External Ids for INTS5 Gene
Previous HGNC Symbols for INTS5 Gene
Previous GeneCards Identifiers for INTS5 Gene
The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
GeneCards Summary for INTS5 Gene
INTS5 (Integrator Complex Subunit 5) is a Protein Coding gene. Diseases associated with INTS5 include Tay-Sachs Disease and Polycystic Liver Disease. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression.
UniProtKB/Swiss-Prot Summary for INTS5 Gene
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).