Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INSL6 Gene

Aliases for INSL6 Gene

  • Insulin Like 6 2 3 5
  • Relaxin/Insulin-Like Factor 1 2 3 4
  • Insulin-Like Peptide 6 3 4
  • RIF1 3 4
  • Insulin-Like Peptide INSL6 3
  • Insulin-Like Peptide 5 3
  • Insulin-Like 6 2

External Ids for INSL6 Gene

Previous GeneCards Identifiers for INSL6 Gene

  • GC09M005317
  • GC09M005145
  • GC09M005153
  • GC09M005119
  • GC09M005163
  • GC09M005141

Summaries for INSL6 Gene

Entrez Gene Summary for INSL6 Gene

  • The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]

GeneCards Summary for INSL6 Gene

INSL6 (Insulin Like 6) is a Protein Coding gene. Diseases associated with INSL6 include Thrombocythemia 3 and Lymphoblastic Leukemia, Acute, With Lymphomatous Features. Gene Ontology (GO) annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for INSL6 Gene

  • May have a role in sperm development and fertilization.

Additional gene information for INSL6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INSL6 Gene

Genomics for INSL6 Gene

GeneHancer (GH) Regulatory Elements for INSL6 Gene

Promoters and enhancers for INSL6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J005186 Enhancer 0.6 ENCODE 650.7 -0.9 -906 0.2 SCRT1 CTCF ZNF654 REST ETV5 RAD21 ZNF664 CTBP1 GATA3 SCRT2 INSL6 INSL4 PLGRKT ENSG00000237553
GH09J005185 Promoter 0.5 EPDnew 650.7 +0.1 51 0.1 INSL6 PIR39847
GH09J005086 Enhancer 0.3 FANTOM5 1.3 +99.4 99430 0.4 GC09M005128 PDSS1P1 JAK2 INSL4 CD274 INSL6 CDC37L1 MTND6P5
GH09J004996 Promoter 0.5 EPDnew 0.1 +188.8 188821 0.1 JAK2 CSNK1G2P1 GC09M004845 INSL6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INSL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INSL6 gene promoter:
  • LHX3b
  • Lhx3a
  • E2F-1
  • E2F
  • IRF-7A
  • CUTL1
  • Pax-2b
  • Pax-2a
  • Pax-2
  • Pax-4a

Genomic Locations for INSL6 Gene

Genomic Locations for INSL6 Gene
193,762 bases
Minus strand
53,690 bases
Minus strand

Genomic View for INSL6 Gene

Genes around INSL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INSL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INSL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INSL6 Gene

Proteins for INSL6 Gene

  • Protein details for INSL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like peptide INSL6
    Protein Accession:
    Secondary Accessions:
    • A0AVS0
    • Q9NS16

    Protein attributes for INSL6 Gene

    213 amino acids
    Molecular mass:
    24860 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INSL6 Gene

Post-translational modifications for INSL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INSL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INSL6 Gene

Domains & Families for INSL6 Gene

Gene Families for INSL6 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for INSL6 Gene

Suggested Antigen Peptide Sequences for INSL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the insulin family.
  • Belongs to the insulin family.
genes like me logo Genes that share domains with INSL6: view

Function for INSL6 Gene

Molecular function for INSL6 Gene

UniProtKB/Swiss-Prot Function:
May have a role in sperm development and fertilization.
GENATLAS Biochemistry:
insulin-like 6,expressed in the testis

Phenotypes From GWAS Catalog for INSL6 Gene

Gene Ontology (GO) - Molecular Function for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity NAS 10598589
genes like me logo Genes that share ontologies with INSL6: view
genes like me logo Genes that share phenotypes with INSL6: view

Animal Models for INSL6 Gene

MGI Knock Outs for INSL6:

Animal Model Products

  • Taconic Biosciences Mouse Models for INSL6

miRNA for INSL6 Gene

miRTarBase miRNAs that target INSL6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSL6 Gene

