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The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008] See more...
Aliases for IRAG2 Gene
Aliases for IRAG2 Gene
External Ids for IRAG2 Gene
- HGNC: 6690
- NCBI Entrez Gene: 4033
- Ensembl: ENSG00000118308
- OMIM®: 602003
- UniProtKB/Swiss-Prot: Q12912
Previous HGNC Symbols for IRAG2 Gene
- LRMP
Summaries for IRAG2 Gene
-
The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRAG2 Gene
IRAG2 (Inositol 1,4,5-Triphosphate Receptor Associated 2) is a Protein Coding gene. Diseases associated with IRAG2 include Respiratory System Benign Neoplasm and Lung Adenoma. Among its related pathways are Innate Immune System. An important paralog of this gene is IRAG1.
UniProtKB/Swiss-Prot Summary for IRAG2 Gene
-
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.
Additional gene information for IRAG2 Gene
- HGNC (6690)
- NCBI Entrez Gene (4033)
- Ensembl (ENSG00000118308)
- OMIM® (602003)
- UniProtKB/Swiss-Prot (Q12912)
- Open Targets Platform(ENSG00000118308)
- Alliance of Genome Resources
- Search for IRAG2 at DataMed
- Search for IRAG2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IRAG2 Gene
Genomics for IRAG2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IRAG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IRAG2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IRAG2
Genomic Locations for IRAG2 Gene
Latest Assembly
- chr12:25,004,342-25,108,335
- (GRCh38/hg38)
- Size:
- 103,994 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:25,205,162-25,261,269
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 56,108 bases
- Orientation:
- Plus strand
Genomic View for IRAG2 Gene
Genes around IRAG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.1 by HGNC
- 12p12.1 by Entrez Gene
- 12p12.1 by Ensembl
IRAG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IRAG2 Gene
Proteins for IRAG2 Gene
-
Protein details for IRAG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12912-IRAG2_HUMAN
- Recommended name:
- Inositol 1,4,5-triphosphate receptor associated 2
- Protein Accession:
- Q12912
- A0AVM2
- B4E077
- Q8N301
Protein attributes for IRAG2 Gene
- Size:
- 555 amino acids
- Molecular mass:
- 62122 Da
- Quaternary structure:
-
- Interacts (via coiled-coil domain) with ITPR3. Interacts with SUN1 and SUN2. Interacts with microtubules.
- SequenceCaution:
-
- Sequence=AAH29391.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAI26418.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Post-translational modifications for IRAG2 Gene
- The removal of the C-terminal lumenal domain occurs by proteolytic processing.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for IRAG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for IRAG2
-
Abcam antibodies for IRAG2
- Invitrogen Antibodies for IRAG2 (AFLGC-LRMP)
-
Custom Antibody ServicesProSci Antibodies for IRAG2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IRAG2
- Origene Custom Protein Services for IRAG2
- Novus Biologicals proteins for IRAG2
- antibodies-online: Show 5 available LRMP Proteins ranked by validation data
- Compare Top LRMP Proteins
-
Quality Products:
-
Abcam proteins for IRAG2
Assay products for research
- antibodies-online: Search results for available LRMP related products ranked by validation data
No data available for DME Specific Peptides for IRAG2 Gene
Domains & Families for IRAG2 Gene
Gene Families for IRAG2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IRAG2 Gene
- InterPro:
Suggested Antigen Peptide Sequences for IRAG2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein Jaw1 (LRMP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q12912- Family:
-
- Belongs to the IRAG2 family.
Function for IRAG2 Gene
Molecular function for IRAG2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.
Phenotypes From GWAS Catalog for IRAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008017 | microtubule binding | ISS | -- |
Phenotypes for IRAG2 Gene
- MGI mutant phenotypes for IRAG2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IRAG2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
Animal Models for IRAG2 Gene
- MGI Knock Outs for IRAG2:
-
- Lrmp Lrmp<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IRAG2 - Starting at $85 >
- * IRAG2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IRAG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRAG2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRAG2
- Browse OriGene Inhibitory RNA Products For IRAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRAG2
Clone products for research
- Applied Biological Materials (abm): Clones for IRAG2 - Starting at $45 >
- * IRAG2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IRAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRAG2
Cell Lines for research
-
Horizon Cell Lines for IRAG2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IRAG2 Gene
Localization for IRAG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IRAG2 Gene
- [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm.
