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This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicate... See more...
Aliases for IQSEC2 Gene
Aliases for IQSEC2 Gene
External Ids for IQSEC2 Gene
- HGNC: 29059
- Entrez Gene: 23096
- Ensembl: ENSG00000124313
- OMIM: 300522
- UniProtKB: Q5JU85
Previous HGNC Symbols for IQSEC2 Gene
- MRX1
- MRX78
- MRX18
Previous GeneCards Identifiers for IQSEC2 Gene
- GC0XM053146
- GC0XM053278
- GC0XM050327
Summaries for IQSEC2 Gene
-
This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for IQSEC2 Gene
IQSEC2 (IQ Motif And Sec7 Domain ArfGEF 2) is a Protein Coding gene. Diseases associated with IQSEC2 include Severe Intellectual Disability-Progressive Postnatal Microcephaly-Midline Stereotypic Hand Movements Syndrome and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is IQSEC1.
UniProtKB/Swiss-Prot Summary for IQSEC2 Gene
-
Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.
Additional gene information for IQSEC2 Gene
- HGNC(29059)
- Entrez Gene(23096)
- Ensembl(ENSG00000124313)
- OMIM(300522)
- UniProtKB(Q5JU85)
- Open Targets Platform(ENSG00000124313)
- Monarch Initiative
- Search for IQSEC2 at DataMed
- Search for IQSEC2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQSEC2 Gene
Genomics for IQSEC2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IQSEC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IQSEC2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQSEC2
- Top Transcription factor binding sites by QIAGEN in the IQSEC2 gene promoter:
-
- AREB6
- CP2
- HEN1
- NF-1
- NF-1/L
- Nkx2-5
- Pax-4a
- POU2F1
- POU2F1a
Genomic Locations for IQSEC2 Gene
Genomic Locations for IQSEC2 Gene
- chrX:53,225,784-53,321,356
- (GRCh38/hg38)
- Size:
- 95,573 bases
- Orientation:
- Minus strand
- chrX:53,262,058-53,350,522
- (GRCh37/hg19)
- Size:
- 88,465 bases
- Orientation:
- Minus strand
Genomic View for IQSEC2 Gene
Genes around IQSEC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by HGNC
- Xp11.22 by Entrez Gene
- Xp11.22 by Ensembl
IQSEC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IQSEC2 Gene
Proteins for IQSEC2 Gene
-
Protein details for IQSEC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5JU85-IQEC2_HUMAN
- Recommended name:
- IQ motif and SEC7 domain-containing protein 2
- Protein Accession:
- Q5JU85
- A0A1W2PQN3
- B3KT97
- C7SDG1
- O60275
- Q5JUX1
Protein attributes for IQSEC2 Gene
- Size:
- 1488 amino acids
- Molecular mass:
- 162784 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA25448.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA25448.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAI42091.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for IQSEC2 Gene
Post-translational modifications for IQSEC2 Gene
Other Protein References for IQSEC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-IQSEC2 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for IQSEC2
- Novus Biologicals Antibodies for IQSEC2
- Invitrogen Antibodies for IQSEC2 (AFLGC-IQSEC2)
-
Boster Bio Antibodies for IQSEC2
-
Custom Antibody ServicesProSci Antibodies for IQSEC2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IQSEC2
- Origene Custom Protein Services for IQSEC2
No data available for DME Specific Peptides for IQSEC2 Gene
Domains & Families for IQSEC2 Gene
Gene Families for IQSEC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for IQSEC2 Gene
- InterPro:
- Blocks:
-
- SEC7-like domain
- ProtoNet:
Suggested Antigen Peptide Sequences for IQSEC2 Gene
- GenScript: Design optimal peptide antigens:
-
- Brefeldin A resistant Arf-guanine nucleotide exchange factor 1b (C7SDG0_HUMAN)
- Brefeldin A resistant Arf-guanine nucleotide exchange factor 1 (C7SDG2_HUMAN)
- Brefeldin A resistant Arf-guanine nucleotide exchange factor 1 (C7SDG3_HUMAN)
- IQ motif and SEC7 domain-containing protein 2 (IQEC2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5JU85- Family:
-
- Belongs to the BRAG family.
Function for IQSEC2 Gene
Molecular function for IQSEC2 Gene
- UniProtKB/Swiss-Prot Function:
- Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IMP | 26793055 |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for IQSEC2 Gene
- MGI mutant phenotypes for IQSEC2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for IQSEC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IQSEC2 - Select products 50% OFF >
- * IQSEC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IQSEC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IQSEC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IQSEC2
miRNA for IQSEC2 Gene
- miRTarBase miRNAs that target IQSEC2
-
- mmu-miR-324-3p (MIRT010847)
- hsa-miR-4728-5p (MIRT487950)
- hsa-miR-8085 (MIRT487951)
- hsa-miR-3175 (MIRT487952)
- hsa-miR-6731-5p (MIRT487953)
- hsa-miR-650 (MIRT487954)
- hsa-miR-3612 (MIRT487955)
- hsa-miR-5192 (MIRT487956)
- hsa-miR-4644 (MIRT487957)
- hsa-miR-4306 (MIRT487958)
- hsa-miR-8077 (MIRT487959)
- hsa-miR-185-5p (MIRT487960)
- hsa-miR-4722-5p (MIRT487961)
- hsa-miR-6133 (MIRT487962)
- hsa-miR-6130 (MIRT487963)
- hsa-miR-6129 (MIRT487964)
- hsa-miR-6127 (MIRT487965)
- hsa-miR-4510 (MIRT487966)
- hsa-miR-4419a (MIRT487967)
- hsa-miR-1827 (MIRT487968)
- hsa-miR-3160-3p (MIRT487969)
- hsa-miR-4739 (MIRT487970)
- hsa-miR-4756-5p (MIRT487971)
- hsa-miR-1321 (MIRT487972)
- hsa-miR-940 (MIRT487973)
- hsa-miR-6893-5p (MIRT487974)
- hsa-miR-6808-5p (MIRT487975)
- hsa-miR-708-5p (MIRT487976)
- hsa-miR-3139 (MIRT487977)
- hsa-miR-28-5p (MIRT487978)
- hsa-miR-6873-5p (MIRT487979)
- hsa-miR-1252-5p (MIRT736516)
- hsa-miR-1299 (MIRT737244)
- hsa-miR-196a-3p (MIRT738645)
- hsa-miR-3202 (MIRT741149)
- hsa-miR-4496 (MIRT745338)
- hsa-miR-4533 (MIRT746013)
- hsa-miR-6128 (MIRT752145)
- hsa-miR-651-3p (MIRT753256)
- hsa-miR-6771-3p (MIRT755304)
- hsa-miR-875-3p (MIRT760354)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IQSEC2
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Clone Products
- Applied Biological Materials (abm): Clones for IQSEC2 - Select products 50% OFF >
- * IQSEC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IQSEC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IQSEC2
Cell Line Products
-
Horizon Cell Lines for IQSEC2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for IQSEC2 Gene
Localization for IQSEC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IQSEC2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| plasma membrane | 2 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0098685 | Schaffer collateral - CA1 synapse | IMP | 27009485 |
Pathways & Interactions for IQSEC2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endocytosis | ||
Pathways by source for IQSEC2 Gene
1 KEGG pathway for IQSEC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030036 | actin cytoskeleton organization | IBA | 21873635 |
| GO:0032012 | regulation of ARF protein signal transduction | IEA | -- |
| GO:0050804 | modulation of chemical synaptic transmission | IMP | 27009485 |
| GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | IMP | 27009485 |
No data available for SIGNOR curated interactions for IQSEC2 Gene
Transcripts for IQSEC2 Gene
mRNA/cDNA for IQSEC2 Gene
- 3 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000375365 4004 nts (view in UCSC)
- ENST00000462054 730 nts (view in UCSC)
- ENST00000485377 835 nts (view in UCSC)
- ENST00000498281 673 nts (view in UCSC)
- ENST00000638521 4501 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IQSEC2 - Select products 50% OFF >
- * IQSEC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IQSEC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IQSEC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IQSEC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IQSEC2
- Browse OriGene Inhibitory RNA Products For IQSEC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQSEC2
Clone Products
- Applied Biological Materials (abm): Clones for IQSEC2 - Select products 50% OFF >
- * IQSEC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IQSEC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IQSEC2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: |
Relevant External Links for IQSEC2 Gene
- GeneLoc Exon Structure for
- IQSEC2
Expression for IQSEC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
mRNA differential expression in normal tissues according to GTEx for IQSEC2 Gene
This gene is overexpressed in Brain - Cortex (x4.4).
This gene is overexpressed in Brain (12.7), Breast (10.5), Peripheral blood mononuclear cells (10.0), Urine (8.7), Cervix (8.2), Platelet (8.1), and Frontal cortex (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IQSEC2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQSEC2
SOURCE GeneReport for Unigene cluster for IQSEC2 Gene:
Hs.496138mRNA Expression by UniProt/SwissProt for IQSEC2 Gene:
Q5JU85-IQEC2_HUMAN
Tissue specificity:
Expressed in brain, kidney and small intestine. Weakly expressed in placenta, pancreas, ovary, prostate and liver.
Evidence on tissue expression from TISSUES for IQSEC2 Gene
- Nervous system(4.5)
- Liver(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IQSEC2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- salivary gland
- skull
- tooth
Thorax:
- lung
- rib
- rib cage
Pelvis:
- pelvis
- testicle
- urinary bladder
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for IQSEC2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for IQSEC2 Gene
Orthologs for IQSEC2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IQSEC2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IQSEC2 31 |
|
OneToOne | |
| LOC491895 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | IQSEC2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Iqsec2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Iqsec2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IQSEC2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IQSEC2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IQSEC2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | iqsec2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | iqsec2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | siz 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for IQSEC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IQSEC2 Gene
- ENSEMBL:
- Gene Tree for IQSEC2 (if available)
- TreeFam:
- Gene Tree for IQSEC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IQSEC2: view image
Paralogs for IQSEC2 Gene
Paralogs for IQSEC2 Gene
(4) SIMAP similar genes for IQSEC2 Gene using alignment to 2 proteins:
- IQEC2_HUMAN
- L8E757_HUMAN
Variants for IQSEC2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQSEC2 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 637967 | Pathogenic/Likely Pathogenic: Intellectual disability; not provided | 53,250,985(-) | G/A | NONSENSE | |
| 639042 | Pathogenic: Mental retardation, X-linked 1 | 53,254,745(-) | C/A | NONSENSE | |
| 639819 | Uncertain Significance: Mental retardation, X-linked 1 | 53,234,653(-) | G/A | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 642501 | Uncertain Significance: Mental retardation, X-linked 1 | 53,250,888(-) | C/T | MISSENSE_VARIANT | |
| 644370 | Uncertain Significance: Mental retardation, X-linked 1 | 53,234,854(-) | C/T | MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT |
Residual Variation Intolerance Score:
3.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.83;
34.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IQSEC2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQSEC2 Gene
Disorders for IQSEC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| severe intellectual disability-progressive postnatal microcephaly-midline stereotypic hand movements syndrome |
|
|
| non-syndromic x-linked intellectual disability |
|
|
| alacrima, achalasia, and mental retardation syndrome |
|
|
| iqsec2 |
|
|
| chromosome xp11.23-p11.22 duplication syndrome |
|
|
Search IQSEC2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IQEC2_HUMAN- Mental retardation, X-linked 1 (MRX1) [MIM:309530]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:20473311, ECO:0000269 PubMed:26793055}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IQSEC2
No data available for Genatlas for IQSEC2 Gene
Publications for IQSEC2 Gene
- Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked Intellectual Disability in the MRX78 Family. (PMID: 26793055) Kalscheuer VM … Harvey RJ (Frontiers in molecular neuroscience 2015) 2 3 4
- Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability. (PMID: 20473311) Shoubridge C … Gécz J (Nature genetics 2010) 2 3 4
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for IQSEC2 Gene
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- Sino Biological Human cDNA Clone for IQSEC2
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Antibodies
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- Browse ELISA Kits
- Invitrogen Antibodies for IQSEC2 (AFLGC-IQSEC2)
- VectorBuilder Custom and pre-made DNA vectors for IQSEC2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IQSEC2 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 3 available IQSEC2 Antibodies ranked by validation data
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- antibodies-online: Search results for available IQSEC2 related products ranked by validation data
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- Browse GeneCopoeia Cell Lines
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- Boster Bio Antibodies for IQSEC2
- Browse Boster Bio ELISA Kits
Sources for IQSEC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
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- (33) SGD
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- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (55) TGDB
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- (59) ProSpec
- (60) Sino Biological
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- (64) Proteopedia
- (65) MOPED
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
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- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
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- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
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- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (104) diseasecard
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
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- (154) Biorbyt
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- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB