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Aliases for IQGAP3 Gene

Aliases for IQGAP3 Gene

  • IQ Motif Containing GTPase Activating Protein 3 2 3 5
  • Ras GTPase-Activating-Like Protein IQGAP3 3 4

External Ids for IQGAP3 Gene

Previous GeneCards Identifiers for IQGAP3 Gene

  • GC01M153273
  • GC01M153713
  • GC01M153711
  • GC01M153308
  • GC01M154761
  • GC01M127855

Summaries for IQGAP3 Gene

GeneCards Summary for IQGAP3 Gene

IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include calmodulin binding and Ras GTPase binding. An important paralog of this gene is IQGAP1.

Additional gene information for IQGAP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP3 Gene

Genomics for IQGAP3 Gene

GeneHancer (GH) Regulatory Elements for IQGAP3 Gene

Promoters and enhancers for IQGAP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156569 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 600.7 +1.1 1059 3.3 ZNF652 SIX5 NKRF ZNF384 MAFK ZBTB7A SP7 ELF1 CREM CREB1 IQGAP3 NAXE MEF2D BCAN CCT3 TSACC GPATCH4 TTC24 GC01P156524
GH01J156599 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.3 -28.7 -28654 3.5 CTCF ELF3 MNT ZNF148 NKRF ZNF121 POLR2A GTF2F1 ZNF384 ZNF687 GPATCH4 IQGAP3 GON4L RRNAD1 ISG20L2 KHDC4 NAXE MSTO1 MSTO2P CCT3
GH01J156523 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.2 +47.6 47635 2.4 CBFA2T2 ZNF639 SMARCA4 ZBED1 IKZF1 BACH1 ZIC2 ZNF740 PKNOX1 POLR2A GC01P156524 NAXE IQGAP3 C1orf61 MIR9-1 GPATCH4 ENSG00000260460 MEF2D RRNAD1
GH01J156419 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5 +150.7 150677 4.3 SP1 CBFA2T2 ZNF148 ZNF121 ZNF687 SP7 POLR2A KLF14 CREM IKZF1 MIR9-1 C1orf61 KHDC4 GON4L RRNAD1 ENSG00000271267 MSTO1 MSTO2P CCT3 PRCC
GH01J156526 Enhancer 0.6 ENCODE dbSUPER 11.2 +46.3 46310 0.2 SIN3A EGR2 GC01P156524 IQGAP3 NAXE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQGAP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQGAP3 gene promoter:
  • AML1a
  • NF-1
  • RFX1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5B
  • YY1
  • Zic3

Genomic Locations for IQGAP3 Gene

Genomic Locations for IQGAP3 Gene
chr1:156,525,405-156,572,604
(GRCh38/hg38)
Size:
47,200 bases
Orientation:
Minus strand
chr1:156,495,197-156,542,396
(GRCh37/hg19)
Size:
47,200 bases
Orientation:
Minus strand

Genomic View for IQGAP3 Gene

Genes around IQGAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQGAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP3 Gene

Proteins for IQGAP3 Gene

  • Protein details for IQGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI3-IQGA3_HUMAN
    Recommended name:
    Ras GTPase-activating-like protein IQGAP3
    Protein Accession:
    Q86VI3
    Secondary Accessions:
    • Q5T3H8

    Protein attributes for IQGAP3 Gene

    Size:
    1631 amino acids
    Molecular mass:
    184699 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQGAP3 Gene

neXtProt entry for IQGAP3 Gene

Post-translational modifications for IQGAP3 Gene

  • Ubiquitination at isoforms=1067, isoforms=1158, and posLast=12451245
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IQGAP3 Gene

Domains & Families for IQGAP3 Gene

Gene Families for IQGAP3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IQGAP3 Gene

GenScript: Design optimal peptide antigens:
  • IQ motif containing GTPase activating protein 3 (A2RRC9_HUMAN)
  • Ras GTPase-activating-like protein IQGAP3 (IQGA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQGAP3: view

No data available for UniProtKB/Swiss-Prot for IQGAP3 Gene

Function for IQGAP3 Gene

Phenotypes From GWAS Catalog for IQGAP3 Gene

Gene Ontology (GO) - Molecular Function for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding IPI 21299499
GO:0017016 Ras GTPase binding IEA --
GO:0017048 Rho GTPase binding IEA --
GO:0070856 myosin VI light chain binding IPI 21299499
genes like me logo Genes that share ontologies with IQGAP3: view
genes like me logo Genes that share phenotypes with IQGAP3: view

Animal Model Products

CRISPR Products

miRNA for IQGAP3 Gene

miRTarBase miRNAs that target IQGAP3

Clone Products

  • Applied Biological Materials (abm): Clones for IQGAP3 - Now 50% OFF >
  • * IQGAP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IQGAP3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQGAP3 Gene

