From GWAS Catalog for IRAK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS,IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | -- |
| GO:0004704 | NF-kappaB-inducing kinase activity | TAS | 8599092 |
| GO:0005515 | protein binding | IPI | 10383454 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for IRAK1 Gene
- MGI mutant phenotypes for IRAK1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for IRAK1:
-
- Increased mitotic index
- Decreased substrate adherent cell growth
- Increased viability with TRAIL
- Decreased telomerase activity
- Decreased viability
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Increased cell number in S
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Models for IRAK1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for IRAK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for IRAK1
-
CRISPR Products
-
OriGene CRISPR knockouts for IRAK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRAK1
- genomics-online: gRNA clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- Applied Biological Materials CRISPR for IRAK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRAK1
- GenScript: Design CRISPR guide RNA sequences for IRAK1
miRNA for IRAK1 Gene
- miRTarBase miRNAs that target IRAK1
-
- hsa-mir-146a-5p (MIRT000712)
- hsa-mir-146b-5p (MIRT005395)
- hsa-mir-215-5p (MIRT024479)
- hsa-mir-192-5p (MIRT026216)
- hsa-mir-1226-3p (MIRT036505)
- hsa-mir-744-5p (MIRT037612)
- hsa-mir-330-5p (MIRT038255)
- hsa-mir-93-3p (MIRT038891)
- hsa-mir-193b-3p (MIRT041223)
- hsa-mir-423-3p (MIRT042485)
- hsa-mir-328-3p (MIRT043810)
- hsa-mir-132-3p (MIRT045847)
- hsa-mir-222-3p (MIRT046662)
- hsa-mir-92a-3p (MIRT049357)
- hsa-mir-17-5p (MIRT051021)
- hsa-mir-21-5p (MIRT054357)
- mmu-mir-146a-5p (MIRT054373)
- hsa-mir-142-3p (MIRT440429)
- hsa-mir-146b-3p (MIRT734968)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IRAK1
- Browse OriGene Inhibitory RNA Products For IRAK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRAK1
- genomics-online: shRNA clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
Clone Products
-
OriGene ORF clones in human for IRAK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for IRAK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IRAK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IRAK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRAK1
- Applied Biological Materials Clones for IRAK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IRAK1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRAK1 Gene
Localization for IRAK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IRAK1 Gene
- Cytoplasm. Nucleus. Lipid droplet. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
| extracellular | 2 |
| peroxisome | 2 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005811 | lipid droplet | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for IRAK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll Comparative Pathway |
.61
|
.39
.34
|
| 4 | Toll-like Receptor Signaling Pathway | ||
| 5 | IL-1 signaling pathway | ||
Pathways by source for IRAK1 Gene
1 GeneTex pathway for IRAK1 Gene
14 BioSystems pathways for IRAK1 Gene
37 Reactome pathways for IRAK1 Gene
11 KEGG pathways for IRAK1 Gene
11 GeneGo (Thomson Reuters) pathways for IRAK1 Gene
1 R&D Systems pathway for IRAK1 Gene
13 Qiagen pathways for IRAK1 Gene
1 Cell Signaling Technology pathway for IRAK1 Gene
Interacting Proteins for IRAK1 Gene
Selected Interacting proteins:
P51617-IRAK1_HUMAN
ENSP00000358997
for IRAK1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IRAK1
SIGNOR curated interactions for IRAK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | IMP | 10383454 |
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | 10383454 |
Drugs & Compounds for IRAK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Magnesium | Approved | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 | ||
| IRAK inhibitor 2 | Pharma | 0 | ||||
| IRAK inhibitor 3 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
(4) ApexBio Compounds for IRAK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| IRAK inhibitor 2 | 928333-30-6 | |
| IRAK inhibitor 3 | 1012343-93-9 | |
| IRAK inhibitor 4 | IRAK inhibitor | 1012104-68-5 |
| IRAK-1-4 Inhibitor I | IRAK-1/4 inhibitor | 509093-47-4 |
Transcripts for IRAK1 Gene
mRNA/cDNA for IRAK1 Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (629) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369980 3666 bps (uc004fjs.2)
- ENST00000369974 3319 bps (uc004fjt.2)
- ENST00000444230 1125 bps (uc065cag.1)
- ENST00000477274 705 bps (uc065cah.1)
- ENST00000455690 784 bps (uc065cai.1)
Unigene Clusters for IRAK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IRAK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRAK1
- genomics-online: gRNA clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- Applied Biological Materials CRISPR for IRAK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRAK1
- GenScript: Design CRISPR guide RNA sequences for IRAK1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IRAK1
- Browse OriGene Inhibitory RNA Products For IRAK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRAK1
- genomics-online: shRNA clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
Clone Products
-
OriGene ORF clones in human for IRAK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for IRAK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IRAK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IRAK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRAK1
- Applied Biological Materials Clones for IRAK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for IRAK1 Gene
This gene is overexpressed in Serum (36.8), Lung (21.8), and Bone (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRAK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of IRAK1 Gene:
IRAK1SOURCE GeneReport for Unigene cluster for IRAK1 Gene:
Hs.522819mRNA Expression by UniProt/SwissProt for IRAK1 Gene:
P51617-IRAK1_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.
