This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been ... See more...

Aliases for IQGAP2 Gene

Aliases for IQGAP2 Gene

  • IQ Motif Containing GTPase Activating Protein 2 2 3 5
  • Ras GTPase-Activating-Like Protein IQGAP2 3 4
  • IQGAP2 5

External Ids for IQGAP2 Gene

Previous GeneCards Identifiers for IQGAP2 Gene

  • GC05P074504
  • GC05P075933
  • GC05P075737
  • GC05P075783
  • GC05P075734
  • GC05P075699
  • GC05P070906

Summaries for IQGAP2 Gene

Entrez Gene Summary for IQGAP2 Gene

  • This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GeneCards Summary for IQGAP2 Gene

IQGAP2 (IQ Motif Containing GTPase Activating Protein 2) is a Protein Coding gene. Diseases associated with IQGAP2 include Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is IQGAP1.

UniProtKB/Swiss-Prot Summary for IQGAP2 Gene

  • Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Gene Wiki entry for IQGAP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQGAP2 Gene

Genomics for IQGAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IQGAP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQGAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQGAP2

Top Transcription factor binding sites by QIAGEN in the IQGAP2 gene promoter:
  • AML1a
  • HNF-1
  • HNF-1A
  • LCR-F1
  • Lmo2
  • MIF-1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • Zic3

Genomic Locations for IQGAP2 Gene

Genomic Locations for IQGAP2 Gene
chr5:76,403,285-76,708,132
(GRCh38/hg38)
Size:
304,848 bases
Orientation:
Plus strand
chr5:75,699,074-76,003,957
(GRCh37/hg19)
Size:
304,884 bases
Orientation:
Plus strand

Genomic View for IQGAP2 Gene

Genes around IQGAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP2 Gene

Proteins for IQGAP2 Gene

  • Protein details for IQGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13576-IQGA2_HUMAN
    Recommended name:
    Ras GTPase-activating-like protein IQGAP2
    Protein Accession:
    Q13576
    Secondary Accessions:
    • A8K4V1
    • B7Z8A4
    • J3KR91

    Protein attributes for IQGAP2 Gene

    Size:
    1575 amino acids
    Molecular mass:
    180578 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQGAP2 Gene

    Alternative splice isoforms for IQGAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQGAP2 Gene

Post-translational modifications for IQGAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQGAP2 Gene

Domains & Families for IQGAP2 Gene

Gene Families for IQGAP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IQGAP2 Gene

InterPro:
Blocks:
  • IQ calmodulin-binding region
  • Calponin-like actin-binding
  • Ras GTPase-activating protein
  • RasGAP protein, C-terminal
  • RasGAP
ProtoNet:

Suggested Antigen Peptide Sequences for IQGAP2 Gene

GenScript: Design optimal peptide antigens:
  • Ras GTPase-activating-like protein IQGAP2 (IQGA2_HUMAN)
genes like me logo Genes that share domains with IQGAP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IQGAP2 Gene

Function for IQGAP2 Gene

Molecular function for IQGAP2 Gene

UniProtKB/Swiss-Prot Function:
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
GENATLAS Biochemistry:
IQ motif containing GTPase activating protein 2,S pombe RasGAP-like protein SAR1 homolog,expressed in liver,potential effector for CDC42,may be involved in cell morphology

Phenotypes From GWAS Catalog for IQGAP2 Gene

Gene Ontology (GO) - Molecular Function for IQGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 8756646
GO:0005095 GTPase inhibitor activity TAS 8756646
GO:0005515 protein binding IEA --
GO:0005516 calmodulin binding IPI 21299499
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 22493426
genes like me logo Genes that share ontologies with IQGAP2: view
genes like me logo Genes that share phenotypes with IQGAP2: view

Animal Models for IQGAP2 Gene

MGI Knock Outs for IQGAP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQGAP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IQGAP2 Gene

Localization for IQGAP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQGAP2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IQGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12515716
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005902 microvillus IEA --
GO:0009986 cell surface IDA 12515716
genes like me logo Genes that share ontologies with IQGAP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP2 Gene

Pathways & Interactions for IQGAP2 Gene

genes like me logo Genes that share pathways with IQGAP2: view

Pathways by source for IQGAP2 Gene

1 BioSystems pathway for IQGAP2 Gene
1 KEGG pathway for IQGAP2 Gene
2 Qiagen pathways for IQGAP2 Gene
  • CDC42 Pathway
  • Rac1 Pathway
1 Cell Signaling Technology pathway for IQGAP2 Gene

Gene Ontology (GO) - Biological Process for IQGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,TAS 8756646
GO:0032956 regulation of actin cytoskeleton organization IBA 21873635
GO:0034260 negative regulation of GTPase activity IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA 12515716
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with IQGAP2: view

No data available for SIGNOR curated interactions for IQGAP2 Gene

Drugs & Compounds for IQGAP2 Gene

No Compound Related Data Available

Transcripts for IQGAP2 Gene

mRNA/cDNA for IQGAP2 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQGAP2

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for IQGAP2 Gene

GeneLoc Exon Structure for
IQGAP2

Expression for IQGAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP2 Gene

This gene is overexpressed in Liver (x7.7) and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for IQGAP2 Gene

This gene is overexpressed in Salivary gland (12.2), Peripheral blood mononuclear cells (12.1), and Liver (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IQGAP2 Gene



Protein tissue co-expression partners for IQGAP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQGAP2

SOURCE GeneReport for Unigene cluster for IQGAP2 Gene:

Hs.291030

mRNA Expression by UniProt/SwissProt for IQGAP2 Gene:

Q13576-IQGA2_HUMAN
Tissue specificity: Isoform 2 expression is enhanced in testis.

