Aliases for IQGAP2 Gene
External Ids for IQGAP2 Gene
Previous GeneCards Identifiers for IQGAP2 Gene
This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
GeneCards Summary for IQGAP2 Gene
IQGAP2 (IQ Motif Containing GTPase Activating Protein 2) is a Protein Coding gene. Diseases associated with IQGAP2 include Lung Papillary Adenocarcinoma and Colon Mucinous Adenocarcinoma. Among its related pathways are Innate Immune System and RHO GTPases activate IQGAPs. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is IQGAP1.
UniProtKB/Swiss-Prot Summary for IQGAP2 Gene
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.