Aliases for INTS14 Gene

Aliases for INTS14 Gene

  • Integrator Complex Subunit 14 2 3 4 5
  • Von Willebrand Factor A Domain-Containing Protein 9 3 4
  • Von Willebrand Factor A Domain Containing 9 2 3
  • C15orf44 3 4
  • VWA9 3 4
  • Chromosome 15 Open Reading Frame 44 2
  • UPF0464 Protein C15orf44 3

External Ids for INTS14 Gene

Previous HGNC Symbols for INTS14 Gene

  • C15orf44
  • VWA9

Summaries for INTS14 Gene

GeneCards Summary for INTS14 Gene

INTS14 (Integrator Complex Subunit 14) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat.

UniProtKB/Swiss-Prot Summary for INTS14 Gene

  • Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

Additional gene information for INTS14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS14 Gene

Genomics for INTS14 Gene

GeneHancer (GH) Regulatory Elements for INTS14 Gene

Promoters and enhancers for INTS14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INTS14

Genomic Locations for INTS14 Gene

Genomic Locations for INTS14 Gene
32,537 bases
Minus strand
32,537 bases
Minus strand

Genomic View for INTS14 Gene

Genes around INTS14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS14 Gene

Proteins for INTS14 Gene

  • Protein details for INTS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrator complex subunit 14
    Protein Accession:
    Secondary Accessions:
    • B4DDI6
    • B4DVD5
    • Q49AH8
    • Q96HX5
    • Q9H0S5

    Protein attributes for INTS14 Gene

    518 amino acids
    Molecular mass:
    57471 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for INTS14 Gene


neXtProt entry for INTS14 Gene

Post-translational modifications for INTS14 Gene

  • Ubiquitination at Lys195, Lys418, and Lys442
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INTS14 Gene

Domains & Families for INTS14 Gene

Gene Families for INTS14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for INTS14 Gene

  • Von Willebrand factor type A domain signature

Suggested Antigen Peptide Sequences for INTS14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50701 (B4DVD5_HUMAN)
  • cDNA FLJ50705 (B4DVT3_HUMAN)
  • UPF0464 protein C15orf44 (CO044_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the INTS14 family.
  • Belongs to the INTS14 family.
genes like me logo Genes that share domains with INTS14: view

Function for INTS14 Gene

Molecular function for INTS14 Gene

UniProtKB/Swiss-Prot Function:
Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

Phenotypes From GWAS Catalog for INTS14 Gene

genes like me logo Genes that share phenotypes with INTS14: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS14 Gene

Localization for INTS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS14 gene
Compartment Confidence
nucleus 5
plasma membrane 2
mitochondrion 2
cytosol 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032039 integrator complex IBA 21873635
genes like me logo Genes that share ontologies with INTS14: view

Pathways & Interactions for INTS14 Gene

genes like me logo Genes that share pathways with INTS14: view

Pathways by source for INTS14 Gene

2 Reactome pathways for INTS14 Gene

Gene Ontology (GO) - Biological Process for INTS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034472 snRNA 3'-end processing IBA 21873635
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS14: view

No data available for SIGNOR curated interactions for INTS14 Gene

Drugs & Compounds for INTS14 Gene

No Compound Related Data Available

Transcripts for INTS14 Gene

mRNA/cDNA for INTS14 Gene

19 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS14 Gene

No ASD Table

Relevant External Links for INTS14 Gene

GeneLoc Exon Structure for

Expression for INTS14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INTS14

mRNA Expression by UniProt/SwissProt for INTS14 Gene:

Tissue specificity: Strongly expressed in numerous cancer cells compared with their non-cancerous counterparts (lung, prostate, colon, stomach and skin).

Evidence on tissue expression from TISSUES for INTS14 Gene

  • Nervous system(4.8)
  • Adrenal gland(4.2)
  • Lung(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS14 Gene

Orthologs for INTS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia VWA9 31 30
  • 99.79 (n)
(Canis familiaris)
Mammalia VWA9 31 30
  • 93.95 (n)
(Bos Taurus)
Mammalia VWA9 31 30
  • 92.52 (n)
(Mus musculus)
Mammalia Vwa9 31 30
  • 90.97 (n)
Ints14 17
(Rattus norvegicus)
Mammalia Vwa9 30
  • 90.75 (n)
(Monodelphis domestica)
Mammalia VWA9 31
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia VWA9 31
  • 77 (a)
(Gallus gallus)
Aves VWA9 31
  • 82 (a)
C10H15ORF44 30
  • 81.41 (n)
(Anolis carolinensis)
Reptilia VWA9 31
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia vwa9 30
  • 77.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3805 30
(Danio rerio)
Actinopterygii vwa9 31 30
  • 71.63 (n)
wufi19c12 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007540 30
  • 49.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4785 31 30
  • 47.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7256 31
  • 36 (a)
Species where no ortholog for INTS14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INTS14 Gene

Gene Tree for INTS14 (if available)
Gene Tree for INTS14 (if available)
Evolutionary constrained regions (ECRs) for INTS14: view image

Paralogs for INTS14 Gene

No data available for Paralogs for INTS14 Gene

Variants for INTS14 Gene

Additional dbSNP identifiers (rs#s) for INTS14 Gene

Structural Variations from Database of Genomic Variants (DGV) for INTS14 Gene

Variant ID Type Subtype PubMed ID
esv2669017 CNV deletion 23128226
esv3552577 CNV deletion 23714750
nsv1150102 CNV deletion 26484159
nsv833042 CNV loss 17160897
nsv94754 CNV deletion 16902084

Variation tolerance for INTS14 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INTS14 Gene

Disorders for INTS14 Gene

Additional Disease Information for INTS14

No disorders were found for INTS14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS14 Gene

Publications for INTS14 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 54
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  3. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 54

Products for INTS14 Gene

Sources for INTS14 Gene