Aliases for INTS13 Gene

Aliases for INTS13 Gene

  • Integrator Complex Subunit 13 2 3 4 5
  • Asunder, Spermatogenesis Regulator Homolog (Drosphila) 2 3
  • Cell Cycle Regulator Mat89Bb Homolog 3 4
  • Spermatogenesis Associated 30 2 3
  • Sarcoma Antigen NY-SAR-95 3 4
  • Protein Asunder Homolog 3 4
  • Germ Cell Tumor 1 3 4
  • C12orf11 3 4
  • ASUN 3 4
  • GCT1 3 4
  • Chromosome 12 Open Reading Frame 11 2
  • Mat89Bb 3
  • SPATA30 3
  • NET48 3

External Ids for INTS13 Gene

Previous HGNC Symbols for INTS13 Gene

  • C12orf11
  • ASUN

Summaries for INTS13 Gene

GeneCards Summary for INTS13 Gene

INTS13 (Integrator Complex Subunit 13) is a Protein Coding gene. Diseases associated with INTS13 include Choriocarcinoma Of The Testis and Juvenile Type Testicular Granulosa Cell Tumor. Among its related pathways are Gene Expression and Formation of HIV-1 elongation complex containing HIV-1 Tat.

UniProtKB/Swiss-Prot Summary for INTS13 Gene

  • Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).

Gene Wiki entry for INTS13 Gene

Additional gene information for INTS13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS13 Gene

Genomics for INTS13 Gene

GeneHancer (GH) Regulatory Elements for INTS13 Gene

Promoters and enhancers for INTS13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J026935 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.0 -969 8.3 EP300 ZNF217 SIN3A NRF1 POLR2G SP1 PHF8 KDM6A ZBTB10 POLR2A FGFR1OP2 INTS13 ENSG00000247903 TM7SF3 MED21 ITPR2 piR-38553
GH12J027800 Enhancer 0.3 Ensembl 4.3 -863.1 -863074 2.4 PKNOX1 ENSG00000256512 ENSG00000257042 KLHL42 INTS13 RN7SKP15 lnc-MANSC4-5
GH12J026918 Enhancer 0.7 Ensembl ENCODE 0.4 +19.4 19395 1.5 CTCF CUX1 EP300 FOXA1 DPF2 RAD21 GATA3 ZNF579 ZNF121 ZNF394 ENSG00000247903 TM7SF3 lnc-TM7SF3-2 lnc-TM7SF3-1 INTS13
GH12J026931 Enhancer 0.4 dbSUPER 0.4 +5.0 5022 2.8 PBX2 NFE2 ZNF366 CEBPB PRDM1 ENSG00000247903 TM7SF3 lnc-FGFR1OP2-3 INTS13
GH12J026906 Enhancer 0.6 Ensembl ENCODE 0.3 +31.2 31245 1.4 GATA3 RCOR1 MAFG GATA2 ENSG00000247903 TM7SF3 piR-35674-096 lnc-TM7SF3-2 HSALNG0089991 INTS13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS13 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INTS13

Genomic Locations for INTS13 Gene

Genomic Locations for INTS13 Gene
chr12:26,905,057-26,938,326
(GRCh38/hg38)
Size:
33,270 bases
Orientation:
Minus strand
chr12:27,058,112-27,091,259
(GRCh37/hg19)
Size:
33,148 bases
Orientation:
Minus strand

Genomic View for INTS13 Gene

Genes around INTS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS13 Gene

Proteins for INTS13 Gene

  • Protein details for INTS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM9-INT13_HUMAN
    Recommended name:
    Integrator complex subunit 13
    Protein Accession:
    Q9NVM9
    Secondary Accessions:
    • B4DNK1
    • Q86WE2
    • Q96HM2
    • Q9BTX2
    • Q9NTB6
    • Q9NVM5

    Protein attributes for INTS13 Gene

    Size:
    706 amino acids
    Molecular mass:
    80225 Da
    Quaternary structure:
    • Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase.
    Miscellaneous:
    • RNAi in HeLa cells results in a multinucleated phenotype.
    SequenceCaution:
    • Sequence=AAO65180.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS13 Gene

Post-translational modifications for INTS13 Gene

  • Ubiquitination at Lys73 and Lys436
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INTS13 Gene

Domains & Families for INTS13 Gene

Gene Families for INTS13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INTS13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS13 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58152 (B4DNK1_HUMAN)
  • Sarcoma antigen NY-SAR-95 (M89BB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVM9

UniProtKB/Swiss-Prot:

INT13_HUMAN :
  • Belongs to the asunder family.
Family:
  • Belongs to the asunder family.
genes like me logo Genes that share domains with INTS13: view

Function for INTS13 Gene

Molecular function for INTS13 Gene

UniProtKB/Swiss-Prot Function:
Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS13 Gene

Gene Ontology (GO) - Molecular Function for INTS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with INTS13: view
genes like me logo Genes that share phenotypes with INTS13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS13 Gene

Localization for INTS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS13 Gene

Nucleus. Cytoplasm. Note=Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. {ECO:0000269 PubMed:17974005}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS13 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nuclear bodies (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0016604 nuclear body IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with INTS13: view

Pathways & Interactions for INTS13 Gene

genes like me logo Genes that share pathways with INTS13: view

Pathways by source for INTS13 Gene

2 Reactome pathways for INTS13 Gene

Gene Ontology (GO) - Biological Process for INTS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization IMP 23097494
GO:0007346 regulation of mitotic cell cycle IMP 15737938
GO:0030317 flagellated sperm motility ISS --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS13: view

No data available for SIGNOR curated interactions for INTS13 Gene

Drugs & Compounds for INTS13 Gene

No Compound Related Data Available

Transcripts for INTS13 Gene

mRNA/cDNA for INTS13 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS13

Alternative Splicing Database (ASD) splice patterns (SP) for INTS13 Gene

No ASD Table

Relevant External Links for INTS13 Gene

GeneLoc Exon Structure for
INTS13

Expression for INTS13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INTS13

mRNA Expression by UniProt/SwissProt for INTS13 Gene:

Q9NVM9-INT13_HUMAN
Tissue specificity: Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.

Evidence on tissue expression from TISSUES for INTS13 Gene

  • Heart(5)
  • Liver(4.2)
  • Eye(4.1)
  • Nervous system(2.3)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS13 Gene

Orthologs for INTS13 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASUN 31 30
  • 99.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12ORF11 31
  • 99 (a)
OneToOne
ASUN 30
  • 94.38 (n)
oppossum
(Monodelphis domestica)
Mammalia ASUN 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASUN 31 30
  • 95.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asun 30
  • 88.82 (n)
mouse
(Mus musculus)
Mammalia Asun 31 30
  • 88.67 (n)
OneToOne
Ints13 17
platypus
(Ornithorhynchus anatinus)
Mammalia ASUN 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASUN 31
  • 94 (a)
OneToOne
C1H12ORF11 30
  • 83.71 (n)
lizard
(Anolis carolinensis)
Reptilia ASUN 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asun 30
  • 72.1 (n)
Str.10184 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.25220 30
zebrafish
(Danio rerio)
Actinopterygii asun 31 30
  • 70.09 (n)
OneToOne
wufi39e09 30
fruit fly
(Drosophila melanogaster)
Insecta asun 31 30
  • 48.32 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002295 30
  • 46.99 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_R02D3.4 30
  • 43.52 (n)
R02D3.4 31
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Species where no ortholog for INTS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS13 Gene

ENSEMBL:
Gene Tree for INTS13 (if available)
TreeFam:
Gene Tree for INTS13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS13: view image

Paralogs for INTS13 Gene

No data available for Paralogs for INTS13 Gene

Variants for INTS13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INTS13 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_035673 A colorectal cancer sample p.Ser227Pro
rs2306852 - p.Met66Thr

Additional dbSNP identifiers (rs#s) for INTS13 Gene

Structural Variations from Database of Genomic Variants (DGV) for INTS13 Gene

Variant ID Type Subtype PubMed ID
esv2674002 CNV deletion 23128226

Variation tolerance for INTS13 Gene

Residual Variation Intolerance Score: 9.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS13 Gene

Human Gene Mutation Database (HGMD)
INTS13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS13 Gene

Disorders for INTS13 Gene

MalaCards: The human disease database

(4) MalaCards diseases for INTS13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
choriocarcinoma of the testis
  • testicular choriocarcinoma
juvenile type testicular granulosa cell tumor
  • juvenile granulosa cell tumor
testicular granulosa cell tumor
  • granulosa cell tumor of testis
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for INTS13

genes like me logo Genes that share disorders with INTS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS13 Gene

Publications for INTS13 Gene

  1. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. (PMID: 23097494) Jodoin JN … Lee LA (Molecular biology of the cell 2012) 2 3 4 54
  2. Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes. (PMID: 12414650) Bourdon V … Chaganti RS (Cancer research 2002) 2 3 4 54
  3. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 54
  4. Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. (PMID: 19357193) Anderson MA … Lee LA (Molecular biology of the cell 2009) 2 3 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for INTS13 Gene

Sources for INTS13 Gene