Aliases for INSYN2B Gene

Aliases for INSYN2B Gene

  • Inhibitory Synaptic Factor Family Member 2B 2 3 4 5
  • Family With Sequence Similarity 196 Member B 2 3
  • Protein INSYN2B 3 4
  • C5orf57 3 4
  • FAM196B 3 4
  • Family With Sequence Similarity 196, Member B 2
  • Chromosome 5 Open Reading Frame 57 2
  • Protein FAM196B 3

External Ids for INSYN2B Gene

Previous HGNC Symbols for INSYN2B Gene

  • C5orf57
  • FAM196B

Summaries for INSYN2B Gene

GeneCards Summary for INSYN2B Gene

INSYN2B (Inhibitory Synaptic Factor Family Member 2B) is a Protein Coding gene. An important paralog of this gene is INSYN2A.

Additional gene information for INSYN2B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INSYN2B Gene

Genomics for INSYN2B Gene

GeneHancer (GH) Regulatory Elements for INSYN2B Gene

Promoters and enhancers for INSYN2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J169975 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 30.8 +2.2 2207 5.5 CTCF TCF12 JUND FOS TEAD4 REST TRIM28 EP300 RAD21 TRIM22 lnc-LCP2-6 INSYN2B piR-34093-032 DOCK2
GH05J169969 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 28.4 +8.3 8266 5.9 JUND EP300 ATF2 USF2 FOSL2 JUN NR2F2 USF1 FOS NR2C2 INSYN2B ENSG00000253269 RANBP17 lnc-LCP2-6 piR-34093-032 DOCK2
GH05J169944 Enhancer 0.9 Ensembl ENCODE dbSUPER 23.3 +34.9 34939 3.6 ZIC2 NFIC FOS USF1 FOXP2 NFIB ZNF664 RAD21 LCORL SMAD1 INSYN2B ENSG00000253269 lnc-LCP2-6 piR-34093-032 DOCK2
GH05J169801 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10 +178.4 178373 8.1 SP1 FOS EP300 REST TRIM28 HES1 RELA MEF2C CTBP1 RAD21 ENSG00000253269 INSYN2B SPDL1 DOCK2 LCP2 piR-34093-032
GH05J169953 Enhancer 0.4 Ensembl dbSUPER 28 +27.5 27539 1.6 FOS INSYN2B lnc-LCP2-6 piR-34093-032 DOCK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INSYN2B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INSYN2B

Genomic Locations for INSYN2B Gene

Genomic Locations for INSYN2B Gene
chr5:169,861,291-169,980,740
(GRCh38/hg38)
Size:
119,450 bases
Orientation:
Minus strand
chr5:169,290,719-169,407,744
(GRCh37/hg19)
Size:
117,026 bases
Orientation:
Minus strand

Genomic View for INSYN2B Gene

Genes around INSYN2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSYN2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSYN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSYN2B Gene

Proteins for INSYN2B Gene

  • Protein details for INSYN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMK8-INY2B_HUMAN
    Recommended name:
    Protein INSYN2B
    Protein Accession:
    A6NMK8

    Protein attributes for INSYN2B Gene

    Size:
    535 amino acids
    Molecular mass:
    59204 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INSYN2B Gene

Post-translational modifications for INSYN2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSYN2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSYN2B Gene

Domains & Families for INSYN2B Gene

Gene Families for INSYN2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INSYN2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INSYN2B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM196B (F196B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMK8

UniProtKB/Swiss-Prot:

INY2B_HUMAN :
  • Belongs to the INSYN2 family.
Family:
  • Belongs to the INSYN2 family.
genes like me logo Genes that share domains with INSYN2B: view

Function for INSYN2B Gene

Phenotypes From GWAS Catalog for INSYN2B Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INSYN2B Gene

Localization for INSYN2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INSYN2B gene
Compartment Confidence
nucleus 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for INSYN2B Gene

Pathways & Interactions for INSYN2B Gene

PathCards logo

SuperPathways for INSYN2B Gene

No Data Available

Interacting Proteins for INSYN2B Gene

;

Gene Ontology (GO) - Biological Process for INSYN2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for INSYN2B Gene

Drugs & Compounds for INSYN2B Gene

No Compound Related Data Available

Transcripts for INSYN2B Gene

mRNA/cDNA for INSYN2B Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSYN2B Gene

No ASD Table

Relevant External Links for INSYN2B Gene

GeneLoc Exon Structure for
INSYN2B

Expression for INSYN2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INSYN2B

SOURCE GeneReport for Unigene cluster for INSYN2B Gene:

Hs.721917
genes like me logo Genes that share expression patterns with INSYN2B: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for INSYN2B Gene

Orthologs for INSYN2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for INSYN2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM196B 31 30
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM196B 31 30
  • 88.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM196B 31 30
  • 85.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam196b 31 30
  • 82.06 (n)
OneToOne
Insyn2b 17
rat
(Rattus norvegicus)
Mammalia Fam196b 30
  • 81.18 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM196B 31
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM196B 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM196B 31 30
  • 58.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM196B 31
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734510 30
  • 71.68 (n)
zebrafish
(Danio rerio)
Actinopterygii FAM196B 31
  • 17 (a)
OneToOne
Species where no ortholog for INSYN2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INSYN2B Gene

ENSEMBL:
Gene Tree for INSYN2B (if available)
TreeFam:
Gene Tree for INSYN2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INSYN2B: view image

Paralogs for INSYN2B Gene

Paralogs for INSYN2B Gene

genes like me logo Genes that share paralogs with INSYN2B: view

Variants for INSYN2B Gene

Additional dbSNP identifiers (rs#s) for INSYN2B Gene

Structural Variations from Database of Genomic Variants (DGV) for INSYN2B Gene

Variant ID Type Subtype PubMed ID
esv2731060 CNV deletion 23290073
esv3566992 CNV deletion 23714750
esv3607554 CNV loss 21293372
esv3607558 CNV loss 21293372
esv3607559 CNV gain 21293372
esv3607560 CNV loss 21293372
esv988430 CNV insertion 20482838
nsv328128 CNV deletion 16902084
nsv474386 CNV novel sequence insertion 20440878
nsv600259 CNV loss 21841781
nsv969011 CNV duplication 23825009

Variation tolerance for INSYN2B Gene

Gene Damage Index Score: 6.13; 75.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INSYN2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INSYN2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INSYN2B Gene

Disorders for INSYN2B Gene

Additional Disease Information for INSYN2B

No disorders were found for INSYN2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INSYN2B Gene

Publications for INSYN2B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 54
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 54

Products for INSYN2B Gene

Sources for INSYN2B Gene