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The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
IPO8 (Importin 8) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is IPO7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17785517 |
GO:0008536 | Ran GTPase binding | IEA | -- |
GO:0031267 | small GTPase binding | TAS | 9214382 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005635 | nuclear envelope | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitotic Prophase | ||
2 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006606 | protein import into nucleus | IBA | 21873635 |
GO:0006886 | intracellular protein transport | IEA | -- |
GO:0007165 | signal transduction | TAS | 9214382 |
GO:0015031 | protein transport | IEA | -- |
GO:0060964 | regulation of gene silencing by miRNA | TAS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: |
ExUns: | 25 | ^ | 26a | · | 26b |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IPO8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IPO8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IPO8 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IPO8 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ipo8 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IPO8 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC686774 30 |
|
||
Chicken (Gallus gallus) |
Aves | IPO8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IPO8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ipo8 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ipo8 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | msk 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SXM1 31 |
|
ManyToMany | |
NMD5 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3218 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1368954140 | Likely Benign: not provided | 30,669,290(-) |
G/A NM_006390.4(IPO8):c.1045-8C>T |
INTRON | |
rs138980303 | Benign: not provided | 30,669,174(-) |
C/T NM_006390.4(IPO8):c.1144+9G>A |
INTRON | |
rs141041651 | Likely Benign: not provided | 30,663,588(-) |
C/T NM_006390.4(IPO8):c.1495G>A (p.Val499Ile) |
MISSENSE | |
rs142168065 | Benign: not provided | 30,674,652(-) |
T/C NM_006390.4(IPO8):c.824+7A>G |
INTRON | |
rs143442160 | Likely Benign: not provided | 30,637,088(-) |
G/A NM_006390.4(IPO8):c.2589C>T (p.Pro863=) |
SYNONYMOUS |
No disorders were found for IPO8 Gene.