Aliases for INSR Gene
Aliases for INSR Gene
External Ids for INSR Gene
- HGNC: 6091
- Entrez Gene: 3643
- Ensembl: ENSG00000171105
- OMIM: 147670
- UniProtKB: P06213
Previous GeneCards Identifiers for INSR Gene
- GC19M007225
- GC19M007056
- GC19M007067
- GC19M006847
Summaries for INSR Gene
-
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for INSR Gene
INSR (Insulin Receptor) is a Protein Coding gene. Diseases associated with INSR include Donohue Syndrome and Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities. Among its related pathways are Beta-Adrenergic Signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is IGF1R.
UniProtKB/Swiss-Prot for INSR Gene
-
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
-
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin.
Additional gene information for INSR Gene
- Monarch Initiative
- Search for INSR at DataMed
- Search for INSR at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSR Gene
Genomics for INSR Gene
GeneHancer (GH) Regulatory Elements for INSR Gene
Promoters and enhancers for INSR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around INSR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the INSR gene promoter:
Regulatory Element Products
Genomic Locations for INSR Gene
Genomic Locations for INSR Gene
- chr19:7,112,255-7,294,034
- (GRCh38/hg38)
- Size:
- 181,780 bases
- Orientation:
- Minus strand
- chr19:7,112,266-7,294,045
- (GRCh37/hg19)
Genomic View for INSR Gene
Genes around INSR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
INSR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for INSR Gene
Proteins for INSR Gene
-
Protein details for INSR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P06213-INSR_HUMAN
- Recommended name:
- Insulin receptor
- Protein Accession:
- P06213
- Q17RW0
- Q59H98
- Q9UCB7
- Q9UCB8
- Q9UCB9
Protein attributes for INSR Gene
- Size:
- 1382 amino acids
- Molecular mass:
- 156333 Da
- Quaternary structure:
-
- Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with SORBS1 but dissociates from it following insulin stimulation. Binds SH2B2. Activated form of INSR interacts (via Tyr-999) with the PTB/PID domains of IRS1 and SHC1. The sequences surrounding the phosphorylated NPXY motif contribute differentially to either IRS1 or SHC1 recognition. Interacts (via tyrosines in the C-terminus) with IRS2 (via PTB domain and 591-786 AA); the 591-786 would be the primary anchor of IRS2 to INSR while the PTB domain would have a stabilizing action on the interaction with INSR. Interacts with the SH2 domains of the 85 kDa regulatory subunit of PI3K (PIK3R1) in vitro, when autophosphorylated on tyrosine residues. Interacts with SOCS7. Interacts (via the phosphorylated Tyr-999), with SOCS3. Interacts (via the phosphorylated Tyr-1185, Tyr-1189, Tyr-1190) with SOCS1. Interacts with CAV2 (tyrosine-phosphorylated form); the interaction is increased with Tyr-27phosphorylation of CAV2 (By similarity). Interacts with ARRB2 (By similarity). Interacts with GRB10; this interaction blocks the association between IRS1/IRS2 and INSR, significantly reduces insulin-stimulated tyrosine phosphorylation of IRS1 and IRS2 and thus decreases insulin signaling. Interacts with GRB7. Interacts with PDPK1. Interacts (via Tyr-1190) with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop from dephosphorylation, but promotes dephosphorylation of Tyr-999, this results in decreased interaction with, and phosphorylation of, IRS1. Interacts (via subunit alpha) with ENPP1 (via 485-599 AA); this interaction blocks autophosphorylation. Interacts with PTPRE; this interaction is dependent of Tyr-1185, Tyr-1189 and Tyr-1190 of the INSR. Interacts with STAT5B (via SH2 domain). Interacts with PTPRF. Interacts with ATIC; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling netwok regulating INSR autophosphorylation and endocytosis (By similarity). Interacts with the cone snail venom insulin Con-Ins G1 (PubMed:27617429).
