Aliases for IQCH Gene

Aliases for IQCH Gene

  • IQ Motif Containing H 2 3 5
  • Testis Development Protein NYD-SP5 3 4
  • IQ Domain-Containing Protein H 3 4
  • NYDSP5 3

External Ids for IQCH Gene

Previous GeneCards Identifiers for IQCH Gene

  • GC15P065335
  • GC15P067547
  • GC15P044381

Summaries for IQCH Gene

GeneCards Summary for IQCH Gene

IQCH (IQ Motif Containing H) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for IQCH Gene

Additional gene information for IQCH Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQCH Gene

Genomics for IQCH Gene

GeneHancer (GH) Regulatory Elements for IQCH Gene

Promoters and enhancers for IQCH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J067253 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 508.4 -0.4 -373 2.8 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G IQCH AAGAB lnc-LCTL-3 TIPIN RPL35AP32 PIAS1 MAP2K5 ZWILCH SKOR1 ENSG00000260773
GH15J067260 Promoter 0.3 EPDnew 500.4 +5.8 5757 0.1 IQCH AAGAB piR-43105-215
GH15J067171 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 17.3 -78.3 -78307 10.5 ZNF217 TCF12 JUND FOS ZNF10 ZBTB10 ZNF623 HES1 MYC CTBP1 IQCH SMAD3 ZWILCH SNAPC5 TIPIN AAGAB SNORD16 ENSG00000260773 MAP2K5 SKOR1
GH15J067192 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.4 -57.7 -57705 9.9 POLR2G FOS ZNF639 ZNF341 OSR2 BCL11A WT1 ZNF316 ZBTB17 MAFF IQCH AAGAB TIPIN SKOR1 ZWILCH MAP2K5 SMAD3 piR-47234 lnc-IQCH-5 RPS24P16
GH15J067182 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.5 -67.6 -67626 9.7 ZNF623 MXI1 ZNF341 NR2F2 RELA CEBPB POLR2A SAP130 POLR2G RBM22 IQCH AAGAB MAP2K5 piR-47234 lnc-IQCH-5 SMAD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQCH on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQCH

Top Transcription factor binding sites by QIAGEN in the IQCH gene promoter:
  • aMEF-2
  • C/EBPalpha
  • Chx10
  • MEF-2A
  • MyoD

Genomic Locations for IQCH Gene

Genomic Locations for IQCH Gene
chr15:67,254,774-67,506,612
(GRCh38/hg38)
Size:
251,839 bases
Orientation:
Plus strand
chr15:67,547,138-67,794,598
(GRCh37/hg19)
Size:
247,461 bases
Orientation:
Plus strand

Genomic View for IQCH Gene

Genes around IQCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCH Gene

Proteins for IQCH Gene

  • Protein details for IQCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VS3-IQCH_HUMAN
    Recommended name:
    IQ domain-containing protein H
    Protein Accession:
    Q86VS3
    Secondary Accessions:
    • A8K8W3
    • C9JPR6
    • D6RJ88
    • Q4G0S6
    • Q8NEH9
    • Q9BWX2
    • Q9H9Y1
    • Q9UF88

    Protein attributes for IQCH Gene

    Size:
    1027 amino acids
    Molecular mass:
    117349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCH Gene

Post-translational modifications for IQCH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCH Gene

Domains & Families for IQCH Gene

Gene Families for IQCH Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCH Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57443 (B4E2J4_HUMAN)
  • Testis development protein NYD-SP5 (IQCH_HUMAN)
genes like me logo Genes that share domains with IQCH: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IQCH Gene

Function for IQCH Gene

Molecular function for IQCH Gene

UniProtKB/Swiss-Prot Function:
May play a regulatory role in spermatogenesis.

Phenotypes From GWAS Catalog for IQCH Gene

Gene Ontology (GO) - Molecular Function for IQCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with IQCH: view
genes like me logo Genes that share phenotypes with IQCH: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCH Gene

Localization for IQCH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCH gene
Compartment Confidence
cytosol 3
nucleus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IQCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with IQCH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQCH Gene

Pathways & Interactions for IQCH Gene

PathCards logo

SuperPathways for IQCH Gene

No Data Available

Interacting Proteins for IQCH Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000336861 Q86VS3-IQCH_HUMAN for IQCH Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for IQCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IQCH: view

No data available for Pathways by source and SIGNOR curated interactions for IQCH Gene

Drugs & Compounds for IQCH Gene

No Compound Related Data Available

Transcripts for IQCH Gene

mRNA/cDNA for IQCH Gene

11 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -

ExUns: 22c ^ 23
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for IQCH Gene

GeneLoc Exon Structure for
IQCH

Expression for IQCH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQCH Gene

mRNA differential expression in normal tissues according to GTEx for IQCH Gene

This gene is overexpressed in Testis (x10.6).

Protein differential expression in normal tissues from HIPED for IQCH Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCH Gene



Protein tissue co-expression partners for IQCH Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQCH

SOURCE GeneReport for Unigene cluster for IQCH Gene:

Hs.657894

mRNA Expression by UniProt/SwissProt for IQCH Gene:

Q86VS3-IQCH_HUMAN
Tissue specificity: Expressed in fetal and adult testis, in germ cells but not somatic cells.
genes like me logo Genes that share expression patterns with IQCH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCH Gene

Orthologs for IQCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCH 31 30
  • 99.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IQCH 31 30
  • 88.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IQCH 31 30
  • 85.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Iqch 17 31 30
  • 80.75 (n)
rat
(Rattus norvegicus)
Mammalia Iqch 30
  • 79.4 (n)
oppossum
(Monodelphis domestica)
Mammalia IQCH 31
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQCH 31
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC415554 30
  • 66.56 (n)
IQCH 31
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQCH 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqch 30
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13986 30
zebrafish
(Danio rerio)
Actinopterygii iqch 31 30
  • 54.18 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToOne
Cin.13356 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13356 30
Species where no ortholog for IQCH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCH Gene

ENSEMBL:
Gene Tree for IQCH (if available)
TreeFam:
Gene Tree for IQCH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQCH: view image

Paralogs for IQCH Gene

No data available for Paralogs for IQCH Gene

Variants for IQCH Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQCH Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
722494 Benign: not provided 67,400,108(+) T/G INTRON_VARIANT
722880 Benign: not provided 67,372,272(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
726116 Benign: not provided 67,254,917(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
727748 Likely Benign: not provided 67,388,870(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs3985641 - p.Val932Leu

Additional dbSNP identifiers (rs#s) for IQCH Gene

Structural Variations from Database of Genomic Variants (DGV) for IQCH Gene

Variant ID Type Subtype PubMed ID
esv2660716 CNV deletion 23128226
esv2663197 CNV deletion 23128226
esv2666605 CNV deletion 23128226
esv3307361 CNV mobile element insertion 20981092
esv3321784 CNV insertion 20981092
esv3337306 CNV insertion 20981092
esv3350012 CNV insertion 20981092
esv3636778 CNV loss 21293372
esv3636781 CNV loss 21293372
esv3636784 CNV loss 21293372
esv3636785 CNV loss 21293372
esv3636786 CNV loss 21293372
nsv1049980 CNV loss 25217958
nsv1129568 CNV tandem duplication 24896259
nsv471817 CNV novel sequence insertion 20440878
nsv473557 CNV novel sequence insertion 20440878
nsv827371 CNV loss 20364138
nsv827372 CNV loss 20364138

Variation tolerance for IQCH Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCH Gene

Disorders for IQCH Gene

Additional Disease Information for IQCH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IQCH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCH Gene

Publications for IQCH Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 41 54
  3. Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians. (PMID: 18491143) Kimura T … Inoko H (Human genetics 2008) 3 41 54
  4. Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis. (PMID: 15897968) Yin LL … Sha JH (Asian journal of andrology 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for IQCH Gene

Sources for IQCH Gene