Aliases for INTS9 Gene
External Ids for INTS9 Gene
Previous GeneCards Identifiers for INTS9 Gene
This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
GeneCards Summary for INTS9 Gene
INTS9 (Integrator Complex Subunit 9) is a Protein Coding gene. Diseases associated with INTS9 include Von Willebrand Disease, Type 3. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression. An important paralog of this gene is CPSF3.
UniProtKB/Swiss-Prot Summary for INTS9 Gene
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).