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Aliases for INTS11 Gene

Aliases for INTS11 Gene

  • Integrator Complex Subunit 11 2 3 3 5
  • Cleavage And Polyadenylation-Specific Factor 3-Like Protein 3 4
  • Cleavage And Polyadenylation Specific Factor 3-Like 2 3
  • Protein Related To CPSF Subunits Of 68 KDa 3 4
  • CPSF3-Like Protein 3 4
  • CPSF3L 3 4
  • RC-68 3 4
  • RC68 3 4
  • Related To CPSF Subunits 68 KDa 3
  • EC 3.1.27.- 4
  • CPSF73L 3
  • INT11 3
  • Int11 4

External Ids for INTS11 Gene

Previous HGNC Symbols for INTS11 Gene

  • CPSF3L

Summaries for INTS11 Gene

Entrez Gene Summary for INTS11 Gene

  • The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS11 Gene

INTS11 (Integrator Complex Subunit 11) is a Protein Coding gene. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Gene Expression. An important paralog of this gene is CPSF3.

UniProtKB/Swiss-Prot for INTS11 Gene

  • Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Gene Wiki entry for INTS11 Gene

Additional gene information for INTS11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS11 Gene

Genomics for INTS11 Gene

GeneHancer (GH) Regulatory Elements for INTS11 Gene

Promoters and enhancers for INTS11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001323 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.4 -398 2.6 SMAD1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 POLR2B GLIS2 CPTP INTS11 ANKRD65 SCNN1D MRPL20 PIR50275
GH01J001312 Promoter 0.8 EPDnew 650.4 +11.9 11947 0.1 ZFP69B ZNF692 POLR2A RBM22 ZNF600 BCL11B SUPT5H MIR6727 INTS11 ENSG00000240731
GH01J001397 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 70.9 -75.4 -75423 5.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CCNL2 LOC148413 INTS11 ATAD3B ENSG00000240731 LOC100288379 ENSG00000230092 SLC35E2A LOC100129381 CDK11A
GH01J001775 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 56.4 -454.8 -454835 8.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 NADK INTS11 CCNL2 CDK11A ATAD3B ENSG00000230092 ENSG00000240731 FAAP20 LOC100288379 LINC00115
GH01J000998 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 54.1 +324.2 324202 3.8 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ISG15 HES4 ATAD3B WASH7P INTS11 ENSG00000230092 ENSG00000240731 CDK11A CCNL2 LOC100288379
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS11 on UCSC Golden Path with GeneCards custom track

Genomic Locations for INTS11 Gene

Genomic Locations for INTS11 Gene
chr1:1,311,585-1,324,691
(GRCh38/hg38)
Size:
13,107 bases
Orientation:
Minus strand
chr1:1,246,965-1,260,071
(GRCh37/hg19)
Size:
13,107 bases
Orientation:
Minus strand

Genomic View for INTS11 Gene

Genes around INTS11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS11 Gene

Proteins for INTS11 Gene

  • Protein details for INTS11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA45-INT11_HUMAN
    Recommended name:
    Integrator complex subunit 11
    Protein Accession:
    Q5TA45
    Secondary Accessions:
    • A8K5S2
    • B3KPR3
    • B4DM87
    • G3V1S5
    • Q5TA46
    • Q5TA48
    • Q5TA52
    • Q5TA53
    • Q5TA54
    • Q7L3D7
    • Q96HY1
    • Q9BW36
    • Q9H0F9
    • Q9H8R5
    • Q9HAA6
    • Q9NWX9

    Protein attributes for INTS11 Gene

    Size:
    600 amino acids
    Molecular mass:
    67663 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
    SequenceCaution:
    • Sequence=BAA91246.1; Type=Frameshift; Positions=587; Evidence={ECO:0000305}; Sequence=BAB14541.1; Type=Frameshift; Positions=248; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INTS11 Gene

    Alternative splice isoforms for INTS11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS11 Gene

Post-translational modifications for INTS11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS11 Gene

Domains & Families for INTS11 Gene

Gene Families for INTS11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q5TA45

UniProtKB/Swiss-Prot:

INT11_HUMAN :
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
Domain:
  • The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
genes like me logo Genes that share domains with INTS11: view

Function for INTS11 Gene

Molecular function for INTS11 Gene

UniProtKB/Swiss-Prot Function:
Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3 cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Enzyme Numbers (IUBMB) for INTS11 Gene

Phenotypes From GWAS Catalog for INTS11 Gene

Gene Ontology (GO) - Molecular Function for INTS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with INTS11: view
genes like me logo Genes that share phenotypes with INTS11: view

