The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's ... See more...

Aliases for IPO7 Gene

Aliases for IPO7 Gene

  • Importin 7 2 3 5
  • Imp7 2 3 4
  • Importin-7 3 4
  • RANBP7 3 4
  • RAN Binding Protein 7 2
  • RAN-Binding Protein 7 3
  • Ran-Binding Protein 7 4
  • RanBP7 4
  • IPO7 5

External Ids for IPO7 Gene

Previous HGNC Symbols for IPO7 Gene

  • RANBP7

Previous GeneCards Identifiers for IPO7 Gene

  • GC11P009976
  • GC11P009445
  • GC11P009370
  • GC11P009362
  • GC11P009077

Summaries for IPO7 Gene

Entrez Gene Summary for IPO7 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPO7 Gene

IPO7 (Importin 7) is a Protein Coding gene. Diseases associated with IPO7 include Pediatric Ependymoma and Malignant Ependymoma. Gene Ontology (GO) annotations related to this gene include binding and histone binding. An important paralog of this gene is IPO8.

UniProtKB/Swiss-Prot Summary for IPO7 Gene

  • Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.
  • (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev.

Gene Wiki entry for IPO7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IPO7 Gene

Genomics for IPO7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IPO7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPO7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IPO7

Top Transcription factor binding sites by QIAGEN in the IPO7 gene promoter:
  • c-Ets-1
  • GR
  • GR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-1
  • NF-1/L
  • USF-1
  • USF1
  • YY1

Genomic Locations for IPO7 Gene

Genomic Locations for IPO7 Gene
chr11:9,384,652-9,448,127
(GRCh38/hg38)
Size:
63,476 bases
Orientation:
Plus strand
chr11:9,406,169-9,469,674
(GRCh37/hg19)
Size:
63,506 bases
Orientation:
Plus strand

Genomic View for IPO7 Gene

Genes around IPO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO7 Gene

Proteins for IPO7 Gene

  • Protein details for IPO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95373-IPO7_HUMAN
    Recommended name:
    Importin-7
    Protein Accession:
    O95373
    Secondary Accessions:
    • A6NNM5
    • B2R786
    • Q1RMF7
    • Q9H177
    • Q9NTE3

    Protein attributes for IPO7 Gene

    Size:
    1038 amino acids
    Molecular mass:
    119517 Da
    Quaternary structure:
    • Interacts with H2A, H2B, H3 and H4 histones (By similarity). Forms a heterodimer with KPNB1. Interacts with KPNB1, SNUPN, XPO1, RPL23A, RPS7, and RPL5. Binds directly to nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Interacts with SMAD4 and NUP93; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (PubMed:26878725).
    • (Microbial infection) Interacts with HIV-1 reverse transcription complex integrase and rev.

neXtProt entry for IPO7 Gene

Post-translational modifications for IPO7 Gene

  • Ubiquitination at Lys990 and Lys1018
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO7 Gene

No data available for DME Specific Peptides for IPO7 Gene

Domains & Families for IPO7 Gene

Gene Families for IPO7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for IPO7 Gene

InterPro:
Blocks:
  • Importin-beta, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for IPO7 Gene

GenScript: Design optimal peptide antigens:
  • Ran-binding protein 7 (IPO7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95373

UniProtKB/Swiss-Prot:

IPO7_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO7: view

Function for IPO7 Gene

Molecular function for IPO7 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev.

Phenotypes From GWAS Catalog for IPO7 Gene

Gene Ontology (GO) - Molecular Function for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9214382
GO:0005515 protein binding IPI 15282309
GO:0008536 Ran GTPase binding IEA --
GO:0030695 GTPase regulator activity TAS 9214382
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with IPO7: view
genes like me logo Genes that share phenotypes with IPO7: view

Animal Model Products

CRISPR Products

miRNA for IPO7 Gene

miRTarBase miRNAs that target IPO7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPO7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO7 Gene

Localization for IPO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA 21873635
GO:0005643 nuclear pore TAS 9214382
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IPO7: view

Pathways & Interactions for IPO7 Gene

PathCards logo

SuperPathways for IPO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA,IBA 21873635
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 9214382
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with IPO7: view

No data available for Pathways by source and SIGNOR curated interactions for IPO7 Gene

Drugs & Compounds for IPO7 Gene

(2) Drugs for IPO7 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Investigational Pharma 0
genes like me logo Genes that share compounds with IPO7: view

