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This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been ... See more...
Aliases for IQGAP2 Gene
Aliases for IQGAP2 Gene
External Ids for IQGAP2 Gene
- HGNC: 6111
- NCBI Entrez Gene: 10788
- Ensembl: ENSG00000145703
- OMIM®: 605401
- UniProtKB/Swiss-Prot: Q13576
Previous GeneCards Identifiers for IQGAP2 Gene
- GC05P074504
- GC05P075933
- GC05P075737
- GC05P075783
- GC05P075734
- GC05P075699
- GC05P070906
Summaries for IQGAP2 Gene
-
This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
GeneCards Summary for IQGAP2 Gene
IQGAP2 (IQ Motif Containing GTPase Activating Protein 2) is a Protein Coding gene. Diseases associated with IQGAP2 include Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Signaling by GPCR and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is IQGAP1.
UniProtKB/Swiss-Prot Summary for IQGAP2 Gene
-
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Additional gene information for IQGAP2 Gene
- HGNC (6111)
- NCBI Entrez Gene (10788)
- Ensembl (ENSG00000145703)
- OMIM® (605401)
- UniProtKB/Swiss-Prot (Q13576)
- Open Targets Platform(ENSG00000145703)
- Monarch Initiative
- Alliance of Genome Resources
- Search for IQGAP2 at DataMed
- Search for IQGAP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQGAP2 Gene
Genomics for IQGAP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IQGAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IQGAP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQGAP2
- Top Transcription factor binding sites by QIAGEN in the IQGAP2 gene promoter:
-
- AML1a
- HNF-1
- HNF-1A
- LCR-F1
- Lmo2
- MIF-1
- Nkx2-5
- POU2F1
- POU2F1a
- Zic3
Genomic Locations for IQGAP2 Gene
Latest Assembly
- chr5:76,403,285-76,708,132
- (GRCh38/hg38)
- Size:
- 304,848 bases
- Orientation:
- Plus strand
Previous Assembly
- chr5:75,699,110-76,003,957
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 304,848 bases
- Orientation:
- Plus strand
Genomic View for IQGAP2 Gene
Genes around IQGAP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.3 by HGNC
- 5q13.3 by Entrez Gene
- 5q13.3 by Ensembl
IQGAP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IQGAP2 Gene
Proteins for IQGAP2 Gene
-
Protein details for IQGAP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13576-IQGA2_HUMAN
- Recommended name:
- Ras GTPase-activating-like protein IQGAP2
- Protein Accession:
- Q13576
- A8K4V1
- B7Z8A4
- J3KR91
Protein attributes for IQGAP2 Gene
- Size:
- 1575 amino acids
- Molecular mass:
- 180578 Da
- Quaternary structure:
- No Data Available
Protein Expression for IQGAP2 Gene
Post-translational modifications for IQGAP2 Gene
Other Protein References for IQGAP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for IQGAP2
-
Abcam antibodies for IQGAP2
- Invitrogen Antibodies for IQGAP2 (AFLGC-IQGAP2)
-
Biorbyt antibodies for IQGAP2
-
Boster Bio Antibodies for IQGAP2
-
Custom Antibody ServicesProSci Antibodies for IQGAP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IQGAP2
Protein products for research
-
OriGene Purified Proteins for IQGAP2
- Search Origene for MassSpec and Protein Over-expression Lysates for IQGAP2
- Origene Custom Protein Services for IQGAP2
- Novus Biologicals proteins for IQGAP2
- antibodies-online: Show 5 available IQGAP2 Proteins ranked by validation data
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-
Quality Products:
-
Abcam proteins for IQGAP2
Assay products for research
- antibodies-online: Show 8 available IQGAP2 Elisa Kits ranked by validation data
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Quality Products:
No data available for DME Specific Peptides for IQGAP2 Gene
Domains & Families for IQGAP2 Gene
Gene Families for IQGAP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IQGAP2 Gene
- InterPro:
- Blocks:
-
- IQ calmodulin-binding region
- Calponin-like actin-binding
- Ras GTPase-activating protein
- RasGAP protein, C-terminal
- RasGAP
Suggested Antigen Peptide Sequences for IQGAP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Ras GTPase-activating-like protein IQGAP2 (IQGA2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IQGAP2 Gene
Function for IQGAP2 Gene
Molecular function for IQGAP2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
- GENATLAS Biochemistry:
- IQ motif containing GTPase activating protein 2,S pombe RasGAP-like protein SAR1 homolog,expressed in liver,potential effector for CDC42,may be involved in cell morphology
Phenotypes From GWAS Catalog for IQGAP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | TAS | 8756646 |
| GO:0005095 | GTPase inhibitor activity | TAS | 8756646 |
| GO:0005096 | GTPase activator activity | IBA | 21873635 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0005516 | calmodulin binding | IBA,IPI | 21299499 |
