The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP an... See more...

Aliases for IPO8 Gene

Aliases for IPO8 Gene

  • Importin 8 2 3 5
  • Ran-Binding Protein 8 3 4
  • RAN Binding Protein 8 2 3
  • Importin-8 3 4
  • RANBP8 3 4
  • Imp8 3 4
  • RanBP8 4

External Ids for IPO8 Gene

Previous HGNC Symbols for IPO8 Gene

  • RANBP8

Previous GeneCards Identifiers for IPO8 Gene

  • GC12M030805
  • GC12M030682
  • GC12M030673
  • GC12M030675
  • GC12M030547

Summaries for IPO8 Gene

Entrez Gene Summary for IPO8 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IPO8 Gene

IPO8 (Importin 8) is a Protein Coding gene. Diseases associated with IPO8 include Caffey Disease. Among its related pathways are Gene Expression and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is IPO7.

UniProtKB/Swiss-Prot Summary for IPO8 Gene

  • Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

Additional gene information for IPO8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IPO8 Gene

Genomics for IPO8 Gene

GeneHancer (GH) Regulatory Elements for IPO8 Gene

Promoters and enhancers for IPO8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPO8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IPO8

Top Transcription factor binding sites by QIAGEN in the IPO8 gene promoter:
  • AP-4
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for IPO8 Gene

Genomic Locations for IPO8 Gene
chr12:30,628,981-30,695,995
(GRCh38/hg38)
Size:
67,015 bases
Orientation:
Minus strand
chr12:30,781,915-30,848,929
(GRCh37/hg19)
Size:
67,015 bases
Orientation:
Minus strand

Genomic View for IPO8 Gene

Genes around IPO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO8 Gene

Proteins for IPO8 Gene

  • Protein details for IPO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15397-IPO8_HUMAN
    Recommended name:
    Importin-8
    Protein Accession:
    O15397
    Secondary Accessions:
    • B7Z7M3

    Protein attributes for IPO8 Gene

    Size:
    1037 amino acids
    Molecular mass:
    119938 Da
    Quaternary structure:
    • Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes.

    Alternative splice isoforms for IPO8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO8 Gene

Post-translational modifications for IPO8 Gene

  • Ubiquitination at Lys510
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPO8 Gene

Domains & Families for IPO8 Gene

Gene Families for IPO8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for IPO8 Gene

Blocks:
  • Importin-beta, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IPO8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55655, highly similar to Importin-8 (B7Z7M3_HUMAN)
  • Ran-binding protein 8 (IPO8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15397

UniProtKB/Swiss-Prot:

IPO8_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO8: view

Function for IPO8 Gene

Molecular function for IPO8 Gene

UniProtKB/Swiss-Prot Function:
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

Phenotypes From GWAS Catalog for IPO8 Gene

Gene Ontology (GO) - Molecular Function for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17785517
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with IPO8: view
genes like me logo Genes that share phenotypes with IPO8: view

Animal Models for IPO8 Gene

MGI Knock Outs for IPO8:
  • Ipo8 Ipo8<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPO8 Gene

Localization for IPO8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO8 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IPO8: view

Pathways & Interactions for IPO8 Gene

PathCards logo

SuperPathways for IPO8 Gene

genes like me logo Genes that share pathways with IPO8: view

Pathways by source for IPO8 Gene

Gene Ontology (GO) - Biological Process for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IBA 21873635
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 9214382
GO:0015031 protein transport IEA --
GO:0060964 regulation of gene silencing by miRNA TAS --
genes like me logo Genes that share ontologies with IPO8: view

No data available for SIGNOR curated interactions for IPO8 Gene

Drugs & Compounds for IPO8 Gene

(2) Drugs for IPO8 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Investigational Pharma 0
genes like me logo Genes that share compounds with IPO8: view

Transcripts for IPO8 Gene

mRNA/cDNA for IPO8 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26a · 26b
SP1:
SP2:
SP3:

Relevant External Links for IPO8 Gene

GeneLoc Exon Structure for
IPO8

Expression for IPO8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPO8 Gene

Protein differential expression in normal tissues from HIPED for IPO8 Gene

This gene is overexpressed in Bone (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPO8 Gene



Protein tissue co-expression partners for IPO8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IPO8

SOURCE GeneReport for Unigene cluster for IPO8 Gene:

Hs.505136

Evidence on tissue expression from TISSUES for IPO8 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with IPO8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO8 Gene

Orthologs for IPO8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPO8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO8 31 30
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IPO8 31 30
  • 93.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IPO8 31 30
  • 93.44 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO8 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo8 17 31 30
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO8 31
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686774 30
  • 82.29 (n)
chicken
(Gallus gallus)
Aves IPO8 31 30
  • 79.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO8 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo8 30
  • 70.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ipo8 31 30
  • 68.49 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta msk 31
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SXM1 31
  • 21 (a)
ManyToMany
NMD5 31
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3218 31
  • 49 (a)
OneToMany
Species where no ortholog for IPO8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO8 Gene

ENSEMBL:
Gene Tree for IPO8 (if available)
TreeFam:
Gene Tree for IPO8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IPO8: view image

Paralogs for IPO8 Gene

Paralogs for IPO8 Gene

(1) SIMAP similar genes for IPO8 Gene using alignment to 8 proteins:

  • IPO8_HUMAN
  • F5GXT5_HUMAN
  • F5H009_HUMAN
  • F5H244_HUMAN
  • F5H292_HUMAN
  • F5H2I3_HUMAN
  • F5H815_HUMAN
  • H0YH64_HUMAN

Pseudogenes.org Pseudogenes for IPO8 Gene

genes like me logo Genes that share paralogs with IPO8: view

Variants for IPO8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IPO8 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
712730 Likely Benign: not provided 30,630,927(-) C/A MISSENSE_VARIANT
715646 Likely Benign: not provided 30,663,588(-) C/T MISSENSE_VARIANT
716430 Likely Benign: not provided 30,637,088(-) G/A SYNONYMOUS_VARIANT
725614 Benign: not provided 30,674,652(-) T/C INTRON_VARIANT
770229 Likely Benign: not provided 30,669,290(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for IPO8 Gene

Structural Variations from Database of Genomic Variants (DGV) for IPO8 Gene

Variant ID Type Subtype PubMed ID
nsv515645 CNV loss 19592680
nsv832361 CNV loss 17160897

Variation tolerance for IPO8 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPO8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO8 Gene

Disorders for IPO8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPO8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
caffey disease
  • cafyd
- elite association - COSMIC cancer census association via MalaCards
Search IPO8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IPO8

genes like me logo Genes that share disorders with IPO8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO8 Gene

Publications for IPO8 Gene

  1. A novel class of RanGTP binding proteins. (PMID: 9214382) Görlich D … Izaurralde E (The Journal of cell biology 1997) 2 3 4 54
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L … Meister G (Cell 2009) 3 23 54
  3. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PMID: 19014639) Nguewa PA … Calvo A (BMC molecular biology 2008) 3 23 54
  4. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PMID: 11682607) Dean KA … Fried HM (Journal of cell science 2001) 3 4 54
  5. Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion. (PMID: 31678930) Méant A … Roux PP (Molecular & cellular proteomics : MCP 2020) 3 54

Products for IPO8 Gene

Sources for IPO8 Gene