Aliases for IQGAP1 Gene
Aliases for IQGAP1 Gene
External Ids for IQGAP1 Gene
- HGNC: 6110
- Entrez Gene: 8826
- Ensembl: ENSG00000140575
- OMIM: 603379
- UniProtKB: P46940
Previous GeneCards Identifiers for IQGAP1 Gene
- GC15M087129
- GC15P084438
- GC15P088518
- GC15P088661
- GC15P088732
- GC15P090931
- GC15P067043
Summaries for IQGAP1 Gene
-
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
GeneCards Summary for IQGAP1 Gene
IQGAP1 (IQ Motif Containing GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with IQGAP1 include Bullous Skin Disease and Wolf-Hirschhorn Syndrome. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is IQGAP3.
UniProtKB/Swiss-Prot for IQGAP1 Gene
-
Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Additional gene information for IQGAP1 Gene
- Monarch Initiative
- Search for IQGAP1 at DataMed
- Search for IQGAP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP1 Gene
Genomics for IQGAP1 Gene
GeneHancer (GH) Regulatory Elements for IQGAP1 Gene
Promoters and enhancers for IQGAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IQGAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IQGAP1 gene promoter:
Regulatory Element Products
Genomic Locations for IQGAP1 Gene
Genomic Locations for IQGAP1 Gene
- chr15:90,388,218-90,502,243
- (GRCh38/hg38)
- Size:
- 114,026 bases
- Orientation:
- Plus strand
- chr15:90,931,450-91,045,475
- (GRCh37/hg19)
Genomic View for IQGAP1 Gene
Genes around IQGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.1 by Ensembl
- 15q26.1 by Entrez Gene
- 15q26.1 by HGNC
IQGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IQGAP1 Gene
Proteins for IQGAP1 Gene
-
Protein details for IQGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46940-IQGA1_HUMAN
- Recommended name:
- Ras GTPase-activating-like protein IQGAP1
- Protein Accession:
- P46940
- A7MBM3
Protein attributes for IQGAP1 Gene
- Size:
- 1657 amino acids
- Molecular mass:
- 189252 Da
- Quaternary structure:
-
- Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.
- SequenceCaution:
-
- Sequence=BAA06123.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for IQGAP1 Gene
Post-translational modifications for IQGAP1 Gene
- Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
- Ubiquitination at isoforms=88, isoforms=348, posLast=811811, posLast=10881088, posLast=11441144, isoforms=1155, posLast=11651165, posLast=12301230, isoforms=1477, and posLast=15281528
- Modification sites at PhosphoSitePlus
Other Protein References for IQGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IQGAP1 (IQGAP1)
- Novus Biologicals Antibodies for IQGAP1
-
Abcam antibodies for IQGAP1
- Invitrogen Antibodies for IQGAP1
- Search GeneTex for Antibodies for IQGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IQGAP1
Protein Products
-
OriGene Purified Proteins for IQGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for IQGAP1
- Origene Custom Protein Services for IQGAP1
- Search GeneTex for Proteins for IQGAP1
-
Abcam proteins for IQGAP1
Assay Products
No data available for DME Specific Peptides for IQGAP1 Gene
Domains & Families for IQGAP1 Gene
Gene Families for IQGAP1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IQGAP1 Gene
Suggested Antigen Peptide Sequences for IQGAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46940UniProtKB/Swiss-Prot:
IQGA1_HUMAN :- Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.
- Domain:
-
- Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.
