This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in t... See more...

Aliases for IQGAP1 Gene

Aliases for IQGAP1 Gene

  • IQ Motif Containing GTPase Activating Protein 1 2 3 5
  • P195 2 3 4
  • Ras GTPase-Activating-Like Protein IQGAP1 3 4
  • RasGAP-Like With IQ Motifs 2 3
  • HUMORFA01 2 3
  • KIAA0051 2 4
  • SAR1 2 3
  • IQGAP1 5

External Ids for IQGAP1 Gene

Previous GeneCards Identifiers for IQGAP1 Gene

  • GC15M087129
  • GC15P084438
  • GC15P088518
  • GC15P088661
  • GC15P088732
  • GC15P090931
  • GC15P067043

Summaries for IQGAP1 Gene

Entrez Gene Summary for IQGAP1 Gene

  • This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for IQGAP1 Gene

IQGAP1 (IQ Motif Containing GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with IQGAP1 include Wolf-Hirschhorn Syndrome and Gastric Cancer. Among its related pathways are RET signaling and Paradoxical activation of RAF signaling by kinase inactive BRAF. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is IQGAP2.

UniProtKB/Swiss-Prot Summary for IQGAP1 Gene

  • Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).

Gene Wiki entry for IQGAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQGAP1 Gene

Genomics for IQGAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IQGAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J090387 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 629.1 +0.6 559 3.2 HNRNPL CREB1 POLR2A BACH1 ZHX2 LARP7 GABPA PHF21A RBFOX2 PATZ1 IQGAP1 lnc-CIB1-5 ZNF774 ENSG00000259177 CRTC3
GH15J090351 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 619 -35.8 -35760 1.8 SP1 CREB1 PRDM10 ZNF629 RFX1 SIX5 IKZF1 ZNF692 RCOR2 BACH1 IQGAP1 ZNF774 ENSG00000259314 TTLL13P NDUFA3P4
GH15J090386 Enhancer 0.2 Ensembl 600.7 -1.5 -1541 0.2 IQGAP1 NDUFA3P4 lnc-CIB1-5 ENSG00000259177 ZNF774
GH15J090398 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 34.2 +13.1 13141 5.6 CREB1 GATAD2A ZNF629 RFX1 RCOR2 ZNF7 JUND FOXA1 STAT3 PRDM1 IQGAP1 CRTC3 RPL36AP43 ZNF774 GABARAPL3 ARPIN CIB1 ZNF710 FES GDPGP1
GH15J090411 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 37 +25.3 25299 4.9 TEAD4 PRDM10 IKZF1 ZHX2 JUND PRDM1 PKNOX1 IKZF2 ZNF600 SCRT2 IQGAP1 ZNF710 CIB1 FES FJ601684-136 lnc-CRTC3-1 CRTC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQGAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQGAP1

Top Transcription factor binding sites by QIAGEN in the IQGAP1 gene promoter:
  • ATF6
  • CUTL1
  • E47
  • FOXI1
  • HFH-3
  • IRF-7A
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • Sp1

Genomic Locations for IQGAP1 Gene

Genomic Locations for IQGAP1 Gene
chr15:90,388,242-90,502,239
(GRCh38/hg38)
Size:
113,998 bases
Orientation:
Plus strand
chr15:90,931,450-91,045,475
(GRCh37/hg19)
Size:
114,026 bases
Orientation:
Plus strand

Genomic View for IQGAP1 Gene

Genes around IQGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP1 Gene

Proteins for IQGAP1 Gene

  • Protein details for IQGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46940-IQGA1_HUMAN
    Recommended name:
    Ras GTPase-activating-like protein IQGAP1
    Protein Accession:
    P46940
    Secondary Accessions:
    • A7MBM3

    Protein attributes for IQGAP1 Gene

    Size:
    1657 amino acids
    Molecular mass:
    189252 Da
    Quaternary structure:
    • Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state (PubMed:15355962). Interacts with RAC1 (PubMed:15355962). Does not interact with RHOA. Interacts with TSG101 (PubMed:17853893). Interacts with PAK6 (PubMed:18642328). Interacts with TMEM14B; this interaction increases IQGAP1 phosphorylation and induces its nuclear translocation (PubMed:29033352). Interacts with SASH1 (PubMed:23333244).
    • (Microbial infection) Interacts with ebolavirus vp40.
    SequenceCaution:
    • Sequence=BAA06123.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IQGAP1 Gene

neXtProt entry for IQGAP1 Gene

Post-translational modifications for IQGAP1 Gene

  • Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
  • Ubiquitination at Lys88, Lys348, Lys811, Lys1088, Lys1144, Lys1155, Lys1165, Lys1230, Lys1477, and Lys1528
  • Modification sites at PhosphoSitePlus

