Aliases for INTS10 Gene
External Ids for INTS10 Gene
Previous HGNC Symbols for INTS10 Gene
Previous GeneCards Identifiers for INTS10 Gene
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
GeneCards Summary for INTS10 Gene
INTS10 (Integrator Complex Subunit 10) is a Protein Coding gene. Diseases associated with INTS10 include Kbg Syndrome. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Gene Expression.
UniProtKB/Swiss-Prot Summary for INTS10 Gene
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).