Evidence on tissue expression from TISSUES for IRAK1 Gene
- Lung(4)
- Skin(3.8)
- Intestine(3.7)
- Nervous system(3.7)
- Kidney(3.2)
- Pancreas(3)
- Blood(2.8)
- Spleen(2.7)
- Lymph node(2.4)
- Bone marrow(2.3)
- Liver(2.1)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for IRAK1
-
OriGene qPCR primer pairs for IRAK1
- genomics-online: primer clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRAK1 Gene
Orthologs for IRAK1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IRAK1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IRAK1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IRAK1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Irak1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Irak1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IRAK1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IRAK1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | IRAK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | irak1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15551 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | irak1 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | pll 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | pik-1 34 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G32710 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IRAK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for IRAK1 Gene
- ENSEMBL:
- Gene Tree for IRAK1 (if available)
- TreeFam:
- Gene Tree for IRAK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IRAK1: view image
Paralogs for IRAK1 Gene
Variants for IRAK1 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040574 | A glioblastoma multiforme sample | p.Val412Met | |||
| VAR_040575 | A breast pleomorphic lobular carcinoma sample | p.Gln421His | |||
| VAR_040580 | A lung adenocarcinoma sample | p.Ser690Gly | |||
| rs267608360 | benign, not specified | 154,021,864(-) | GGGGGGGGGG/GGGGGGGG/GGGGGGGGG/GGGGGGGGGGG | upstream_transcript_variant | |
| rs267608391 | benign, not specified | 154,021,867(-) | G/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.62;
45.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IRAK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK1 Gene
Disorders for IRAK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pediatric systemic lupus erythematosus |
|
|
| lubs x-linked mental retardation syndrome |
|
|
| mumps |
|
|
| leber congenital amaurosis 10 |
|
|
| pleuropneumonia |
|
|
Search IRAK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IRAK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IRAK1 Gene
Publications for IRAK1 Gene
- IRAK: a kinase associated with the interleukin-1 receptor. (PMID: 8599092) Cao Z … Gao X (Science (New York, N.Y.) 1996) 2 3 4 22 58
- IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). (PMID: 20400509) Dunne A … O'Neill LA (The Journal of biological chemistry 2010) 3 4 22 58
- Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. (PMID: 19329491) Jacob CO … Mohan C (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 44 58
- The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PMID: 17997719) Ordureau A … Cohen P (The Biochemical journal 2008) 3 4 22 58
- Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. (PMID: 18347055) Conze DB … Ashwell JD (Molecular and cellular biology 2008) 3 4 22 58
Products for IRAK1 Gene
- R&D Systems Antibodies for IRAK1 (IRAK1)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for IRAK1 (IRAK1)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IRAK1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IRAK1
- Search Origene for MassSpec and Protein Over-expression Lysates for IRAK1
- Origene Custom Protein Services for IRAK1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IRAK1
- Browse OriGene Inhibitory RNA Products For IRAK1
- OriGene qPCR primer pairs and template standards for IRAK1
- OriGene qPCR primer pairs for IRAK1
- OriGene CRISPR knockouts for IRAK1
- OriGene ORF clones in human for IRAK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IRAK1
- GenScript: Next-day shipping of latest version cDNA ORF clones for IRAK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IRAK1
- GenScript Custom Assay Services for IRAK1
- GenScript Custom overexpressing Cell Line Services for IRAK1
- GenScript: Design CRISPR guide RNA sequences for IRAK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IRAK1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IRAK1
- Novus Biologicals lysates and proteins for IRAK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IRAK1
- Abcam proteins for IRAK1
- Abcam assays for IRAK1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for IRAK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IRAK1
- ApexBio compounds for IRAK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for IRAK1
- VectorBuilder custom plasmid, inducible vectors for IRAK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IRAK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IRAK1
- antibodies-online: Search results for 286 available IRAK1 Antibodies ranked by validation data
- Compare Top IRAK1 Antibodies
- Recommended
- 180 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 74 WB Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 48 IF (p) Antibodies (anti-rat)
- 43 WB Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 29 available IRAK1 Elisa Kits ranked by validation data
- Compare Top IRAK1 Elisa Kits
- antibodies-online: Search results for 10 available IRAK1 Proteins ranked by validation data
- Compare Top IRAK1 Proteins
- GeneTex IRAK1 Antibody for IRAK1
- GeneTex Proteins for IRAK1
- Santa Cruz Biotechnology (SCBT) Antibodies for IRAK1
- Search Santa Cruz Biotechnology (SCBT) for IRAK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IRAK1
- Custom Antibody ServicesProSci Antibodies for IRAK1
- ProSci Proteins for IRAK1
- Horizon Cell Lines for IRAK1
- genomics-online: cdna clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- orf clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- genomics-online: gRNA clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- genomics-online: primer clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- genomics-online: shRNA clones - Search results for 134 available IRAK1 gene related products
- Overview of 134 available IRAK1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRAK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRAK1
- GeneCopoeia miRNA 3'UTR Target clone products for IRAK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRAK1
Sources for IRAK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt