This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of ... See more...

Aliases for IPMK Gene

Aliases for IPMK Gene

  • Inositol Polyphosphate Multikinase 2 3 4 5
  • Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase 3 4
  • EC 2.7.1.140 4
  • EC 2.7.1.151 4
  • EC 2.7.1.153 4
  • IPMK 5
  • IMPK 4

External Ids for IPMK Gene

Previous GeneCards Identifiers for IPMK Gene

  • GC10M059625
  • GC10M059951
  • GC10M053944

Summaries for IPMK Gene

Entrez Gene Summary for IPMK Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

GeneCards Summary for IPMK Gene

IPMK (Inositol Polyphosphate Multikinase) is a Protein Coding gene. Diseases associated with IPMK include Hereditary Neuroendocrine Tumor Of Small Intestine and Small Intestine Neuroendocrine Neoplasm. Among its related pathways are Inositol phosphate metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol tetrakisphosphate 3-kinase activity. An important paralog of this gene is IP6K1.

UniProtKB/Swiss-Prot Summary for IPMK Gene

  • Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IPMK Gene

Genomics for IPMK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IPMK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J058264 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 262.5 +2.3 2282 6.7 SP1 MYC ZNF600 IKZF1 ZNF580 ZNF592 KLF9 POLR2A CEBPA ZNF10 CISD1 IPMK HSALNG0078168 NONHSAG005951.2 UBE2D1 TFAM MN309086
GH10J058511 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 8.8 -244.2 -244222 5.5 ZNF600 ZNF580 ZSCAN16 ZIC2 CEBPB ZNF639 ZNF341 SIN3A FOXA2 KLF9 BICC1 lnc-TFAM-3 IPMK CISD1 piR-45726-006 PHYHIPL
GH10J058322 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.5 -52.6 -52640 3.6 CEBPA YY1 CEBPB FEZF1 HOMEZ THAP11 FOXA2 KDM6A SMAD4 RXRA CISD1 IPMK TFAM UBE2D1 ENSG00000261076 ENSG00000228527
GH10J058236 Enhancer 0.9 Ensembl ENCODE 11.6 +30.7 30738 5.2 JUND CEBPA CEBPB HOMEZ EP300 FOXA2 SAP130 RARA TEAD3 TCF7L2 MN309086 SNODB318 CISD1 IPMK piR-49423-031
GH10J058330 Enhancer 0.7 FANTOM5 Ensembl 12.4 -60.8 -60840 4.8 MCM7 MCM3 ZNF610 TAL1 SPI1 CBFA2T3 LOC112268068 CISD1 IPMK TFAM UBE2D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPMK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IPMK

Top Transcription factor binding sites by QIAGEN in the IPMK gene promoter:
  • AML1a
  • Cdc5
  • CUTL1
  • E47
  • LyF-1
  • p53
  • Pbx1a
  • Tal-1beta
  • ZIC2

Genomic Locations for IPMK Gene

Latest Assembly
chr10:58,191,517-58,269,961
(GRCh38/hg38)
Size:
78,445 bases
Orientation:
Minus strand

Previous Assembly
chr10:59,951,278-60,027,654
(GRCh37/hg19 by Entrez Gene)
Size:
76,377 bases
Orientation:
Minus strand

chr10:59,951,278-60,027,694
(GRCh37/hg19 by Ensembl)
Size:
76,417 bases
Orientation:
Minus strand

Genomic View for IPMK Gene

Genes around IPMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPMK Gene

Proteins for IPMK Gene

  • Protein details for IPMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU5-IPMK_HUMAN
    Recommended name:
    Inositol polyphosphate multikinase
    Protein Accession:
    Q8NFU5

    Protein attributes for IPMK Gene

    Size:
    416 amino acids
    Molecular mass:
    47222 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IPMK Gene

neXtProt entry for IPMK Gene

Post-translational modifications for IPMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IPMK Gene

No data available for DME Specific Peptides for IPMK Gene

Domains & Families for IPMK Gene

Gene Families for IPMK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IPMK Gene

InterPro:

Suggested Antigen Peptide Sequences for IPMK Gene

GenScript: Design optimal peptide antigens:
  • Inositol 1,3,4,6-tetrakisphosphate 5-kinase (IPMK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NFU5

UniProtKB/Swiss-Prot:

IPMK_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IPMK: view

Function for IPMK Gene

Molecular function for IPMK Gene

UniProtKB/Swiss-Prot Function:
Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+); Xref=Rhea:RHEA:32359, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733, ChEBI:CHEBI:203600, ChEBI:CHEBI:456216; EC=2.7.1.151; Evidence={ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:30624931};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+); Xref=Rhea:RHEA:12717, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57660, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216; EC=2.7.1.140; Evidence={ECO:0000269|PubMed:12223481};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+); Xref=Rhea:RHEA:43396, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77137, ChEBI:CHEBI:83243, ChEBI:CHEBI:456216; Evidence={ECO:0000305|PubMed:28882892, ECO:0000305|PubMed:30420721};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153; Evidence={ECO:0000250|UniProtKB:Q99NI4};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=112 nM for myo-inositol-1,4,5-trisphosphate {ECO:0000269|PubMed:12223481}; KM=295 nM for myo-inositol-1,3,4,6-tetrakisphosphate {ECO:0000269|PubMed:12223481}; KM=129 nM for myo-inositol-1,3,4,5-tetrakisphosphate {ECO:0000269|PubMed:12223481}; KM=61 uM for ATP {ECO:0000269|PubMed:30420721}; KM=39 uM for phosphatidylinositol 4,5-bisphosphate {ECO:0000269|PubMed:30420721}; Vmax=27 nmol/min/mg enzyme with myo-inositol-1,4,5-trisphosphate as substrate {ECO:0000269|PubMed:12223481}; Vmax=114 nmol/min/mg enzyme with myo-inositol-1,3,4,6-tetrakisphosphate as substrate {ECO:0000269|PubMed:12223481}; Vmax=1.1 nmol/min/mg enzyme with myo-inositol-1,3,4,5-tetrakisphosphate as substrate {ECO:0000269|PubMed:12223481};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by flavonoids that occupy the ATP-binding pocket. Inhibited by myricetin, quercetin, luteolin, kaempferol, isorhamnetin and diosmetin, and to a lesser degree by rhamnetin and apigenin.

Enzyme Numbers (IUBMB) for IPMK Gene

Phenotypes From GWAS Catalog for IPMK Gene

Gene Ontology (GO) - Molecular Function for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity IEA --
GO:0000824 inositol tetrakisphosphate 3-kinase activity TAS --
GO:0000825 inositol tetrakisphosphate 6-kinase activity TAS --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IPMK: view
genes like me logo Genes that share phenotypes with IPMK: view

Animal Models for IPMK Gene

MGI Knock Outs for IPMK:
  • Ipmk Ipmk<tm1Yrk>
  • Ipmk Ipmk<tm1.2Snyd>

Animal Models for research

  • Taconic Biosciences Mouse Models for IPMK

miRNA for IPMK Gene

miRTarBase miRNAs that target IPMK

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPMK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPMK Gene

Localization for IPMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPMK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPMK gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with IPMK: view

Pathways & Interactions for IPMK Gene

genes like me logo Genes that share pathways with IPMK: view

UniProtKB/Swiss-Prot Q8NFU5-IPMK_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylinositol metabolism.

Gene Ontology (GO) - Biological Process for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0032957 inositol trisphosphate metabolic process IDA 30624931
GO:0032958 inositol phosphate biosynthetic process IBA 21873635
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with IPMK: view

No data available for SIGNOR curated interactions for IPMK Gene

Drugs & Compounds for IPMK Gene

(4) Drugs for IPMK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myo-Inositol 1,4,5-trisphosphate Experimental Pharma 0
ATP Investigational Nutra 0

(5) Additional Compounds for IPMK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
D-myo-Inositol 1,4,5,6-tetrakisphosphate
  • Inositol 1,4,5,6-tetrakisphosphate
  • Inositol 1,4,5,6-tetrakisphosphoric acid
  • D-Myo-inositol 1,4,5,6-tetrakisphosphoric acid
  • 1D-Myo-inositol 1,4,5,6-tetrakisphosphoric acid
  • Ins(1,4,5,6)P3
109837-24-3
myo-Inositol 1,3,4,5,6-pentakisphosphate
  • 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
  • D-myo-Inositol 1,3,4,5,6-pentakisphosphate
  • 1D-myo-Inositol 1,3,4,5,6-pentakisphosphoric acid
  • Inositol 1,3,4,5,6-pentakisphosphoric acid
  • D-myo-Inositol 1,3,4,5,6-pentakisphosphoric acid
20298-95-7
genes like me logo Genes that share compounds with IPMK: view

