Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IQCD Gene

Aliases for IQCD Gene

  • IQ Motif Containing D 2 3 5
  • Dynein Regulatory Complex Subunit 10 2 3
  • IQ Domain-Containing Protein D 3
  • 4933433C09Rik 3
  • CFAP84 3
  • DRC10 3

External Ids for IQCD Gene

Previous GeneCards Identifiers for IQCD Gene

  • GC12M112095
  • GC12M112117
  • GC12M113633
  • GC12M110645

Summaries for IQCD Gene

GeneCards Summary for IQCD Gene

IQCD (IQ Motif Containing D) is a Protein Coding gene.

Additional gene information for IQCD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCD Gene

Genomics for IQCD Gene

GeneHancer (GH) Regulatory Elements for IQCD Gene

Promoters and enhancers for IQCD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I113220 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.3 -1264 4.2 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 TPCN1 IQCD RITA1 RASAL1 DDX54 ENSG00000201208 RBM19 ENSG00000277566
GH12I113235 Enhancer 1.4 Ensembl ENCODE dbSUPER 12 -21.3 -21302 13.4 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 RITA1 RASAL1 TPCN1 IQCD DDX54 ENSG00000201208 PLBD2 ENSG00000277566
GH12I113192 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.8 +26.7 26674 3.6 HDAC1 ELF3 FOXA2 ZNF76 THRB RAD21 RARA ZNF121 GLIS2 EGR1 IQCD TPCN1 RITA1 SDSL ENSG00000257286 GC12M113206
GH12I113196 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.9 +24.0 23993 0.6 CTCF ZNF384 RAD21 CC2D1A ZNF121 ZNF664 GATAD1 POLR2A VEZF1 SMC3 TPCN1 IQCD RITA1 SDSL ENSG00000257286 GC12M113206
GH12I113325 Enhancer 0.7 Ensembl ENCODE 11.3 -105.4 -105406 2.2 SMARCA5 CTCF ZMYM3 NFE2 ZBTB33 NR2F2 PLBD2 IQCD TPCN1 GC12M113308 SLC8B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCD gene promoter:

Genomic Locations for IQCD Gene

Genomic Locations for IQCD Gene
chr12:113,195,441-113,221,094
(GRCh38/hg38)
Size:
25,654 bases
Orientation:
Minus strand
chr12:113,633,246-113,658,899
(GRCh37/hg19)

Genomic View for IQCD Gene

Genes around IQCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCD Gene

Proteins for IQCD Gene

  • Protein details for IQCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DY2-IQCD_HUMAN
    Recommended name:
    IQ domain-containing protein D
    Protein Accession:
    Q96DY2
    Secondary Accessions:
    • Q6ZSU0

    Protein attributes for IQCD Gene

    Size:
    449 amino acids
    Molecular mass:
    52359 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCD Gene

Post-translational modifications for IQCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCD Gene

Domains & Families for IQCD Gene

Gene Families for IQCD Gene

Protein Domains for IQCD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCD: view

No data available for UniProtKB/Swiss-Prot for IQCD Gene

Function for IQCD Gene

genes like me logo Genes that share phenotypes with IQCD: view

miRNA for IQCD Gene

miRTarBase miRNAs that target IQCD

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCD Gene

Localization for IQCD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCD gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCD Gene

Pathways & Interactions for IQCD Gene

No Data Available

Interacting Proteins for IQCD Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299732%0d%0a9606.ENSP00000303178%0d%0a9606.ENSP00000302968%0d%0a9606.ENSP00000250838%0d%0a
Selected Interacting proteins: ENSP00000299732 for IQCD Gene via STRING

Gene Ontology (GO) - Biological Process for IQCD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCD Gene

Drugs & Compounds for IQCD Gene

No Compound Related Data Available

Transcripts for IQCD Gene

mRNA/cDNA for IQCD Gene

Unigene Clusters for IQCD Gene

IQ motif containing D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: -
SP3: - - - - - - -
SP4:
SP5: - -

Relevant External Links for IQCD Gene

GeneLoc Exon Structure for
IQCD
ECgene alternative splicing isoforms for
IQCD

Expression for IQCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCD Gene

mRNA differential expression in normal tissues according to GTEx for IQCD Gene

This gene is overexpressed in Testis (x20.0).

Protein differential expression in normal tissues from HIPED for IQCD Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCD Gene



Protein tissue co-expression partners for IQCD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCD Gene:

IQCD

SOURCE GeneReport for Unigene cluster for IQCD Gene:

Hs.568276
genes like me logo Genes that share expression patterns with IQCD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCD Gene

Orthologs for IQCD Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCD 33 34
  • 98.17 (n)
dog
(Canis familiaris)
Mammalia IQCD 33 34
  • 79.61 (n)
cow
(Bos Taurus)
Mammalia IQCD 33 34
  • 75.28 (n)
mouse
(Mus musculus)
Mammalia Iqcd 33 16 34
  • 61 (n)
oppossum
(Monodelphis domestica)
Mammalia IQCD 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves IQCD 33 34
  • 52.62 (n)
lizard
(Anolis carolinensis)
Reptilia IQCD 34
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqcd 33
  • 48.33 (n)
zebrafish
(Danio rerio)
Actinopterygii iqcd 33 34
  • 47.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToOne
Species where no ortholog for IQCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCD Gene

ENSEMBL:
Gene Tree for IQCD (if available)
TreeFam:
Gene Tree for IQCD (if available)

Paralogs for IQCD Gene

No data available for Paralogs for IQCD Gene

Variants for IQCD Gene

Sequence variations from dbSNP and Humsavar for IQCD Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000193900 -- 113,198,582(-) C/T intron_variant
rs1000251422 -- 113,223,148(-) G/C upstream_transcript_variant
rs1000326898 -- 113,223,342(-) G/A upstream_transcript_variant
rs1000344568 -- 113,209,892(-) G/A intron_variant
rs1000452027 -- 113,205,238(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCD Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv519540 CNV gain+loss 19592680

Variation tolerance for IQCD Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCD Gene

Disorders for IQCD Gene

Additional Disease Information for IQCD

No disorders were found for IQCD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCD Gene

Publications for IQCD Gene

  1. Chromosome-centric human proteome project: deciphering proteins associated with glioma and neurodegenerative disorders on chromosome 12. (PMID: 24804578) Gupta MK … Sirdeshmukh R (Journal of proteome research 2014) 2 3 58
  2. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R … Porter ME (Molecular biology of the cell 2013) 2 3 58
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for IQCD Gene

Sources for IQCD Gene

Content
Loading form....