Localization for IQGAP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQGAP3 gene
Compartment Confidence
cytosol 4
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP3 Gene

Pathways & Interactions for IQGAP3 Gene

genes like me logo Genes that share pathways with IQGAP3: view

Pathways by source for IQGAP3 Gene

1 KEGG pathway for IQGAP3 Gene

Gene Ontology (GO) - Biological Process for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for SIGNOR curated interactions for IQGAP3 Gene

Drugs & Compounds for IQGAP3 Gene

No Compound Related Data Available

Transcripts for IQGAP3 Gene

mRNA/cDNA for IQGAP3 Gene

Unigene Clusters for IQGAP3 Gene

IQ motif containing GTPase activating protein 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for IQGAP3 - Now 50% OFF >
  • * IQGAP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IQGAP3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39
SP1:
SP2:
SP3:

Relevant External Links for IQGAP3 Gene

GeneLoc Exon Structure for
IQGAP3
ECgene alternative splicing isoforms for
IQGAP3

Expression for IQGAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP3 Gene

This gene is overexpressed in Colon - Transverse (x4.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for IQGAP3 Gene

This gene is overexpressed in Breast (38.0) and Bone (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IQGAP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of IQGAP3 Gene:

IQGAP3

SOURCE GeneReport for Unigene cluster for IQGAP3 Gene:

Hs.591495

Evidence on tissue expression from TISSUES for IQGAP3 Gene

  • Liver(3)
  • Lung(2.5)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with IQGAP3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQGAP3 Gene

Orthologs for IQGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQGAP3 35 34
  • 98.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IQGAP3 35 34
  • 89.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IQGAP3 35 34
  • 85.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iqgap3 34
  • 84.98 (n)
mouse
(Mus musculus)
Mammalia Iqgap3 17 35 34
  • 84.9 (n)
oppossum
(Monodelphis domestica)
Mammalia IQGAP3 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia iqgap3 34
  • 66.32 (n)
zebrafish
(Danio rerio)
Actinopterygii IQGAP3 35
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7754 34
worm
(Caenorhabditis elegans)
Secernentea pes-7 35 34
  • 43.08 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 37 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for IQGAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IQGAP3 Gene

ENSEMBL:
Gene Tree for IQGAP3 (if available)
TreeFam:
Gene Tree for IQGAP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQGAP3: view image

Paralogs for IQGAP3 Gene

Paralogs for IQGAP3 Gene

(2) SIMAP similar genes for IQGAP3 Gene using alignment to 3 proteins:

  • IQGA3_HUMAN
  • A2RRC9_HUMAN
  • F2Z2E2_HUMAN
genes like me logo Genes that share paralogs with IQGAP3: view

Variants for IQGAP3 Gene

Sequence variations from dbSNP and Humsavar for IQGAP3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024878 -- 156,538,926(-) A/G coding_sequence_variant, missense_variant
rs1000222596 -- 156,560,234(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000224720 -- 156,560,556(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000255627 -- 156,560,233(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000294317 -- 156,526,870(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQGAP3 Gene

Variant ID Type Subtype PubMed ID
dgv205n106 CNV deletion 24896259
esv1007783 CNV deletion 20482838
esv1268515 CNV deletion 17803354
esv2384844 CNV deletion 18987734
esv2506598 CNV deletion 19546169
esv2675734 CNV deletion 23128226
esv2718440 CNV deletion 23290073
esv2824 CNV loss 18987735
esv2849569 CNV deletion 24192839
esv3541123 CNV deletion 23714750
esv3587638 CNV loss 21293372
esv8068 CNV loss 19470904
esv994163 CNV deletion 20482838
nsv1078255 CNV deletion 25765185
nsv1119404 CNV insertion 24896259
nsv3077 CNV deletion 18451855
nsv436331 CNV deletion 17901297
nsv511716 CNV loss 21212237
nsv952215 CNV deletion 24416366
nsv957909 CNV deletion 24416366

Variation tolerance for IQGAP3 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.99; 98.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQGAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQGAP3
Human Gene Mutation Database (HGMD)
IQGAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP3 Gene

Disorders for IQGAP3 Gene

Additional Disease Information for IQGAP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IQGAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQGAP3 Gene

Publications for IQGAP3 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria. (PMID: 30446454) Xu Y … Kim WJ (Urologic oncology 2019) 3 58
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 58
  5. Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer. (PMID: 29131081) Oue N … Yasui W (Pathobiology : journal of immunopathology, molecular and cellular biology 2018) 3 58

Products for IQGAP3 Gene

Sources for IQGAP3 Gene

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