Three dimensional structures from OCA and Proteopedia for INSR Gene
Protein Expression for INSR Gene
Selected DME Specific Peptides for INSR Gene
- P06213:
-
- DGQDACG
- LMRMCWQ
- PESLKDG
- RDLAARN
- YALVIFEM
- KCIPECPSGYT
- YVPDEWEV
- FPNLTVI
- GLLPVRWM
- GVVLWEI
- RERIEFLNEASVMK
- FGMVYEG
- HCQKVCP
- KTIDSVTSAQ
- LFFNYALV
- KFVHRDLAARNCMV
- HVVRLLGV
- NITRGSVRIEKN
- EGHLQILLMF
- PNGNITHY
- TDYLLLFRVYGLESL
- LKPWTQYA
- HFTGYRIE
- SQIILKWKPPS
- DGMAYLNA
- EIADGMAYL
- RTYGAKS
- FVHRDLA
- QPYQGLSNE
- GPCPKVC
- KGLKLPSRTW
- PNGLIVLYEV
Post-translational modifications for INSR Gene
- After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane.
- Autophosphorylated on tyrosine residues in response to insulin. Phosphorylation of Tyr-999 is required for binding to IRS1, SHC1 and STAT5B. Dephosphorylated by PTPRE at Tyr-999, Tyr-1185, Tyr-1189 and Tyr-1190. Dephosphorylated by PTPRF and PTPN1. Dephosphorylated by PTPN2; down-regulates insulin-induced signaling.
- Ubiquitination at isoforms=21057
- Glycosylation at posLast=4343, isoforms=252, posLast=105105, posLast=138138, posLast=242242, isoforms=2282, posLast=322322, isoforms=2364, posLast=424424, posLast=445445, posLast=541541, posLast=633633, posLast=651651, posLast=698698, posLast=769769, isoforms=2782, posLast=920920, and posLast=933933
- Modification sites at PhosphoSitePlus
Other Protein References for INSR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for INSR (Insulin R/CD220)
- Novus Biologicals Antibodies for INSR
-
Abcam antibodies for INSR
-
Cloud-Clone Corp. Antibodies for INSR
- Invitrogen Antibodies for INSR
- antibodies-online: Search results for 348 available Insulin Receptor Antibodies ranked by validation data
- Compare Top Insulin Receptor Antibodies
-
Recommended
- 181 WB Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 18 IHC (p) Antibodies (anti-human)
- 16 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 107 WB Antibodies (anti-mouse)
- 1 IP Antibody (anti-rat)
- 2 IF Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 78 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 107 WB Antibodies (anti-mouse)
- 1 Neut Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 16 IP Antibodies (anti-human)
- 18 IHC (p) Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 181 WB Antibodies (anti-human)
- 1 IP Antibody (anti-rat)
- 2 IF Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 78 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 107 WB Antibodies (anti-mouse)
- 1 Neut Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 3 DB Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 16 IP Antibodies (anti-human)
- 18 IHC (p) Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 181 WB Antibodies (anti-human)
- 1 IP Antibody (anti-rat)
- 2 IF Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 78 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- GeneTex INSR antibody for INSR
-
Santa Cruz Biotechnology (SCBT) Antibodies for INSR
- Sino Biological Antibodies for INSR
Protein Products
- R&D Systems Proteins and Enzymes for INSR (Insulin R/CD220)
-
OriGene Purified Proteins for INSR
- Search Origene for MassSpec and Protein Over-expression Lysates for INSR
- Origene Custom Protein Services for INSR
- Sino Biological Cell Lysates for INSR
- Sino Biological Recombinant Proteins for INSR
- ProSpec Recombinant Proteins for INSR
-
Cloud-Clone Corp. Proteins for INSR
- Search GeneTex for Proteins for INSR
-
Abcam proteins for INSR
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for INSR (Insulin R/CD220)
- antibodies-online: Search results for 39 available INSR Elisa Kits ranked by validation data
- Compare Top INSR Elisa Kits
-
Recommended
- 1 Monkey ELISA Kit
- 4 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 1 Rabbit ELISA Kit
- 2 Pig (Porcine) ELISA Kits
- 4 Mouse (Murine) ELISA Kits
- 1 Monkey ELISA Kit
- 18 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 2 Dog (Canine) ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Chicken ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 18 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 2 Dog (Canine) ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Chicken ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 7 Rat (Rattus) ELISA Kits
- 1 Rabbit ELISA Kit
- 2 Pig (Porcine) ELISA Kits
- 4 Mouse (Murine) ELISA Kits
- 1 Monkey ELISA Kit
- 18 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Goat ELISA Kit
- 2 Dog (Canine) ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 1 Chicken ELISA Kit
Domains & Families for INSR Gene
Gene Families for INSR Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for INSR Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for INSR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P06213UniProtKB/Swiss-Prot:
INSR_HUMAN :- The tetrameric insulin receptor binds insulin via non-identical regions from two alpha chains, primarily via the C-terminal region of the first INSR alpha chain. Residues from the leucine-rich N-terminus of the other INSR alpha chain also contribute to this insulin binding site. A secondary insulin-binding site is formed by residues at the junction of fibronectin type-III domain 1 and 2.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Domain:
-
- The tetrameric insulin receptor binds insulin via non-identical regions from two alpha chains, primarily via the C-terminal region of the first INSR alpha chain. Residues from the leucine-rich N-terminus of the other INSR alpha chain also contribute to this insulin binding site. A secondary insulin-binding site is formed by residues at the junction of fibronectin type-III domain 1 and 2.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Function for INSR Gene
Molecular function for INSR Gene
- GENATLAS Biochemistry:
- insulin receptor precursor of two subunits alpha and beta
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated in response to insulin. Autophosphorylation activates the kinase activity. PTPN1, PTPRE and PTPRF dephosphorylate important tyrosine residues, thereby reducing INSR activity. Inhibited by ENPP1. GRB10 and GRB14 inhibit the catalytic activity of the INSR, they block access of substrates to the activated receptor. SOCS1 and SOCS3 act as negative regulators of INSR activity, they bind to the activated INRS and interfere with the phosphorylation of INSR substrates.
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Enzyme Numbers (IUBMB) for INSR Gene
Phenotypes From GWAS Catalog for INSR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001540 | amyloid-beta binding | IPI | 19406747 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IDA,IMP | 7537849 |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | IDA | 6849137 |
Phenotypes for INSR Gene
- MGI mutant phenotypes for INSR:
-
inferred from 7 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for INSR:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased viability
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased substrate adherent cell growth
- Paclitaxel antagonistic effect
- Decreased viability in HMC1.1 cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for INSR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for INSR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for INSR gene
- Search ViGene Biosciences for INSR
CRISPR Products
-
OriGene CRISPR knockouts for INSR
- genomics-online: gRNA clones - Search results for 145 available INSR gene related products
- Overview of 145 available INSR gene related products
- Applied Biological Materials CRISPR for INSR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for INSR
- GenScript: Design CRISPR guide RNA sequences for INSR
miRNA for INSR Gene
- miRTarBase miRNAs that target INSR
miRNA Products
- Search ViGene Biosciences for INSR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for INSR
- Browse OriGene Inhibitory RNA Products For INSR
- genomics-online: shRNA clones - Search results for 145 available INSR gene related products
- Overview of 145 available INSR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for INSR gene
Clone Products
- Sino Biological Human cDNA Clone for INSR
- VectorBuilder custom plasmid, inducible vectors for INSR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INSR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for INSR
- Applied Biological Materials Clones for INSR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for INSR (Insulin R/CD220)
Cell Line Products
-
Horizon Cell Lines for INSR
-
ViGene Biosciences adenoviral particle packaged cDNA for INSR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for INSR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for INSR gene
No data available for Transcription Factor Targets and HOMER Transcription for INSR Gene
Localization for INSR Gene
Subcellular locations from UniProtKB/Swiss-Prot for INSR Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 4 |
| mitochondrion | 1 |
| nucleus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | ISS | -- |
| GO:0005635 | colocalizes_with nuclear envelope | IDA | 19406747 |
| GO:0005886 | plasma membrane | TAS,IC | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 9092559 |
| GO:0005899 | insulin receptor complex | IMP | 15069075 |
Pathways & Interactions for INSR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | Regulation of lipid metabolism Insulin signaling-generic cascades |
.01
|
|
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | ERK Signaling |
.61
.58
|
.49
|
Pathways by source for INSR Gene
1 Sino Biological pathway for INSR Gene
1 GeneTex pathway for INSR Gene
17 BioSystems pathways for INSR Gene
26 Reactome pathways for INSR Gene
1 PharmGKB pathway for INSR Gene
20 KEGG pathways for INSR Gene
6 GeneGo (Thomson Reuters) pathways for INSR Gene
4 R&D Systems pathways for INSR Gene
5 Tocris pathways for INSR Gene
41 Qiagen pathways for INSR Gene
2 Cell Signaling Technology pathways for INSR Gene
Interacting Proteins for INSR Gene
Selected Interacting proteins:
ENSP00000303830
P06213-INSR_HUMAN
for INSR Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for INSR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IMP | 17001305 |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 7556070 |
| GO:0003007 | heart morphogenesis | IMP | 7693131 |
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IMP | 12881524 |
Drugs & Compounds for INSR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Insulin Aspart | Approved | Pharma | Target, agonist | 482 | ||
| Insulin Detemir | Approved | Pharma | Target, agonist | 214 | ||
| Insulin Glargine | Approved | Pharma | Target, agonist | 557 | ||
| Insulin-glulisine | Approved | Pharma | Target, agonist | 109 | ||
| Chromic chloride | Approved | Pharma | Target, activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Insulin (human) recombinant |
|
11061-68-0 |
|
|
||
| Picropodophyllotoxin |
|
477-47-4 |
|
|
(5) Tocris Compounds for INSR Gene
| Compound | Action | Cas Number |
|---|---|---|
| Demethylasterriquinone B1 | Selective insulin RTK activator | 78860-34-1 |
| GSK 1838705 | Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK) | 1116235-97-2 |
| Insulin (human) recombinant | Endogenous peptide agonist | 11061-68-0 |
| Picropodophyllotoxin | Selective IGF1R inhibitor | 477-47-4 |
| PQ 401 | IGF1R inhibitor | 196868-63-0 |
(7) ApexBio Compounds for INSR Gene
| Compound | Action | Cas Number |
|---|---|---|
| BMS-536924 | IR/IGF-1R inhibitor | 468740-43-4 |
| BMS-754807 | IGF-1R/InsR inhibitor,potent and selective | 1001350-96-4 |
| Demethylasterriquinone B1 | 78860-34-1 | |
| GSK1838705A | IGF-IR/IR/ALK inhibitor, ATP-competitive | 1116235-97-2 |
| GSK1904529A | Selective IGF-1R/IR inhibitor | 1089283-49-7 |
| HNGF6A | 1093111-54-6 | |
| Linsitinib | IGF1R/IR inhibitor,potent and novel | 867160-71-2 |
Transcripts for INSR Gene
mRNA/cDNA for INSR Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (343) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for INSR
- genomics-online: gRNA clones - Search results for 145 available INSR gene related products
- Overview of 145 available INSR gene related products
- Applied Biological Materials CRISPR for INSR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for INSR
- GenScript: Design CRISPR guide RNA sequences for INSR
miRNA Products
- Search ViGene Biosciences for INSR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for INSR
- Browse OriGene Inhibitory RNA Products For INSR
- genomics-online: shRNA clones - Search results for 145 available INSR gene related products
- Overview of 145 available INSR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for INSR gene
Clone Products
- Sino Biological Human cDNA Clone for INSR
- VectorBuilder custom plasmid, inducible vectors for INSR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for INSR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for INSR
- Applied Biological Materials Clones for INSR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for INSR (Insulin R/CD220)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
Expression for INSR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- 8-Cell Embryo Morula
- Blood (Hematopoietic System)
- Endothelium (Cardiovascular System)
- Brain (Nervous System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for INSR Gene
This gene is overexpressed in Pancreas (x4.2).
This gene is overexpressed in Plasma (10.2), Pancreas (9.9), and Placenta (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INSR Gene
NURSA nuclear receptor signaling pathways regulating expression of INSR Gene:
INSRSOURCE GeneReport for Unigene cluster for INSR Gene:
Hs.465744mRNA Expression by UniProt/SwissProt for INSR Gene:
P06213-INSR_HUMAN
Tissue specificity:
Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.