Other Protein References for IQGAP1 Gene

No data available for DME Specific Peptides for IQGAP1 Gene

Domains & Families for IQGAP1 Gene

Gene Families for IQGAP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IQGAP1 Gene

InterPro:
Blocks:
  • IQ calmodulin-binding region
  • Calponin-like actin-binding
  • Ras GTPase-activating protein
  • RasGAP protein, C-terminal
  • RasGAP
ProtoNet:

Suggested Antigen Peptide Sequences for IQGAP1 Gene

GenScript: Design optimal peptide antigens:
  • IQ motif containing GTPase activating protein 1 (A4QPB0_HUMAN)
  • p195 (IQGA1_HUMAN)
  • IQGAP1 protein (Q05DN7_HUMAN)
  • IQGAP1 protein (Q5FWG8_HUMAN)
  • IQGAP1 protein (Q6P1N4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46940

UniProtKB/Swiss-Prot:

IQGA1_HUMAN :
  • Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.
Domain:
  • Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.
genes like me logo Genes that share domains with IQGAP1: view

Function for IQGAP1 Gene

Molecular function for IQGAP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).
GENATLAS Biochemistry:
IQ motif containing GTPase activating protein 1,S pombe RasGAP-like protein SAR1 homolog,potential effector for CDC42,may be involved in cell morphology

Phenotypes From GWAS Catalog for IQGAP1 Gene

Gene Ontology (GO) - Molecular Function for IQGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005078 MAP-kinase scaffold activity IPI 18567582
GO:0005095 GTPase inhibitor activity TAS 8670801
GO:0005096 GTPase activator activity TAS 8051149
GO:0005509 calcium ion binding IDA 18567582
GO:0005515 protein binding IEA,IPI 10793131
genes like me logo Genes that share ontologies with IQGAP1: view
genes like me logo Genes that share phenotypes with IQGAP1: view

Animal Models for IQGAP1 Gene

MGI Knock Outs for IQGAP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQGAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IQGAP1 Gene

Localization for IQGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IQGAP1 Gene

Cell membrane. Nucleus. Cytoplasm. Note=Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816). {ECO:0000269 PubMed:20883816}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQGAP1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IQGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 25554515
GO:0005634 nucleus IEA,IDA 20883816
GO:0005737 cytoplasm IEA,IDA 25554515
GO:0005829 cytosol TAS --
GO:0005874 microtubule IDA 21525035
genes like me logo Genes that share ontologies with IQGAP1: view

Pathways & Interactions for IQGAP1 Gene

PathCards logo

SuperPathways for IQGAP1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 Innate Immune System
4 Regulation of actin cytoskeleton
5 Developmental Biology
genes like me logo Genes that share pathways with IQGAP1: view

Pathways by source for IQGAP1 Gene

1 R&D Systems pathway for IQGAP1 Gene
6 Qiagen pathways for IQGAP1 Gene
  • CDC42 Pathway
  • Epithelial Adherens Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Rac1 Pathway
  • Remodeling of Adherens Junctions
1 Cell Signaling Technology pathway for IQGAP1 Gene

SIGNOR curated interactions for IQGAP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IQGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0007165 signal transduction IEA,TAS 8051149
GO:0007173 epidermal growth factor receptor signaling pathway IMP 17563371
GO:0007346 regulation of mitotic cell cycle IMP 20883816
GO:0008543 fibroblast growth factor receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with IQGAP1: view

Drugs & Compounds for IQGAP1 Gene

(6) Drugs for IQGAP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Experimental, Investigational Pharma Target, ligand 115
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for IQGAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IQGAP1: view

Transcripts for IQGAP1 Gene

mRNA/cDNA for IQGAP1 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQGAP1

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP1 Gene

No ASD Table

Relevant External Links for IQGAP1 Gene

GeneLoc Exon Structure for
IQGAP1

Expression for IQGAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQGAP1 Gene

mRNA differential expression in normal tissues according to GTEx for IQGAP1 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for IQGAP1 Gene

This gene is overexpressed in Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IQGAP1 Gene



Protein tissue co-expression partners for IQGAP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQGAP1

SOURCE GeneReport for Unigene cluster for IQGAP1 Gene:

Hs.430551

mRNA Expression by UniProt/SwissProt for IQGAP1 Gene:

P46940-IQGA1_HUMAN
Tissue specificity: Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for IQGAP1 Gene

