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Aliases for INTS6 Gene

Aliases for INTS6 Gene

  • Integrator Complex Subunit 6 2 3 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26 2 3
  • Protein Deleted In Cancer 1 3 4
  • DDX26A 3 4
  • DDX26 3 4
  • DBI-1 3 4
  • DICE1 3 4
  • DEAD Box Protein 3
  • RNA Helicase HDB 3
  • Protein DDX26 4
  • Notchl2 3
  • INT6 3
  • DBI1 4
  • Int6 4
  • HDB 3

External Ids for INTS6 Gene

Previous HGNC Symbols for INTS6 Gene

  • DDX26

Previous GeneCards Identifiers for INTS6 Gene

  • GC13M050833
  • GC13M051928
  • GC13M032724

Summaries for INTS6 Gene

Entrez Gene Summary for INTS6 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

GeneCards Summary for INTS6 Gene

INTS6 (Integrator Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Gene Expression. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is INTS6L.

UniProtKB/Swiss-Prot for INTS6 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144).

Gene Wiki entry for INTS6 Gene

Additional gene information for INTS6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS6 Gene

Genomics for INTS6 Gene

GeneHancer (GH) Regulatory Elements for INTS6 Gene

Promoters and enhancers for INTS6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J051450 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.2 1206 5.6 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 RPS4XP16 INTS6-AS1 INTS6 MRPS31P5 SERPINE3 CCDC70 LINC02333 DHRS12 ENSG00000231856 UTP14C
GH13J052193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 27.1 -740.4 -740396 2.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MRPS31P5 ALG11 RPS4XP16 SUGT1 CKAP2 INTS6 SERPINE3 INTS6-AS1 TPTE2P2 UTP14C
GH13J051801 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -349.2 -349206 4.2 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 ZNF143 DHRS12 ENSG00000231856 HNRNPA1L2 INTS6-AS1 INTS6 ALG11 WDFY2 PIR35271 ENSG00000285444
GH13J052009 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.8 -557.5 -557478 3.8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ATP7B ALG11 NEK3 TPTE2P2 INTS6 FABP5P2
GH13J051315 Enhancer 0.8 Ensembl ENCODE 18.6 +138.6 138558 1.3 USF1 GFI1B ZSCAN4 MAX ZNF662 REST ZNF670 ZIC2 IKZF1 GLIS1 ALG11 INTS6 SERPINE3 UTP14C FAM124A RNASEH2B GC13P051260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INTS6 gene promoter:
  • FAC1
  • Egr-2
  • S8
  • p53
  • NF-1
  • GATA-1
  • CUTL1
  • AML1a
  • FOXO1
  • FOXO1a

Genomic Locations for INTS6 Gene

Genomic Locations for INTS6 Gene
chr13:51,353,862-51,454,264
(GRCh38/hg38)
Size:
100,403 bases
Orientation:
Minus strand
chr13:51,928,213-52,028,400
(GRCh37/hg19)
Size:
100,188 bases
Orientation:
Minus strand

Genomic View for INTS6 Gene

Genes around INTS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS6 Gene

Proteins for INTS6 Gene

  • Protein details for INTS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL03-INT6_HUMAN
    Recommended name:
    Integrator complex subunit 6
    Protein Accession:
    Q9UL03
    Secondary Accessions:
    • Q0P664
    • Q6PJP4
    • Q9UFK0
    • Q9Y5M9

    Protein attributes for INTS6 Gene

    Size:
    887 amino acids
    Molecular mass:
    100390 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
    SequenceCaution:
    • Sequence=AAH13358.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AL833524; Type=Erroneous termination; Positions=796; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=CAB56020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS6 Gene

Post-translational modifications for INTS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS6 Gene

Domains & Families for INTS6 Gene

Gene Families for INTS6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9UL03

UniProtKB/Swiss-Prot:

INT6_HUMAN :
  • Belongs to the Integrator subunit 6 family.
Family:
  • Belongs to the Integrator subunit 6 family.
genes like me logo Genes that share domains with INTS6: view

Function for INTS6 Gene

Molecular function for INTS6 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144).
UniProtKB/Swiss-Prot Induction:
Frequently down-regulated in nonsmall cell lung carcinomas and prostate cancers. Down-regulation in prostate cancer is due to CpG hypermethylation of its promoter. However, some involvement in cancer is unclear.

