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Aliases for IQCH Gene

Aliases for IQCH Gene

  • IQ Motif Containing H 2 3 5
  • Testis Development Protein NYD-SP5 3 4
  • IQ Domain-Containing Protein H 3
  • NYDSP5 3

External Ids for IQCH Gene

Previous GeneCards Identifiers for IQCH Gene

  • GC15P065335
  • GC15P067547
  • GC15P044381

Summaries for IQCH Gene

GeneCards Summary for IQCH Gene

IQCH (IQ Motif Containing H) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQCH Gene

  • May play a regulatory role in spermatogenesis.

Additional gene information for IQCH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCH Gene

Genomics for IQCH Gene

GeneHancer (GH) Regulatory Elements for IQCH Gene

Promoters and enhancers for IQCH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I067253 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 558.5 -0.5 -455 2.6 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 IQCH AAGAB RPL35AP32 SNORD16 TIPIN PIAS1 MAP2K5 ZWILCH RPL4 ENSG00000260773
GH15I067372 Promoter 0.5 EPDnew 550.1 +117.3 117349 0.1 IQCH PIR57050 AAGAB
GH15I067171 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.3 -78.3 -78267 10.4 PKNOX1 ATF1 ARNT ZFP64 SIN3A TCF12 GATA2 FOS ATF7 RUNX3 ENSG00000260773 SNORD16 IQCH RPL35AP32 SMAD3 ZWILCH SNAPC5 TIPIN AAGAB IQCH-AS1
GH15I067196 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -55.9 -55856 5.5 KLF17 SIN3A ZNF2 ZNF335 ZNF366 ZNF391 FOS BCLAF1 RUNX3 ELF1 IQCH AAGAB MAP2K5 SMAD3 PIR40233 RPS24P16
GH15I067129 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -113.6 -113553 23 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SMAD3 PIR53240 SKOR1 SNORD16 DIS3L IQCH AAGAB ENSG00000260773 ENSG00000259202 PIR54457
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCH gene promoter:

Genomic Locations for IQCH Gene

Genomic Locations for IQCH Gene
chr15:67,254,774-67,506,612
(GRCh38/hg38)
Size:
251,839 bases
Orientation:
Plus strand
chr15:67,547,138-67,794,598
(GRCh37/hg19)

Genomic View for IQCH Gene

Genes around IQCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCH Gene

Proteins for IQCH Gene

  • Protein details for IQCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VS3-IQCH_HUMAN
    Recommended name:
    IQ domain-containing protein H
    Protein Accession:
    Q86VS3
    Secondary Accessions:
    • A8K8W3
    • C9JPR6
    • D6RJ88
    • Q4G0S6
    • Q8NEH9
    • Q9BWX2
    • Q9H9Y1
    • Q9UF88

    Protein attributes for IQCH Gene

    Size:
    1027 amino acids
    Molecular mass:
    117349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCH Gene

Post-translational modifications for IQCH Gene

No Post-translational modifications

No data available for DME Specific Peptides for IQCH Gene

Domains & Families for IQCH Gene

Gene Families for IQCH Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCH Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCH: view

No data available for UniProtKB/Swiss-Prot for IQCH Gene

Function for IQCH Gene

Molecular function for IQCH Gene

UniProtKB/Swiss-Prot Function:
May play a regulatory role in spermatogenesis.

Phenotypes From GWAS Catalog for IQCH Gene

Gene Ontology (GO) - Molecular Function for IQCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with IQCH: view
genes like me logo Genes that share phenotypes with IQCH: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCH Gene

Localization for IQCH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCH gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IQCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with IQCH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQCH Gene

Pathways & Interactions for IQCH Gene

No Data Available

Interacting Proteins for IQCH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000336861%0d%0a9606.ENSP00000384490%0d%0a9606.ENSP00000354871%0d%0a
Selected Interacting proteins: Q86VS3-IQCH_HUMAN ENSP00000336861 for IQCH Gene via IID STRING

Gene Ontology (GO) - Biological Process for IQCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IQCH: view

No data available for Pathways by source and SIGNOR curated interactions for IQCH Gene

Drugs & Compounds for IQCH Gene

No Compound Related Data Available

Transcripts for IQCH Gene

Unigene Clusters for IQCH Gene

IQ motif containing H:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -

ExUns: 22c ^ 23
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for IQCH Gene

GeneLoc Exon Structure for
IQCH
ECgene alternative splicing isoforms for
IQCH

Expression for IQCH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCH Gene

mRNA differential expression in normal tissues according to GTEx for IQCH Gene

This gene is overexpressed in Testis (x10.6).

Protein differential expression in normal tissues from HIPED for IQCH Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCH Gene



Protein tissue co-expression partners for IQCH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCH Gene:

IQCH

SOURCE GeneReport for Unigene cluster for IQCH Gene:

Hs.657894

mRNA Expression by UniProt/SwissProt for IQCH Gene:

Q86VS3-IQCH_HUMAN
Tissue specificity: Expressed in fetal and adult testis, in germ cells but not somatic cells.
genes like me logo Genes that share expression patterns with IQCH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCH Gene

Orthologs for IQCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCH 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia IQCH 33 34
  • 88.09 (n)
cow
(Bos Taurus)
Mammalia IQCH 33 34
  • 85.9 (n)
mouse
(Mus musculus)
Mammalia Iqch 33 16 34
  • 80.75 (n)
rat
(Rattus norvegicus)
Mammalia Iqch 33
  • 79.4 (n)
oppossum
(Monodelphis domestica)
Mammalia IQCH 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQCH 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC415554 33
  • 66.56 (n)
IQCH 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQCH 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqch 33
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13986 33
zebrafish
(Danio rerio)
Actinopterygii iqch 33 34
  • 54.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13356 33
Species where no ortholog for IQCH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCH Gene

ENSEMBL:
Gene Tree for IQCH (if available)
TreeFam:
Gene Tree for IQCH (if available)

Paralogs for IQCH Gene

No data available for Paralogs for IQCH Gene

Variants for IQCH Gene

Sequence variations from dbSNP and Humsavar for IQCH Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000004452 -- 67,342,026(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000031142 -- 67,436,569(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000049406 -- 67,291,667(+) T/C intron_variant
rs1000055887 -- 67,485,419(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000067544 -- 67,337,409(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCH Gene

Variant ID Type Subtype PubMed ID
nsv827372 CNV loss 20364138
nsv827371 CNV loss 20364138
nsv473557 CNV novel sequence insertion 20440878
nsv471817 CNV novel sequence insertion 20440878
nsv1129568 CNV tandem duplication 24896259
nsv1049980 CNV loss 25217958
esv3636786 CNV loss 21293372
esv3636785 CNV loss 21293372
esv3636784 CNV loss 21293372
esv3636781 CNV loss 21293372
esv3636778 CNV loss 21293372
esv3350012 CNV insertion 20981092
esv3337306 CNV insertion 20981092
esv3321784 CNV insertion 20981092
esv3307361 CNV mobile element insertion 20981092
esv2666605 CNV deletion 23128226
esv2663197 CNV deletion 23128226
esv2660716 CNV deletion 23128226

Variation tolerance for IQCH Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCH Gene

Disorders for IQCH Gene

Additional Disease Information for IQCH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IQCH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCH Gene

Publications for IQCH Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
  3. Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians. (PMID: 18491143) Kimura T … Inoko H (Human genetics 2008) 3 44 58
  4. Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis. (PMID: 15897968) Yin LL … Sha JH (Asian journal of andrology 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for IQCH Gene

Sources for IQCH Gene

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