Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the... See more...

Aliases for IPO5 Gene

Aliases for IPO5 Gene

  • Importin 5 2 3 5
  • Karyopherin (Importin) Beta 3 2 3
  • Importin Subunit Beta-3 3 4
  • RAN Binding Protein 5 2 3
  • Ran-Binding Protein 5 3 4
  • Karyopherin Beta-3 3 4
  • Importin-5 3 4
  • RANBP5 3 4
  • KPNB3 3 4
  • IMB3 2 3
  • Pse1 2 3
  • Imp5 3 4
  • Ran_GTP Binding Protein 5 3
  • Importin Beta-3 Subunit 3
  • MGC2068 2
  • RanBP5 4
  • IPO5 5

External Ids for IPO5 Gene

Previous HGNC Symbols for IPO5 Gene

  • KPNB3
  • RANBP5

Previous GeneCards Identifiers for IPO5 Gene

  • GC13P097404
  • GC13P098605
  • GC13P079203

Summaries for IPO5 Gene

Entrez Gene Summary for IPO5 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPO5 Gene

IPO5 (Importin 5) is a Protein Coding gene. Diseases associated with IPO5 include Noonan Syndrome 1. Among its related pathways are HIV Life Cycle and Development_TGF-beta receptor signaling. Gene Ontology (GO) annotations related to this gene include protein transporter activity. An important paralog of this gene is RANBP6.

UniProtKB/Swiss-Prot Summary for IPO5 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Wiki entry for IPO5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IPO5 Gene

Genomics for IPO5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IPO5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J097975 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 261.8 +23.9 23860 5 TBP SP1 NR2C1 IKZF1 SMAD5 POLR2A NONO ZIC2 THAP11 SIN3A IPO5 RF00017-1473 lnc-RNF113B-9 FARP1
GH13J097953 Promoter/Enhancer 0.7 EPDnew ENCODE 250.7 +0.1 124 0.9 ATF2 ATF1 CREB1 HSALNG0098830 IPO5 ENSG00000270725 RF00017-1473 FARP1
GH13J097575 Enhancer 0.6 FANTOM5 24.9 -378.3 -378282 0.2 HOMEZ TRIM22 MIER3 BCL6 CTCF GATAD1 RAD21 ELF3 RXRB IKZF5 IPO5 piR-57421 piR-31937-066 LOC105370324 RAP2A ENSG00000226134
GH13J097986 Enhancer 0.6 Ensembl ENCODE 11.8 +33.4 33360 0.4 IRF4 SPI1 BHLHE40 RAD51 FTLP8 lnc-RNF113B-9 IPO5 RF00017-1473 FARP1
GH13J097928 Enhancer 0.2 Ensembl 13.2 -24.7 -24740 0.6 IPO5 HSALNG0098820 HSALNG0098827 RAP2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPO5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IPO5

Top Transcription factor binding sites by QIAGEN in the IPO5 gene promoter:
  • c-Rel
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RFX1

Genomic Locations for IPO5 Gene

Latest Assembly
chr13:97,953,641-98,024,296
(GRCh38/hg38)
Size:
70,656 bases
Orientation:
Plus strand

Previous Assembly
chr13:98,605,929-98,676,550
(GRCh37/hg19 by Entrez Gene)
Size:
70,622 bases
Orientation:
Plus strand

chr13:98,605,912-98,676,551
(GRCh37/hg19 by Ensembl)
Size:
70,640 bases
Orientation:
Plus strand

Genomic View for IPO5 Gene

Genes around IPO5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO5 Gene

Proteins for IPO5 Gene

  • Protein details for IPO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00410-IPO5_HUMAN
    Recommended name:
    Importin-5
    Protein Accession:
    O00410
    Secondary Accessions:
    • B4DZA0
    • O15257
    • Q5T578
    • Q86XC7

