Aliases for IQCD Gene

Aliases for IQCD Gene

  • IQ Motif Containing D 2 3 5
  • DRC10 2 3 4
  • Dynein Regulatory Complex Subunit 10 2 3
  • Dynein Regulatory Complex Protein 10 3 4
  • IQ Domain-Containing Protein D 3 4
  • CFAP84 2 3
  • 4933433C09Rik 3
  • IQCD 5

External Ids for IQCD Gene

Previous GeneCards Identifiers for IQCD Gene

  • GC12M112095
  • GC12M112117
  • GC12M113633
  • GC12M110645

Summaries for IQCD Gene

GeneCards Summary for IQCD Gene

IQCD (IQ Motif Containing D) is a Protein Coding gene. Diseases associated with IQCD include Primary Ciliary Dyskinesia.

UniProtKB/Swiss-Prot Summary for IQCD Gene

  • Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.

Additional gene information for IQCD Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IQCD Gene

Genomics for IQCD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IQCD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J113220 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.0 -1017 4.2 SP1 CREB1 GATAD2A HNRNPL RFX1 IKZF1 KDM1A ZNF692 POLR2A BACH1 TPCN1 IQCD RITA1 RBM19 RASAL1 PTPN11 DDX54 ENSG00000201208 RF00017-1284 lnc-TPCN1-2
GH12J113235 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 12 -21.1 -21055 13.4 HNRNPL CREB1 PRDM10 ZNF629 REST IKZF1 TARDBP ZHX2 JUND FOXA1 RITA1 RASAL1 TPCN1 IQCD DDX54 ENSG00000201208 PLBD2 ENSG00000277566 RF00017-1284 lnc-TPCN1-2
GH12J113192 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.8 +27.1 27140 4.4 IKZF1 JUND PRDM1 ZIC2 RXRB ZNF600 SOX6 SCRT2 KLF9 SP1 TPCN1 IQCD RITA1 SDSL ENSG00000257286 lnc-TPCN1-2
GH12J113196 Enhancer 0.7 ENCODE 12.9 +24.2 24240 0.2 CTCF JUND ZNF143 REST RAD21 TRIM22 RUNX3 BCLAF1 SMC3 DEK lnc-TPCN1-2 TPCN1 IQCD SDSL ENSG00000257286 RITA1
GH12J113325 Enhancer 0.7 Ensembl ENCODE 11.3 -105.2 -105159 2.2 CTCF NFE2 NR2F2 SMARCA5 RXRA ZBTB33 ZMYM3 SP1 PLBD2 IQCD TPCN1 piR-57137-009 lnc-TPCN1-1 SLC8B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IQCD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IQCD

Top Transcription factor binding sites by QIAGEN in the IQCD gene promoter:
  • aMEF-2
  • ARP-1
  • CBF(2)
  • CBF-A
  • E47
  • LUN-1
  • MEF-2A
  • MyoD
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for IQCD Gene

Genomic Locations for IQCD Gene
chr12:113,195,441-113,221,341
(GRCh38/hg38)
Size:
25,901 bases
Orientation:
Minus strand
chr12:113,633,246-113,658,899
(GRCh37/hg19)
Size:
25,654 bases
Orientation:
Minus strand

Genomic View for IQCD Gene

Genes around IQCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCD Gene

Proteins for IQCD Gene

  • Protein details for IQCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DY2-DRC10_HUMAN
    Recommended name:
    Dynein regulatory complex protein 10
    Protein Accession:
    Q96DY2
    Secondary Accessions:
    • Q6ZSU0

    Protein attributes for IQCD Gene

    Size:
    449 amino acids
    Molecular mass:
    52359 Da
    Quaternary structure:
    • Component of the nexin-dynein regulatory complex (N-DRC).

    Alternative splice isoforms for IQCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCD Gene

Post-translational modifications for IQCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCD Gene

Domains & Families for IQCD Gene

Gene Families for IQCD Gene

Protein Domains for IQCD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCD Gene

GenScript: Design optimal peptide antigens:
  • IQ domain-containing protein D (IQCD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96DY2

UniProtKB/Swiss-Prot:

DRC10_HUMAN :
  • Belongs to the DRC10 family.
Family:
  • Belongs to the DRC10 family.
genes like me logo Genes that share domains with IQCD: view

Function for IQCD Gene

Molecular function for IQCD Gene

UniProtKB/Swiss-Prot Function:
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.

Phenotypes From GWAS Catalog for IQCD Gene

Gene Ontology (GO) - Molecular Function for IQCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with IQCD: view
genes like me logo Genes that share phenotypes with IQCD: view

Animal Model Products

CRISPR Products

miRNA for IQCD Gene

miRTarBase miRNAs that target IQCD

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQCD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCD Gene

Localization for IQCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for IQCD Gene

Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCD gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 1
mitochondrion 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IQCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
GO:0031514 motile cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with IQCD: view

Pathways & Interactions for IQCD Gene

PathCards logo

SuperPathways for IQCD Gene

No Data Available

Interacting Proteins for IQCD Gene

Selected Interacting proteins: Q96DY2-DRC10_HUMAN for IQCD Gene via UniProtKB

Symbol External ID(s) Details
TACC3

Gene Ontology (GO) - Biological Process for IQCD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCD Gene

Drugs & Compounds for IQCD Gene

No Compound Related Data Available

Transcripts for IQCD Gene

mRNA/cDNA for IQCD Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IQCD

Alternative Splicing Database (ASD) splice patterns (SP) for IQCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: -
SP3: - - - - - - -
SP4:
SP5: - -

Relevant External Links for IQCD Gene

GeneLoc Exon Structure for
IQCD

Expression for IQCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQCD Gene

mRNA differential expression in normal tissues according to GTEx for IQCD Gene

This gene is overexpressed in Testis (x20.0).

Protein differential expression in normal tissues from HIPED for IQCD Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCD Gene



Protein tissue co-expression partners for IQCD Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IQCD

SOURCE GeneReport for Unigene cluster for IQCD Gene:

Hs.568276

Evidence on tissue expression from TISSUES for IQCD Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IQCD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCD Gene

Orthologs for IQCD Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IQCD 30 31
  • 98.17 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IQCD 30 31
  • 79.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IQCD 30 31
  • 75.28 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Iqcd 30 17 31
  • 61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IQCD 31
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IQCD 30 31
  • 52.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IQCD 31
  • 22 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia iqcd 30
  • 48.33 (n)
Zebrafish
(Danio rerio)
Actinopterygii iqcd 30 31
  • 47.12 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToOne
Species where no ortholog for IQCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IQCD Gene

ENSEMBL:
Gene Tree for IQCD (if available)
TreeFam:
Gene Tree for IQCD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IQCD: view image

Paralogs for IQCD Gene

No data available for Paralogs for IQCD Gene

Variants for IQCD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IQCD Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs7966313 - p.Leu136Val

Additional dbSNP identifiers (rs#s) for IQCD Gene

Structural Variations from Database of Genomic Variants (DGV) for IQCD Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv519540 CNV gain+loss 19592680

Variation tolerance for IQCD Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCD Gene

Disorders for IQCD Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQCD Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search IQCD in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with IQCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQCD Gene

Publications for IQCD Gene

  1. Chromosome-centric human proteome project: deciphering proteins associated with glioma and neurodegenerative disorders on chromosome 12. (PMID: 24804578) Gupta MK … Sirdeshmukh R (Journal of proteome research 2014) 2 3
  2. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R … Porter ME (Molecular biology of the cell 2013) 2 3
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for IQCD Gene

  • Signalway Proteins for IQCD

Sources for IQCD Gene