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Aliases for IPMK Gene

Aliases for IPMK Gene

  • Inositol Polyphosphate Multikinase 2 3 3 5
  • Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase 3 4
  • EC 4
  • IMPK 4

External Ids for IPMK Gene

Previous GeneCards Identifiers for IPMK Gene

  • GC10M059625
  • GC10M059951
  • GC10M053944

Summaries for IPMK Gene

Entrez Gene Summary for IPMK Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

GeneCards Summary for IPMK Gene

IPMK (Inositol Polyphosphate Multikinase) is a Protein Coding gene. Diseases associated with IPMK include Hereditary Neuroendocrine Tumor Of Small Intestine. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol tetrakisphosphate 3-kinase activity. An important paralog of this gene is IP6K2.

UniProtKB/Swiss-Prot for IPMK Gene

  • Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).

Additional gene information for IPMK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPMK Gene

Genomics for IPMK Gene

GeneHancer (GH) Regulatory Elements for IPMK Gene

Promoters and enhancers for IPMK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J058264 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662.6 +0.3 258 6.7 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC CISD1 IPMK TFAM UBE2D1 TPT1P10
GH10J058511 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.8 -246.3 -246293 5.4 FOXA2 ZNF133 SIN3A ZNF2 YY1 GLIS2 SP3 YY2 REST ZNF610 BICC1 GC10P058514 ENSG00000232115 TRAF6P1 CISD1 IPMK GC10P058574
GH10J058322 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.5 -54.9 -54923 1.5 ELF3 FOXA2 INSM2 MZF1 FEZF1 DMAP1 THRB RARA YY1 ZNF614 CISD1 IPMK TFAM UBE2D1 ENSG00000261076 ENSG00000228527
GH10J058236 Enhancer 1 Ensembl ENCODE 11.6 +28.7 28714 5.2 ELF3 FOXA2 RARA ETS1 FOS CREM CEBPB KAT8 SP1 GLIS1 CISD1 IPMK TPT1P10
GH10J058414 Enhancer 0.8 Ensembl ENCODE 10 -146.8 -146827 1.2 SCRT1 CTCF ZNF654 FOXA2 RAD21 ATF2 RFX5 SP1 SCRT2 SMC3 TFAM CISD1 IPMK LOC105378316
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IPMK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IPMK gene promoter:
  • AML1a
  • CUTL1
  • LyF-1
  • p53
  • Pbx1a
  • Cdc5
  • Tal-1beta
  • E47
  • ZIC2

Genomic Locations for IPMK Gene

Genomic Locations for IPMK Gene
76,421 bases
Minus strand
76,417 bases
Minus strand

Genomic View for IPMK Gene

Genes around IPMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPMK Gene

Proteins for IPMK Gene

  • Protein details for IPMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol polyphosphate multikinase
    Protein Accession:

    Protein attributes for IPMK Gene

    416 amino acids
    Molecular mass:
    47222 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IPMK Gene

neXtProt entry for IPMK Gene

Post-translational modifications for IPMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IPMK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPMK Gene

Domains & Families for IPMK Gene

Gene Families for IPMK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IPMK Gene


Suggested Antigen Peptide Sequences for IPMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol phosphokinase (IPK) family.
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IPMK: view

Function for IPMK Gene

Molecular function for IPMK Gene

UniProtKB/Swiss-Prot Function:
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).
UniProtKB/Swiss-Prot CatalyticActivity:
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

Enzyme Numbers (IUBMB) for IPMK Gene

Phenotypes From GWAS Catalog for IPMK Gene

Gene Ontology (GO) - Molecular Function for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity IEA --
GO:0000824 inositol tetrakisphosphate 3-kinase activity TAS --
GO:0000825 inositol tetrakisphosphate 6-kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity TAS --
genes like me logo Genes that share ontologies with IPMK: view
genes like me logo Genes that share phenotypes with IPMK: view

Animal Models for IPMK Gene

MGI Knock Outs for IPMK:
  • Ipmk Ipmk<tm1Yrk>
  • Ipmk Ipmk<tm1.2Snyd>

Animal Model Products

  • Taconic Biosciences Mouse Models for IPMK

miRNA for IPMK Gene

miRTarBase miRNAs that target IPMK

Clone Products

  • Addgene plasmids for IPMK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPMK Gene

Localization for IPMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPMK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPMK gene
Compartment Confidence
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with IPMK: view

Pathways & Interactions for IPMK Gene

genes like me logo Genes that share pathways with IPMK: view

Gene Ontology (GO) - Biological Process for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0032958 inositol phosphate biosynthetic process IEA --
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with IPMK: view

No data available for SIGNOR curated interactions for IPMK Gene

Drugs & Compounds for IPMK Gene

(3) Drugs for IPMK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(6) Additional Compounds for IPMK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 1,4,5,6-tetrakisphosphate
  • D-myo-Inositol 1,4,5,6-tetrakisphosphate
  • Inositol 1,4,5,6-tetrakisphosphate
  • D-myo-Inositol 1,4,5,6-tetrakisphosphoric acid
  • 1D-myo-Inositol 1,4,5,6-tetrakisphosphoric acid
  • Inositol 1,4,5,6-tetrakisphosphoric acid
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Inositol 1,3,4,5,6-pentakisphosphate
  • 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
  • D-myo-Inositol 1,3,4,5,6-pentakisphosphate
  • 1D-myo-Inositol 1,3,4,5,6-pentakisphosphoric acid
  • Inositol 1,3,4,5,6-pentakisphosphoric acid
  • D-myo-Inositol 1,3,4,5,6-pentakisphosphoric acid
Inositol 1,4,5-trisphosphate
  • 1,4,5-Insp3
  • D-myo-Inositol 1,4,5-trisphosphate
  • D-myo-INOSITOL-1,4,5-triphosphATE
  • Ins(1,4,5)P3
  • InsP3
genes like me logo Genes that share compounds with IPMK: view

Transcripts for IPMK Gene

mRNA/cDNA for IPMK Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IPMK Gene

Inositol polyphosphate multikinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for IPMK

Alternative Splicing Database (ASD) splice patterns (SP) for IPMK Gene

No ASD Table

Relevant External Links for IPMK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IPMK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPMK Gene

mRNA differential expression in normal tissues according to GTEx for IPMK Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for IPMK Gene

This gene is overexpressed in Esophagus (26.8), Fetal testis (15.5), and Fetal heart (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IPMK Gene

Protein tissue co-expression partners for IPMK Gene

NURSA nuclear receptor signaling pathways regulating expression of IPMK Gene:


SOURCE GeneReport for Unigene cluster for IPMK Gene:


mRNA Expression by UniProt/SwissProt for IPMK Gene:

Tissue specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.

Evidence on tissue expression from TISSUES for IPMK Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IPMK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPMK Gene

Orthologs for IPMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPMK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IPMK 34 33
  • 99.6 (n)
(Bos Taurus)
Mammalia IPMK 34 33
  • 92.47 (n)
(Ornithorhynchus anatinus)
Mammalia IPMK 34
  • 84 (a)
(Mus musculus)
Mammalia Ipmk 16 34 33
  • 80.98 (n)
(Rattus norvegicus)
Mammalia Ipmk 33
  • 80.98 (n)
(Monodelphis domestica)
Mammalia IPMK 34
  • 79 (a)
(Gallus gallus)
Aves IPMK 34 33
  • 75.52 (n)
(Anolis carolinensis)
Reptilia IPMK 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ipmk 33
  • 68.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1741 33
(Danio rerio)
Actinopterygii ipmkb 34 33
  • 61.11 (n)
ipmka 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ipk2 34 33
  • 48.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012099 33
  • 44.44 (n)
(Caenorhabditis elegans)
Secernentea CELE_ZK795.1 33
  • 47.5 (n)
ZK795.1 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 34
  • 7 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons IPK2a 33
  • 44.07 (n)
(Oryza sativa)
Liliopsida Os02g0523800 33
  • 38.12 (n)
Species where no ortholog for IPMK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IPMK Gene

Gene Tree for IPMK (if available)
Gene Tree for IPMK (if available)
Evolutionary constrained regions (ECRs) for IPMK: view image

Paralogs for IPMK Gene

Paralogs for IPMK Gene Pseudogenes for IPMK Gene

genes like me logo Genes that share paralogs with IPMK: view

Variants for IPMK Gene

Sequence variations from dbSNP and Humsavar for IPMK Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000000602 -- 58,216,414(-) G/A intron_variant
rs1000025768 -- 58,257,292(-) C/G/T intron_variant
rs1000038188 -- 58,264,639(-) T/A intron_variant
rs1000057446 -- 58,257,529(-) A/C intron_variant
rs1000068568 -- 58,249,337(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IPMK Gene

Variant ID Type Subtype PubMed ID
nsv1113302 CNV deletion 24896259
nsv948026 CNV duplication 23825009
nsv948027 CNV duplication 23825009

Variation tolerance for IPMK Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPMK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPMK Gene

Disorders for IPMK Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPMK Gene - From: Orphanet

Disorder Aliases PubMed IDs
hereditary neuroendocrine tumor of small intestine
  • hereditary neuroendocrine tumor of small bowel
- elite association - COSMIC cancer census association via MalaCards
Search IPMK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IPMK

genes like me logo Genes that share disorders with IPMK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPMK Gene

Publications for IPMK Gene

  1. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. (PMID: 12223481) Chang SC … Majerus PW (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (PMID: 12027805) Nalaskowski MM … Mayr GW (The Biochemical journal 2002) 2 3 4 22 58
  3. Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. (PMID: 17981594) Resnick AC … Saiardi A (Frontiers in bioscience : a journal and virtual library 2008) 3 22 58
  4. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. (PMID: 16293229) Chang SC … Majerus PW (Biochemical and biophysical research communications 2006) 3 22 58
  5. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. (PMID: 16247451) Morgan-Lappe S … Leverson JD (Oncogene 2006) 3 22 58

Products for IPMK Gene

  • Addgene plasmids for IPMK

Sources for IPMK Gene

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