Evidence on tissue expression from TISSUES for IQGAP2 Gene

  • Liver(4.7)
  • Blood(4.6)
  • Nervous system(3.8)
  • Pancreas(3.2)
  • Lung(2.8)
  • Kidney(2.7)
  • Stomach(2.5)
  • Intestine(2.5)
  • Spleen(2.1)
  • Adrenal gland(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with IQGAP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IQGAP2 Gene

Orthologs for IQGAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IQGAP2 30 31
  • 99.66 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IQGAP2 30 31
  • 89.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IQGAP2 30 31
  • 88.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Iqgap2 30
  • 85.38 (n)
Mouse
(Mus musculus)
Mammalia Iqgap2 30 17 31
  • 85.31 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IQGAP2 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves IQGAP2 30 31
  • 73.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IQGAP2 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia iqgap2 30
  • 69.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii iqgap2 30 31
  • 64.82 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea pes-7 31
  • 26 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 31
  • 18 (a)
OneToMany
Species where no ortholog for IQGAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for IQGAP2 Gene

ENSEMBL:
Gene Tree for IQGAP2 (if available)
TreeFam:
Gene Tree for IQGAP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQGAP2: view image

Paralogs for IQGAP2 Gene

Paralogs for IQGAP2 Gene

(2) SIMAP similar genes for IQGAP2 Gene using alignment to 10 proteins:

  • IQGA2_HUMAN
  • D6R939_HUMAN
  • D6R999_HUMAN
  • D6RDK8_HUMAN
  • D6RGC6_HUMAN
  • E7EWC2_HUMAN
  • E9PDT6_HUMAN
  • F5H7S7_HUMAN
  • H0YA28_HUMAN
  • J3KR91_HUMAN
genes like me logo Genes that share paralogs with IQGAP2: view

Variants for IQGAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQGAP2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
717196 Benign: not provided 76,673,976(+) A/G SYNONYMOUS_VARIANT
720792 Benign: not provided 76,590,467(+) G/A MISSENSE_VARIANT
723267 Likely Benign: not provided 76,461,580(+) C/T SYNONYMOUS_VARIANT
724090 Benign: not provided 76,683,183(+) G/A SYNONYMOUS_VARIANT
729524 Benign: not provided 76,403,579(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IQGAP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IQGAP2 Gene

Variant ID Type Subtype PubMed ID
dgv1615e212 CNV loss 25503493
dgv5702n100 CNV loss 25217958
dgv9884n54 CNV loss 21841781
esv2663233 CNV deletion 23128226
esv2730320 CNV deletion 23290073
esv2730321 CNV deletion 23290073
esv2730322 CNV deletion 23290073
esv3303477 CNV mobile element insertion 20981092
esv3309501 CNV mobile element insertion 20981092
esv3344330 CNV insertion 20981092
esv3345107 CNV duplication 20981092
esv3352135 CNV insertion 20981092
esv3363156 CNV insertion 20981092
esv3394748 CNV insertion 20981092
esv3566123 CNV deletion 23714750
esv3570204 CNV loss 25503493
esv3570205 CNV loss 25503493
esv3570206 CNV loss 25503493
esv3605466 CNV loss 21293372
esv3605467 CNV loss 21293372
esv3605470 CNV loss 21293372
nsv1017025 CNV gain 25217958
nsv1022032 CNV gain 25217958
nsv1031881 CNV gain 25217958
nsv1035135 CNV gain 25217958
nsv1123960 CNV deletion 24896259
nsv1128172 CNV deletion 24896259
nsv474780 CNV novel sequence insertion 20440878
nsv4884 CNV insertion 18451855
nsv4885 CNV insertion 18451855
nsv598681 CNV loss 21841781
nsv950091 CNV duplication 24416366
nsv950092 CNV duplication 24416366
nsv950093 CNV duplication 24416366
nsv956477 CNV deletion 24416366

Variation tolerance for IQGAP2 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.06; 90.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQGAP2 Gene

Human Gene Mutation Database (HGMD)
IQGAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQGAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP2 Gene

Disorders for IQGAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQGAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
enchondromatosis, multiple, ollier type
  • osteochondromatosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IQGAP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IQGAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQGAP2 Gene

Publications for IQGAP2 Gene

  1. A genome-wide association study for age-related hearing impairment in the Saami. (PMID: 20068591) Van Laer L … Van Camp G (European journal of human genetics : EJHG 2010) 3 23 41
  2. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. (PMID: 8756646) Brill S … Snijders AJ (Molecular and cellular biology 1996) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41

Products for IQGAP2 Gene

Sources for IQGAP2 Gene