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Aliases for IQCF1 Gene

Aliases for IQCF1 Gene

  • IQ Motif Containing F1 2 3 5

External Ids for IQCF1 Gene

Previous GeneCards Identifiers for IQCF1 Gene

  • GC03M051818
  • GC03M051903
  • GC03M051843

Summaries for IQCF1 Gene

GeneCards Summary for IQCF1 Gene

IQCF1 (IQ Motif Containing F1) is a Protein Coding gene. An important paralog of this gene is IQCF5.

UniProtKB/Swiss-Prot for IQCF1 Gene

  • Involved in sperm capacitation and acrosome reaction.

Additional gene information for IQCF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCF1 Gene

Genomics for IQCF1 Gene

GeneHancer (GH) Regulatory Elements for IQCF1 Gene

Promoters and enhancers for IQCF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I051902 Enhancer 0.6 ENCODE 550.8 +0.8 810 0.2 ZNF639 KLF1 SP3 INSM2 ZNF223 KLF17 TSHZ1 JUND ZNF629 FOS IQCF1 IQCF5 IQCF5-AS1 RN7SL504P IQCF3 IQCF4 GPR62 PCBP4 IQCF2
GH03I051903 Promoter 0.6 EPDnew 550.8 0.0 -3 0.1 CREB1 IQCF1 IQCF5 IQCF5-AS1 RN7SL504P IQCF3 IQCF4 GPR62 PCBP4 RRP9
GH03I052243 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.7 -342.5 -342516 4.9 HDGF PKNOX1 SIN3A IRF4 ZNF48 YY1 GLIS2 ZNF143 ATF7 FOS PPM1M PBRM1 LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03I052074 Enhancer 0.4 FANTOM5 29.7 -171.2 -171221 0.2 ZFP36 ZMYM3 IQCF2 PHF7 IQCF5 IQCF1 IQCF6 LINC00696 POC1A
GH03I051678 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.7 +222.4 222407 4.1 HDGF HDAC1 ELF3 PKNOX1 RB1 ARID4B KLF5 RAD21 TCF12 ZNF207 IQCF6 DCAF1 RNU6ATAC29P GPR62 IQCF1 IQCF5 IQCF2 RNA5SP132 PIR41340 TEX264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCF1 gene promoter:

Genomic Locations for IQCF1 Gene

Genomic Locations for IQCF1 Gene
8,495 bases
Minus strand

Genomic View for IQCF1 Gene

Genes around IQCF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCF1 Gene

Proteins for IQCF1 Gene

  • Protein details for IQCF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ domain-containing protein F1
    Protein Accession:
    Secondary Accessions:
    • Q8N711

    Protein attributes for IQCF1 Gene

    205 amino acids
    Molecular mass:
    23699 Da
    Quaternary structure:
    • Interacts with calmodulin.

    Alternative splice isoforms for IQCF1 Gene


neXtProt entry for IQCF1 Gene

Post-translational modifications for IQCF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQCF1 Gene

No data available for DME Specific Peptides for IQCF1 Gene

Domains & Families for IQCF1 Gene

Gene Families for IQCF1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for IQCF1 Gene


Suggested Antigen Peptide Sequences for IQCF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCF1: view

No data available for UniProtKB/Swiss-Prot for IQCF1 Gene

Function for IQCF1 Gene

Molecular function for IQCF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in sperm capacitation and acrosome reaction.

Phenotypes From GWAS Catalog for IQCF1 Gene

Gene Ontology (GO) - Molecular Function for IQCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with IQCF1: view
genes like me logo Genes that share phenotypes with IQCF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCF1 Gene

Localization for IQCF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IQCF1 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCF1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IQCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IDA 25380116
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with IQCF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IQCF1 Gene

Pathways & Interactions for IQCF1 Gene

SuperPathways for IQCF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IQCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060474 positive regulation of flagellated sperm motility involved in capacitation ISS --
GO:2000344 positive regulation of acrosome reaction IBA,ISS --
genes like me logo Genes that share ontologies with IQCF1: view

No data available for Pathways by source and SIGNOR curated interactions for IQCF1 Gene

Drugs & Compounds for IQCF1 Gene

No Compound Related Data Available

Transcripts for IQCF1 Gene

mRNA/cDNA for IQCF1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IQCF1 Gene

IQ motif containing F1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP2: -

Relevant External Links for IQCF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCF1 Gene

mRNA differential expression in normal tissues according to GTEx for IQCF1 Gene

This gene is overexpressed in Testis (x50.7).

Protein differential expression in normal tissues from HIPED for IQCF1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCF1 Gene

Protein tissue co-expression partners for IQCF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCF1 Gene:


SOURCE GeneReport for Unigene cluster for IQCF1 Gene:


Evidence on tissue expression from TISSUES for IQCF1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with IQCF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCF1 Gene

Orthologs for IQCF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQCF1 33 34
  • 98.86 (n)
(Canis familiaris)
Mammalia IQCF1 33 34
  • 77.59 (n)
(Rattus norvegicus)
Mammalia Iqcf1 33
  • 75.79 (n)
(Mus musculus)
Mammalia Iqcf1 33 16 34
  • 74.3 (n)
(Bos Taurus)
Mammalia IQCF1 33 34
  • 72.55 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
Species where no ortholog for IQCF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IQCF1 Gene

Gene Tree for IQCF1 (if available)
Gene Tree for IQCF1 (if available)

Paralogs for IQCF1 Gene

Paralogs for IQCF1 Gene

(4) SIMAP similar genes for IQCF1 Gene using alignment to 2 proteins: Pseudogenes for IQCF1 Gene

genes like me logo Genes that share paralogs with IQCF1: view

Variants for IQCF1 Gene

Sequence variations from dbSNP and Humsavar for IQCF1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000047768 -- 51,903,945(-) C/T upstream_transcript_variant
rs1000062819 -- 51,896,967(-) G/A/C intron_variant
rs1001561934 -- 51,898,106(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001588468 -- 51,905,354(-) G/A upstream_transcript_variant
rs1001734149 -- 51,898,406(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCF1 Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV gain 19592680
nsv963317 CNV duplication 23825009

Variation tolerance for IQCF1 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCF1 Gene

Disorders for IQCF1 Gene

Additional Disease Information for IQCF1

No disorders were found for IQCF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCF1 Gene

Publications for IQCF1 Gene

  1. A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. (PMID: 25380116) Fang P … Qiao Z (Andrology 2015) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for IQCF1 Gene

Sources for IQCF1 Gene

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