Function for IQGAP1 Gene
Molecular function for IQGAP1 Gene
- GENATLAS Biochemistry:
- IQ motif containing GTPase activating protein 1,S pombe RasGAP-like protein SAR1 homolog,potential effector for CDC42,may be involved in cell morphology
- UniProtKB/Swiss-Prot Function:
- Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Phenotypes From GWAS Catalog for IQGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005095 | GTPase inhibitor activity | TAS | 8670801 |
| GO:0005096 | GTPase activator activity | TAS | 8051149 |
| GO:0005509 | calcium ion binding | TAS | 18567582 |
| GO:0005515 | protein binding | IPI | 10793131 |
| GO:0005516 | calmodulin binding | IDA | 18567582 |
Phenotypes for IQGAP1 Gene
- MGI mutant phenotypes for IQGAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IQGAP1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell number in S
- Decreased Hepatitis C virus replication
- Decreased Salmonella enterica Typhimurium binding
- Decreased viability with paclitaxel
Animal Models for IQGAP1 Gene
- MGI Knock Outs for IQGAP1:
-
- Iqgap1 tm1Aber
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IQGAP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IQGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IQGAP1 gene
- Search ViGene Biosciences for IQGAP1
CRISPR Products
-
OriGene CRISPR knockouts for IQGAP1
- genomics-online: gRNA clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
- Applied Biological Materials CRISPR for IQGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IQGAP1
- GenScript: Design CRISPR guide RNA sequences for IQGAP1
miRNA for IQGAP1 Gene
- miRTarBase miRNAs that target IQGAP1
-
- hsa-mir-124-3p (MIRT002697)
- hsa-mir-215-5p (MIRT024313)
- hsa-mir-192-5p (MIRT026798)
- hsa-mir-324-3p (MIRT042850)
- hsa-mir-92a-3p (MIRT049578)
- hsa-mir-376a-3p (MIRT440432)
- hsa-mir-544a (MIRT440433)
- hsa-mir-136-3p (MIRT724396)
- hsa-mir-3074-3p (MIRT724397)
- hsa-mir-449b-3p (MIRT724398)
- hsa-mir-506-3p (MIRT733787)
- hsa-mir-506-5p (MIRT734339)
miRNA Products
- Search ViGene Biosciences for IQGAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IQGAP1
- Browse OriGene Inhibitory RNA Products For IQGAP1
- genomics-online: shRNA clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IQGAP1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for IQGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IQGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IQGAP1
- Applied Biological Materials Clones for IQGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IQGAP1
-
ViGene Biosciences adenoviral particle packaged cDNA for IQGAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IQGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IQGAP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IQGAP1 Gene
Localization for IQGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IQGAP1 Gene
- Cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 4 |
| endosome | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IDA | 25554515 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 25554515 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005874 | microtubule | IDA | 21525035 |
Pathways & Interactions for IQGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Signaling by moderate kinase activity BRAF mutants | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Regulation of actin cytoskeleton | ||
| 5 | Developmental Biology |
.51
|
|
Pathways by source for IQGAP1 Gene
11 BioSystems pathways for IQGAP1 Gene
65 Reactome pathways for IQGAP1 Gene
3 KEGG pathways for IQGAP1 Gene
1 R&D Systems pathway for IQGAP1 Gene
6 Qiagen pathways for IQGAP1 Gene
1 Cell Signaling Technology pathway for IQGAP1 Gene
Interacting Proteins for IQGAP1 Gene
Selected Interacting proteins:
P46940-IQGA1_HUMAN
ENSP00000268182
for IQGAP1 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001817 | regulation of cytokine production | IEA | -- |
| GO:0007165 | signal transduction | IEA,TAS | 8051149 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IEA,IMP | 17563371 |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IEA | -- |
| GO:0034260 | negative regulation of GTPase activity | IEA | -- |
Drugs & Compounds for IQGAP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IQGAP1 Gene
mRNA/cDNA for IQGAP1 Gene
- (1) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (540) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IQGAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IQGAP1
- genomics-online: gRNA clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
- Applied Biological Materials CRISPR for IQGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IQGAP1
- GenScript: Design CRISPR guide RNA sequences for IQGAP1
miRNA Products
- Search ViGene Biosciences for IQGAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IQGAP1
- Browse OriGene Inhibitory RNA Products For IQGAP1
- genomics-online: shRNA clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IQGAP1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for IQGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IQGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IQGAP1
- Applied Biological Materials Clones for IQGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IQGAP1 Gene
mRNA differential expression in normal tissues according to GTEx for IQGAP1 Gene
This gene is overexpressed in Whole Blood (x5.7).
