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Aliases for IP6K1 Gene

Aliases for IP6K1 Gene

  • Inositol Hexakisphosphate Kinase 1 2 3 3 5
  • Inositol Hexaphosphate Kinase 1 2 3 4
  • InsP6 Kinase 1 3 4
  • IHPK1 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • Pi Uptake Stimulator 3
  • EC 4
  • KIAA0263 4
  • PiUS 3

External Ids for IP6K1 Gene

Previous HGNC Symbols for IP6K1 Gene

  • IHPK1

Previous GeneCards Identifiers for IP6K1 Gene

  • GC03M049737
  • GC03M049761
  • GC03M049739
  • GC03M049743
  • GC03M049747
  • GC03M049752
  • GC03M049759
  • GC03M049775
  • GC03M049782
  • GC03M049793

Summaries for IP6K1 Gene

Entrez Gene Summary for IP6K1 Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

GeneCards Summary for IP6K1 Gene

IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K3.

UniProtKB/Swiss-Prot for IP6K1 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Gene Wiki entry for IP6K1 Gene

Additional gene information for IP6K1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K1 Gene

Genomics for IP6K1 Gene

GeneHancer (GH) Regulatory Elements for IP6K1 Gene

Promoters and enhancers for IP6K1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049784 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 0.0 -18 3.2 HDGF PKNOX1 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 IP6K1 QRICH1 CDHR4 RBM5 USP19 INKA1 CCDC36 ENSG00000225399 AMT ENSG00000235236
GH03J049721 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.8 +62.5 62469 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 GC03M049731 GMPPB PIR59970 PIR51040 GC03P049723 GC03M049732 INKA1 AMT PHF5EP IP6K1
GH03J050234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.8 -458.7 -458714 21.2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 GNAI2 RBM5 RBM6 SEMA3F-AS1 HYAL3 TMEM115 HYAL1 CYB561D2 RHOA-IT1 AMT
GH03J049686 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.1 +98.2 98194 4.2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MST1 PIR39139 RNF123 AMT RBM6 QRICH1 CDHR4 AMIGO3 GMPPB IMPDH2
GH03J049016 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.7 +766.3 766281 6.8 CLOCK ZFP64 FEZF1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZFP41 DALRD3 GC03M049024 MIR191 NDUFAF3 MIR425 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IP6K1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IP6K1 gene promoter:
  • GR
  • GR-alpha
  • AREB6
  • HOXA5
  • AhR
  • NF-1/L
  • NF-1
  • AML1a
  • AP-2alphaA

Genomic Locations for IP6K1 Gene

Genomic Locations for IP6K1 Gene
62,249 bases
Minus strand
62,249 bases
Minus strand

Genomic View for IP6K1 Gene

Genes around IP6K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IP6K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IP6K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K1 Gene

Proteins for IP6K1 Gene

  • Protein details for IP6K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol hexakisphosphate kinase 1
    Protein Accession:
    Secondary Accessions:
    • A8K157
    • A8MUX4
    • Q7L3I7
    • Q96E38

    Protein attributes for IP6K1 Gene

    441 amino acids
    Molecular mass:
    50236 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA13393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IP6K1 Gene


neXtProt entry for IP6K1 Gene

Post-translational modifications for IP6K1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IP6K1 Gene

No data available for DME Specific Peptides for IP6K1 Gene

Domains & Families for IP6K1 Gene

Gene Families for IP6K1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IP6K1 Gene


Suggested Antigen Peptide Sequences for IP6K1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol phosphokinase (IPK) family.
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K1: view

Function for IP6K1 Gene

Molecular function for IP6K1 Gene

UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Enzyme Numbers (IUBMB) for IP6K1 Gene

Phenotypes From GWAS Catalog for IP6K1 Gene

Gene Ontology (GO) - Molecular Function for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity TAS --
GO:0000828 inositol hexakisphosphate kinase activity TAS,IDA --
GO:0000829 inositol heptakisphosphate kinase activity TAS --
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IP6K1: view
genes like me logo Genes that share phenotypes with IP6K1: view

Animal Models for IP6K1 Gene

MGI Knock Outs for IP6K1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IP6K1

miRNA for IP6K1 Gene

miRTarBase miRNAs that target IP6K1

Clone Products

  • Addgene plasmids for IP6K1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IP6K1 Gene

Localization for IP6K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IP6K1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IP6K1: view

Pathways & Interactions for IP6K1 Gene

genes like me logo Genes that share pathways with IP6K1: view

Gene Ontology (GO) - Biological Process for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0032958 inositol phosphate biosynthetic process IEA --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0046854 phosphatidylinositol phosphorylation IDA 10574768
genes like me logo Genes that share ontologies with IP6K1: view

No data available for SIGNOR curated interactions for IP6K1 Gene

Drugs & Compounds for IP6K1 Gene

(1) Drugs for IP6K1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for IP6K1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Myo-inositol hexakisphosphate
  • 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-myo-Inositol hexakisphosphate
  • D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • myo-Inositol 1,2,3,4,5,6-hexakisphosphate
genes like me logo Genes that share compounds with IP6K1: view

Transcripts for IP6K1 Gene

mRNA/cDNA for IP6K1 Gene

Unigene Clusters for IP6K1 Gene

Inositol hexakisphosphate kinase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for IP6K1

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: -

Relevant External Links for IP6K1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IP6K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IP6K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IP6K1 Gene

This gene is overexpressed in Heart (25.0), Testis (10.2), Fetal Brain (8.3), and Fetal testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IP6K1 Gene

Protein tissue co-expression partners for IP6K1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IP6K1 Gene:


SOURCE GeneReport for Unigene cluster for IP6K1 Gene:


Evidence on tissue expression from TISSUES for IP6K1 Gene

  • Nervous system(4.9)
  • Bone marrow(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with IP6K1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IP6K1 Gene

Orthologs for IP6K1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IP6K1 34 33
  • 99.55 (n)
(Canis familiaris)
Mammalia IP6K1 34 33
  • 92.37 (n)
(Bos Taurus)
Mammalia IP6K1 34 33
  • 92.14 (n)
(Mus musculus)
Mammalia Ip6k1 16 34 33
  • 91.61 (n)
(Rattus norvegicus)
Mammalia Ip6k1 33
  • 91.38 (n)
(Ornithorhynchus anatinus)
Mammalia IP6K1 34
  • 85 (a)
(Monodelphis domestica)
Mammalia IP6K1 34
  • 76 (a)
(Gallus gallus)
Aves IP6K1 34 33
  • 78.21 (n)
(Anolis carolinensis)
Reptilia IP6K1 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ip6k1 33
  • 75.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15102 33
(Danio rerio)
Actinopterygii ip6k1 34 33
  • 70.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10082 34
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F30A10.3 34 33
  • 47.35 (n)
Y22D7AR.6 34
  • 30 (a)
T20F7.3 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 34
  • 11 (a)
ARG82 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
-- 34
  • 30 (a)
Species where no ortholog for IP6K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IP6K1 Gene

Gene Tree for IP6K1 (if available)
Gene Tree for IP6K1 (if available)
Evolutionary constrained regions (ECRs) for IP6K1: view image

Paralogs for IP6K1 Gene

Paralogs for IP6K1 Gene

(3) SIMAP similar genes for IP6K1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IP6K1: view

Variants for IP6K1 Gene

Sequence variations from dbSNP and Humsavar for IP6K1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000024504 -- 49,726,919(-) G/A 3_prime_UTR_variant
rs1000074637 -- 49,754,396(-) G/C intron_variant
rs1000078248 -- 49,774,315(-) G/A intron_variant
rs1000237234 -- 49,754,671(-) G/A intron_variant
rs1000264222 -- 49,748,150(-) T/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IP6K1 Gene

Variant ID Type Subtype PubMed ID
dgv116n6 CNV deletion 16902084
esv1442016 CNV insertion 17803354
esv2544793 CNV insertion 19546169
nsv1139114 CNV deletion 24896259
nsv508217 CNV deletion 20534489
nsv834688 CNV loss 17160897
nsv965165 CNV duplication 23825009

Variation tolerance for IP6K1 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IP6K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K1 Gene

Disorders for IP6K1 Gene

Additional Disease Information for IP6K1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IP6K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K1 Gene

Publications for IP6K1 Gene

  1. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan AR … Ferguson LR (Human immunology 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. (PMID: 15221640) Kamimura J … Matsumoto N (Journal of human genetics 2004) 3 22 58
  4. Identification and characterization of a novel inositol hexakisphosphate kinase. (PMID: 11502751) Saiardi A … Snyder SH (The Journal of biological chemistry 2001) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58

Products for IP6K1 Gene

Sources for IP6K1 Gene

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