Aliases for INTS7 Gene
External Ids for INTS7 Gene
Previous HGNC Symbols for INTS7 Gene
Previous GeneCards Identifiers for INTS7 Gene
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for INTS7 Gene
INTS7 (Integrator Complex Subunit 7) is a Protein Coding gene. Diseases associated with INTS7 include Gastric Cancer and Obsessive-Compulsive Personality Disorder. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for INTS7 Gene
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).