Phenotypes for IQGAP2 Gene
- MGI mutant phenotypes for IQGAP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IQGAP2:
Animal Models for IQGAP2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IQGAP2 - Starting at $85 >
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- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
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miRNA for IQGAP2 Gene
- miRTarBase miRNAs that target IQGAP2
-
- mmu-miR-301b-3p (MIRT007776)
- mmu-miR-34b-5p (MIRT012707)
- hsa-miR-499a-5p (MIRT442389)
- hsa-miR-208b-3p (MIRT442390)
- hsa-miR-208a-3p (MIRT442391)
- hsa-miR-549a (MIRT442392)
- hsa-miR-641 (MIRT442393)
- hsa-miR-3617-5p (MIRT442394)
- hsa-miR-548e-5p (MIRT442395)
- mmu-miR-684 (MIRT578449)
- mmu-miR-466l-5p (MIRT603855)
- mmu-miR-466k (MIRT603856)
- mmu-miR-466i-5p (MIRT603857)
- mmu-miR-466d-5p (MIRT603858)
- mmu-miR-760-5p (MIRT603859)
- hsa-miR-92a-1-5p (MIRT733482)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IQGAP2
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Clone products for research
- Applied Biological Materials (abm): Clones for IQGAP2 - Starting at $45 >
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- Sino Biological Human cDNA Clone for IQGAP2
- Addgene plasmids for IQGAP2
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Cell Lines for research
-
Horizon Cell Lines for IQGAP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IQGAP2 Gene
Localization for IQGAP2 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 4 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 12515716 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005874 | microtubule | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005902 | microvillus | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP2 Gene
Pathways & Interactions for IQGAP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Signaling by Rho GTPases | ||
| 3 | Cytoskeletal Signaling | ||
| 4 | Regulation of actin cytoskeleton | ||
| 5 | Actin Nucleation by ARP-WASP Complex |
CDC42 Pathway
.41
|
|
Pathways by source for IQGAP2 Gene
1 BioSystems pathway for IQGAP2 Gene
7 Reactome pathways for IQGAP2 Gene
1 KEGG pathway for IQGAP2 Gene
2 Qiagen pathways for IQGAP2 Gene
- CDC42 Pathway
- Rac1 Pathway
1 Cell Signaling Technology pathway for IQGAP2 Gene
Interacting Proteins for IQGAP2 Gene
Selected Interacting proteins:
Q13576-IQGA2_HUMAN
ENSP00000274364
for IQGAP2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for IQGAP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA,TAS | 8756646 |
| GO:0032956 | regulation of actin cytoskeleton organization | IBA | 21873635 |
| GO:0034260 | negative regulation of GTPase activity | IEA | -- |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | IDA | 12515716 |
| GO:0043087 | regulation of GTPase activity | IEA | -- |
No data available for SIGNOR curated interactions for IQGAP2 Gene
Transcripts for IQGAP2 Gene
mRNA/cDNA for IQGAP2 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000274364 5808 nts (view in UCSC)
- ENST00000379730 5442 nts (view in UCSC)
- ENST00000396234 3376 nts (view in UCSC)
- ENST00000502745 3404 nts (view in UCSC)
- ENST00000504254 562 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IQGAP2 - Starting at $85 >
- * IQGAP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IQGAP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IQGAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IQGAP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IQGAP2
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Clone products for research
- Applied Biological Materials (abm): Clones for IQGAP2 - Starting at $45 >
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- Sino Biological Human cDNA Clone for IQGAP2
- Addgene plasmids for IQGAP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IQGAP2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | · | 33c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: |
Relevant External Links for IQGAP2 Gene
- GeneLoc Exon Structure for
- IQGAP2
Expression for IQGAP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
- Intermediate Mesoderm (Gastrulation Derivatives)
- Intestine (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for IQGAP2 Gene
This gene is overexpressed in Liver (x7.7) and Whole Blood (x4.6).
This gene is overexpressed in Salivary gland (12.2), Peripheral blood mononuclear cells (12.1), and Liver (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IQGAP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQGAP2
SOURCE GeneReport for Unigene cluster for IQGAP2 Gene:
Hs.291030mRNA Expression by UniProt/SwissProt for IQGAP2 Gene:
Q13576-IQGA2_HUMAN
Tissue specificity:
Isoform 2 expression is enhanced in testis.
