INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] See more...

Aliases for INTS4 Gene

Aliases for INTS4 Gene

  • Integrator Complex Subunit 4 2 3 4 5
  • MSTP093 3
  • MST093 3
  • INT4 3
  • Int4 4

External Ids for INTS4 Gene

Previous GeneCards Identifiers for INTS4 Gene

  • GC11M077269
  • GC11M077589
  • GC07P064459

Summaries for INTS4 Gene

Entrez Gene Summary for INTS4 Gene

  • INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS4 Gene

INTS4 (Integrator Complex Subunit 4) is a Protein Coding gene. Diseases associated with INTS4 include Leigh Syndrome. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for INTS4 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Additional gene information for INTS4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS4 Gene

Genomics for INTS4 Gene

GeneHancer (GH) Regulatory Elements for INTS4 Gene

Promoters and enhancers for INTS4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INTS4

Top Transcription factor binding sites by QIAGEN in the INTS4 gene promoter:
  • aMEF-2
  • AREB6
  • E4BP4
  • ITF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • RORalpha2
  • STAT5A
  • Tal-1beta

Genomic Locations for INTS4 Gene

Genomic Locations for INTS4 Gene
chr11:77,878,720-77,994,842
(GRCh38/hg38)
Size:
116,123 bases
Orientation:
Minus strand
chr11:77,589,766-77,705,724
(GRCh37/hg19)
Size:
115,959 bases
Orientation:
Minus strand

Genomic View for INTS4 Gene

Genes around INTS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS4 Gene

Proteins for INTS4 Gene

  • Protein details for INTS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HW7-INT4_HUMAN
    Recommended name:
    Integrator complex subunit 4
    Protein Accession:
    Q96HW7
    Secondary Accessions:
    • Q2YD62
    • Q6PJG4
    • Q7Z4E7
    • Q96G32
    • Q96GA1
    • Q9BRC0

    Protein attributes for INTS4 Gene

    Size:
    963 amino acids
    Molecular mass:
    108171 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

    Alternative splice isoforms for INTS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS4 Gene

Post-translational modifications for INTS4 Gene

  • Ubiquitination at Lys593
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INTS4 Gene

Domains & Families for INTS4 Gene

Gene Families for INTS4 Gene

Protein Domains for INTS4 Gene

Blocks:
  • HEAT repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS4 Gene

GenScript: Design optimal peptide antigens:
  • Integrator complex subunit 4 (INT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HW7

UniProtKB/Swiss-Prot:

INT4_HUMAN :
  • Belongs to the Integrator subunit 4 family.
Family:
  • Belongs to the Integrator subunit 4 family.
genes like me logo Genes that share domains with INTS4: view

Function for INTS4 Gene

Molecular function for INTS4 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS4 Gene

Gene Ontology (GO) - Molecular Function for INTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS4: view
genes like me logo Genes that share phenotypes with INTS4: view

Animal Model Products

CRISPR Products

miRNA for INTS4 Gene

miRTarBase miRNAs that target INTS4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS4 Gene

Localization for INTS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS4 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23904267
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS4: view

Pathways & Interactions for INTS4 Gene

genes like me logo Genes that share pathways with INTS4: view

Pathways by source for INTS4 Gene

2 Reactome pathways for INTS4 Gene

Gene Ontology (GO) - Biological Process for INTS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS4: view

No data available for SIGNOR curated interactions for INTS4 Gene

Drugs & Compounds for INTS4 Gene

(19) Drugs for INTS4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(26) Additional Compounds for INTS4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS4: view

Transcripts for INTS4 Gene

mRNA/cDNA for INTS4 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS4 Gene

No ASD Table

Relevant External Links for INTS4 Gene

GeneLoc Exon Structure for
INTS4

Expression for INTS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INTS4 Gene

Protein differential expression in normal tissues from HIPED for INTS4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Lymph node (9.8), and CD8 Tcells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INTS4 Gene



Protein tissue co-expression partners for INTS4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INTS4

SOURCE GeneReport for Unigene cluster for INTS4 Gene:

Hs.533723

Evidence on tissue expression from TISSUES for INTS4 Gene

  • Nervous system(4.4)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with INTS4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS4 Gene

Orthologs for INTS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS4 31 30
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 98 (a)
OneToMany
INTS4 30
  • 92.42 (n)
-- 31
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia INTS4 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS4 31 30
  • 92.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ints4 17 31 30
  • 90.27 (n)
rat
(Rattus norvegicus)
Mammalia Ints4 30
  • 89.93 (n)
chicken
(Gallus gallus)
Aves INTS4 31 30
  • 79.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS4 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints4 30
  • 75.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29729 30
zebrafish
(Danio rerio)
Actinopterygii INTS4 31
  • 78 (a)
OneToOne
si:ch73-39g20.4 30
  • 70.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta IntS4 31 30
  • 48.08 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001286 30
  • 47.79 (n)
worm
(Caenorhabditis elegans)
Secernentea W04A4.5 31
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
OneToOne
Species where no ortholog for INTS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS4 Gene

ENSEMBL:
Gene Tree for INTS4 (if available)
TreeFam:
Gene Tree for INTS4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS4: view image

Paralogs for INTS4 Gene

(2) SIMAP similar genes for INTS4 Gene using alignment to 3 proteins:

  • INT4_HUMAN
  • E9PIM3_HUMAN
  • F8WAA7_HUMAN
genes like me logo Genes that share paralogs with INTS4: view

No data available for Paralogs for INTS4 Gene

Variants for INTS4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INTS4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
768468 Likely Benign: not provided 77,924,836(-) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for INTS4 Gene

Structural Variations from Database of Genomic Variants (DGV) for INTS4 Gene

Variant ID Type Subtype PubMed ID
esv3626890 CNV loss 21293372
nsv1050891 CNV gain 25217958
nsv1122646 CNV deletion 24896259
nsv400 CNV insertion 18451855
nsv507601 OTHER sequence alteration 20534489
nsv520740 CNV gain 19592680
nsv524537 CNV loss 19592680
nsv526268 CNV gain 19592680
nsv555453 CNV loss 21841781
nsv8841 CNV loss 18304495
nsv975205 CNV duplication 23825009
nsv975954 CNV duplication 23825009

Variation tolerance for INTS4 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS4 Gene

Disorders for INTS4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INTS4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leigh syndrome
  • ls
- elite association - COSMIC cancer census association via MalaCards
Search INTS4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INTS4

genes like me logo Genes that share disorders with INTS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS4 Gene

Publications for INTS4 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 54
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  5. Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma. (PMID: 29331416) Zhu R … Liu Z (Cancer letters 2018) 3 54

Products for INTS4 Gene

Sources for INTS4 Gene