IRAK1 Gene (Protein Coding)

Interleukin 1 Receptor Associated Kinase 1

GC0XM154010
GIFtS:
49
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found... See more...

Aliases for IRAK1 Gene

Aliases for IRAK1 Gene

  • Interleukin 1 Receptor Associated Kinase 1 2 3 5
  • Interleukin-1 Receptor-Associated Kinase 1 3 4
  • IRAK-1 3 4
  • IRAK 3 4
  • EC 2.7.11.1'); 52
  • Pelle Homolog 3
  • EC 2.7.11.1 4
  • EC 2.7.11 52
  • Pelle 3

External Ids for IRAK1 Gene

Previous GeneCards Identifiers for IRAK1 Gene

  • GC0XM147413
  • GC0XM149730
  • GC0XM150861
  • GC0XM151743
  • GC0XM152796
  • GC0XM152929
  • GC0XM153277
  • GC0XM141927

Summaries for IRAK1 Gene

Entrez Gene Summary for IRAK1 Gene

  • This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRAK1 Gene

IRAK1 (Interleukin 1 Receptor Associated Kinase 1) is a Protein Coding gene. Diseases associated with IRAK1 include Pediatric Systemic Lupus Erythematosus and Mumps. Among its related pathways are Toll-like Receptor Signaling Pathway and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK2.

UniProtKB/Swiss-Prot Summary for IRAK1 Gene

  • Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

Tocris Summary for IRAK1 Gene

  • The IRAKs (Interleukin-1 receptor-associated kinases) are serine-threonine kinases, EC 2.7.11.1, that are essential regulators of IL-1R and TLR-mediated signaling. Four IRAK isoforms have been identified to date, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.

Gene Wiki entry for IRAK1 Gene

Additional gene information for IRAK1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRAK1 Gene

Genomics for IRAK1 Gene

GeneHancer (GH) Regulatory Elements for IRAK1 Gene

Promoters and enhancers for IRAK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ154017 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +4.6 4624 4.3 PHF8 ZFX ZIC2 POLR2A ZBTB11 ZBTB26 MYC ZNF341 CTCF ZBTB17 IRAK1 MIR718 lnc-TMEM187-3 TMEM187 lnc-MECP2-1 MECP2
GH0XJ154025 Enhancer 0.2 ENCODE 500.7 -1.5 -1459 0.1 IRAK1 HCFC1 TMEM187 HCFC1-AS1 RF00017-8809 MECP2
GH0XJ154135 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.3 -112.0 -112039 2.1 CTCF ZBTB10 ZNF423 ZBTB26 REST MYC CTBP1 RAD21 ZBTB7A SMC3 MECP2 lnc-MECP2-2 IRAK1 TMEM187 PLXNA3 RENBP ARHGAP4 TAZ IKBKG ABCD1
GH0XJ154093 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 13.2 -71.8 -71798 4.8 NRF1 POLR2G SP1 GTF2E2 TEAD4 ZBTB11 ZNF423 ZBTB26 ZNF740 NFYB MECP2 DKC1 TMEM187 SNORA70 IRAK1 SLC10A3 SNORA56 NONHSAG055577.2 piR-37575 lnc-MECP2-2
GH0XJ154056 Enhancer 1.1 Ensembl ENCODE 13.6 -42.5 -42517 22.6 POLR2G NCOR1 JUND ZIC2 RFX1 REST ZBTB25 TGIF2 SKI MYC TMEM187 IRAK1 HCFC1 HCFC1-AS1 PLXNA3 ATP6AP1 piR-45035-192 lnc-OPN1LW-2 lnc-IRAK1-1 MECP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRAK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRAK1

Top Transcription factor binding sites by QIAGEN in the IRAK1 gene promoter:
  • ATF-2
  • c-Rel
  • Elk-1
  • STAT3

Genomic Locations for IRAK1 Gene

Genomic Locations for IRAK1 Gene
chrX:154,010,506-154,024,584
(GRCh38/hg38)
Size:
14,079 bases
Orientation:
Minus strand
chrX:153,275,951-153,285,431
(GRCh37/hg19)
Size:
9,481 bases
Orientation:
Minus strand

Genomic View for IRAK1 Gene

Genes around IRAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRAK1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IRAK1 Gene

Proteins for IRAK1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IRAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51617-IRAK1_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase 1
    Protein Accession:
    P51617
    Secondary Accessions:
    • D3DWW3
    • D3DWW4
    • Q7Z5V4
    • Q96C06
    • Q96RL2

    Protein attributes for IRAK1 Gene

    Size:
    712 amino acids
    Molecular mass:
    76537 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (PubMed:16951688). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (PubMed:9430229). Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (PubMed:10854325). Interacts with IL1RL1 (PubMed:16286016). Interacts with PELI1 and TRAF6 (PubMed:12496252). Interacts (when polyubiquitinated) with IKBKG/NEMO (PubMed:18347055). Interacts with RSAD2/viperin (By similarity). Interacts with IRAK1BP1 (By similarity). Interacts with PELI2 (By similarity). Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity). Interacts with IRAK4 (PubMed:11960013). Interacts with PELI3 (PubMed:12874243). Interacts with INAVA; the interaction takes place upon PRR stimulation (PubMed:28436939). Interacts (via C-terminus) with NFATC4 (via N-terminus) (PubMed:18691762).
    • (Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation.
    Miscellaneous:
    • [Isoform 2]: Inactive.

    Three dimensional structures from OCA and Proteopedia for IRAK1 Gene

    Alternative splice isoforms for IRAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRAK1 Gene

Protein Expression for IRAK1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for IRAK1 Gene

P51617:
  • GEPAAPG
  • LGDFGLA

Post-translational modifications for IRAK1 Gene

  • Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity.
  • Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation.
  • Ubiquitination at Lys134, Lys180, Lys342, Lys355, and Lys397
  • Modification sites at PhosphoSitePlus

Other Protein References for IRAK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for IRAK1 Gene

Gene Families for IRAK1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IRAK1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IRAK1 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-1 receptor-associated kinase 1 (IRAK1_HUMAN)
  • Interleukin-1 receptor-associated kinase 1 (Q96C06_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51617

UniProtKB/Swiss-Prot:

IRAK1_HUMAN :
  • The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Domain:
  • The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK1: view

Function for IRAK1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IRAK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
GENATLAS Biochemistry:
interleukin-1 receptor-associated kinase,100kDa,Drosophila Pelle homolog,forming a complex with IL1R1 after induction by IL1 through its association with IL1RAP and subsequently interacting with TRAF6 required for IL-1 mediated NFKB activation,see symbols

Enzyme Numbers (IUBMB) for IRAK1 Gene

Phenotypes From GWAS Catalog for IRAK1 Gene

Gene Ontology (GO) - Molecular Function for IRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS --
GO:0004674 protein serine/threonine kinase activity NAS,IEA 11397809
GO:0004704 NF-kappaB-inducing kinase activity TAS 8599092
GO:0005515 protein binding IPI,IEA 11397809
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with IRAK1: view
genes like me logo Genes that share phenotypes with IRAK1: view

Human Phenotype Ontology for IRAK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRAK1 Gene

MGI Knock Outs for IRAK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IRAK1

CRISPR Products

Clone Products

  • Addgene plasmids for IRAK1

No data available for Transcription Factor Targets and HOMER Transcription for IRAK1 Gene

Localization for IRAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRAK1 Gene

Cytoplasm. Nucleus. Lipid droplet. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRAK1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endosome 5
cytosol 5
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005811 lipid droplet ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRAK1: view

Pathways & Interactions for IRAK1 Gene

PathCards logo

SuperPathways for IRAK1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
activated TAK1 mediates p38 MAPK activation
.01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
.01
2 Diseases associated with the TLR signaling cascade
Toll-like Receptor Signaling
.44
TLR4 Signaling and Tolerance
.38
Simplified Depiction of MYD88 Distinct Input-Output Pathway
.34
Interleukin-1 Induced Activation of NF-kappa-B
.32
IRAK1 recruits IKK complex
.31
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
.01
3 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Hepatitis B
.37
Chagas disease (American trypanosomiasis)
.31
4 Toll Comparative Pathway
TLR-TRIF Pathway
.61
Toll Comparative Pathway
.61
Immune response MIF in innate immunity response
.46
IL-1 Pathway
.39
iNOS Signaling
.34
5 IL-1 signaling pathway
IL-1 signaling pathway
.51
Structural Pathway of Interleukin 1 (IL-1)
.51
Interleukin-1 signaling
.41
IL1-mediated signaling events
.40
genes like me logo Genes that share pathways with IRAK1: view

Pathways by source for IRAK1 Gene

11 GeneGo (Thomson Reuters) pathways for IRAK1 Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Bacterial infections in CF airways
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • IL-1 beta-dependent CFTR expression
  • Immune response Bacterial infections in normal airways
1 R&D Systems pathway for IRAK1 Gene
13 Qiagen pathways for IRAK1 Gene
  • 14-3-3 Induced Apoptosis
  • IL-1 Pathway
  • iNOS Signaling
  • MAPK Signaling
  • NF-KappaB (p50-p65) Pathway
1 Cell Signaling Technology pathway for IRAK1 Gene
1 GeneTex pathway for IRAK1 Gene

SIGNOR curated interactions for IRAK1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0001959 regulation of cytokine-mediated signaling pathway IMP 10383454
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
genes like me logo Genes that share ontologies with IRAK1: view