Animal Model Products

miRNA for INTS11 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INTS11 Gene

Localization for INTS11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS11 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS11 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23904267
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA,IEA 23904267
GO:0005829 cytosol IDA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS11: view

Pathways & Interactions for INTS11 Gene

genes like me logo Genes that share pathways with INTS11: view

Pathways by source for INTS11 Gene

2 Reactome pathways for INTS11 Gene

Gene Ontology (GO) - Biological Process for INTS11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS11: view

No data available for SIGNOR curated interactions for INTS11 Gene

Drugs & Compounds for INTS11 Gene

No Compound Related Data Available

Transcripts for INTS11 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INTS11 Gene

No ASD Table

Relevant External Links for INTS11 Gene

GeneLoc Exon Structure for
INTS11
ECgene alternative splicing isoforms for
INTS11

Expression for INTS11 Gene

NURSA nuclear receptor signaling pathways regulating expression of INTS11 Gene:

INTS11

Evidence on tissue expression from TISSUES for INTS11 Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Kidney(2.2)
  • Skin(2.2)
  • Blood(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS11 Gene

Orthologs for INTS11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INTS11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPSF3L 33
  • 96.05 (n)
oppossum
(Monodelphis domestica)
Mammalia CPSF3L 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPSF3L 34 33
  • 90.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF3L 34 33
  • 90.28 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpsf3l 33
  • 87.28 (n)
mouse
(Mus musculus)
Mammalia Cpsf3l 34 33
  • 87.11 (n)
OneToOne
Ints11 16
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF3L 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPSF3L 34 33
  • 78.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF3L 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpsf3l 33
  • 75.94 (n)
Str.7162 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9205 33
zebrafish
(Danio rerio)
Actinopterygii cpsf3l 34 33
  • 77.07 (n)
OneToOne
Dr.20157 33
fruit fly
(Drosophila melanogaster)
Insecta IntS11 34 33
  • 68.19 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009923 33
  • 66.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F10B5.8 34 33
  • 57.54 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YSH1 34
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CPSF73-II 33
  • 52.32 (n)
rice
(Oryza sativa)
Liliopsida Os09g0397900 33
  • 57.28 (n)
Os.27823 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToOne
Cin.4823 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4823 33
Species where no ortholog for INTS11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS11 Gene

ENSEMBL:
Gene Tree for INTS11 (if available)
TreeFam:
Gene Tree for INTS11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS11: view image

Paralogs for INTS11 Gene

Paralogs for INTS11 Gene

genes like me logo Genes that share paralogs with INTS11: view

Variants for INTS11 Gene

Sequence variations from dbSNP and Humsavar for INTS11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003240 -- 1,324,638(-) G/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000073352 -- 1,325,526(-) C/T upstream_transcript_variant
rs1000438273 -- 1,324,775(-) G/A upstream_transcript_variant
rs1000633999 -- 1,317,892(-) G/A intron_variant
rs1000732571 -- 1,317,752(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INTS11 Gene

Variant ID Type Subtype PubMed ID
dgv26n54 CNV loss 21841781
dgv2n67 CNV gain 20364138
dgv6n100 CNV gain+loss 25217958
dgv7n100 CNV loss 25217958
esv2758912 CNV loss 17122850
esv3366182 CNV duplication 20981092
esv3547454 CNV deletion 23714750
esv3584992 CNV gain 21293372
esv3890636 CNV loss 25118596
nsv1000169 CNV gain 25217958
nsv1009541 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074436 CNV deletion 25765185
nsv1118092 CNV deletion 24896259
nsv1130939 CNV deletion 24896259
nsv1160772 CNV duplication 26073780
nsv1160788 CNV deletion 26073780
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv476469 CNV novel sequence insertion 20440878
nsv482937 CNV loss 15286789
nsv544969 CNV loss 21841781
nsv544971 CNV loss 21841781
nsv544972 CNV loss 21841781
nsv950452 CNV deletion 24416366
nsv997291 CNV gain 25217958

Variation tolerance for INTS11 Gene

Residual Variation Intolerance Score: 6.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INTS11 Gene

Disorders for INTS11 Gene

Additional Disease Information for INTS11

No disorders were found for INTS11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INTS11 Gene

Publications for INTS11 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4 58
  2. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100. (PMID: 15684398) Dominski Z … Marzluff WF (Molecular and cellular biology 2005) 2 3 4 58
  3. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for INTS11 Gene

Sources for INTS11 Gene

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