INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] See more...

Aliases for INTS10 Gene

Aliases for INTS10 Gene

  • Integrator Complex Subunit 10 2 3 4 5
  • C8orf35 3 4
  • INT10 2 3
  • Chromosome 8 Open Reading Frame 35 2
  • FLJ10569 2
  • INTS10 5
  • Int10 4

External Ids for INTS10 Gene

Previous HGNC Symbols for INTS10 Gene

  • C8orf35

Previous GeneCards Identifiers for INTS10 Gene

  • GC08P019721
  • GC08P019674
  • GC08P018215

Summaries for INTS10 Gene

Entrez Gene Summary for INTS10 Gene

  • INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

GeneCards Summary for INTS10 Gene

INTS10 (Integrator Complex Subunit 10) is a Protein Coding gene. Diseases associated with INTS10 include Kbg Syndrome. Among its related pathways are Gene Expression and HIV Transcription Elongation.

UniProtKB/Swiss-Prot Summary for INTS10 Gene

  • Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INTS10 Gene

Genomics for INTS10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INTS10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J019816 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 608.2 +0.7 652 3.2 SP1 GATAD2A HNRNPL TEAD4 ZNF629 ZNF512 NFKBIZ RFX5 ZNF692 POLR2A INTS10 RF00017-6869 LPL
GH08J020196 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 +383.6 383582 8.7 CEBPG GATAD2A REST TFE3 ZNF512 LEF1 IKZF1 ZNF692 POLR2A ZNF7 ATP6V1B2 INTS10 RNU6-892P HSALNG0063796 RF00026-1058 LZTS1
GH08J019412 Enhancer 0.9 Ensembl ENCODE 24.1 -403.4 -403386 4.7 CREB1 GATAD2A ATF7 PRDM1 ZSCAN4 REST ZNF239 ZNF792 CEBPB SP1 CSGALNACT1 INTS10 RPL35P6 LOC102724881 SH2D4A LOC105379308
GH08J020310 Enhancer 1 Ensembl ENCODE 20.2 +493.9 493851 1.6 ATF7 PRDM10 ZNF629 ZNF512 ZIC2 ZSCAN4 PATZ1 ZBTB44 ZNF140 KLF9 INTS10 RNU6-892P ENSG00000253164 LZTS1 RF00017-6872
GH08J019602 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 -214.7 -214749 1.2 CTCF ZIC2 ZSCAN4 PATZ1 EZH2 ZNF600 RAD21 ZXDB ZBTB26 ZBTB17 CSGALNACT1 INTS10 SH2D4A piR-46501-095 LOC105379308 lnc-SLC18A1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INTS10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INTS10

Top Transcription factor binding sites by QIAGEN in the INTS10 gene promoter:
  • AREB6
  • CUTL1
  • Evi-1
  • FOXO1
  • FOXO1a
  • HNF-1
  • HNF-1A
  • HTF
  • MRF-2
  • Roaz

Genomic Locations for INTS10 Gene

Genomic Locations for INTS10 Gene
chr8:19,817,149-19,852,083
(GRCh38/hg38)
Size:
34,935 bases
Orientation:
Plus strand
chr8:19,674,651-19,709,594
(GRCh37/hg19)
Size:
34,944 bases
Orientation:
Plus strand

Genomic View for INTS10 Gene

Genes around INTS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INTS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INTS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS10 Gene

Proteins for INTS10 Gene

  • Protein details for INTS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR2-INT10_HUMAN
    Recommended name:
    Integrator complex subunit 10
    Protein Accession:
    Q9NVR2
    Secondary Accessions:
    • Q6IA93
    • Q7L538
    • Q7L8C8
    • Q9H3W8

    Protein attributes for INTS10 Gene

    Size:
    710 amino acids
    Molecular mass:
    82236 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Interacts with POLR2A.
    SequenceCaution:
    • Sequence=BAA91687.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for INTS10 Gene

Post-translational modifications for INTS10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INTS10 Gene

Domains & Families for INTS10 Gene

Gene Families for INTS10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INTS10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INTS10 Gene

GenScript: Design optimal peptide antigens:
  • Integrator complex subunit 10 (INT10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NVR2

UniProtKB/Swiss-Prot:

INT10_HUMAN :
  • Belongs to the Integrator subunit 10 family.
Family:
  • Belongs to the Integrator subunit 10 family.
genes like me logo Genes that share domains with INTS10: view

Function for INTS10 Gene

Molecular function for INTS10 Gene

UniProtKB/Swiss-Prot Function:
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267).

