External Ids for INTS2 Gene
Previous HGNC Symbols for INTS2 Gene
Previous GeneCards Identifiers for INTS2 Gene
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
GeneCards Summary for INTS2 Gene
INTS2 (Integrator Complex Subunit 2) is a Protein Coding gene. Diseases associated with INTS2 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 4. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression.
UniProtKB/Swiss-Prot Summary for INTS2 Gene
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).