    Protein attributes for IPO5 Gene

    Size:
    1097 amino acids
    Molecular mass:
    123630 Da
    Quaternary structure:
    • Binds RPL23A, RPS7 and RPL5 (PubMed:9687515). Interacts with H2A, H2B, H3 and H4 histones (By similarity). Interacts with CPEB3; this mediates CPEB3 nuclear import following neuronal stimulation which enhances the interaction in a RAN-regulated manner (PubMed:22730302). Interacts with AIFM2; this interaction likely mediates the translocation of AIFM2 into the nucleus upon oxidative stress.
    • (Microbial infection) Interacts with HIV-1 Rev.
    SequenceCaution:
    • Sequence=CAA70103.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IPO5 Gene

    Alternative splice isoforms for IPO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO5 Gene

Post-translational modifications for IPO5 Gene

  • Ubiquitination at Lys548, Lys556, Lys690, and Lys963
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPO5 Gene

Domains & Families for IPO5 Gene

Gene Families for IPO5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for IPO5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54573, highly similar to Importin beta-3 (B4E0R6_HUMAN)
  • Ran-binding protein 5 (IPO5_HUMAN)
  • Importin 5 (Q5T576_HUMAN)
  • Importin 5 (Q5T577_HUMAN)
  • IPO5 protein (Q9BVS9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00410

UniProtKB/Swiss-Prot:

IPO5_HUMAN :
  • Belongs to the importin beta family. Importin beta-3 subfamily.
Family:
  • Belongs to the importin beta family. Importin beta-3 subfamily.
genes like me logo Genes that share domains with IPO5: view

Function for IPO5 Gene

Molecular function for IPO5 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Phenotypes From GWAS Catalog for IPO5 Gene

Gene Ontology (GO) - Molecular Function for IPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005095 GTPase inhibitor activity TAS 9271386
GO:0005515 protein binding IPI 10799599
GO:0008139 nuclear localization sequence binding IBA 21873635
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with IPO5: view
genes like me logo Genes that share phenotypes with IPO5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPO5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO5 Gene

Localization for IPO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO5 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus. nuclear rim. Found particularly in the nuclear rim and nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO5 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,ISS --
GO:0005643 nuclear pore TAS 9271386
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm TAS,ISS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with IPO5: view

Pathways & Interactions for IPO5 Gene

PathCards logo

SuperPathways for IPO5 Gene

genes like me logo Genes that share pathways with IPO5: view

Pathways by source for IPO5 Gene

2 GeneGo (Thomson Reuters) pathways for IPO5 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
3 Qiagen pathways for IPO5 Gene
  • NFAT in Immune Response
  • Ran Pathway
  • SREBP Proteolysis

Gene Ontology (GO) - Biological Process for IPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IBA 21873635
GO:0006607 NLS-bearing protein import into nucleus TAS,ISS --
GO:0006610 ribosomal protein import into nucleus IDA 9687515
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with IPO5: view

No data available for SIGNOR curated interactions for IPO5 Gene

Drugs & Compounds for IPO5 Gene

(1) Drugs for IPO5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with IPO5: view

Transcripts for IPO5 Gene

mRNA/cDNA for IPO5 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
30 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPO5

Alternative Splicing Database (ASD) splice patterns (SP) for IPO5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for IPO5 Gene

GeneLoc Exon Structure for
IPO5

Expression for IPO5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IPO5 Gene

This gene is overexpressed in Bone (48.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPO5 Gene



Protein tissue co-expression partners for IPO5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IPO5

SOURCE GeneReport for Unigene cluster for IPO5 Gene:

Hs.712598

Evidence on tissue expression from TISSUES for IPO5 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Blood(4.5)
  • Bone marrow(4.3)
  • Thyroid gland(3.6)
  • Kidney(3.6)
  • Liver(3.5)
  • Intestine(3.3)
  • Bone(3.2)
  • Eye(3.1)
  • Heart(2.9)
  • Skin(2.7)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with IPO5: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO5 Gene

