Aliases for IQCN Gene

Aliases for IQCN Gene

  • IQ Motif Containing N 2 3 5
  • KIAA1683 2 3 4
  • IQ Domain-Containing Protein N 3 4

External Ids for IQCN Gene

Previous HGNC Symbols for IQCN Gene

  • KIAA1683

Summaries for IQCN Gene

GeneCards Summary for IQCN Gene

IQCN (IQ Motif Containing N) is a Protein Coding gene. An important paralog of this gene is IQCE.

Gene Wiki entry for IQCN Gene

Additional gene information for IQCN Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQCN Gene

Genomics for IQCN Gene

GeneHancer (GH) Regulatory Elements for IQCN Gene

Promoters and enhancers for IQCN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018273 Promoter/Enhancer 1.3 Ensembl ENCODE 780 -0.9 -882 3.2 SMARCE1 POLR2A NR2F6 ZNF362 MYC CC2D1A L3MBTL2 RAD21 MAX ZNF121 IQCN HSALNG0124605 lnc-JUND-1 SUGP2 PDE4C piR-60690
GH19J018272 Enhancer 0.7 ENCODE 750.6 +2.0 1963 0.2 CTCF ZNF362 L3MBTL2 ZNF384 CEBPA ZEB2 ZNF585B ZNF501 SOX6 MGA IQCN HSALNG0124605 lnc-JUND-1 SUGP2 piR-58470
GH19J018270 Promoter 0.3 EPDnew 750.6 +4.4 4439 0.1 IQCN lnc-JUND-1 piR-58470
GH19J017333 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 101.4 +938.4 938416 6.2 GTF3C2 ZNF785 ZNF24 SP1 ZBTB40 SIX5 ZBTB6 FOXA1 SMARCE1 POLR2A GTPBP3 ANO8 HSALNG0124507 lnc-DDA1-1 CHERP ENSG00000269578 ENSG00000268743 C19orf44 IQCN SIN3B
GH19J018277 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 113 -8.6 -8592 11.8 E2F8 ZNF24 SP1 ZBTB40 CTCF SREBF1 ZBTB6 MLX RBPJ SMARCE1 JUND MIR3188 lnc-PGPEP1-5-001 lnc-PGPEP1-5-002 IQCN UPF1 ENSG00000268030 NR2C2AP ENSG00000268938 COLGALT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQCN on UCSC Golden Path with GeneCards custom track

Genomic Locations for IQCN Gene

Genomic Locations for IQCN Gene
chr19:18,257,096-18,274,509
(GRCh38/hg38)
Size:
17,414 bases
Orientation:
Minus strand
chr19:18,367,906-18,385,319
(GRCh37/hg19)
Size:
17,414 bases
Orientation:
Minus strand

Genomic View for IQCN Gene

Genes around IQCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCN Gene

Proteins for IQCN Gene

  • Protein details for IQCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0B3-IQCN_HUMAN
    Recommended name:
    IQ domain-containing protein N
    Protein Accession:
    Q9H0B3
    Secondary Accessions:
    • B4DYH2
    • E9PDE0
    • E9PH54
    • Q2KHR5
    • Q8N4G8
    • Q96M14
    • Q9C0I0

    Protein attributes for IQCN Gene

    Size:
    1180 amino acids
    Molecular mass:
    127693 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21774.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCN Gene

Post-translational modifications for IQCN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCN Gene

Domains & Families for IQCN Gene

Gene Families for IQCN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCN Gene

Suggested Antigen Peptide Sequences for IQCN Gene

GenScript: Design optimal peptide antigens:
  • KIAA1683 protein (A0JP06_HUMAN)
  • KIAA1683 protein (A0JP07_HUMAN)
  • KIAA1683 protein (Q2KHR5_HUMAN)
genes like me logo Genes that share domains with IQCN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IQCN Gene

Function for IQCN Gene

Phenotypes From GWAS Catalog for IQCN Gene

Gene Ontology (GO) - Molecular Function for IQCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IQCN: view
genes like me logo Genes that share phenotypes with IQCN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQCN

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCN Gene

Localization for IQCN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCN gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 1
plasma membrane 0
extracellular 0
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for IQCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with IQCN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for IQCN Gene

Pathways & Interactions for IQCN Gene

PathCards logo

SuperPathways for IQCN Gene

No Data Available

Gene Ontology (GO) - Biological Process for IQCN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCN Gene

Drugs & Compounds for IQCN Gene

No Compound Related Data Available

Transcripts for IQCN Gene

mRNA/cDNA for IQCN Gene

(3) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQCN

Alternative Splicing Database (ASD) splice patterns (SP) for IQCN Gene

No ASD Table

Relevant External Links for IQCN Gene

GeneLoc Exon Structure for
IQCN
ECgene alternative splicing isoforms for
IQCN

Expression for IQCN Gene

NURSA nuclear receptor signaling pathways regulating expression of IQCN Gene:

IQCN

Evidence on tissue expression from TISSUES for IQCN Gene

  • Nervous system(4.1)
  • Skin(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCN Gene

Orthologs for IQCN Gene

This gene was present in the common ancestor of mammals.

Orthologs for IQCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1683 33 32
  • 97.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1683 33 32
  • 70.94 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1683 33 32
  • 70.02 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1683 33
  • 23 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1683 33
  • 13 (a)
OneToOne
Species where no ortholog for IQCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IQCN Gene

ENSEMBL:
Gene Tree for IQCN (if available)
TreeFam:
Gene Tree for IQCN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQCN: view image

Paralogs for IQCN Gene

Paralogs for IQCN Gene

genes like me logo Genes that share paralogs with IQCN: view

Variants for IQCN Gene

Sequence variations from dbSNP and Humsavar for IQCN Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000128963 -- 18,266,342(-) T/C coding_sequence_variant, missense_variant
rs1000253499 -- 18,275,362(-) T/C upstream_transcript_variant
rs1000717083 -- 18,268,683(-) G/A/T intron_variant
rs1000940649 -- 18,260,160(-) A/C/G intron_variant
rs1001194309 -- 18,274,126(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCN Gene

Variant ID Type Subtype PubMed ID
esv2718287 CNV deletion 23290073
nsv1115541 CNV duplication 24896259
nsv470131 CNV loss 18288195
nsv578744 CNV gain 21841781
nsv828472 CNV loss 20364138
nsv833775 CNV loss 17160897
nsv952420 CNV deletion 24416366

Variation tolerance for IQCN Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCN Gene

Disorders for IQCN Gene

Additional Disease Information for IQCN

No disorders were found for IQCN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCN Gene

Publications for IQCN Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 56
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 56

Products for IQCN Gene

Sources for IQCN Gene