Drugs & Compounds for IRAK1 Gene

Products:

  1. Drug

(21) Drugs for IRAK1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
IRAK inhibitor 2 Pharma 0
IRAK inhibitor 3 Pharma 0

(12) Additional Compounds for IRAK1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(4) ApexBio Compounds for IRAK1 Gene

Compound Action Cas Number
IRAK inhibitor 2 928333-30-6
IRAK inhibitor 3 1012343-93-9
IRAK inhibitor 4 IRAK inhibitor 1012104-68-5
IRAK-1-4 Inhibitor I IRAK-1/4 inhibitor 509093-47-4
genes like me logo Genes that share compounds with IRAK1: view

Transcripts for IRAK1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IRAK1 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for IRAK1

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7: - - -
SP8:
SP9: - -

Relevant External Links for IRAK1 Gene

GeneLoc Exon Structure for
IRAK1

Expression for IRAK1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRAK1 Gene

mRNA expression in normal human tissues for IRAK1 Gene
mRNA expression by GTEx for IRAK1 GenemRNA expression by BioGPS for IRAK1 Gene

Protein differential expression in normal tissues from HIPED for IRAK1 Gene

This gene is overexpressed in Serum (36.8), Lung (21.8), and Bone (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRAK1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRAK1

SOURCE GeneReport for Unigene cluster for IRAK1 Gene:

Hs.522819

mRNA Expression by UniProt/SwissProt for IRAK1 Gene:

P51617-IRAK1_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.

Evidence on tissue expression from TISSUES for IRAK1 Gene

  • Lung(4)
  • Skin(3.8)
  • Intestine(3.7)
  • Nervous system(3.7)
  • Kidney(3.2)
  • Pancreas(3)
  • Blood(2.8)
  • Spleen(2.7)
  • Lymph node(2.4)
  • Bone marrow(2.3)
  • Liver(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with IRAK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRAK1 Gene

Orthologs for IRAK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IRAK1 31 30
  • 99.49 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia IRAK1 31 30
  • 85.11 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia IRAK1 31 30
  • 83.47 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Irak1 17 31 30
  • 82.04 (n)
rat
(Rattus norvegicus)
 Mammalia Irak1 30
  • 81.57 (n)
oppossum
(Monodelphis domestica)
 Mammalia IRAK1 31
  • 60 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IRAK1 31
  • 58 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia IRAK1 31
  • 47 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia irak1 30
  • 53.65 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15551 30
zebrafish
(Danio rerio)
 Actinopterygii irak1 31 30
  • 51.27 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta pll 31 32
  • 28 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea pik-1 31 32
  • 27 (a)
 OneToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G32710 30
  • 48.47 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 43 (a)
 OneToMany
Species where no ortholog for IRAK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IRAK1 Gene

ENSEMBL:
Gene Tree for IRAK1 (if available)
TreeFam:
Gene Tree for IRAK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IRAK1: view image

Paralogs for IRAK1 Gene

Paralogs for IRAK1 Gene

Pseudogenes.org Pseudogenes for IRAK1 Gene

genes like me logo Genes that share paralogs with IRAK1: view

Variants for IRAK1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IRAK1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs1557130252 Uncertain Significance: not provided 154,018,616(-) C/T MISSENSE_VARIANT
VAR_040574 A glioblastoma multiforme sample p.Val412Met
VAR_040575 A breast pleomorphic lobular carcinoma sample p.Gln421His
VAR_040580 A lung adenocarcinoma sample p.Ser690Gly
rs10127175 - p.Cys203Ser

Additional dbSNP identifiers (rs#s) for IRAK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IRAK1 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv1133775 CNV deletion 24896259
nsv469867 CNV loss 16826518

Variation tolerance for IRAK1 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRAK1 Gene

Human Gene Mutation Database (HGMD)
IRAK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRAK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK1 Gene

Disorders for IRAK1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IRAK1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IRAK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IRAK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IRAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRAK1 Gene

Publications for IRAK1 Gene

  1. IRAK: a kinase associated with the interleukin-1 receptor. (PMID: 8599092) Cao Z … Gao X (Science (New York, N.Y.) 1996) 2 3 4 23 54
  2. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). (PMID: 20400509) Dunne A … O'Neill LA (The Journal of biological chemistry 2010) 3 4 23 54
  3. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. (PMID: 19329491) Jacob CO … Mohan C (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41 54
  4. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. (PMID: 18347055) Conze DB … Ashwell JD (Molecular and cellular biology 2008) 3 4 23 54
  5. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PMID: 17997719) Ordureau A … Cohen P (The Biochemical journal 2008) 3 4 23 54

ExternalLinks

View latest publications for IRAK1 gene in Mastermind

Products for IRAK1 Gene

  • Addgene plasmids for IRAK1

Sources for IRAK1 Gene