  • Liver(4.7)
  • Bone marrow(4.5)
  • Nervous system(4.2)
  • Intestine(3.6)
  • Lung(3.5)
  • Kidney(3.5)
  • Pancreas(3.4)
  • Blood(3.2)
  • Heart(3.2)
  • Spleen(3.1)
  • Skin(3)
  • Adrenal gland(2.9)
  • Muscle(2.8)
  • Lymph node(2.8)
  • Stomach(2.6)
  • Thyroid gland(2.5)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with IQGAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQGAP1 Gene

Orthologs for IQGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IQGAP1 30 31
  • 99.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IQGAP1 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia IQGAP1 30 31
  • 92.09 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IQGAP1 31
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 89 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
-- 31
  • 84 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Iqgap1 30 17 31
  • 88.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Iqgap1 30
  • 88.39 (n)
Chicken
(Gallus gallus)
Aves IQGAP1 30 31
  • 79.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IQGAP1 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia iqgap1 30
  • 74.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia XIQGAP1 30
Zebrafish
(Danio rerio)
Actinopterygii iqgap1 30 31
  • 69.95 (n)
OneToOne
Dr.17687 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.515 30
Worm
(Caenorhabditis elegans)
Secernentea pes-7 31
  • 27 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
Species where no ortholog for IQGAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for IQGAP1 Gene

ENSEMBL:
Gene Tree for IQGAP1 (if available)
TreeFam:
Gene Tree for IQGAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQGAP1: view image

Paralogs for IQGAP1 Gene

Paralogs for IQGAP1 Gene

(2) SIMAP similar genes for IQGAP1 Gene using alignment to 7 proteins:

  • IQGA1_HUMAN
  • A4QPB0_HUMAN
  • H0YKA5_HUMAN
  • H0YLE8_HUMAN
  • Q05DN7_HUMAN
  • Q5FWG8_HUMAN
  • Q6P1N4_HUMAN
genes like me logo Genes that share paralogs with IQGAP1: view

Variants for IQGAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQGAP1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
710078 Benign: not provided 90,429,671(+) C/T INTRON_VARIANT
710079 Benign: not provided 90,484,311(+) G/A MISSENSE_VARIANT
712395 Benign: not provided 90,441,637(+) A/G MISSENSE_VARIANT
714664 Benign: not provided 90,441,630(+) C/T SYNONYMOUS_VARIANT
776944 Benign: not provided 90,486,086(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IQGAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IQGAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2658n100 CNV gain 25217958
dgv2659n100 CNV gain 25217958
dgv4705n54 CNV gain 21841781
esv2658494 CNV deletion 23128226
esv2751541 CNV gain 17911159
esv2761843 CNV gain 21179565
esv3637227 CNV loss 21293372
esv3637228 CNV loss 21293372
nsv1045042 CNV gain 25217958
nsv457246 CNV gain 19166990
nsv472186 CNV novel sequence insertion 20440878
nsv474348 CNV novel sequence insertion 20440878
nsv570394 CNV gain 21841781
nsv570396 CNV gain 21841781
nsv833087 CNV loss 17160897
nsv833088 CNV loss 17160897
nsv952027 CNV duplication 24416366

Variation tolerance for IQGAP1 Gene

Residual Variation Intolerance Score: 1.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQGAP1 Gene

Human Gene Mutation Database (HGMD)
IQGAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP1 Gene

Disorders for IQGAP1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IQGAP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wolf-hirschhorn syndrome
  • whs
gastric cancer
  • gastric cancer, somatic
lissencephaly
nephrotic syndrome, type 3
  • nphs3
skin disease
  • genodermatosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IQGAP1

genes like me logo Genes that share disorders with IQGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQGAP1 Gene

Publications for IQGAP1 Gene

  1. Identification of a human rasGAP-related protein containing calmodulin-binding motifs. (PMID: 8051149) Weissbach L … Bernards A (The Journal of biological chemistry 1994) 2 3 4 23
  2. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. (PMID: 15695813) Li Z … Sacks DB (The Journal of biological chemistry 2005) 3 4 23
  3. Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. (PMID: 15355962) Grohmanova K … Kroschewski R (The Journal of biological chemistry 2004) 3 4 23
  4. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. (PMID: 8670801) Hart MJ … Polakis P (The EMBO journal 1996) 2 3 4
  5. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. (PMID: 29033352) Liu J … Wang X (Cell stem cell 2017) 3 4

Products for IQGAP1 Gene

  • Signalway ELISA kits for IQGAP1
  • Signalway Proteins for IQGAP1

Sources for IQGAP1 Gene