Phenotypes From GWAS Catalog for INTS10 Gene

Gene Ontology (GO) - Molecular Function for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 contributes_to protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS10: view
genes like me logo Genes that share phenotypes with INTS10: view

Animal Models for INTS10 Gene

MGI Knock Outs for INTS10:
  • Ints10 Ints10<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INTS10 Gene

Localization for INTS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INTS10 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23904267
GO:0005654 nucleoplasm TAS --
GO:0032039 integrator complex IEA,IDA 16239144
genes like me logo Genes that share ontologies with INTS10: view

Pathways & Interactions for INTS10 Gene

PathCards logo

SuperPathways for INTS10 Gene

genes like me logo Genes that share pathways with INTS10: view

Pathways by source for INTS10 Gene

2 Reactome pathways for INTS10 Gene

Gene Ontology (GO) - Biological Process for INTS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IEA,IDA 16239144
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with INTS10: view

No data available for SIGNOR curated interactions for INTS10 Gene

Drugs & Compounds for INTS10 Gene

(1) Additional Compounds for INTS10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INTS10: view

Transcripts for INTS10 Gene

mRNA/cDNA for INTS10 Gene

19 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INTS10

Alternative Splicing Database (ASD) splice patterns (SP) for INTS10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: - - - - - -
SP8: - -
SP9:
SP10: - -
SP11:
SP12:
SP13: -
SP14:
SP15: - - - -

ExUns: 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c
SP1: - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for INTS10 Gene

GeneLoc Exon Structure for
INTS10

Expression for INTS10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INTS10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INTS10 Gene

This gene is overexpressed in Cervix (44.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INTS10 Gene



Protein tissue co-expression partners for INTS10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INTS10

SOURCE GeneReport for Unigene cluster for INTS10 Gene:

Hs.512627

Evidence on tissue expression from TISSUES for INTS10 Gene

  • Lung(4.3)
  • Lymph node(4.3)
  • Nervous system(4.1)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with INTS10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INTS10 Gene

Orthologs for INTS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for INTS10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia INTS10 30
  • 95.82 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia INTS10 30 31
  • 92.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia INTS10 31
  • 90 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia INTS10 30 31
  • 88.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ints10 30 17 31
  • 87.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ints10 30
  • 87.28 (n)
Chicken
(Gallus gallus)
Aves INTS10 30 31
  • 81.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia INTS10 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ints10 30
  • 74.18 (n)
Str.11986 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15816 30
Zebrafish
(Danio rerio)
Actinopterygii ints10 30 31
  • 66.01 (n)
OneToOne
Dr.28211 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003262 30
  • 43.67 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta IntS10 30 31
  • 42.55 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
-- 31
  • 26 (a)
OneToMany
Species where no ortholog for INTS10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INTS10 Gene

ENSEMBL:
Gene Tree for INTS10 (if available)
TreeFam:
Gene Tree for INTS10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INTS10: view image

Paralogs for INTS10 Gene

No data available for Paralogs for INTS10 Gene

Variants for INTS10 Gene

Additional dbSNP identifiers (rs#s) for INTS10 Gene

Structural Variations from Database of Genomic Variants (DGV) for INTS10 Gene

Variant ID Type Subtype PubMed ID
esv3891372 CNV gain 25118596
nsv522185 CNV gain 19592680
nsv610759 CNV gain 21841781

Variation tolerance for INTS10 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INTS10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INTS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INTS10 Gene

Disorders for INTS10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INTS10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kbg syndrome
  • kbgs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for INTS10

genes like me logo Genes that share disorders with INTS10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INTS10 Gene

Publications for INTS10 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D … Shiekhattar R (Cell 2005) 2 3 4
  2. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. (PMID: 23904267) Jodoin JN … Lee LA (Molecular biology of the cell 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for INTS10 Gene

  • Signalway Proteins for INTS10

Sources for INTS10 Gene