Transcripts for IPMK Gene

mRNA/cDNA for IPMK Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IPMK

Alternative Splicing Database (ASD) splice patterns (SP) for IPMK Gene

No ASD Table

Relevant External Links for IPMK Gene

GeneLoc Exon Structure for
IPMK

Expression for IPMK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPMK Gene

mRNA differential expression in normal tissues according to GTEx for IPMK Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for IPMK Gene

This gene is overexpressed in Esophagus (26.8), Fetal testis (15.5), and Fetal heart (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPMK Gene



Protein tissue co-expression partners for IPMK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IPMK

SOURCE GeneReport for Unigene cluster for IPMK Gene:

Hs.30280

mRNA Expression by UniProt/SwissProt for IPMK Gene:

Q8NFU5-IPMK_HUMAN
Tissue specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.

Evidence on tissue expression from TISSUES for IPMK Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with IPMK: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPMK Gene

Orthologs for IPMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPMK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IPMK 29 30
  • 99.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IPMK 29 30
  • 92.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IPMK 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ipmk 29 16 30
  • 80.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ipmk 29
  • 80.98 (n)
Oppossum
(Monodelphis domestica)
Mammalia IPMK 30
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IPMK 29 30
  • 75.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IPMK 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ipmk 29
  • 68.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1741 29
Zebrafish
(Danio rerio)
Actinopterygii ipmkb 29 30
  • 61.11 (n)
OneToMany
ipmka 30
  • 58 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ipk2 29 30
  • 48.12 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012099 29
  • 44.44 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_ZK795.1 29
  • 47.5 (n)
ZK795.1 30
  • 29 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 30
  • 7 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons IPK2a 29
  • 44.07 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0523800 29
  • 38.12 (n)
Species where no ortholog for IPMK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for IPMK Gene

ENSEMBL:
Gene Tree for IPMK (if available)
TreeFam:
Gene Tree for IPMK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IPMK: view image
Alliance of Genome Resources:
Additional Orthologs for IPMK

Paralogs for IPMK Gene

Paralogs for IPMK Gene

Pseudogenes.org Pseudogenes for IPMK Gene

genes like me logo Genes that share paralogs with IPMK: view

Variants for IPMK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IPMK Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs61740967 Benign: not provided 58,267,516(-) G/C
NM_152230.5(IPMK):c.96C>G (p.Thr32=)
SYNONYMOUS
rs61749177 Benign: not provided 58,227,044(-) G/A
NM_152230.5(IPMK):c.372C>T (p.Asn124=)
SYNONYMOUS
rs2275443 -- p.Met349Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IPMK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IPMK Gene

Variant ID Type Subtype PubMed ID
nsv1113302 CNV deletion 24896259
nsv948026 CNV duplication 23825009
nsv948027 CNV duplication 23825009

Variation tolerance for IPMK Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPMK Gene

Human Gene Mutation Database (HGMD)
IPMK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPMK
Leiden Open Variation Database (LOVD)
IPMK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPMK Gene

Disorders for IPMK Gene

MalaCards: The human disease database

(3) MalaCards diseases for IPMK Gene - From: ORP and COP

Disorder Aliases PubMed IDs
hereditary neuroendocrine tumor of small intestine
  • hereditary neuroendocrine tumor of small bowel
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
small intestine benign neoplasm
  • neoplasm of small intestine
- elite association - COSMIC cancer census association via MalaCards
Search IPMK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IPMK

genes like me logo Genes that share disorders with IPMK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPMK Gene

Publications for IPMK Gene

  1. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (PMID: 12027805) Nalaskowski MM … Mayr GW (The Biochemical journal 2002) 2 3 4 22
  2. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. (PMID: 12223481) Chang SC … Majerus PW (The Journal of biological chemistry 2002) 2 3 4 22
  3. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. (PMID: 30624931) Gu C … Wang H (Journal of medicinal chemistry 2019) 3 4
  4. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. (PMID: 29883610) Dovey CM … Carette JE (Molecular cell 2018) 3 4
  5. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. (PMID: 28882892) Wang H … Shears SB (The Journal of biological chemistry 2017) 3 4

Products for IPMK Gene

Sources for IPMK Gene