Transcripts for IPO7 Gene

mRNA/cDNA for IPO7 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPO7

Alternative Splicing Database (ASD) splice patterns (SP) for IPO7 Gene

No ASD Table

Relevant External Links for IPO7 Gene

GeneLoc Exon Structure for
IPO7

Expression for IPO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPO7 Gene

mRNA differential expression in normal tissues according to GTEx for IPO7 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for IPO7 Gene

This gene is overexpressed in Bone (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPO7 Gene



Protein tissue co-expression partners for IPO7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IPO7

SOURCE GeneReport for Unigene cluster for IPO7 Gene:

Hs.744911

Evidence on tissue expression from TISSUES for IPO7 Gene

  • Liver(4.5)
  • Blood(4.5)
  • Nervous system(4.3)
  • Kidney(2.8)
  • Muscle(2.7)
  • Heart(2.7)
  • Lung(2.5)
  • Spleen(2.3)
  • Skin(2.2)
  • Intestine(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with IPO7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO7 Gene

Orthologs for IPO7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IPO7 30 31
  • 99.78 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia IPO7 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia IPO7 30 31
  • 94.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IPO7 30 31
  • 94.77 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ipo7 30 17 31
  • 92.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ipo7 30
  • 91.94 (n)
Chicken
(Gallus gallus)
Aves IPO7 30 31
  • 85.07 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IPO7 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ipo7 30
  • 78.72 (n)
Str.1398 30
African clawed frog
(Xenopus laevis)
Amphibia MGC52556 30
Zebrafish
(Danio rerio)
Actinopterygii ipo7 30 31
  • 73.64 (n)
OneToOne
zgc66425 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9019 30
Fruit Fly
(Drosophila melanogaster)
Insecta msk 30 31
  • 56.35 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007299 30
  • 54.94 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD5 30 31 33
  • 44.04 (n)
ManyToMany
SXM1 31
  • 22 (a)
ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04202g 30
  • 43.36 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABL068C 30
  • 43 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G59020 30
  • 45.05 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0474700 30
  • 47.04 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3218 31
  • 52 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC550.11 30
  • 45.52 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01939 30
  • 43.37 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2845 30
Species where no ortholog for IPO7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IPO7 Gene

ENSEMBL:
Gene Tree for IPO7 (if available)
TreeFam:
Gene Tree for IPO7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IPO7: view image

Paralogs for IPO7 Gene

Paralogs for IPO7 Gene

(32) SIMAP similar genes for IPO7 Gene using alignment to 4 proteins:

  • IPO7_HUMAN
  • E9PLB2_HUMAN
  • E9PLJ0_HUMAN
  • L8E8A9_HUMAN

Pseudogenes.org Pseudogenes for IPO7 Gene

genes like me logo Genes that share paralogs with IPO7: view

Variants for IPO7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IPO7 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11042340 - p.Thr111Asn

Additional dbSNP identifiers (rs#s) for IPO7 Gene

Structural Variations from Database of Genomic Variants (DGV) for IPO7 Gene

Variant ID Type Subtype PubMed ID
esv2441718 CNV deletion 19546169
esv2668301 CNV deletion 23128226
esv2672268 CNV deletion 23128226
esv3547298 CNV deletion 23714750
nsv1039537 CNV gain 25217958
nsv1055078 CNV gain 25217958
nsv1069560 CNV deletion 25765185
nsv1127160 CNV deletion 24896259
nsv1134090 CNV deletion 24896259
nsv442218 CNV loss 18776908
nsv499766 OTHER inversion 21111241
nsv508617 CNV deletion 20534489
nsv7215 OTHER inversion 18451855
nsv975149 CNV duplication 23825009
nsv982982 CNV duplication 23825009

Variation tolerance for IPO7 Gene

Residual Variation Intolerance Score: 4.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPO7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO7 Gene

Disorders for IPO7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IPO7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pediatric ependymoma
  • childhood ependymoma
malignant ependymoma
  • ependymal neoplasm
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
Search IPO7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IPO7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IPO7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO7 Gene

Publications for IPO7 Gene

  1. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PMID: 16704975) Arnold M … Kehlenbach RH (The Journal of biological chemistry 2006) 3 4 23
  2. Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7. (PMID: 12853482) Fassati A … Mingot JM (The EMBO journal 2003) 3 4 23
  3. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. (PMID: 10228156) Jäkel S … Görlich D (The EMBO journal 1999) 3 4 23
  4. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jäkel S … Görlich D (The EMBO journal 1998) 3 4 23
  5. A novel class of RanGTP binding proteins. (PMID: 9214382) Görlich D … Izaurralde E (The Journal of cell biology 1997) 2 3 4

Products for IPO7 Gene

Sources for IPO7 Gene