- Endoplasmic reticulum membrane. Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250 UniProtKB:Q60664}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| lysosome | 4 |
| cytoskeleton | 3 |
| cytosol | 2 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| mitochondrion | 0 |
| peroxisome | 0 |
| golgi apparatus | 0 |
- Cytosol (1)
- Nucleoplasm (1)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | ISS | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for IRAG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for IRAG2 Gene
3 Reactome pathways for IRAG2 Gene
Interacting Proteins for IRAG2 Gene
GPS-Prot Interaction Network for IRAG2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006903 | vesicle targeting | TAS | 8021504 |
| GO:0006906 | vesicle fusion | TAS | 8021504 |
| GO:0006997 | nucleus organization | ISS | -- |
| GO:0007338 | single fertilization | IEA | -- |
No data available for SIGNOR curated interactions for IRAG2 Gene
Transcripts for IRAG2 Gene
mRNA/cDNA for IRAG2 Gene
- 13 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354454 2504 nts (view in UCSC)
- ENST00000361433 2715 nts (view in UCSC)
- ENST00000536173 2120 nts (view in UCSC)
- ENST00000547044 2208 nts (view in UCSC)
- ENST00000548766 2193 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IRAG2 - Starting at $85 >
- * IRAG2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IRAG2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRAG2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRAG2
- Browse OriGene Inhibitory RNA Products For IRAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRAG2
Clone products for research
- Applied Biological Materials (abm): Clones for IRAG2 - Starting at $45 >
- * IRAG2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IRAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRAG2
Relevant External Links for IRAG2 Gene
- GeneLoc Exon Structure for
- IRAG2
Expression for IRAG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Thymus (Hematopoietic System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IRAG2
SOURCE GeneReport for Unigene cluster for IRAG2 Gene:
Hs.124922mRNA Expression by UniProt/SwissProt for IRAG2 Gene:
Q12912-IRAG2_HUMAN
Tissue specificity:
Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.
Evidence on tissue expression from TISSUES for IRAG2 Gene
- Nervous system(4.3)
- Liver(4.1)
- Lymph node(2.7)
- Blood(2.3)
- Intestine(2.1)
- Spleen(2.1)
Primer products for research
-
OriGene qPCR primer pairs for IRAG2
-
OriGene qPCR primer pairs and template standards for IRAG2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRAG2 Gene
Orthologs for IRAG2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LRMP 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LRMP 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | LRMP 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Lrmp 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Lrmp 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | LRMP 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | LRMP 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | lrmp 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | lrmp 29 30 |
|
OneToOne |
- Species where no ortholog for IRAG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IRAG2 Gene
- ENSEMBL:
- Gene Tree for IRAG2 (if available)
- TreeFam:
- Gene Tree for IRAG2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IRAG2: view image
- Alliance of Genome Resources:
- Additional Orthologs for IRAG2
Paralogs for IRAG2 Gene
Variants for IRAG2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2412n54 | CNV | gain | 21841781 |
| esv1073866 | CNV | insertion | 17803354 |
| esv1691407 | CNV | insertion | 17803354 |
| esv2422312 | CNV | duplication | 17116639 |
| esv2521669 | CNV | insertion | 19546169 |
| esv2759884 | CNV | loss | 17122850 |
| esv3892163 | CNV | loss | 25118596 |
| nsv469169 | CNV | gain | 19166990 |
| nsv469173 | CNV | gain | 19166990 |
| nsv52528 | CNV | deletion | 16902084 |
| nsv557775 | CNV | gain | 21841781 |
| nsv951340 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.73;
96.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IRAG2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAG2 Gene
Disorders for IRAG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| respiratory system benign neoplasm |
|
|
| lung adenoma |
|
|
Search IRAG2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IRAG2
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IRAG2 Gene
Publications for IRAG2 Gene
- Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. (PMID: 8021504) Behrens TW … Staudt LM (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 4 22
- Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas. (PMID: 16739114) Tedoldi S … Marafioti T (The Journal of pathology 2006) 4 22
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Carboxyl-terminal targeting and novel post-translational processing of JAW1, a lymphoid protein of the endoplasmic reticulum. (PMID: 8798562) Behrens TW … Staudt LM (The Journal of biological chemistry 1996) 3 22
- Clinical variability and probable founder effect in oculocutaneous albinism type 7. (PMID: 31694064) Bataille P … Hadj-Rabia S (Clinical genetics 2020) 3
ExternalLinks
Products for IRAG2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IRAG2
- Origene Custom Protein Services for IRAG2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRAG2
- Browse OriGene Inhibitory RNA Products For IRAG2
- OriGene qPCR primer pairs for IRAG2
- OriGene qPCR primer pairs and template standards for IRAG2
- OriGene CRISPR knockouts for IRAG2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for IRAG2
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IRAG2
- Novus Biologicals proteins for IRAG2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IRAG2
- Abcam proteins for IRAG2
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for IRAG2 (AFLGC-LRMP)
- VectorBuilder Custom and pre-made DNA vectors for IRAG2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IRAG2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IRAG2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IRAG2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IRAG2
- antibodies-online: Show 12 available LRMP Antibodies ranked by validation data
- Compare Top LRMP Antibodies
- antibodies-online: Search results for available LRMP related products ranked by validation data
- antibodies-online: Show 5 available LRMP Proteins ranked by validation data
- Compare Top LRMP Proteins
- Quality Products:
- Horizon Cell Lines for IRAG2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IRAG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IRAG2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IRAG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRAG2
Sources for IRAG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources