Aliases for IQCJ Gene

Aliases for IQCJ Gene

  • IQ Motif Containing J 2 3 5
  • IQ Domain-Containing Protein J 3 4
  • Calmodulin Binding Protein 3

External Ids for IQCJ Gene

Previous GeneCards Identifiers for IQCJ Gene

  • GC03U900617
  • GC03P160269
  • GC03P158680
  • GC03P156182

Summaries for IQCJ Gene

GeneCards Summary for IQCJ Gene

IQCJ (IQ Motif Containing J) is a Protein Coding gene.

Additional gene information for IQCJ Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQCJ Gene

Genomics for IQCJ Gene

GeneHancer (GH) Regulatory Elements for IQCJ Gene

Promoters and enhancers for IQCJ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J158961 Enhancer 0.6 Ensembl ENCODE 500.7 -1.1 -1057 1.1 USF1 POLR2A YY1 TAF1 EP300 TBP IQCJ IQCJ-SCHIP1 RF00017-4153
GH03J159069 Promoter/Enhancer 0.6 EPDnew Ensembl 500.1 +106.4 106373 0.2 POLR2A IQCJ piR-40476-050 HSALNG0030189 IQCJ-SCHIP1
GH03J159025 Promoter 0.3 EPDnew 500.2 +63.1 63061 0.1 IQCJ HSALNG0030189 piR-60885-085 IQCJ-SCHIP1
GH03J158991 Enhancer 0.7 Ensembl ENCODE 11.7 +28.5 28473 1.2 ZNF217 KLF7 YY1 TCF12 FOXA1 SNIP1 GLIS1 ZFP69B KLF1 MNT piR-60885-085 IQCJ MLF1 IQCJ-SCHIP1 HSALNG0030189
GH03J158917 Enhancer 0.7 Ensembl ENCODE 11.4 -44.8 -44826 1 EP300 CTCF ZIC2 RAD21 SMC3 FOS PKNOX1 ZNF654 POLR2A ZNF143 IQCJ GFM1 RSRC1 HSALNG0030186 HSALNG0030188
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQCJ on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQCJ

Top Transcription factor binding sites by QIAGEN in the IQCJ gene promoter:
  • CUTL1
  • FOXF2
  • HNF-1
  • HNF-1A
  • Msx-1
  • Pax-6
  • POU2F1
  • POU2F1a
  • PPAR-alpha

Genomic Locations for IQCJ Gene

Genomic Locations for IQCJ Gene
chr3:158,962,928-159,266,307
(GRCh38/hg38)
Size:
303,380 bases
Orientation:
Plus strand
chr3:158,680,717-158,984,096
(GRCh37/hg19)
Size:
303,380 bases
Orientation:
Plus strand

Genomic View for IQCJ Gene

Genes around IQCJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCJ Gene

Proteins for IQCJ Gene

  • Protein details for IQCJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1A5X6-IQCJ_HUMAN
    Recommended name:
    IQ domain-containing protein J
    Protein Accession:
    Q1A5X6
    Secondary Accessions:
    • B7ZMM2
    • B9EH97
    • Q1A5X5

    Protein attributes for IQCJ Gene

    Size:
    159 amino acids
    Molecular mass:
    18226 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCJ Gene

Post-translational modifications for IQCJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQCJ Gene

No data available for DME Specific Peptides for IQCJ Gene

Domains & Families for IQCJ Gene

Gene Families for IQCJ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCJ Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCJ Gene

GenScript: Design optimal peptide antigens:
  • IQ domain-containing protein J (IQCJ_HUMAN)
genes like me logo Genes that share domains with IQCJ: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IQCJ Gene

Function for IQCJ Gene

Phenotypes From GWAS Catalog for IQCJ Gene

genes like me logo Genes that share phenotypes with IQCJ: view

Animal Model Products

CRISPR Products

miRNA for IQCJ Gene

miRTarBase miRNAs that target IQCJ

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQCJ

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCJ Gene

Localization for IQCJ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IQCJ Gene

Pathways & Interactions for IQCJ Gene

PathCards logo

SuperPathways for IQCJ Gene

No Data Available

Interacting Proteins for IQCJ Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000402153 for IQCJ Gene via STRING

;

Gene Ontology (GO) - Biological Process for IQCJ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCJ Gene

Drugs & Compounds for IQCJ Gene

No Compound Related Data Available

Transcripts for IQCJ Gene

mRNA/cDNA for IQCJ Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQCJ

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCJ Gene

No ASD Table

Relevant External Links for IQCJ Gene

GeneLoc Exon Structure for
IQCJ

Expression for IQCJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQCJ Gene

mRNA differential expression in normal tissues according to GTEx for IQCJ Gene

This gene is overexpressed in Testis (x10.8), Pituitary (x4.8), and Brain - Amygdala (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCJ Gene



Protein tissue co-expression partners for IQCJ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQCJ

SOURCE GeneReport for Unigene cluster for IQCJ Gene:

Hs.570685

Evidence on tissue expression from TISSUES for IQCJ Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with IQCJ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCJ Gene

Orthologs for IQCJ Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCJ 31 30
  • 99.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Iqcj 17 31 30
  • 88.55 (n)
cow
(Bos Taurus)
Mammalia IQCJ 31
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IQCJ 31
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQCJ 31
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IQCJ 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves IQCJ 31
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQCJ 31
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IQCJ 31
  • 45 (a)
OneToOne
Species where no ortholog for IQCJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCJ Gene

ENSEMBL:
Gene Tree for IQCJ (if available)
TreeFam:
Gene Tree for IQCJ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQCJ: view image

Paralogs for IQCJ Gene

(1) SIMAP similar genes for IQCJ Gene using alignment to 1 proteins:

  • IQCJ_HUMAN
genes like me logo Genes that share paralogs with IQCJ: view

No data available for Paralogs for IQCJ Gene

Variants for IQCJ Gene

Additional dbSNP identifiers (rs#s) for IQCJ Gene

Structural Variations from Database of Genomic Variants (DGV) for IQCJ Gene

Variant ID Type Subtype PubMed ID
esv23950 CNV loss 19812545
esv24169 CNV loss 19812545
esv2421756 CNV deletion 20811451
esv2516721 CNV insertion 19546169
esv2656480 CNV deletion 23128226
esv2726104 CNV deletion 23290073
esv2762352 CNV gain 21179565
esv3562788 CNV deletion 23714750
esv3598351 CNV loss 21293372
esv3598352 CNV loss 21293372
esv3598354 CNV loss 21293372
esv3598355 CNV gain 21293372
esv3598356 CNV loss 21293372
esv3598357 CNV loss 21293372
esv3598360 CNV loss 21293372
esv3893792 CNV loss 25118596
esv5527 OTHER inversion 19470904
nsv1004124 CNV gain 25217958
nsv1010336 CNV loss 25217958
nsv1010828 CNV gain 25217958
nsv437890 CNV loss 16468122
nsv470971 CNV gain 18288195
nsv592125 CNV loss 21841781
nsv998949 CNV gain 25217958

Variation tolerance for IQCJ Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCJ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQCJ Gene

Disorders for IQCJ Gene

Additional Disease Information for IQCJ

No disorders were found for IQCJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCJ Gene

Publications for IQCJ Gene

  1. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. (PMID: 17045569) Kwaśnicka-Crawford DA … Scherer SW (Biochemical and biophysical research communications 2006) 2 3 4 54
  2. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. (PMID: 28625976) Hou P … Huang J (Cancer research 2017) 3 54
  3. Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans. (PMID: 28134766) Vallée Marcotte B … Vohl MC (International journal of molecular sciences 2017) 3 54
  4. Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation. (PMID: 27160456) Vallée Marcotte B … Vohl MC (Journal of nutrigenetics and nutrigenomics 2016) 3 54
  5. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. (PMID: 18550753) Martin PM … Goutebroze L (The Journal of neuroscience : the official journal of the Society for Neuroscience 2008) 3 54

Products for IQCJ Gene

Sources for IQCJ Gene