Orthologs for IPO5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IPO5 30 31
  • 99.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RANBP6 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia IPO5 30 31
  • 93.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 92 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Ipo5 30
  • 89.78 (n)
Mouse
(Mus musculus)
Mammalia Ipo5 30 17 31
  • 89.73 (n)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 92 (a)
OneToMany
IPO5 30
  • 82.65 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 93 (a)
ManyToMany
-- 31
  • 83 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ipo5 30
  • 79.08 (n)
Str.15322 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7748 30
Zebrafish
(Danio rerio)
Actinopterygii kpnb3 30 31
  • 74.22 (n)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta Karybeta3 30 31
  • 56.91 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003769 30
  • 55.5 (n)
Worm
(Caenorhabditis elegans)
Secernentea imb-3 30 31
  • 47.73 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSE1 30 31 33
  • 46.12 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGL349C 30
  • 45.73 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14157g 30
  • 45.45 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons emb2734 30
  • 49.76 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0575100 30
  • 49.92 (n)
Os.7742 30
Barley
(Hordeum vulgare)
Liliopsida Hv.2027 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10777 31
  • 53 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sal3 30
  • 48.5 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02357 30
  • 48.25 (n)
Species where no ortholog for IPO5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for IPO5 Gene

ENSEMBL:
Gene Tree for IPO5 (if available)
TreeFam:
Gene Tree for IPO5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IPO5: view image

Paralogs for IPO5 Gene

Paralogs for IPO5 Gene

(1) SIMAP similar genes for IPO5 Gene using alignment to 21 proteins:

  • IPO5_HUMAN
  • B4E0R6_HUMAN
  • C9J583_HUMAN
  • C9J875_HUMAN
  • C9JMV5_HUMAN
  • C9JQT6_HUMAN
  • C9JXE0_HUMAN
  • C9JZ53_HUMAN
  • C9JZD8_HUMAN
  • E7EQT5_HUMAN
  • E7ESA1_HUMAN
  • E7ESZ1_HUMAN
  • E7ETV3_HUMAN
  • E7ETV8_HUMAN
  • E7EV12_HUMAN
  • E7EWK4_HUMAN
  • E7EX05_HUMAN
  • F8WF30_HUMAN
  • H0Y3V4_HUMAN
  • H0Y8C6_HUMAN
  • Q9BVS9_HUMAN

Pseudogenes.org Pseudogenes for IPO5 Gene

genes like me logo Genes that share paralogs with IPO5: view

Variants for IPO5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IPO5 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs145817156 Benign: not provided 97,990,441(+) G/A
NM_002271.6(IPO5):c.573G>A (p.Thr191=)
SYNONYMOUS
rs525939 Benign: not provided 98,018,634(+) G/A
NM_002271.6(IPO5):c.2766G>A (p.Arg922=)
SYNONYMOUS
rs1053814 - p.Leu286Ile
rs1804740 - p.Tyr905Cys
rs1804741 - p.Thr969Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IPO5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IPO5 Gene

Variant ID Type Subtype PubMed ID
esv1006772 CNV insertion 20482838
esv24236 CNV loss 19812545
esv3365564 CNV insertion 20981092
nsv1126350 CNV deletion 24896259
nsv7246 OTHER inversion 18451855

Variation tolerance for IPO5 Gene

Residual Variation Intolerance Score: 3.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPO5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO5 Gene

Disorders for IPO5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPO5 Gene - From: COP

Disorder Aliases PubMed IDs
noonan syndrome 1
  • ns1
- elite association - COSMIC cancer census association via MalaCards
Search IPO5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IPO5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IPO5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO5 Gene

Publications for IPO5 Gene

  1. Cloning and characterization of human karyopherin beta3. (PMID: 9114010) Yaseen NR … Blobel G (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23
  2. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jäkel S … Görlich D (The EMBO journal 1998) 3 4 23
  3. Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. (PMID: 9271386) Deane R … Bischoff FR (Molecular and cellular biology 1997) 2 3 4
  4. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. (PMID: 22730302) Chao HW … Huang YS (Nucleic acids research 2012) 3 4
  5. A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion. (PMID: 18562802) Chung KM … Jang SK (Molecules and cells 2008) 3 23

Products for IPO5 Gene

Sources for IPO5 Gene