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Aliases for IPO13 Gene

Aliases for IPO13 Gene

  • Importin 13 2 3 5
  • Ran-Binding Protein 13 3 4
  • RANBP13 3 4
  • Ran Binding Protein 13 3
  • Late Gestation Lung 2 3
  • Karyopherin 13 3
  • Karyopherin-13 4
  • Importin-13 3
  • KIAA0724 4
  • RanBP13 4
  • IMP13 3
  • KAP13 3
  • Imp13 4
  • Kap13 4
  • LGL2 3

External Ids for IPO13 Gene

Previous GeneCards Identifiers for IPO13 Gene

  • GC01P043413
  • GC01P043842
  • GC01P043825
  • GC01P044081
  • GC01P044185
  • GC01P044412
  • GC01P042531

Summaries for IPO13 Gene

Entrez Gene Summary for IPO13 Gene

  • This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]

GeneCards Summary for IPO13 Gene

IPO13 (Importin 13) is a Protein Coding gene. Diseases associated with IPO13 include Mitral Valve Insufficiency. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is TNPO3.

UniProtKB/Swiss-Prot for IPO13 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Gene Wiki entry for IPO13 Gene

Additional gene information for IPO13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO13 Gene

Genomics for IPO13 Gene

GeneHancer (GH) Regulatory Elements for IPO13 Gene

Promoters and enhancers for IPO13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043945 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.2 232 2.7 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC MEF2D LOC101929609 IPO13 DMAP1 ARTN ATP6V0B CCDC24 SZT2 ERI3-IT1 HYI RNF220
GH01J043944 Enhancer 0.5 Ensembl dbSUPER 650.7 -1.9 -1905 0.2 PRDM4 LOC101929609 IPO13 GC01M043942 CCDC24
GH01J043830 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -112.7 -112699 6.3 HDGF PKNOX1 FOXA2 SMAD1 ZNF2 ZNF766 ZNF207 ZNF143 FOS JUNB GC01M043833 ARTN SZT2 LOC101929609 DMAP1 ST3GAL3 IPO13 HYI LOC101929592 KDM4A-AS1
GH01J043529 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -413.1 -413066 9.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 PTPRF ST3GAL3 KDM4A-AS1 ARTN LOC101929609 IPO13 HYI MED8 GC01M043545
GH01J044027 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 +83.7 83697 5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 ZNF207 ZNF143 ENSG00000230615 SLC6A9 SZT2 DMAP1 KDM4A MED8 ERI3-IT1 IPO13 DPH2 ARTN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPO13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IPO13 gene promoter:
  • E2F-2
  • E2F
  • E2F-1
  • Egr-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • MZF-1
  • ATF
  • AP-4

Genomic Locations for IPO13 Gene

Genomic Locations for IPO13 Gene
chr1:43,946,806-43,968,022
(GRCh38/hg38)
Size:
21,217 bases
Orientation:
Plus strand
chr1:44,412,478-44,433,694
(GRCh37/hg19)
Size:
21,217 bases
Orientation:
Plus strand

Genomic View for IPO13 Gene

Genes around IPO13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO13 Gene

Proteins for IPO13 Gene

  • Protein details for IPO13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94829-IPO13_HUMAN
    Recommended name:
    Importin-13
    Protein Accession:
    O94829
    Secondary Accessions:
    • D3DPY4
    • Q5T4X3
    • Q7LC04
    • Q96HS3
    • Q9H8N3
    • Q9UFR1

    Protein attributes for IPO13 Gene

    Size:
    963 amino acids
    Molecular mass:
    108195 Da
    Quaternary structure:
    • Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
    SequenceCaution:
    • Sequence=BAA34444.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14575.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IPO13 Gene

neXtProt entry for IPO13 Gene

Post-translational modifications for IPO13 Gene

  • Ubiquitination at isoforms=923
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO13 Gene

No data available for DME Specific Peptides for IPO13 Gene

Domains & Families for IPO13 Gene

Gene Families for IPO13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for IPO13 Gene

Graphical View of Domain Structure for InterPro Entry

O94829

UniProtKB/Swiss-Prot:

IPO13_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO13: view

Function for IPO13 Gene

Molecular function for IPO13 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Phenotypes From GWAS Catalog for IPO13 Gene

Gene Ontology (GO) - Molecular Function for IPO13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008139 nuclear localization sequence binding IBA --
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with IPO13: view
genes like me logo Genes that share phenotypes with IPO13: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO13 Gene

Localization for IPO13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO13 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO13 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IPO13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0031965 nuclear membrane IBA --
genes like me logo Genes that share ontologies with IPO13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IPO13 Gene

Pathways & Interactions for IPO13 Gene

SuperPathways for IPO13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 15964792
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with IPO13: view

No data available for Pathways by source and SIGNOR curated interactions for IPO13 Gene

Drugs & Compounds for IPO13 Gene

(2) Drugs for IPO13 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Investigational Pharma 0
genes like me logo Genes that share compounds with IPO13: view

Transcripts for IPO13 Gene

mRNA/cDNA for IPO13 Gene

Unigene Clusters for IPO13 Gene

Importin 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:
SP6:

ExUns: 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for IPO13 Gene

GeneLoc Exon Structure for
IPO13
ECgene alternative splicing isoforms for
IPO13

Expression for IPO13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPO13 Gene

mRNA differential expression in normal tissues according to GTEx for IPO13 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for IPO13 Gene

This gene is overexpressed in Bone (60.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPO13 Gene



Protein tissue co-expression partners for IPO13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPO13 Gene:

IPO13

SOURCE GeneReport for Unigene cluster for IPO13 Gene:

Hs.158497

mRNA Expression by UniProt/SwissProt for IPO13 Gene:

O94829-IPO13_HUMAN
Tissue specificity: Expressed in fetal brain, heart, intestine and kidney.

Evidence on tissue expression from TISSUES for IPO13 Gene

  • Nervous system(5)
  • Eye(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with IPO13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO13 Gene

Orthologs for IPO13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPO13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO13 34 33
  • 99.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IPO13 34 33
  • 95.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IPO13 34 33
  • 94.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo13 16 34 33
  • 93.18 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO13 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo13 33
  • 92.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IPO13 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPO13 34 33
  • 81.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO13 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo13 33
  • 74.46 (n)
zebrafish
(Danio rerio)
Actinopterygii ipo13 34 33
  • 75.53 (n)
OneToMany
IPO13 (2 of 2) 34
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cdm 34 33
  • 45.74 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009571 33
  • 45.43 (n)
worm
(Caenorhabditis elegans)
Secernentea T16G12.6 34
  • 17 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR10 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for IPO13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IPO13 Gene

ENSEMBL:
Gene Tree for IPO13 (if available)
TreeFam:
Gene Tree for IPO13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IPO13: view image

Paralogs for IPO13 Gene

Paralogs for IPO13 Gene

genes like me logo Genes that share paralogs with IPO13: view

Variants for IPO13 Gene

Sequence variations from dbSNP and Humsavar for IPO13 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000323710 -- 43,965,150(+) G/T intron_variant
rs1000807373 -- 43,965,185(+) T/G intron_variant
rs1000859824 -- 43,965,517(+) C/T intron_variant
rs1001196506 -- 43,950,393(+) A/G intron_variant
rs1001350474 -- 43,948,696(+) G/T intron_variant

Variation tolerance for IPO13 Gene

Residual Variation Intolerance Score: 5.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPO13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IPO13 Gene

Disorders for IPO13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPO13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mitral valve insufficiency
  • congenital insufficiency of mitral valve
- elite association - COSMIC cancer census association via MalaCards
Search IPO13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IPO13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IPO13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO13 Gene

Publications for IPO13 Gene

  1. Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot JM … Görlich D (The EMBO journal 2001) 2 3 4 22 58
  2. Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. (PMID: 19619331) Raby BA … Weiss ST (Respiratory research 2009) 3 22 44 58
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  4. Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation. (PMID: 21139563) Grünwald M … Bono F (The EMBO journal 2011) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for IPO13 Gene

Sources for IPO13 Gene

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