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This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
IQGAP2 (IQ Motif Containing GTPase Activating Protein 2) is a Protein Coding gene. Diseases associated with IQGAP2 include Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is IQGAP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | TAS | 8756646 |
GO:0005095 | GTPase inhibitor activity | TAS | 8756646 |
GO:0005515 | protein binding | IEA | -- |
GO:0005516 | calmodulin binding | IPI | 21299499 |
GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | 22493426 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 12515716 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005902 | microvillus | IEA | -- |
GO:0009986 | cell surface | IDA | 12515716 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Signaling by Rho GTPases | ||
3 | Cytoskeletal Signaling | ||
4 | Regulation of actin cytoskeleton | ||
5 | Actin Nucleation by ARP-WASP Complex |
CDC42 Pathway
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA,TAS | 8756646 |
GO:0032956 | regulation of actin cytoskeleton organization | IBA | 21873635 |
GO:0034260 | negative regulation of GTPase activity | IEA | -- |
GO:0034314 | Arp2/3 complex-mediated actin nucleation | IDA | 12515716 |
GO:0043087 | regulation of GTPase activity | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | · | 33c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | |||||||||||||||||||||||
SP4: | |||||||||||||||||||||||
SP5: | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IQGAP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IQGAP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IQGAP2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Iqgap2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Iqgap2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IQGAP2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | IQGAP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IQGAP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | iqgap2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | iqgap2 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | pes-7 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IQG1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717196 | Benign: not provided | 76,673,976(+) | A/G | SYNONYMOUS_VARIANT | |
720792 | Benign: not provided | 76,590,467(+) | G/A | MISSENSE_VARIANT | |
723267 | Likely Benign: not provided | 76,461,580(+) | C/T | SYNONYMOUS_VARIANT | |
724090 | Benign: not provided | 76,683,183(+) | G/A | SYNONYMOUS_VARIANT | |
729524 | Benign: not provided | 76,403,579(+) | C/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
enchondromatosis, multiple, ollier type |
|
|