Evidence on tissue expression from TISSUES for INSR Gene
- Liver(4.5)
- Nervous system(4.4)
- Skin(4.3)
- Muscle(2.7)
- Pancreas(2.4)
- Lung(2.2)
- Blood(2)
- Spleen(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for INSR Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pituitary gland
- skull
- thyroid
- tooth
Thorax:
- breast
- chest wall
- clavicle
- heart
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- adrenal gland
- biliary tract
- gallbladder
- intestine
- kidney
- liver
- pancreas
Pelvis:
- fallopian tube
- ovary
- pelvis
- penis
- prostate
- testicle
- uterus
- vagina
- vas deferens
- vulva
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- sweat gland
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for INSR
- genomics-online: primer clones - Search results for 145 available INSR gene related products
- Overview of 145 available INSR gene related products
Gene Expression Assay Products
Orthologs for INSR Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | INSR 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | IR-A 34 |
|
OneToOne | |
| INSR 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | INSR 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Insr 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Insr 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | INSR 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | INSR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CTK-1 34 |
|
OneToOne | |
| INSR 33 |
|
||||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100492718 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398006 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | insra 33 34 |
|
||
| insrb 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8035 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | InR 35 |
|
|
|
| CG3837 35 34 |
|
||||
| CG10702 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | W02A2.4 35 |
|
|
|
| K09B11.5 35 |
|
|
|||
| T21G5.1 35 |
|
|
|||
| T25B9.5 35 |
|
|
|||
| Y69E1A.3 35 |
|
|
|||
| daf-2 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for INSR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for INSR Gene
Paralogs for INSR Gene
(23) SIMAP similar genes for INSR Gene using alignment to 3 proteins:
Variants for INSR Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1018733945 | uncertain-significance, Pineal hyperplasia AND diabetes mellitus syndrome, Leprechaunism syndrome, Insulin-resistant diabetes mellitus AND acanthosis nigricans | 7,115,089(-) | C/T | 3_prime_UTR_variant | |
| rs1036149778 | uncertain-significance, Pineal hyperplasia AND diabetes mellitus syndrome, Leprechaunism syndrome, Insulin-resistant diabetes mellitus AND acanthosis nigricans | 7,114,920(-) | A/T | 3_prime_UTR_variant | |
| rs10413914 | likely-benign, Insulin-resistant diabetes mellitus AND acanthosis nigricans, Leprechaunism syndrome, Pineal hyperplasia AND diabetes mellitus syndrome | 7,112,454(-) | G/A | 3_prime_UTR_variant | |
| rs10415841 | benign, Insulin-resistant diabetes mellitus AND acanthosis nigricans, Pineal hyperplasia AND diabetes mellitus syndrome, Leprechaunism syndrome | 7,112,262(-) | A/G | 3_prime_UTR_variant | |
| rs10416396 | benign, Leprechaunism syndrome, Insulin-resistant diabetes mellitus AND acanthosis nigricans, Pineal hyperplasia AND diabetes mellitus syndrome | 7,112,838(-) | C/G | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
3.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.60;
44.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for INSR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSR Gene
Disorders for INSR Gene
(28) MalaCards diseases for INSR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| donohue syndrome |
|
|
| pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
|
|
| hyperinsulinemic hypoglycemia, familial, 5 |
|
|
| diabetes mellitus, insulin-resistant, with acanthosis nigricans |
|
|
| insulin-resistant acanthosis nigricans, type a |
|
|
Search INSR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
INSR_HUMAN- Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:1470163, ECO:0000269 PubMed:1607076, ECO:0000269 PubMed:7657032}. Note=The gene represented in this entry may be involved in disease pathogenesis.
