Aliases for IPO8 Gene
External Ids for IPO8 Gene
Previous HGNC Symbols for IPO8 Gene
Previous GeneCards Identifiers for IPO8 Gene
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for IPO8 Gene
IPO8 (Importin 8) is a Protein Coding gene. Diseases associated with IPO8 include Caffey Disease. Among its related pathways are Gene Expression and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is IPO7.
UniProtKB/Swiss-Prot Summary for IPO8 Gene
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.