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Aliases for IQCF2 Gene

Aliases for IQCF2 Gene

  • IQ Motif Containing F2 2 3 5

External Ids for IQCF2 Gene

Previous GeneCards Identifiers for IQCF2 Gene

  • GC03P051870
  • GC03P051895

Summaries for IQCF2 Gene

GeneCards Summary for IQCF2 Gene

IQCF2 (IQ Motif Containing F2) is a Protein Coding gene. An important paralog of this gene is IQCF1.

Additional gene information for IQCF2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCF2 Gene

Genomics for IQCF2 Gene

GeneHancer (GH) Regulatory Elements for IQCF2 Gene

Promoters and enhancers for IQCF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I051861 Promoter 0.5 EPDnew 550.8 0.0 -33 0.1 IQCF2 IQCF3 IQCF4 IQCF6 GPR62 PCBP4 GC03P051793
GH03I052243 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.8 +384.3 384257 4.9 HDGF PKNOX1 SIN3A IRF4 ZNF48 YY1 GLIS2 ZNF143 ATF7 FOS PPM1M PBRM1 LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03I052074 Enhancer 0.4 FANTOM5 31.6 +213.0 212962 0.2 ZFP36 ZMYM3 IQCF2 PHF7 IQCF5 IQCF1 IQCF6 LINC00696 POC1A
GH03I051902 Enhancer 0.6 ENCODE 7 +40.9 40931 0.2 ZNF639 KLF1 SP3 INSM2 ZNF223 KLF17 TSHZ1 JUND ZNF629 FOS IQCF1 IQCF5 IQCF5-AS1 RN7SL504P IQCF3 IQCF4 GPR62 PCBP4 IQCF2
GH03I051678 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.6 -180.7 -180666 4.1 HDGF HDAC1 ELF3 PKNOX1 RB1 ARID4B KLF5 RAD21 TCF12 ZNF207 IQCF6 DCAF1 RNU6ATAC29P GPR62 IQCF1 IQCF5 IQCF2 PIR41340 RNA5SP132 TEX264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCF2 gene promoter:

Genomic Locations for IQCF2 Gene

Genomic Locations for IQCF2 Gene
1,796 bases
Plus strand

Genomic View for IQCF2 Gene

Genes around IQCF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCF2 Gene

Proteins for IQCF2 Gene

  • Protein details for IQCF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ domain-containing protein F2
    Protein Accession:

    Protein attributes for IQCF2 Gene

    164 amino acids
    Molecular mass:
    19627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IQCF2 Gene

Post-translational modifications for IQCF2 Gene

No Post-translational modifications

Other Protein References for IQCF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQCF2 Gene

Domains & Families for IQCF2 Gene

Gene Families for IQCF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCF2 Gene


Suggested Antigen Peptide Sequences for IQCF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCF2: view

No data available for UniProtKB/Swiss-Prot for IQCF2 Gene

Function for IQCF2 Gene

Phenotypes From GWAS Catalog for IQCF2 Gene

Gene Ontology (GO) - Molecular Function for IQCF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with IQCF2: view

Phenotypes for IQCF2 Gene

GenomeRNAi human phenotypes for IQCF2:
genes like me logo Genes that share phenotypes with IQCF2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCF2 Gene

Localization for IQCF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCF2 gene
Compartment Confidence
extracellular 2
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IQCF2 Gene

Pathways & Interactions for IQCF2 Gene

SuperPathways for IQCF2 Gene

No Data Available

Interacting Proteins for IQCF2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000329904 Q8IXL9-IQCF2_HUMAN for IQCF2 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for IQCF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for IQCF2 Gene

Drugs & Compounds for IQCF2 Gene

No Compound Related Data Available

Transcripts for IQCF2 Gene

mRNA/cDNA for IQCF2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IQCF2 Gene

IQ motif containing F2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCF2 Gene

No ASD Table

Relevant External Links for IQCF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQCF2 Gene

This gene is overexpressed in Testis (x52.9).

NURSA nuclear receptor signaling pathways regulating expression of IQCF2 Gene:


SOURCE GeneReport for Unigene cluster for IQCF2 Gene:


Evidence on tissue expression from TISSUES for IQCF2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with IQCF2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCF2 Gene

Orthologs for IQCF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQCF2 33 34
  • 99.8 (n)
(Canis familiaris)
Mammalia IQCF2 33 34
  • 80.45 (n)
(Rattus norvegicus)
Mammalia Iqcf2 33
  • 80.44 (n)
(Bos Taurus)
Mammalia IQCF2 33 34
  • 78.12 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
Species where no ortholog for IQCF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IQCF2 Gene

Gene Tree for IQCF2 (if available)
Gene Tree for IQCF2 (if available)

Paralogs for IQCF2 Gene

Paralogs for IQCF2 Gene

(4) SIMAP similar genes for IQCF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IQCF2: view

Variants for IQCF2 Gene

Sequence variations from dbSNP and Humsavar for IQCF2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000763602 -- 51,861,248(+) C/G/T upstream_transcript_variant
rs1001193861 -- 51,863,625(+) C/G downstream_transcript_variant
rs1003611610 -- 51,859,985(+) T/C upstream_transcript_variant
rs1003663919 -- 51,859,684(+) A/G upstream_transcript_variant
rs1004055641 -- 51,862,619(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCF2 Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV gain 19592680
nsv3817 CNV insertion 18451855
nsv1001350 CNV gain 25217958

Variation tolerance for IQCF2 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCF2 Gene

Disorders for IQCF2 Gene

Additional Disease Information for IQCF2

No disorders were found for IQCF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCF2 Gene

Publications for IQCF2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for IQCF2 Gene

Sources for IQCF2 Gene

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