- Familial hyperinsulinemic hypoglycemia 5 (HHF5) [MIM:609968]: Familial hyperinsulinemic hypoglycemia [MIM:256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. {ECO:0000269 PubMed:15161766}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A) [MIM:610549]: Characterized by the association of severe insulin resistance (manifested by marked hyperinsulinemia and a failure to respond to exogenous insulin) with the skin lesion acanthosis nigricans and ovarian hyperandrogenism in adolescent female subjects. Women frequently present with hirsutism, acne, amenorrhea or oligomenorrhea, and virilization. This syndrome is different from the type B that has been demonstrated to be secondary to the presence of circulating autoantibodies against the insulin receptor. {ECO:0000269 PubMed:10733238, ECO:0000269 PubMed:11260230, ECO:0000269 PubMed:12107746, ECO:0000269 PubMed:12970295, ECO:0000269 PubMed:1563582, ECO:0000269 PubMed:1963473, ECO:0000269 PubMed:2002058, ECO:0000269 PubMed:2168397, ECO:0000269 PubMed:2365819, ECO:0000269 PubMed:2544998, ECO:0000269 PubMed:28765322, ECO:0000269 PubMed:3283938, ECO:0000269 PubMed:8243830, ECO:0000269 PubMed:8288049, ECO:0000269 PubMed:8314008, ECO:0000269 PubMed:8388389, ECO:0000269 PubMed:9175790}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Leprechaunism (LEPRCH) [MIM:246200]: Represents the most severe form of insulin resistance syndrome, characterized by intrauterine and postnatal growth retardation and death in early infancy. Inheritance is autosomal recessive. {ECO:0000269 PubMed:12023989, ECO:0000269 PubMed:12538626, ECO:0000269 PubMed:12970295, ECO:0000269 PubMed:1607067, ECO:0000269 PubMed:1730625, ECO:0000269 PubMed:22768670, ECO:0000269 PubMed:2365819, ECO:0000269 PubMed:24498630, ECO:0000269 PubMed:2479553, ECO:0000269 PubMed:2834824, ECO:0000269 PubMed:28765322, ECO:0000269 PubMed:7538143, ECO:0000269 PubMed:7815442, ECO:0000269 PubMed:8188715, ECO:0000269 PubMed:8326490, ECO:0000269 PubMed:8419945, ECO:0000269 PubMed:8636294, ECO:0000269 PubMed:9249867, ECO:0000269 PubMed:9299395, ECO:0000269 PubMed:9703342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Rabson-Mendenhall syndrome (RMS) [MIM:262190]: Severe insulin resistance syndrome characterized by insulin-resistant diabetes mellitus with pineal hyperplasia and somatic abnormalities. Typical features include coarse, senile-appearing facies, dental and skin abnormalities, abdominal distension, and phallic enlargement. Inheritance is autosomal recessive. {ECO:0000269 PubMed:10443650, ECO:0000269 PubMed:12023989, ECO:0000269 PubMed:17201797, ECO:0000269 PubMed:2121734, ECO:0000269 PubMed:2365819, ECO:0000269 PubMed:28765322, ECO:0000269 PubMed:8314008}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for INSR Gene
insulin resistance,type A (hyperinsulinemia,decreased insulin binding,acanthocytosis)
Additional Disease Information for INSR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for INSR Gene
- Insulin resistance-related genes and advanced left-sided colorectal adenoma. (PMID: 17416760) Gunter MJ … Peters U (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 22 44 58
- Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. (PMID: 16831875) Slaaby R … Brandt J (The Journal of biological chemistry 2006) 3 4 22 58
- Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. (PMID: 16271887) Li S … Hubbard SR (Structure (London, England : 1993) 2005) 3 4 22 58
- [Correlation between single nucleotide polymorphism of insulin receptor gene with polycystic ovary syndrome]. (PMID: 15498182) Chen ZJ … Chang ZH (Zhonghua fu chan ke za zhi 2004) 3 22 44 58
- Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. (PMID: 10803466) Kasus-Jacobi A … Burnol AF (Oncogene 2000) 3 4 22 58
Products for INSR Gene
- R&D Systems Antibodies for INSR (Insulin R/CD220)
- R&D Systems Proteins and Enzymes for INSR (Insulin R/CD220)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for INSR (Insulin R/CD220)
- R&D Systems cDNA Clones for INSR (Insulin R/CD220)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- OriGene Antibodies for INSR