Aliases for IPO4 Gene

Aliases for IPO4 Gene

  • Importin 4 2 3 5
  • Ran-Binding Protein 4 3 4
  • Importin-4b 3 4
  • Importin-4 3 4
  • RanBP4 3 4
  • Imp4b 3 4
  • Imp4 3 4
  • RANBP4 4
  • IMP4B 4

External Ids for IPO4 Gene

Previous GeneCards Identifiers for IPO4 Gene

  • GC14M018436
  • GC14M022639
  • GC14M023719
  • GC14M024649
  • GC14M004764

Summaries for IPO4 Gene

GeneCards Summary for IPO4 Gene

IPO4 (Importin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is RANBP6.

UniProtKB/Swiss-Prot Summary for IPO4 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for IPO4 Gene

Additional gene information for IPO4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IPO4 Gene

Genomics for IPO4 Gene

GeneHancer (GH) Regulatory Elements for IPO4 Gene

Promoters and enhancers for IPO4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPO4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IPO4

Top Transcription factor binding sites by QIAGEN in the IPO4 gene promoter:
  • c-Ets-1
  • ER-alpha
  • GATA-1
  • HEN1
  • Lmo2
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2
  • RelA
  • RFX1

Genomic Locations for IPO4 Gene

Genomic Locations for IPO4 Gene
chr14:24,180,219-24,188,918
(GRCh38/hg38)
Size:
8,700 bases
Orientation:
Minus strand
chr14:24,649,425-24,658,170
(GRCh37/hg19)
Size:
8,746 bases
Orientation:
Minus strand

Genomic View for IPO4 Gene

Genes around IPO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO4 Gene

Proteins for IPO4 Gene

  • Protein details for IPO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEX9-IPO4_HUMAN
    Recommended name:
    Importin-4
    Protein Accession:
    Q8TEX9
    Secondary Accessions:
    • B2RN95
    • Q2NL96
    • Q86TZ9
    • Q8NCG8
    • Q96SJ3
    • Q9BTI4
    • Q9H5L0

    Protein attributes for IPO4 Gene

    Size:
    1081 amino acids
    Molecular mass:
    118715 Da
    Quaternary structure:
    • Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human cytomegalovirus UL84. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4.
    SequenceCaution:
    • Sequence=BAB15616.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB55421.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11174.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD62595.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IPO4 Gene

    Alternative splice isoforms for IPO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO4 Gene

Post-translational modifications for IPO4 Gene

  • Ubiquitination at Lys81, Lys370, Lys401, Lys788, Lys801, and Lys875
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPO4 Gene

Domains & Families for IPO4 Gene

Gene Families for IPO4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for IPO4 Gene

Blocks:
  • HEAT repeat
  • Importin-beta, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IPO4 Gene

GenScript: Design optimal peptide antigens:
  • Importin 4, isoform CRA_f (D3DS63_HUMAN)
  • Ran-binding protein 4 (IPO4_HUMAN)
  • IPO4 protein (Q6I9Y8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TEX9

UniProtKB/Swiss-Prot:

IPO4_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO4: view

Function for IPO4 Gene

Molecular function for IPO4 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Phenotypes From GWAS Catalog for IPO4 Gene

Gene Ontology (GO) - Molecular Function for IPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 17616579
GO:0008139 nuclear localization sequence binding IBA 21873635
GO:0008536 Ran GTPase binding IEA --
GO:0061608 nuclear import signal receptor activity IBA 21873635
genes like me logo Genes that share ontologies with IPO4: view
genes like me logo Genes that share phenotypes with IPO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPO4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO4 Gene

Localization for IPO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO4 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005623 cell IEA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with IPO4: view

Pathways & Interactions for IPO4 Gene

PathCards logo

SuperPathways for IPO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
GO:0006606 protein import into nucleus IDA,IEA 11823430
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with IPO4: view

No data available for Pathways by source and SIGNOR curated interactions for IPO4 Gene

Drugs & Compounds for IPO4 Gene

(2) Drugs for IPO4 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Investigational Pharma 0
genes like me logo Genes that share compounds with IPO4: view

Transcripts for IPO4 Gene

mRNA/cDNA for IPO4 Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPO4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8: - - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - -
SP12: - - - -
SP13:
SP14:
SP15: - - - -
SP16: - - - - - -
SP17: -
SP18:
SP19:
SP20: -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for IPO4 Gene

GeneLoc Exon Structure for
IPO4

Expression for IPO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPO4 Gene

Protein differential expression in normal tissues from HIPED for IPO4 Gene

This gene is overexpressed in Bone (54.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPO4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IPO4

SOURCE GeneReport for Unigene cluster for IPO4 Gene:

Hs.411865

Evidence on tissue expression from TISSUES for IPO4 Gene

  • Nervous system(4.8)
  • Skin(4.5)
genes like me logo Genes that share expression patterns with IPO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO4 Gene

Orthologs for IPO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO4 31 30
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IPO4 31 30
  • 89.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IPO4 31 30
  • 88.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo4 30
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Ipo4 17 31 30
  • 82.93 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO4 31
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo4 30
  • 55.27 (n)
zebrafish
(Danio rerio)
Actinopterygii ipo4 31 30
  • 55.25 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006942 30
  • 48.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32165 31 30
  • 45.31 (n)
OneToMany
CG32164 31
  • 28 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL298C 30
  • 41.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20769g 30
  • 39.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP123 33 31 30
  • 38.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27640 30
  • 41.11 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05650 30
  • 45.89 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap123 30
  • 40.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToOne
Species where no ortholog for IPO4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO4 Gene

ENSEMBL:
Gene Tree for IPO4 (if available)
TreeFam:
Gene Tree for IPO4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IPO4: view image

Paralogs for IPO4 Gene

Paralogs for IPO4 Gene

genes like me logo Genes that share paralogs with IPO4: view

Variants for IPO4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IPO4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
716382 Benign: not provided 24,183,860(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
776825 Benign: not provided 24,184,909(-) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
787111 Benign: not provided 24,188,730(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs11550452 - p.Pro580Ala
rs7146310 - p.Ala513Val

Additional dbSNP identifiers (rs#s) for IPO4 Gene

Structural Variations from Database of Genomic Variants (DGV) for IPO4 Gene

Variant ID Type Subtype PubMed ID
nsv1220 CNV insertion 18451855
nsv522667 CNV loss 19592680
nsv7249 OTHER inversion 18451855

Variation tolerance for IPO4 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.63; 95.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO4 Gene

Disorders for IPO4 Gene

Additional Disease Information for IPO4

No disorders were found for IPO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO4 Gene

Publications for IPO4 Gene

  1. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 2 3 4 54
  2. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K … Groth A (The EMBO journal 2012) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P … Stamminger T (Journal of virology 2003) 3 4 54

Products for IPO4 Gene

Sources for IPO4 Gene