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Aliases for IQCA1 Gene

Aliases for IQCA1 Gene

  • IQ Motif Containing With AAA Domain 1 2 3 5
  • Dynein Regulatory Complex Subunit 11 2 3
  • IQCA 3 4
  • IQ And AAA Domain-Containing Protein 1 3
  • IQ Motif Containing With AAA Domain 2
  • 4930465P12Rik 3
  • DRC11 3

External Ids for IQCA1 Gene

Previous HGNC Symbols for IQCA1 Gene

  • IQCA

Previous GeneCards Identifiers for IQCA1 Gene

  • GC02M236898
  • GC02M237232
  • GC02M229027

Summaries for IQCA1 Gene

Entrez Gene Summary for IQCA1 Gene

  • The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for IQCA1 Gene

IQCA1 (IQ Motif Containing With AAA Domain 1) is a Protein Coding gene. An important paralog of this gene is IQCA1L.

Additional gene information for IQCA1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCA1 Gene

Genomics for IQCA1 Gene

GeneHancer (GH) Regulatory Elements for IQCA1 Gene

Promoters and enhancers for IQCA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I236507 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 562.2 +0.1 51 0.6 POLR2A NRF1 IQCA1 GC02M236502
GH02I236503 Promoter 0.5 EPDnew 550.8 +3.8 3838 0.1 IQCA1 GC02M236502 GC02M236474
GH02I236536 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.6 -30.1 -30125 3 HDGF PKNOX1 SMAD1 RB1 EBF1 BMI1 YBX1 BATF IRF4 ATF7 ACKR3 IQCA1 LOC105373991
GH02I236564 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.6 -62.1 -62062 11 HDGF PKNOX1 RB1 SIN3A BATF IRF4 RAD21 ZNF366 ZNF207 ZNF143 GC02P236569 ACKR3 IQCA1 LOC105373991
GH02I236575 Enhancer 1 Ensembl ENCODE dbSUPER 17.3 -69.1 -69146 2.8 HDGF CTCF SMAD1 EBF1 ATF2 ZKSCAN1 TARDBP ZNF207 NBN MLLT1 IQCA1 GC02P236569 GC02P236597 ACKR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCA1 gene promoter:

Genomic Locations for IQCA1 Gene

Genomic Locations for IQCA1 Gene
chr2:236,324,147-236,507,552
(GRCh38/hg38)
Size:
183,406 bases
Orientation:
Minus strand
chr2:237,232,794-237,416,185
(GRCh37/hg19)

Genomic View for IQCA1 Gene

Genes around IQCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCA1 Gene

Proteins for IQCA1 Gene

  • Protein details for IQCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XH1-IQCA1_HUMAN
    Recommended name:
    IQ and AAA domain-containing protein 1
    Protein Accession:
    Q86XH1
    Secondary Accessions:
    • B4DFH9
    • E7EWQ0
    • Q4G164
    • Q53R37
    • Q53RV3
    • Q96NS7
    • Q9H680

    Protein attributes for IQCA1 Gene

    Size:
    822 amino acids
    Molecular mass:
    95341 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15384.1; Type=Frameshift; Positions=802; Evidence={ECO:0000305}; Sequence=BAB15384.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=BAB70798.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCA1 Gene

Post-translational modifications for IQCA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCA1 Gene

Domains & Families for IQCA1 Gene

Gene Families for IQCA1 Gene

Protein Domains for IQCA1 Gene

Suggested Antigen Peptide Sequences for IQCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XH1

UniProtKB/Swiss-Prot:

IQCA1_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with IQCA1: view

Function for IQCA1 Gene

Phenotypes From GWAS Catalog for IQCA1 Gene

Gene Ontology (GO) - Molecular Function for IQCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with IQCA1: view
genes like me logo Genes that share phenotypes with IQCA1: view

miRNA for IQCA1 Gene

miRTarBase miRNAs that target IQCA1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCA1 Gene

Localization for IQCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCA1 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCA1 Gene

Pathways & Interactions for IQCA1 Gene

SuperPathways for IQCA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IQCA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCA1 Gene

Drugs & Compounds for IQCA1 Gene

No Compound Related Data Available

Transcripts for IQCA1 Gene

mRNA/cDNA for IQCA1 Gene

(7) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for IQCA1 Gene

GeneLoc Exon Structure for
IQCA1
ECgene alternative splicing isoforms for
IQCA1

Expression for IQCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQCA1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.7), Brain - Putamen (basal ganglia) (x5.3), Brain - Nucleus accumbens (basal ganglia) (x4.7), and Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for IQCA1 Gene

This gene is overexpressed in Serum (57.7) and Placenta (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCA1 Gene



Protein tissue co-expression partners for IQCA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IQCA1 Gene:

IQCA1

SOURCE GeneReport for Unigene cluster for IQCA1 Gene:

Hs.591594

Evidence on tissue expression from TISSUES for IQCA1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with IQCA1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCA1 Gene

Orthologs for IQCA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCA1 33 34
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia IQCA1 33 34
  • 82.66 (n)
cow
(Bos Taurus)
Mammalia IQCA1 33 34
  • 82.29 (n)
mouse
(Mus musculus)
Mammalia Iqca 33 16 34
  • 77.85 (n)
rat
(Rattus norvegicus)
Mammalia Iqca1 33
  • 74.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IQCA1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves IQCA1 33 34
  • 65.63 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 58 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia iqca1 33
  • 63.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15358 33
zebrafish
(Danio rerio)
Actinopterygii zgc:153738 33
  • 59.67 (n)
iqca1 34
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011967 33
  • 50.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16789 33 34
  • 47.63 (n)
CG14183 34
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA6 34
  • 16 (a)
ManyToMany
SAP1 34
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13576 33
Species where no ortholog for IQCA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCA1 Gene

ENSEMBL:
Gene Tree for IQCA1 (if available)
TreeFam:
Gene Tree for IQCA1 (if available)

Paralogs for IQCA1 Gene

Paralogs for IQCA1 Gene

(2) SIMAP similar genes for IQCA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IQCA1: view

Variants for IQCA1 Gene

Sequence variations from dbSNP and Humsavar for IQCA1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000000758 -- 236,401,732(-) G/A intron_variant
rs1000004888 -- 236,506,175(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000017138 -- 236,453,442(-) C/G intron_variant
rs1000030593 -- 236,402,003(-) A/G intron_variant
rs1000030912 -- 236,375,373(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCA1 Gene

Variant ID Type Subtype PubMed ID
esv2672367 CNV deletion 23128226
esv2676346 CNV deletion 23128226
esv2721703 CNV deletion 23290073
esv2721704 CNV deletion 23290073
esv2721705 CNV deletion 23290073
esv28807 CNV loss 19812545
esv3412687 OTHER inversion 20981092
esv3575342 CNV gain 25503493
esv3594724 CNV loss 21293372
esv3594725 CNV loss 21293372
esv3594726 CNV gain 21293372
nsv1000252 CNV loss 25217958
nsv1005677 CNV gain 25217958
nsv1072084 CNV deletion 25765185
nsv1073024 CNV deletion 25765185
nsv1114187 CNV deletion 24896259
nsv1127807 CNV deletion 24896259
nsv1147273 CNV duplication 26484159
nsv3223 CNV deletion 18451855
nsv821925 CNV loss 20364138
nsv834576 CNV gain 17160897
nsv963783 CNV duplication 23825009
nsv997438 CNV gain 25217958

Variation tolerance for IQCA1 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCA1 Gene

Disorders for IQCA1 Gene

Additional Disease Information for IQCA1

No disorders were found for IQCA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCA1 Gene

Publications for IQCA1 Gene

  1. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R … Porter ME (Molecular biology of the cell 2013) 2 3 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber MJ … Krauss RM (PloS one 2010) 3 58

Products for IQCA1 Gene

Sources for IQCA1 Gene

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