The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 smal... See more...

Aliases for INTS3 Gene

Aliases for INTS3 Gene

  • Integrator Complex Subunit 3 2 3 4 5
  • Sensor Of Single-Strand DNA Complex Subunit A 2 3 4
  • Sensor Of SsDNA Subunit A 3 4
  • SOSS Complex Subunit A 3 4
  • C1orf193 3 4
  • C1orf60 3 4
  • SOSS-A 3 4
  • Chromosome 1 Open Reading Frame 60 2
  • SOSSA 3
  • INT3 3
  • Int3 4

External Ids for INTS3 Gene

Previous HGNC Symbols for INTS3 Gene

  • C1orf60

Previous GeneCards Identifiers for INTS3 Gene

  • GC01P151967
  • GC01P153700
  • GC01P125063

Summaries for INTS3 Gene

Entrez Gene Summary for INTS3 Gene

  • The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]

GeneCards Summary for INTS3 Gene

INTS3 (Integrator Complex Subunit 3) is a Protein Coding gene. Diseases associated with INTS3 include Mental Retardation, Autosomal Dominant 18 and Retinitis Pigmentosa 70. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat.

UniProtKB/Swiss-Prot Summary for INTS3 Gene

  • Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Gene Wiki entry for INTS3 Gene

Additional gene information for INTS3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS3 Gene

Genomics for INTS3 Gene

GeneHancer (GH) Regulatory Elements for INTS3 Gene

Promoters and enhancers for INTS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INTS3

Top Transcription factor binding sites by QIAGEN in the INTS3 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for INTS3 Gene

Genomic Locations for INTS3 Gene
chr1:153,728,050-153,774,808
(GRCh38/hg38)
Size:
46,759 bases
Orientation:
Plus strand
chr1:153,700,543-153,746,555
(GRCh37/hg19)
Size:
46,013 bases
Orientation:
Plus strand

Genomic View for INTS3 Gene

Genes around INTS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS3 Gene

Proteins for INTS3 Gene

  • Protein details for INTS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68E01-INT3_HUMAN
    Recommended name:
    Integrator complex subunit 3
    Protein Accession:
    Q68E01
    Secondary Accessions:
    • A8K1W0
    • B4DQC8
    • B4E3U9
    • D3DV57
    • Q4G0E5
    • Q5VUQ5
    • Q5VUQ6
    • Q5VUR0
    • Q5VUR1
    • Q68DJ1
    • Q69YR5
    • Q6AI57
    • Q6DKG7
    • Q6MZQ4
    • Q6MZZ9
    • Q8NC46
    • Q8TB23
    • Q9H6S9

    Protein attributes for INTS3 Gene

    Size:
    1043 amino acids
    Molecular mass:
    118070 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with SOSS-B1/NABP2, SOSS-B2/NABP1 and SOSS-C/INIP; the interaction is direct. Interacts with NBN/NBS1.
    SequenceCaution:
    • Sequence=AAH25254.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH54513.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15174.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11329.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18229.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INTS3 Gene

    Alternative splice isoforms for INTS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS3 Gene

Post-translational modifications for INTS3 Gene

  • Ubiquitination at Lys859, Lys898, and Lys915
  • Modification sites at PhosphoSitePlus

Other Protein References for INTS3 Gene

No data available for DME Specific Peptides for INTS3 Gene

Domains & Families for INTS3 Gene

Gene Families for INTS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INTS3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS3 Gene

GenScript: Design optimal peptide antigens:
  • Sensor of single-strand DNA complex subunit A (INT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q68E01

UniProtKB/Swiss-Prot:

INT3_HUMAN :
  • Belongs to the Integrator subunit 3 family.
Family:
  • Belongs to the Integrator subunit 3 family.
genes like me logo Genes that share domains with INTS3: view

Function for INTS3 Gene

Molecular function for INTS3 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Phenotypes From GWAS Catalog for INTS3 Gene

Gene Ontology (GO) - Molecular Function for INTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS3: view
genes like me logo Genes that share phenotypes with INTS3: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for INTS3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS3 Gene

Localization for INTS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS3 Gene

Nucleus. Cytoplasm. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19683501
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 23904267
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS3: view

Pathways & Interactions for INTS3 Gene

genes like me logo Genes that share pathways with INTS3: view

Pathways by source for INTS3 Gene

2 Reactome pathways for INTS3 Gene

Gene Ontology (GO) - Biological Process for INTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 19605351
GO:0006974 cellular response to DNA damage stimulus IMP 19683501
GO:0007093 mitotic cell cycle checkpoint IMP 19683501
GO:0010212 response to ionizing radiation IMP 19605351
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS3: view

No data available for SIGNOR curated interactions for INTS3 Gene

Drugs & Compounds for INTS3 Gene

(27) Drugs for INTS3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miriplatin hydrate Pharma Used in lipiodolization for hepatocellular carcinoma treatment 0

(41) Additional Compounds for INTS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for INTS3 Gene

Compound Action Cas Number
Miriplatin hydrate Used in lipiodolization for hepatocellular carcinoma treatment 250159-48-9
genes like me logo Genes that share compounds with INTS3: view

Drug Products

Transcripts for INTS3 Gene

mRNA/cDNA for INTS3 Gene

2 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for INTS3

Alternative Splicing Database (ASD) splice patterns (SP) for INTS3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
SP1: - - - - - - - - -
SP2:
SP3:
SP4: - - - -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13: -
SP14:
SP15:
SP16:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for INTS3 Gene

GeneLoc Exon Structure for
INTS3

Expression for INTS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INTS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS3 Gene

This gene is overexpressed in Pancreas (10.6) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INTS3 Gene



Protein tissue co-expression partners for INTS3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INTS3

SOURCE GeneReport for Unigene cluster for INTS3 Gene:

Hs.516522

Evidence on tissue expression from TISSUES for INTS3 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Lung(4.3)
  • Skin(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with INTS3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS3 Gene

Orthologs for INTS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INTS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS3 31 30
  • 99.84 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS3 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS3 31 30
  • 92.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ints3 30
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Ints3 17 31 30
  • 91.57 (n)
dog
(Canis familiaris)
Mammalia INTS3 31 30
  • 88.77 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS3 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS3 31 30
  • 81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS3 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11354 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15160 30
zebrafish
(Danio rerio)
Actinopterygii ints3 31 30
  • 76.09 (n)
OneToOne
Dr.15113 30
African malaria mosquito
(Anopheles gambiae)
Insecta INT3_ANOGA 30
  • 53.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta IntS3 31 30
  • 50.94 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y92H12A.4 30
  • 39.89 (n)
Y92H12A.3 31
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2739 30
  • 48.11 (n)
rice
(Oryza sativa)
Liliopsida Os11g0171400 30
  • 51.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToOne
Species where no ortholog for INTS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS3 Gene

ENSEMBL:
Gene Tree for INTS3 (if available)
TreeFam:
Gene Tree for INTS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS3: view image

Paralogs for INTS3 Gene

No data available for Paralogs for INTS3 Gene

Variants for INTS3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INTS3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs193920901 Uncertain Significance: Malignant tumor of prostate 153,763,296(+) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for INTS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for INTS3 Gene

Variant ID Type Subtype PubMed ID
dgv582n54 CNV gain 21841781
nsv1002328 CNV gain 25217958
nsv1110880 OTHER inversion 24896259
nsv1119724 CNV deletion 24896259
nsv464028 CNV gain 19166990
nsv547941 CNV loss 21841781

Variation tolerance for INTS3 Gene

Residual Variation Intolerance Score: 1.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS3 Gene

Disorders for INTS3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for INTS3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search INTS3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INTS3

genes like me logo Genes that share disorders with INTS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS3 Gene

Publications for INTS3 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 54
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 54
  3. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y … Wang W (The Journal of biological chemistry 2009) 3 4 54
  4. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J … Chen J (Molecular cell 2009) 3 4 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54

Products for INTS3 Gene

  • Signalway ELISA kits for INTS3
  • Signalway Proteins for INTS3

Sources for INTS3 Gene