The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] See more...

Aliases for IPP Gene

Aliases for IPP Gene

  • Intracisternal A Particle-Promoted Polypeptide 2 3 4 5
  • Kelch-Like Family Member 27 2 3
  • Actin-Binding Protein IPP 3 4
  • Kelch-Like Protein 27 3 4
  • KLHL27 3 4

External Ids for IPP Gene

Previous GeneCards Identifiers for IPP Gene

  • GC01M045891
  • GC01M045164
  • GC01M045594
  • GC01M045577
  • GC01M045829
  • GC01M046159
  • GC01M044271

Summaries for IPP Gene

Entrez Gene Summary for IPP Gene

  • The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPP Gene

IPP (Intracisternal A Particle-Promoted Polypeptide) is a Protein Coding gene. Diseases associated with IPP include Penile Disease and Peroneal Nerve Paralysis. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is KLHL20.

UniProtKB/Swiss-Prot Summary for IPP Gene

Additional gene information for IPP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IPP Gene

Genomics for IPP Gene

GeneHancer (GH) Regulatory Elements for IPP Gene

Promoters and enhancers for IPP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IPP gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • ER-alpha
  • FOXC1
  • POU3F1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for IPP Gene

Genomic Locations for IPP Gene
56,490 bases
Minus strand
56,490 bases
Minus strand

Genomic View for IPP Gene

Genes around IPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPP Gene

Proteins for IPP Gene

  • Protein details for IPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-binding protein IPP
    Protein Accession:
    Secondary Accessions:
    • A2A6V4
    • D3DQ11
    • Q8N5C3

    Protein attributes for IPP Gene

    584 amino acids
    Molecular mass:
    65261 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IPP Gene


neXtProt entry for IPP Gene

Post-translational modifications for IPP Gene

  • Ubiquitination at Lys238 and Lys279
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPP Gene

Domains & Families for IPP Gene

Gene Families for IPP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IPP Gene

GenScript: Design optimal peptide antigens:
  • Intracisternal A particle-promoted polypeptide (A2A6V3_HUMAN)
  • Kelch-like protein 27 (IPP_HUMAN)
genes like me logo Genes that share domains with IPP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IPP Gene

Function for IPP Gene

Molecular function for IPP Gene

UniProtKB/Swiss-Prot Function:
May play a role in organizing the actin cytoskeleton.
GENATLAS Biochemistry:
intracisternal A-particle (IAP)-promoted,placenta,mouse homolog,Kelch family member

Phenotypes From GWAS Catalog for IPP Gene

Gene Ontology (GO) - Molecular Function for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with IPP: view
genes like me logo Genes that share phenotypes with IPP: view

Animal Models for IPP Gene

MGI Knock Outs for IPP:
  • Ipp Ipp<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for IPP Gene

miRTarBase miRNAs that target IPP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPP Gene

Localization for IPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPP Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPP gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton TAS 10072760
genes like me logo Genes that share ontologies with IPP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IPP Gene

Pathways & Interactions for IPP Gene

PathCards logo

SuperPathways for IPP Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPP Gene


No data available for Pathways by source and SIGNOR curated interactions for IPP Gene

Drugs & Compounds for IPP Gene

No Compound Related Data Available

Transcripts for IPP Gene

mRNA/cDNA for IPP Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPP Gene

No ASD Table

Relevant External Links for IPP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPP Gene

Protein differential expression in normal tissues from HIPED for IPP Gene

This gene is overexpressed in Heart (50.1) and Placenta (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPP Gene

Protein tissue co-expression partners for IPP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPP Gene:


SOURCE GeneReport for Unigene cluster for IPP Gene:


Evidence on tissue expression from TISSUES for IPP Gene

  • Thyroid gland(4.2)
  • Blood(2.2)
  • Nervous system(2.2)
  • Intestine(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with IPP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPP Gene

Orthologs for IPP Gene

This gene was present in the common ancestor of animals.

Orthologs for IPP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IPP 33 32
  • 99.76 (n)
(Canis familiaris)
Mammalia IPP 33 32
  • 94.92 (n)
(Bos Taurus)
Mammalia IPP 33 32
  • 93.95 (n)
(Ornithorhynchus anatinus)
Mammalia IPP 33
  • 91 (a)
(Mus musculus)
Mammalia Ipp 17 33 32
  • 89.5 (n)
(Rattus norvegicus)
Mammalia Ipp 32
  • 89.33 (n)
(Monodelphis domestica)
Mammalia IPP 33
  • 89 (a)
(Gallus gallus)
Aves IPP 33 32
  • 75.59 (n)
(Anolis carolinensis)
Reptilia IPP 33
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ipp 32
  • 70.43 (n)
(Danio rerio)
Actinopterygii ipp 33 32
  • 67.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2413 32
fruit fly
(Drosophila melanogaster)
Insecta CG9426 33 34 32
  • 48.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009913 32
  • 47.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 34 (a)
-- 33
  • 32 (a)
-- 33
  • 31 (a)
-- 33
  • 31 (a)
CSA.6551 33
  • 30 (a)
-- 33
  • 29 (a)
CSA.2774 33
  • 27 (a)
-- 33
  • 25 (a)
-- 33
  • 25 (a)
-- 33
  • 24 (a)
-- 33
  • 22 (a)
Species where no ortholog for IPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPP Gene

Gene Tree for IPP (if available)
Gene Tree for IPP (if available)
Evolutionary constrained regions (ECRs) for IPP: view image

Paralogs for IPP Gene

Variants for IPP Gene

Sequence variations from dbSNP and Humsavar for IPP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000011065 -- 45,709,058(-) AAAAAAAA/AAAAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000013616 -- 45,696,316(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000129756 -- 45,740,145(-) T/C intron_variant
rs1000193583 -- 45,742,240(-) T/G intron_variant
rs1000222642 -- 45,740,558(-) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IPP Gene

Variant ID Type Subtype PubMed ID
dgv159n100 CNV gain 25217958
esv1007960 CNV insertion 20482838
esv1730955 CNV deletion 17803354
esv2023284 CNV deletion 18987734
esv2747830 CNV deletion 23290073
esv3561582 CNV deletion 23714750
esv3577360 CNV gain 25503493
esv3577471 CNV gain 25503493
esv3585914 CNV gain 21293372
esv3585915 CNV gain 21293372
esv3585916 CNV gain 21293372
esv3893512 CNV gain 25118596
esv4646 CNV loss 18987735
nsv1014128 CNV gain 25217958
nsv1113112 CNV deletion 24896259
nsv1149283 CNV deletion 26484159
nsv159558 CNV deletion 16902084
nsv436781 CNV insertion 17901297
nsv945922 CNV duplication 23825009

Variation tolerance for IPP Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPP Gene

Disorders for IPP Gene

MalaCards: The human disease database

(2) MalaCards diseases for IPP Gene - From: DISEASES

Disorder Aliases PubMed IDs
penile disease
  • penile diseases
peroneal nerve paralysis
  • peroneal nerve palsy
- elite association - COSMIC cancer census association via MalaCards
Search IPP in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with IPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPP Gene

Publications for IPP Gene

  1. The IPP gene is assigned to human chromosome 1p32-1p22. (PMID: 8432546) Chang-Yeh A … Huang RC (Genomics 1993) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. (PMID: 10072760) Kim IF … Huang RC (Gene 1999) 3 4 56
  4. Cell lineage-specific expression of the MIPP gene. (PMID: 1905535) Mold DE … Huang RC (Biochemical and biophysical research communications 1991) 2 3 56
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56

Products for IPP Gene

Sources for IPP Gene