Localization for INSL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INSL6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INSL6 gene
Compartment Confidence
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with INSL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INSL6 Gene

Pathways & Interactions for INSL6 Gene

SuperPathways for INSL6 Gene

No Data Available

Interacting Proteins for INSL6 Gene

Gene Ontology (GO) - Biological Process for INSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with INSL6: view

No data available for Pathways by source and SIGNOR curated interactions for INSL6 Gene

Drugs & Compounds for INSL6 Gene

No Compound Related Data Available

Transcripts for INSL6 Gene

mRNA/cDNA for INSL6 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for INSL6 Gene

Insulin-like 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INSL6 Gene

No ASD Table

Relevant External Links for INSL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INSL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INSL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INSL6 Gene

This gene is overexpressed in Testis (x47.1).

Protein differential expression in normal tissues from HIPED for INSL6 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INSL6 Gene

Protein tissue co-expression partners for INSL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INSL6 Gene:


SOURCE GeneReport for Unigene cluster for INSL6 Gene:


mRNA Expression by UniProt/SwissProt for INSL6 Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with INSL6: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for INSL6 Gene

Orthologs for INSL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INSL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INSL6 34 33
  • 99.06 (n)
(Canis familiaris)
Mammalia INSL6 34 33
  • 80.16 (n)
(Bos Taurus)
Mammalia INSL6 34 33
  • 79.23 (n)
(Mus musculus)
Mammalia Insl6 16 34 33
  • 67.64 (n)
(Rattus norvegicus)
Mammalia Insl6 33
  • 65.1 (n)
Species where no ortholog for INSL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INSL6 Gene

Gene Tree for INSL6 (if available)
Gene Tree for INSL6 (if available)
Evolutionary constrained regions (ECRs) for INSL6: view image

Paralogs for INSL6 Gene

No data available for Paralogs for INSL6 Gene

Variants for INSL6 Gene

Sequence variations from dbSNP and Humsavar for INSL6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1038207109 uncertain-significance, Budd-Chiari syndrome 5,128,176(-) TTACTTTA/TTACTTTACTTTA genic_downstream_transcript_variant, intron_variant
rs1057515592 uncertain-significance, Budd-Chiari syndrome 5,069,165(-) T/C genic_downstream_transcript_variant, intron_variant
rs1057515594 uncertain-significance, Budd-Chiari syndrome 5,126,880(-) ATTATTAT/ATTAT genic_downstream_transcript_variant, intron_variant
rs1057515595 uncertain-significance, Budd-Chiari syndrome 5,127,908(-) T/C genic_downstream_transcript_variant, intron_variant
rs1057515597 uncertain-significance, Budd-Chiari syndrome 5,128,079(-) T/TGT genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INSL6 Gene

Variant ID Type Subtype PubMed ID
dgv2127e212 CNV gain 25503493
dgv7384n100 CNV gain 25217958
esv2764165 CNV gain+loss 21179565
esv3619370 CNV loss 21293372
nsv466100 CNV gain 19166990
nsv525777 CNV loss 19592680
nsv527495 CNV gain 19592680
nsv613178 CNV gain 21841781
nsv613179 CNV gain 21841781
nsv613180 CNV loss 21841781
nsv831495 CNV loss 17160897

Variation tolerance for INSL6 Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INSL6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL6 Gene

Disorders for INSL6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for INSL6 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search INSL6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INSL6

genes like me logo Genes that share disorders with INSL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INSL6 Gene

Publications for INSL6 Gene

  1. Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and rat. (PMID: 10819760) Lok S … Jaspers SR (Biology of reproduction 2000) 2 3 4 22 58
  2. Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. (PMID: 10598589) Hsu SY (Molecular endocrinology (Baltimore, Md.) 1999) 3 4 22 58
  3. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PMID: 19915573) Asano K … Kubo M (Nature genetics 2009) 3 44 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for INSL6 Gene

Sources for INSL6 Gene

Loading form....