This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2... See more...

Aliases for IQCK Gene

Aliases for IQCK Gene

  • IQ Motif Containing K 2 3 5
  • IQ Domain-Containing Protein K 3 4

External Ids for IQCK Gene

Previous GeneCards Identifiers for IQCK Gene

  • GC16P019636
  • GC16P018264

Summaries for IQCK Gene

Entrez Gene Summary for IQCK Gene

  • This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for IQCK Gene

IQCK (IQ Motif Containing K) is a Protein Coding gene. Diseases associated with IQCK include Obsessive-Compulsive Disorder and Lens Subluxation.

Additional gene information for IQCK Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQCK Gene

Genomics for IQCK Gene

GeneHancer (GH) Regulatory Elements for IQCK Gene

Promoters and enhancers for IQCK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J019715 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.8 +1.3 1294 4.1 EP300 ZBTB40 ZNF217 SIN3A MYC POLR2G USF1 NCOR1 PHF8 SIX5 KNOP1 IQCK NONHSAG018797.2 RPS15A
GH16J019742 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +28.8 28823 5 FOXK2 NCOR1 ZIC2 TCF7 FOXA1 SKI TEAD1 TBX3 ZKSCAN8 ZSCAN9 KNOP1 IQCK VPS35L ENSG00000261195 NONHSAG018797.2
GH16J019783 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.3 +68.2 68183 3.3 KMT2B FOXA2 NR2F2 FOXA1 ZGPAT ZKSCAN1 TFAP4 HLF NFYC SOX5 KNOP1 IQCK RF00017-2001 LOC105371115 NONHSAG018797.2
GH16J019644 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.2 -70.9 -70943 1.9 ZSCAN5C ZIC2 ATF2 OSR2 IKZF3 ZNF843 PRDM6 GLIS1 ZNF398 MAZ VPS35L IQCK KNOP1 piR-44883-005 HSALNG0110010
GH16J019637 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.1 -77.5 -77455 2.5 RBM25 NFIC FOS TAL1 HDAC2 TCF12 KDM1A JUND TEAD4 KLF16 KNOP1 VPS35L IQCK piR-44883-005 HSALNG0110010
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQCK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQCK

Top Transcription factor binding sites by QIAGEN in the IQCK gene promoter:
  • AREB6
  • GCNF
  • GCNF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Roaz
  • TGIF

Genomic Locations for IQCK Gene

Genomic Locations for IQCK Gene
142,012 bases
Plus strand
141,130 bases
Plus strand

Genomic View for IQCK Gene

Genes around IQCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCK Gene

Proteins for IQCK Gene

  • Protein details for IQCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ domain-containing protein K
    Protein Accession:
    Secondary Accessions:
    • B2RDU0
    • O43327
    • Q8NFF4

    Protein attributes for IQCK Gene

    287 amino acids
    Molecular mass:
    33292 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCK Gene


neXtProt entry for IQCK Gene

Post-translational modifications for IQCK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCK Gene

Domains & Families for IQCK Gene

Gene Families for IQCK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCK Gene


Suggested Antigen Peptide Sequences for IQCK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50424 (B4DXE1_HUMAN)
  • cDNA FLJ52048 (B4E1V3_HUMAN)
  • IQ domain-containing protein K (IQCK_HUMAN)
  • IQCK protein (Q96FR4_HUMAN)
genes like me logo Genes that share domains with IQCK: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IQCK Gene

Function for IQCK Gene

Phenotypes From GWAS Catalog for IQCK Gene

genes like me logo Genes that share phenotypes with IQCK: view

Animal Model Products

CRISPR Products

miRNA for IQCK Gene

miRTarBase miRNAs that target IQCK

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCK Gene

Localization for IQCK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCK gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCK Gene

Pathways & Interactions for IQCK Gene

PathCards logo

SuperPathways for IQCK Gene

No Data Available

Interacting Proteins for IQCK Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000324901 Q8N0W5-IQCK_HUMAN for IQCK Gene via STRING IID


Gene Ontology (GO) - Biological Process for IQCK Gene


No data available for Pathways by source and SIGNOR curated interactions for IQCK Gene

Drugs & Compounds for IQCK Gene

No Compound Related Data Available

Transcripts for IQCK Gene

mRNA/cDNA for IQCK Gene

11 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP8: -

Relevant External Links for IQCK Gene

GeneLoc Exon Structure for

Expression for IQCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQCK Gene

Protein differential expression in normal tissues from HIPED for IQCK Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCK Gene

Protein tissue co-expression partners for IQCK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQCK

SOURCE GeneReport for Unigene cluster for IQCK Gene:

genes like me logo Genes that share expression patterns with IQCK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCK Gene

Orthologs for IQCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQCK 31 30
  • 98.49 (n)
(Canis familiaris)
Mammalia IQCK 31 30
  • 83.27 (n)
(Bos Taurus)
Mammalia IQCK 31 30
  • 81.29 (n)
(Mus musculus)
Mammalia Iqck 17 31 30
  • 77.54 (n)
(Rattus norvegicus)
Mammalia Iqck 30
  • 76.26 (n)
(Monodelphis domestica)
Mammalia IQCK 31
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 49 (a)
-- 31
  • 40 (a)
(Gallus gallus)
Aves IQCK 31 30
  • 71.78 (n)
(Anolis carolinensis)
Reptilia IQCK 31
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqck 30
  • 59.6 (n)
Str.14127 30
(Danio rerio)
Actinopterygii iqck 31
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
Species where no ortholog for IQCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCK Gene

Gene Tree for IQCK (if available)
Gene Tree for IQCK (if available)
Evolutionary constrained regions (ECRs) for IQCK: view image

Paralogs for IQCK Gene

(1) SIMAP similar genes for IQCK Gene using alignment to 9 proteins:

  • B4E1V3_HUMAN
  • H3BU74_HUMAN
  • H3BV97_HUMAN
  • I3L193_HUMAN
  • Q96FR4_HUMAN Pseudogenes for IQCK Gene

genes like me logo Genes that share paralogs with IQCK: view

No data available for Paralogs for IQCK Gene

Variants for IQCK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQCK Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
791060 Likely Benign: not provided 19,764,081(+) A/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs7191155 - p.Leu220Pro

Additional dbSNP identifiers (rs#s) for IQCK Gene

Structural Variations from Database of Genomic Variants (DGV) for IQCK Gene

Variant ID Type Subtype PubMed ID
esv275046 CNV gain+loss 21479260
esv2761903 CNV gain 21179565
nsv1037002 CNV gain 25217958
nsv1127474 CNV deletion 24896259
nsv1131230 CNV deletion 24896259
nsv428321 CNV loss 18775914
nsv436835 CNV insertion 17901297
nsv571582 CNV gain 21841781

Variation tolerance for IQCK Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.14; 93.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCK Gene

Disorders for IQCK Gene

MalaCards: The human disease database

(2) MalaCards diseases for IQCK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obsessive-compulsive disorder
  • ocd
lens subluxation
  • subluxation of lens
- elite association - COSMIC cancer census association via MalaCards
Search IQCK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IQCK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IQCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQCK Gene

Publications for IQCK Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. (PMID: 24821223) Mattheisen M … Nestadt G (Molecular psychiatry 2015) 3 54

Products for IQCK Gene

Sources for IQCK Gene