Phenotypes From GWAS Catalog for INTS6 Gene

Gene Ontology (GO) - Molecular Function for INTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10467397
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS6: view
genes like me logo Genes that share phenotypes with INTS6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS6 Gene

Localization for INTS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Actin filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 23904267
GO:0005654 nucleoplasm TAS --
GO:0015629 actin cytoskeleton IDA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS6: view

Pathways & Interactions for INTS6 Gene

genes like me logo Genes that share pathways with INTS6: view

Pathways by source for INTS6 Gene

2 Reactome pathways for INTS6 Gene

Gene Ontology (GO) - Biological Process for INTS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0016180 snRNA processing IDA 16239144
GO:0034472 snRNA 3-end processing IBA --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS6: view

No data available for SIGNOR curated interactions for INTS6 Gene

Drugs & Compounds for INTS6 Gene

(7) Drugs for INTS6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for INTS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS6: view

Transcripts for INTS6 Gene

Unigene Clusters for INTS6 Gene

Integrator complex subunit 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - - -
SP13:
SP14:
SP15:
SP16:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for INTS6 Gene

GeneLoc Exon Structure for
INTS6
ECgene alternative splicing isoforms for
INTS6

Expression for INTS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INTS6 Gene

Protein differential expression in normal tissues from HIPED for INTS6 Gene

This gene is overexpressed in Testis (10.6), Placenta (10.6), Peripheral blood mononuclear cells (10.3), Pancreas (9.4), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INTS6 Gene



Protein tissue co-expression partners for INTS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INTS6 Gene:

INTS6

SOURCE GeneReport for Unigene cluster for INTS6 Gene:

Hs.439440

mRNA Expression by UniProt/SwissProt for INTS6 Gene:

Q9UL03-INT6_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for INTS6 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with INTS6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS6 Gene

Orthologs for INTS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS6 34 33
  • 98.65 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS6 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS6 34 33
  • 95.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia INTS6 34 33
  • 93.94 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ints6 16 34 33
  • 92.68 (n)
rat
(Rattus norvegicus)
Mammalia Ints6 33
  • 92.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INTS6 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS6 34 33
  • 82.39 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10794 33
zebrafish
(Danio rerio)
Actinopterygii ints6 34 33
  • 67.31 (n)
OneToOne
Dr.11487 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000631 33
  • 48.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta IntS6 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dic-1 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
Species where no ortholog for INTS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS6 Gene

ENSEMBL:
Gene Tree for INTS6 (if available)
TreeFam:
Gene Tree for INTS6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS6: view image

Paralogs for INTS6 Gene

(1) SIMAP similar genes for INTS6 Gene using alignment to 13 proteins:

  • INT6_HUMAN
  • B3KQH5_HUMAN
  • B4DL13_HUMAN
  • B4E1J5_HUMAN
  • C9J0C6_HUMAN
  • C9J885_HUMAN
  • C9JAV7_HUMAN
  • C9JVX2_HUMAN
  • C9JXP6_HUMAN
  • C9K0V7_HUMAN
  • F8WAV7_HUMAN
  • F8WBG1_HUMAN
  • G5E9X1_HUMAN

Pseudogenes.org Pseudogenes for INTS6 Gene

genes like me logo Genes that share paralogs with INTS6: view

Variants for INTS6 Gene

Sequence variations from dbSNP and Humsavar for INTS6 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000015856 -- 51,438,576(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000079703 -- 51,394,911(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000094974 -- 51,406,868(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000183831 -- 51,449,744(-) T/C 3_prime_UTR_variant, intron_variant
rs1000266185 -- 51,420,975(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INTS6 Gene

Variant ID Type Subtype PubMed ID
esv3892343 CNV gain 25118596
nsv561618 CNV loss 21841781
nsv832611 CNV loss 17160897

Variation tolerance for INTS6 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS6 Gene

Human Gene Mutation Database (HGMD)
INTS6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS6 Gene

Disorders for INTS6 Gene

Additional Disease Information for INTS6

No disorders were found for INTS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS6 Gene

Publications for INTS6 Gene

  1. Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. (PMID: 10467397) Wieland I … Weidle UH (Oncogene 1999) 2 3 4 22 58
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 58
  3. Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. (PMID: 16007164) Röpke A … Wieacker PF (Oncogene 2005) 3 4 22 58
  4. Ectopic expression of DICE1 suppresses tumor cell growth. (PMID: 15254679) Wieland I … Wieacker P (Oncology reports 2004) 3 4 22 58
  5. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 58

Products for INTS6 Gene

Sources for INTS6 Gene

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