This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same... See more...

Aliases for IP6K3 Gene

Aliases for IP6K3 Gene

  • Inositol Hexakisphosphate Kinase 3 2 3 4 5
  • Inositol Hexaphosphate Kinase 3 2 3 4
  • InsP6 Kinase 3 3 4
  • EC 2.7.4.21 4 54
  • IHPK3 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • INSP6K3 3

External Ids for IP6K3 Gene

Previous HGNC Symbols for IP6K3 Gene

  • IHPK3

Previous GeneCards Identifiers for IP6K3 Gene

  • GC06M033798
  • GC06M033689
  • GC06M033430

Summaries for IP6K3 Gene

Entrez Gene Summary for IP6K3 Gene

  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

GeneCards Summary for IP6K3 Gene

IP6K3 (Inositol Hexakisphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K1.

UniProtKB/Swiss-Prot Summary for IP6K3 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Additional gene information for IP6K3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IP6K3 Gene

Genomics for IP6K3 Gene

GeneHancer (GH) Regulatory Elements for IP6K3 Gene

Promoters and enhancers for IP6K3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033743 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 772.7 +1.2 1186 5.2 CTCF LCORL MYC CC2D1A HLF RAD21 MTA3 TEAD4 RERE GTF2F1 IP6K3 LEMD2 BRD2 DAXX WDR46 VPS52 RXRB RPS18 RPS10 HCG25
GH06J033748 Enhancer 0.5 CraniofacialAtlas dbSUPER 762.6 -1.9 -1939 0.6 ZNF692 USF1 IP6K3 ITPR3 LEMD2
GH06J033710 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.1 +35.6 35588 2 SIN3A ZBTB40 CTCF MLX SMARCE1 RBPJ POLR2A USF2 MIXL1 RUNX1 UQCC2 piR-57135-036 IP6K3 HLA-DQA2 LINC00336 LEMD2 RPL32P1 HLA-DMA RPS18 MIR3934
GH06J033785 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -40.9 -40882 5.2 ZNF785 ZNF24 SP1 ZBTB40 SIX5 LCORL MLX RBPJ SMARCE1 POLR2A LEMD2 LOC105375024 BRD2 DAXX RXRB WDR46 VPS52 RING1 RGL2 RPL35AP4
GH06J033618 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 +124.9 124900 6.5 SMARCE1 POLR2A ZNF362 ELF1 HLF L3MBTL2 ZNF121 ZNF652 NKRF AHR ITPR3 RING1 PHF1 LEMD2 RPL35AP4 HTATSF1P1 MIR219A1 KRT18P9 CYCSP55 LOC102725019
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IP6K3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IP6K3 gene promoter:
  • AP-4
  • AREB6
  • En-1
  • FOXD1
  • HTF
  • Msx-1
  • p53
  • Pax-2
  • Pax-2a
  • Pbx1a

Genomic Locations for IP6K3 Gene

Genomic Locations for IP6K3 Gene
chr6:33,721,637-33,746,985
(GRCh38/hg38)
Size:
25,349 bases
Orientation:
Minus strand
chr6:33,689,443-33,714,762
(GRCh37/hg19)
Size:
25,320 bases
Orientation:
Minus strand

Genomic View for IP6K3 Gene

Genes around IP6K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IP6K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IP6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K3 Gene

Proteins for IP6K3 Gene

  • Protein details for IP6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PC2-IP6K3_HUMAN
    Recommended name:
    Inositol hexakisphosphate kinase 3
    Protein Accession:
    Q96PC2
    Secondary Accessions:
    • Q96MQ9

    Protein attributes for IP6K3 Gene

    Size:
    410 amino acids
    Molecular mass:
    46417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71225.2; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

neXtProt entry for IP6K3 Gene

Selected DME Specific Peptides for IP6K3 Gene

Q96PC2:
  • SYRFYSSS
  • SREQRFYESLP
  • CGMQVYQ
  • LDLKMGTRQ
  • FGLENLI

Post-translational modifications for IP6K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for IP6K3 Gene

Gene Families for IP6K3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IP6K3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IP6K3 Gene

GenScript: Design optimal peptide antigens:
  • Inositol hexaphosphate kinase 3 (IP6K3_HUMAN)
  • Inositol hexaphosphate kinase 3, isoform CRA_a (Q5TAQ4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96PC2

UniProtKB/Swiss-Prot:

IP6K3_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K3: view

Function for IP6K3 Gene

Molecular function for IP6K3 Gene

UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP; Xref=Rhea:RHEA:12793, ChEBI:CHEBI:30616, ChEBI:CHEBI:58130, ChEBI:CHEBI:58628, ChEBI:CHEBI:456216; EC=2.7.4.21;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP; Xref=Rhea:RHEA:37467, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74946, ChEBI:CHEBI:77983, ChEBI:CHEBI:456216; EC=2.7.4.21;.

Enzyme Numbers (IUBMB) for IP6K3 Gene

Phenotypes From GWAS Catalog for IP6K3 Gene

Gene Ontology (GO) - Molecular Function for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000828 inositol hexakisphosphate kinase activity IDA 11502751
GO:0000831 inositol hexakisphosphate 6-kinase activity IDA 11502751
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with IP6K3: view
genes like me logo Genes that share phenotypes with IP6K3: view

Animal Models for IP6K3 Gene

MGI Knock Outs for IP6K3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IP6K3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IP6K3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IP6K3 Gene

Localization for IP6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IP6K3 gene
Compartment Confidence
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 11502751
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IP6K3: view

Pathways & Interactions for IP6K3 Gene

genes like me logo Genes that share pathways with IP6K3: view

Pathways by source for IP6K3 Gene

Gene Ontology (GO) - Biological Process for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11502751
GO:0016310 phosphorylation IEA --
GO:0032958 inositol phosphate biosynthetic process IEA,IDA 11502751
GO:0043647 inositol phosphate metabolic process TAS --
GO:0046488 phosphatidylinositol metabolic process IDA 11502751
genes like me logo Genes that share ontologies with IP6K3: view

No data available for SIGNOR curated interactions for IP6K3 Gene

Drugs & Compounds for IP6K3 Gene

(2) Drugs for IP6K3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fytic acid Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for IP6K3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with IP6K3: view

Transcripts for IP6K3 Gene

mRNA/cDNA for IP6K3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IP6K3

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for IP6K3 Gene

GeneLoc Exon Structure for
IP6K3
ECgene alternative splicing isoforms for
IP6K3

Expression for IP6K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IP6K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IP6K3 Gene

This gene is overexpressed in Muscle - Skeletal (x32.5).

NURSA nuclear receptor signaling pathways regulating expression of IP6K3 Gene:

IP6K3

SOURCE GeneReport for Unigene cluster for IP6K3 Gene:

Hs.17253

mRNA Expression by UniProt/SwissProt for IP6K3 Gene:

Q96PC2-IP6K3_HUMAN
Tissue specificity: Detected in brain.

Evidence on tissue expression from TISSUES for IP6K3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IP6K3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IP6K3 Gene

Orthologs for IP6K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IP6K3 33 32
  • 98.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IP6K3 33 32
  • 85.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UQCC2 32
  • 85.31 (n)
MNF1 33
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ip6k3 17 33 32
  • 82.18 (n)
rat
(Rattus norvegicus)
Mammalia Ip6k3 32
  • 77.87 (n)
oppossum
(Monodelphis domestica)
Mammalia IP6K3 33
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IP6K3 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves IP6K3 33 32
  • 67.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IP6K3 33
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10082 33
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30A10.3 33
  • 33 (a)
ManyToMany
Y22D7AR.6 33
  • 29 (a)
ManyToMany
T20F7.3 33
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 35 33
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 33 (a)
ManyToMany
-- 33
  • 29 (a)
ManyToMany
Species where no ortholog for IP6K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IP6K3 Gene

ENSEMBL:
Gene Tree for IP6K3 (if available)
TreeFam:
Gene Tree for IP6K3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IP6K3: view image

Paralogs for IP6K3 Gene

Paralogs for IP6K3 Gene

(3) SIMAP similar genes for IP6K3 Gene using alignment to 2 proteins:

  • IP6K3_HUMAN
  • Q5TAQ4_HUMAN
genes like me logo Genes that share paralogs with IP6K3: view

Variants for IP6K3 Gene

Sequence variations from dbSNP and Humsavar for IP6K3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000092290 -- 33,727,765(-) T/G intron_variant
rs1000123645 -- 33,733,596(-) A/C intron_variant
rs1000159912 -- 33,745,577(-) G/A intron_variant
rs1000161612 -- 33,744,852(-) C/T intron_variant
rs1000218044 -- 33,736,004(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IP6K3 Gene

Variant ID Type Subtype PubMed ID
dgv85n68 CNV loss 17160897
esv3608630 CNV gain 21293372
nsv509128 CNV insertion 20534489

Variation tolerance for IP6K3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IP6K3 Gene

Human Gene Mutation Database (HGMD)
IP6K3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IP6K3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K3 Gene

Disorders for IP6K3 Gene

Additional Disease Information for IP6K3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IP6K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K3 Gene

Publications for IP6K3 Gene

  1. Identification and characterization of a novel inositol hexakisphosphate kinase. (PMID: 11502751) Saiardi A … Snyder SH (The Journal of biological chemistry 2001) 2 3 4 23 56
  2. Common genetic variants associate with serum phosphorus concentration. (PMID: 20558539) Kestenbaum B … Fox CS (Journal of the American Society of Nephrology : JASN 2010) 3 43 56
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 43 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for IP6K3 Gene

Sources for IP6K3 Gene