INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] See more...

Aliases for INTS2 Gene

Aliases for INTS2 Gene

  • Integrator Complex Subunit 2 2 3 4 5
  • KIAA1287 2 3 4
  • INT2 3
  • Int2 4

External Ids for INTS2 Gene

Previous HGNC Symbols for INTS2 Gene

  • KIAA1287

Previous GeneCards Identifiers for INTS2 Gene

  • GC17M057298
  • GC17M059942
  • GC17M055308

Summaries for INTS2 Gene

Entrez Gene Summary for INTS2 Gene

  • INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS2 Gene

INTS2 (Integrator Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat.

UniProtKB/Swiss-Prot Summary for INTS2 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Additional gene information for INTS2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS2 Gene

Genomics for INTS2 Gene

GeneHancer (GH) Regulatory Elements for INTS2 Gene

Promoters and enhancers for INTS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INTS2

Top Transcription factor binding sites by QIAGEN in the INTS2 gene promoter:
  • C/EBPbeta
  • E47
  • Hand1
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT4

Genomic Locations for INTS2 Gene

Genomic Locations for INTS2 Gene
chr17:61,865,367-61,928,030
(GRCh38/hg38)
Size:
62,664 bases
Orientation:
Minus strand
chr17:59,942,728-60,005,377
(GRCh37/hg19)
Size:
62,650 bases
Orientation:
Minus strand

Genomic View for INTS2 Gene

Genes around INTS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS2 Gene

Proteins for INTS2 Gene

  • Protein details for INTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0H0-INT2_HUMAN
    Recommended name:
    Integrator complex subunit 2
    Protein Accession:
    Q9H0H0
    Secondary Accessions:
    • Q9ULD3

    Protein attributes for INTS2 Gene

    Size:
    1204 amino acids
    Molecular mass:
    134323 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

neXtProt entry for INTS2 Gene

Post-translational modifications for INTS2 Gene

  • Ubiquitination at Lys108, Lys255, Lys263, and Lys1156
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for INTS2
  • Santa Cruz Biotechnology (SCBT) Antibodies for INTS2

No data available for DME Specific Peptides for INTS2 Gene

Domains & Families for INTS2 Gene

Gene Families for INTS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for INTS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS2 Gene

GenScript: Design optimal peptide antigens:
  • Integrator complex subunit 2 (INT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0H0

UniProtKB/Swiss-Prot:

INT2_HUMAN :
  • Belongs to the Integrator subunit 2 family.
Family:
  • Belongs to the Integrator subunit 2 family.
genes like me logo Genes that share domains with INTS2: view

Function for INTS2 Gene

Molecular function for INTS2 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS2 Gene

Gene Ontology (GO) - Molecular Function for INTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS2: view
genes like me logo Genes that share phenotypes with INTS2: view

Animal Models for INTS2 Gene

MGI Knock Outs for INTS2:
  • Ints2 Ints2<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for INTS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INTS2 Gene

Localization for INTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS2 Gene

Nucleus membrane; Single-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
extracellular 0
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for INTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA,IEA 23904267
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 23904267
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with INTS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INTS2 Gene

Pathways & Interactions for INTS2 Gene

genes like me logo Genes that share pathways with INTS2: view

Pathways by source for INTS2 Gene

2 Reactome pathways for INTS2 Gene

Gene Ontology (GO) - Biological Process for INTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0034472 snRNA 3'-end processing IBA 21873635
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS2: view

No data available for SIGNOR curated interactions for INTS2 Gene

Drugs & Compounds for INTS2 Gene

(29) Drugs for INTS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(53) Additional Compounds for INTS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS2: view

Transcripts for INTS2 Gene

mRNA/cDNA for INTS2 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for INTS2 Gene

GeneLoc Exon Structure for
INTS2

Expression for INTS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INTS2 Gene

Protein differential expression in normal tissues from HIPED for INTS2 Gene

This gene is overexpressed in Placenta (13.5), Blymphocyte (9.6), Peripheral blood mononuclear cells (7.6), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INTS2 Gene



Protein tissue co-expression partners for INTS2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INTS2

SOURCE GeneReport for Unigene cluster for INTS2 Gene:

Hs.279646

Evidence on tissue expression from TISSUES for INTS2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INTS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS2 Gene

Orthologs for INTS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS2 31 30
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia INTS2 31 30
  • 94.38 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS2 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS2 31 30
  • 93.19 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS2 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints2 17 31 30
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Ints2 30
  • 88.5 (n)
chicken
(Gallus gallus)
Aves INTS2 31 30
  • 79.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS2 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ints2 30
  • 75.13 (n)
zebrafish
(Danio rerio)
Actinopterygii ints2 31 30
  • 69.53 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003033 30
  • 51.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta IntS2 31 30
  • 49.27 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZC376.6 31
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Species where no ortholog for INTS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS2 Gene

ENSEMBL:
Gene Tree for INTS2 (if available)
TreeFam:
Gene Tree for INTS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS2: view image

Paralogs for INTS2 Gene

No data available for Paralogs for INTS2 Gene

Variants for INTS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INTS2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
726342 Benign: not provided 61,874,956(-) T/A MISSENSE_VARIANT
rs606072 - p.Asn768His

Additional dbSNP identifiers (rs#s) for INTS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for INTS2 Gene

Variant ID Type Subtype PubMed ID
esv2673812 CNV deletion 23128226
esv3305655 CNV mobile element insertion 20981092
esv3389338 CNV insertion 20981092
esv3640956 CNV gain 21293372
esv3640957 CNV gain 21293372
nsv478183 CNV novel sequence insertion 20440878

Variation tolerance for INTS2 Gene

Residual Variation Intolerance Score: 6.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS2 Gene

Disorders for INTS2 Gene

Additional Disease Information for INTS2

No disorders were found for INTS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS2 Gene

Publications for INTS2 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 54
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 54
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 54
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54

Products for INTS2 Gene

Sources for INTS2 Gene