This gene is overexpressed in Tlymphocyte (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IQGAP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of IQGAP1 Gene:
IQGAP1SOURCE GeneReport for Unigene cluster for IQGAP1 Gene:
Hs.430551mRNA Expression by UniProt/SwissProt for IQGAP1 Gene:
P46940-IQGA1_HUMAN
Tissue specificity:
Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Evidence on tissue expression from TISSUES for IQGAP1 Gene
- Liver(4.6)
- Bone marrow(4.3)
- Nervous system(3.9)
- Intestine(3.2)
- Lung(3.2)
- Pancreas(3.1)
- Kidney(3)
- Blood(2.7)
- Heart(2.6)
- Lymph node(2.3)
- Spleen(2.3)
- Stomach(2.3)
- Adrenal gland(2.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for IQGAP1
- genomics-online: primer clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQGAP1 Gene
Orthologs for IQGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IQGAP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | IQGAP1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IQGAP1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IQGAP1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Iqgap1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Iqgap1 33 |
|
||
| chicken (Gallus gallus) |
Aves | IQGAP1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | IQGAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | iqgap1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | XIQGAP1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | iqgap1 33 34 |
|
||
| Dr.17687 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.515 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pes-7 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IQG1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IQGAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for IQGAP1 Gene
(2) SIMAP similar genes for IQGAP1 Gene using alignment to 7 proteins:
Variants for IQGAP1 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs886039901 | uncertain-significance, not specified | 90,482,219(+) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000010620 | -- | 90,435,419(+) | T/C | intron_variant | |
| rs1000019001 | -- | 90,389,824(+) | G/C | intron_variant | |
| rs1000055867 | -- | 90,476,101(+) | A/G | intron_variant | |
| rs1000064933 | -- | 90,435,101(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2658n100 | CNV | gain | 25217958 |
| dgv2659n100 | CNV | gain | 25217958 |
| dgv4705n54 | CNV | gain | 21841781 |
| esv2658494 | CNV | deletion | 23128226 |
| esv2751541 | CNV | gain | 17911159 |
| esv2761843 | CNV | gain | 21179565 |
| esv3637227 | CNV | loss | 21293372 |
| esv3637228 | CNV | loss | 21293372 |
| nsv1045042 | CNV | gain | 25217958 |
| nsv457246 | CNV | gain | 19166990 |
| nsv472186 | CNV | novel sequence insertion | 20440878 |
| nsv474348 | CNV | novel sequence insertion | 20440878 |
| nsv570394 | CNV | gain | 21841781 |
| nsv570396 | CNV | gain | 21841781 |
| nsv833087 | CNV | loss | 17160897 |
| nsv833088 | CNV | loss | 17160897 |
| nsv952027 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
1.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.55;
44.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IQGAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP1 Gene
Disorders for IQGAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bullous skin disease |
|
|
| wolf-hirschhorn syndrome |
|
|
| neuromuscular junction disease |
|
|
| gastric cancer |
|
|
| leigh syndrome |
|
|
Search IQGAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IQGAP1
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IQGAP1 Gene
Publications for IQGAP1 Gene
- Identification of a human rasGAP-related protein containing calmodulin-binding motifs. (PMID: 8051149) Weissbach L … Bernards A (The Journal of biological chemistry 1994) 2 3 4 22 58
- IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. (PMID: 15695813) Li Z … Sacks DB (The Journal of biological chemistry 2005) 3 4 22 58
- Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. (PMID: 15355962) Grohmanova K … Kroschewski R (The Journal of biological chemistry 2004) 3 4 22 58
- IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. (PMID: 8670801) Hart MJ … Polakis P (The EMBO journal 1996) 2 3 4 58
- Overexpression of IQGAP1 in advanced colorectal cancer correlates with poor prognosis-critical role in tumor invasion. (PMID: 19856315) Hayashi H … Iwasaki H (International journal of cancer 2010) 3 22 58
Products for IQGAP1 Gene
- R&D Systems Antibodies for IQGAP1 (IQGAP1)
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- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for IQGAP1
- Novus Biologicals lysates and proteins for IQGAP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse ELISA Kits
- Abcam antibodies for IQGAP1
- Abcam proteins for IQGAP1
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- Search Knockout (KO) Validated Antibodies
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- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for IQGAP1
- VectorBuilder custom plasmid, inducible vectors for IQGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IQGAP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IQGAP1
- antibodies-online: Search results for 105 available IQGAP1 Antibodies ranked by validation data
- Compare Top IQGAP1 Antibodies
- antibodies-online: Search results for 10 available IQGAP1 Elisa Kits ranked by validation data
- Compare Top IQGAP1 Elisa Kits
- Recommended
- antibodies-online: Search results for available IQGAP1 related products ranked by validation data
- Search GeneTex for Antibodies for IQGAP1
- Search GeneTex for Proteins for IQGAP1
- ViGene Biosciences adenoviral particle packaged cDNA for IQGAP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IQGAP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IQGAP1 gene
- Search ViGene Biosciences for IQGAP1
- Santa Cruz Biotechnology (SCBT) Antibodies for IQGAP1
- Search Santa Cruz Biotechnology (SCBT) for IQGAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IQGAP1
- Horizon Cell Lines for IQGAP1
- genomics-online: cdna clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
- orf clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
- genomics-online: gRNA clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
- genomics-online: primer clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
- genomics-online: shRNA clones - Search results for 82 available IQGAP1 gene related products
- Overview of 82 available IQGAP1 gene related products
Sources for IQGAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems