The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016] See more...

Aliases for INTS5 Gene

Aliases for INTS5 Gene

  • Integrator Complex Subunit 5 2 3 4 5
  • KIAA1698 2 3 4
  • INT5 3
  • Int5 4

External Ids for INTS5 Gene

Previous HGNC Symbols for INTS5 Gene

  • KIAA1698

Previous GeneCards Identifiers for INTS5 Gene

  • GC11M062172
  • GC11M062431
  • GC11M058743
  • GC11M062484
  • GC11M062678
  • GC11M062700
  • GC11M062938
  • GC11M062976
  • GC11M062722
  • GC11M062734
  • GC11M062746
  • GC11M062765
  • GC11M062776
  • GC11M062799
  • GC11M062819
  • GC11M062837

Summaries for INTS5 Gene

Entrez Gene Summary for INTS5 Gene

  • The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]

GeneCards Summary for INTS5 Gene

INTS5 (Integrator Complex Subunit 5) is a Protein Coding gene. Diseases associated with INTS5 include Tay-Sachs Disease and Polycystic Liver Disease. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression.

UniProtKB/Swiss-Prot Summary for INTS5 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Additional gene information for INTS5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS5 Gene

Genomics for INTS5 Gene

GeneHancer (GH) Regulatory Elements for INTS5 Gene

Promoters and enhancers for INTS5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INTS5 gene promoter:
  • AP-4
  • C/EBPalpha
  • LUN-1
  • Max1
  • NF-1
  • POU6F1 (c2)
  • PPAR-alpha
  • RORalpha1
  • Sp1
  • TBP

Genomic Locations for INTS5 Gene

Genomic Locations for INTS5 Gene
chr11:62,646,848-62,653,302
(GRCh38/hg38)
Size:
6,455 bases
Orientation:
Minus strand
chr11:62,414,320-62,420,774
(GRCh37/hg19)
Size:
6,455 bases
Orientation:
Minus strand

Genomic View for INTS5 Gene

Genes around INTS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS5 Gene

Proteins for INTS5 Gene

  • Protein details for INTS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B9-INT5_HUMAN
    Recommended name:
    Integrator complex subunit 5
    Protein Accession:
    Q6P9B9
    Secondary Accessions:
    • Q8N6W5
    • Q9C0G5

    Protein attributes for INTS5 Gene

    Size:
    1019 amino acids
    Molecular mass:
    107995 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
    SequenceCaution:
    • Sequence=AAH28025.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for INTS5 Gene

Post-translational modifications for INTS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INTS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INTS5 Gene

Domains & Families for INTS5 Gene

Gene Families for INTS5 Gene

Protein Domains for INTS5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS5 Gene

GenScript: Design optimal peptide antigens:
  • Integrator complex subunit 5 (INT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P9B9

UniProtKB/Swiss-Prot:

INT5_HUMAN :
  • Belongs to the Integrator subunit 5 family.
Family:
  • Belongs to the Integrator subunit 5 family.
genes like me logo Genes that share domains with INTS5: view

Function for INTS5 Gene

Molecular function for INTS5 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS5 Gene

Gene Ontology (GO) - Molecular Function for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS5: view
genes like me logo Genes that share phenotypes with INTS5: view

Animal Model Products

CRISPR Products

miRNA for INTS5 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS5 Gene

Localization for INTS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS5 Gene

Nucleus membrane; Multi-pass membrane protein. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS5 gene
Compartment Confidence
nucleus 5
plasma membrane 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23904267
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 23904267
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with INTS5: view

Pathways & Interactions for INTS5 Gene

genes like me logo Genes that share pathways with INTS5: view

Pathways by source for INTS5 Gene

2 Reactome pathways for INTS5 Gene

Gene Ontology (GO) - Biological Process for INTS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0034472 snRNA 3'-end processing IBA 21873635
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS5: view

No data available for SIGNOR curated interactions for INTS5 Gene

Drugs & Compounds for INTS5 Gene

(8) Drugs for INTS5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for INTS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS5: view

Transcripts for INTS5 Gene

mRNA/cDNA for INTS5 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS5 Gene

No ASD Table

Relevant External Links for INTS5 Gene

GeneLoc Exon Structure for
INTS5
ECgene alternative splicing isoforms for
INTS5

Expression for INTS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INTS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS5 Gene

This gene is overexpressed in CD8 Tcells (13.0), Fetal gut (11.5), Placenta (10.9), and Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INTS5 Gene



Protein tissue co-expression partners for INTS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INTS5 Gene:

INTS5

SOURCE GeneReport for Unigene cluster for INTS5 Gene:

Hs.458390

Evidence on tissue expression from TISSUES for INTS5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INTS5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS5 Gene

Orthologs for INTS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS5 33 32
  • 99.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1698 33
  • 97 (a)
OneToOne
INTS5 32
  • 90.01 (n)
dog
(Canis familiaris)
Mammalia INTS5 33 32
  • 91.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints5 32
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Ints5 17 33 32
  • 88.47 (n)
oppossum
(Monodelphis domestica)
Mammalia INTS5 33
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750875 32
  • 64.33 (n)
lizard
(Anolis carolinensis)
Reptilia INTS5 33
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints5 32
  • 59.04 (n)
Str.9132 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.1656 32
zebrafish
(Danio rerio)
Actinopterygii LOC564642 32
  • 57.35 (n)
INTS5 (2 of 2) 33
  • 54 (a)
OneToMany
INTS5 (1 of 2) 33
  • 53 (a)
OneToMany
Dr.17427 32
fruit fly
(Drosophila melanogaster)
Insecta omd 33
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 26 (a)
OneToOne
Species where no ortholog for INTS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS5 Gene

ENSEMBL:
Gene Tree for INTS5 (if available)
TreeFam:
Gene Tree for INTS5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS5: view image

Paralogs for INTS5 Gene

No data available for Paralogs for INTS5 Gene

Variants for INTS5 Gene

Sequence variations from dbSNP and Humsavar for INTS5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1565116806 likely-pathogenic, Polycystic liver disease 62,646,562(-) C/T downstream_transcript_variant
rs750723025 pathogenic, Polycystic kidney disease, autosomal dominant 62,646,584(-) CCGCTACCGC/CCGC downstream_transcript_variant
rs1000024694 -- 62,653,844(-) G/A/C upstream_transcript_variant
rs1000067995 -- 62,651,446(-) T/TT intron_variant
rs1000121409 -- 62,651,128(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INTS5 Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for INTS5 Gene

Residual Variation Intolerance Score: 2.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS5 Gene

Human Gene Mutation Database (HGMD)
INTS5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS5 Gene

Disorders for INTS5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for INTS5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tay-sachs disease
  • tsd
polycystic liver disease
  • congenital cystic liver disease
- elite association - COSMIC cancer census association via MalaCards
Search INTS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INTS5

genes like me logo Genes that share disorders with INTS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS5 Gene

Publications for INTS5 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 56
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for INTS5 Gene

Sources for INTS5 Gene