Evidence on tissue expression from TISSUES for IQGAP2 Gene
- Liver(4.7)
- Blood(4.6)
- Nervous system(3.7)
- Pancreas(3.2)
- Lung(2.7)
- Kidney(2.6)
- Stomach(2.4)
- Intestine(2.3)
- Spleen(2.1)
Primer products for research
-
OriGene qPCR primer pairs for IQGAP2
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IQGAP2 Gene
Orthologs for IQGAP2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IQGAP2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IQGAP2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IQGAP2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Iqgap2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Iqgap2 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IQGAP2 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| Chicken (Gallus gallus) |
Aves | IQGAP2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IQGAP2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | iqgap2 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | iqgap2 29 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | pes-7 30 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IQG1 30 |
|
OneToMany |
- Species where no ortholog for IQGAP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for IQGAP2 Gene
- ENSEMBL:
- Gene Tree for IQGAP2 (if available)
- TreeFam:
- Gene Tree for IQGAP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IQGAP2: view image
- Alliance of Genome Resources:
- Additional Orthologs for IQGAP2
Paralogs for IQGAP2 Gene
(2) SIMAP similar genes for IQGAP2 Gene using alignment to 10 proteins:
- IQGA2_HUMAN
- D6R939_HUMAN
- D6R999_HUMAN
- D6RDK8_HUMAN
- D6RGC6_HUMAN
- E7EWC2_HUMAN
- E9PDT6_HUMAN
- F5H7S7_HUMAN
- H0YA28_HUMAN
- J3KR91_HUMAN
Variants for IQGAP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQGAP2 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs145178581 | Benign: not provided | 76,673,976(+) |
A/G NM_006633.4(IQGAP2):c.3234A>G (p.Lys1078=) |
SYNONYMOUS | |
| rs147531108 | Benign: not provided | 76,590,467(+) |
G/A NM_006633.4(IQGAP2):c.700G>A (p.Val234Ile) |
MISSENSE | |
| rs17681908 | Benign: not provided | 76,695,595(+) |
C/Tp.Arg1379Trp NM_006633.4(IQGAP2):c.4135C>T (p.Arg1379Trp) |
MISSENSE | |
| rs192694811 | Uncertain Significance: not specified | 76,570,598(+) |
C/T NM_006633.4(IQGAP2):c.322C>T (p.Arg108Ter) |
NONSENSE | |
| rs2287932 | Benign: not provided | 76,673,535(+) |
G/Tp.Arg1052Ile NM_006633.4(IQGAP2):c.3155G>T (p.Arg1052Ile) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.06;
90.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IQGAP2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP2 Gene
Disorders for IQGAP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| enchondromatosis, multiple, ollier type |
|
|
Search IQGAP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IQGAP2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IQGAP2 Gene
Publications for IQGAP2 Gene
- A genome-wide association study for age-related hearing impairment in the Saami. (PMID: 20068591) Van Laer L … Van Camp G (European journal of human genetics : EJHG 2010) 3 22 40
- The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. (PMID: 8756646) Brill S … Snijders AJ (Molecular and cellular biology 1996) 2 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 40
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
ExternalLinks
Products for IQGAP2 Gene
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- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IQGAP2
- Search Origene for MassSpec and Protein Over-expression Lysates for IQGAP2
- Origene Custom Protein Services for IQGAP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IQGAP2
- Browse OriGene Inhibitory RNA Products For IQGAP2
- OriGene qPCR primer pairs for IQGAP2
- OriGene CRISPR knockouts for IQGAP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IQGAP2
- Sino Biological Human cDNA Clone for IQGAP2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IQGAP2
- Novus Biologicals proteins for IQGAP2
- Browse Antibodies
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- Abcam antibodies for IQGAP2
- Abcam proteins for IQGAP2
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- Browse Primary Antibodies
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- Invitrogen Antibodies for IQGAP2 (AFLGC-IQGAP2)
- VectorBuilder Custom and pre-made DNA vectors for IQGAP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IQGAP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IQGAP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IQGAP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IQGAP2
- Addgene plasmids for IQGAP2
- antibodies-online: Show 11 available IQGAP2 Antibodies ranked by validation data
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- antibodies-online: Show 8 available IQGAP2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 5 available IQGAP2 Proteins ranked by validation data
- Compare Top IQGAP2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for IQGAP2
- Search Santa Cruz Biotechnology (SCBT) for IQGAP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IQGAP2
- Custom Antibody ServicesProSci Antibodies for IQGAP2
- Search for IQGAP2 Proteins at ProSci
- Horizon Cell Lines for IQGAP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IQGAP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IQGAP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IQGAP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQGAP2
- Boster Bio Antibodies for IQGAP2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for IQGAP2
Sources for IQGAP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources